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Significant grey matter changes in a region of the orbitofrontal cortex in healthy participants predicts emotional dysregulation

Social Cognitive and Affective Neuroscience, Jun 30, Predrag Petrovic, Carl Johan Ekman, Johanna Klahr, et al.

The traditional concept of ‘categorical’ psychiatric disorders has been challenged as many of the symptoms display a continuous distribution in the general population. We suggest that this is the case for emotional dysregulation, a key component in several categorical psychiatric disorder constructs. We used voxel-based magnetic resonance imaging morphometry in healthy human ...

Towards Consensus Gene Ages

Genome Biology and Evolution, Jun 01, Benjamin J. Liebeskind, Claire D. McWhite, Edward M. Marcotte

Correctly estimating the age of a gene or gene family is important for a variety of fields, including molecular evolution, comparative genomics, and phylogenetics, and increasingly for systems biology and disease genetics. However, most studies use only a point estimate of a gene’s age, neglecting the substantial uncertainty involved in this estimation. Here, we characterize this ...

Academic Librarians in Data Information Literacy Instruction: A Case Study in Meteorology

College & Research Libraries, Jun 29, Emily P. Frank, Nils Pharo

E-science has reshaped meteorology due to the rate data is generated, collected, analyzed, and stored and brought data skills to a new prominence. Data information literacy—the skills needed to understand, use, manage, share, work with, and produce data—reflects the confluence of data skills with information literacy competencies. This research assessed perceptions of data ...

How Bad Is It? Usefulness of the "7eed Model" for Scoring Severity and Level of Need in Complex Emergencies

PLOS Currents: Disasters, Jun 28, Anneli Eriksson, Martin Gerdin, Richard Garfield, et al.

Background: Humanitarian assistance is designated to save lives and alleviate suffering among people affected by disasters. In 2014, close to 25 billion USD was allocated to humanitarian assistance, more than 80% of it from governmental donors and EU institutions. Most of these funds are devoted to Complex Emergencies (CE). It is widely accepted that the needs of the affected ...

The Unicellular Ancestry of Groucho-Mediated Repression and the Origins of Metazoan Transcription Factors

Genome Biology and Evolution, Jun 01, Richard R. Copley

Groucho is a co-repressor that interacts with many transcription factors playing a crucial role in animal development. The evolutionary origins of Groucho are not clear. It is generally regarded as being a distinct animal-specific protein, although with similarities to the yeast Tup-like proteins. Here, it is shown that Groucho has true orthologs in unicellular relatives of ...

The Role of Transcription Factors at Antisense-Expressing Gene Pairs in Yeast

Genome Biology and Evolution, Jun 01, Yulia Mostovoy, Alexander Thiemicke, Tiffany Y. Hsu, et al.

Genes encoded close to one another on the chromosome are often coexpressed, by a mechanism and regulatory logic that remain poorly understood. We surveyed the yeast genome for tandem gene pairs oriented tail-to-head at which expression antisense to the upstream gene was conserved across species. The intergenic region at most such tandem pairs is a bidirectional promoter, shared by ...

Using Bibliometrics to Demonstrate the Value of Library Journal Collections

College & Research Libraries, Jun 29, Christopher W. Belter, Neal K. Kaske

Although cited reference studies are common in the library and information science literature, they are rarely performed in nonacademic institutions or in the atmospheric and oceanic sciences. In this paper, we analyze more than 400,000 cited references made by authors affiliated with the National Oceanic and Atmospheric Administration between 2009 and 2013. Our results suggest ...

Biomechanical Comparison of Single- and Double-Leg Jump Landings in the Sagittal and Frontal Plane

Orthopaedic Journal of Sports Medicine, Jun 01, Jeffrey B. Taylor, Kevin R. Ford, Anh-Dung Nguyen, et al.

Background: Double-leg forward or drop-jump landing activities are typically used to screen for high-risk movement strategies and to determine the success of neuromuscular injury prevention programs. However, research suggests that these tasks that occur primarily in the sagittal plane may not adequately represent the lower extremity biomechanics that occur during unilateral foot ...

Genome Sequencing of the Phytoseiid Predatory Mite Metaseiulus occidentalis Reveals Completely Atomized Hox Genes and Superdynamic Intron Evolution

Genome Biology and Evolution, Jun 01, Marjorie A. Hoy, Robert M. Waterhouse, Ke Wu, et al.

Metaseiulus occidentalis is an eyeless phytoseiid predatory mite employed for the biological control of agricultural pests including spider mites. Despite appearances, these predator and prey mites are separated by some 400 Myr of evolution and radically different lifestyles. We present a 152-Mb draft assembly of the M. occidentalis genome: Larger than that of its favored prey, ...

Comparative Expression Dynamics of Intergenic Long Noncoding RNAs in the Genus Drosophila

Genome Biology and Evolution, Jun 01, Kevin G. Nyberg, Carlos A. Machado

Thousands of long noncoding RNAs (lncRNAs) have been annotated in eukaryotic genomes, but comparative transcriptomic approaches are necessary to understand their biological impact and evolution. To facilitate such comparative studies in Drosophila, we identified and characterized lncRNAs in a second Drosophilid—the evolutionary model Drosophila pseudoobscura. Using RNA-Seq and ...

Heroes and Holidays: The Status of Diversity Initiatives at Liberal Arts College Libraries

College & Research Libraries, Jun 29, Julie Gilbert

Studies about diversity initiatives in academic libraries have primarily focused on large research libraries. But what kinds of diversity work occur at smaller libraries? This study examines the status of diversity initiatives, especially those aimed at students, at national liberal arts college libraries. Results from a survey of library directors reveal that, while diversity ...

Plastid–Nuclear Interaction and Accelerated Coevolution in Plastid Ribosomal Genes in Geraniaceae

Genome Biology and Evolution, Jun 01, Mao-Lun Weng, Tracey A. Ruhlman, Robert K. Jansen

Plastids and mitochondria have many protein complexes that include subunits encoded by organelle and nuclear genomes. In animal cells, compensatory evolution between mitochondrial and nuclear-encoded subunits was identified and the high mitochondrial mutation rates were hypothesized to drive compensatory evolution in nuclear genomes. In plant cells, compensatory evolution between ...

Strategies for Success: Open Access Policies at North American Educational Institutions

College & Research Libraries, Jun 29, Christine Fruin, Shan Sutton

Recognizing the paucity of quantitative and qualitative data from North American educational institutions that have pursued open access policies, the authors devised a survey to collect information on the characteristics of these institutions, as well as the elements of the open access policies, the methods of promoting these policies, faculty concerns about the policies, and how ...

Highlight—Tiny, Unseeing Mite Defies Expectations

Genome Biology and Evolution, Jun 01, Danielle Venton

Socio-demographic Predictors for Urban Community Disaster Health Risk Perception and Household Based Preparedness in a Chinese Urban City

PLOS Currents: Disasters, Jun 27, Emily YY Chan, Janice Yue, Poyi Lee, et al.

Objectives: There is limited evidence on urban Asian communities' disaster risk perceptions and household level preparedness. Hong Kong is characterized by high population density, and is susceptible to large-scale natural disasters and health crises such as typhoons, fires and infectious disease outbreaks. This research paper investigates the rates and predictors of urban ...

Analysis of the Tibial Epiphysis in the Skeletally Immature Knee Using Magnetic Resonance Imaging: An Update of Anatomic Parameters Pertinent to Physeal-Sparing Anterior Cruciate Ligament Reconstruction

Orthopaedic Journal of Sports Medicine, Jun 01, Derik L. Davis, Ranyah Almardawi, Jason W. Mitchell

Background: Physeal-sparing anterior cruciate ligament (ACL) reconstruction is being performed increasingly in skeletally immature knees.

Horizontal Gene Transfer Contributes to the Evolution of Arthropod Herbivory

Genome Biology and Evolution, Jun 01, Nicky Wybouw, Yannick Pauchet, David G. Heckel, et al.

Within animals, evolutionary transition toward herbivory is severely limited by the hostile characteristics of plants. Arthropods have nonetheless counteracted many nutritional and defensive barriers imposed by plants and are currently considered as the most successful animal herbivores in terrestrial ecosystems. We gather a body of evidence showing that genomes of various plant ...

Building Virtually Free Subject Area Expertise through Social Media: An Exploratory Study

College & Research Libraries, Jun 29, Brian K. Kooy

Central to the ongoing success of the liaison model is the need for liaison librarians to stay informed and up-to-date about recent developments in the subject areas of their assigned academic departments and programs. This article describes an exploratory study conducted to determine whether information obtained from the social media accounts of discipline-based scholarly ...

Comparative Genomics Uncovers Unique Gene Turnover and Evolutionary Rates in a Gene Family Involved in the Detection of Insect Cuticular Pheromones

Genome Biology and Evolution, Jun 01, Montserrat Torres-Oliva, Francisca C. Almeida, Alejandro Sánchez-Gracia, et al.

Chemoreception is an essential process for the survival and reproduction of animals. Many of the proteins responsible for recognizing and transmitting chemical stimuli in insects are encoded by genes that are members of moderately sized multigene families. The members of the CheB family are specialized in gustatory-mediated detection of long-chain hydrocarbon pheromones in ...

Birth of Four Chimeric Plastid Gene Clusters in Japanese Umbrella Pine

Genome Biology and Evolution, Jun 01, Chih-Yao Hsu, Chung-Shien Wu, Shu-Miaw Chaw

Many genes in the plastid genomes (plastomes) of plants are organized as gene clusters, in which genes are co-transcribed, resembling bacterial operons. These plastid operons are highly conserved, even among conifers, whose plastomes are highly rearranged relative to other seed plants. We have determined the complete plastome sequence of Sciadopitys verticillata (Japanese umbrella ...

“Are You a Computer?” Opening Exchanges in Virtual Reference Shape the Potential for Teaching

College & Research Libraries, Jun 29, Paula R. Dempsey

Academic reference librarians frequently work with students who are not aware of their professional roles. In online interactions, a student might not even realize that the librarian is a person. The ways students initiate conversations reveal their understanding of the mutual roles involved in reference encounters. Conversation analysis of live chat transcripts at two institutions ...

Revisiting the Plastid Phylogenomics of Pinaceae with Two Complete Plastomes of Pseudolarix and Tsuga

Genome Biology and Evolution, Jun 01, Edi Sudianto, Chung-Shien Wu, Ching-Ping Lin, et al.

Phylogeny of the ten Pinaceous genera has long been contentious. Plastid genomes (plastomes) provide an opportunity to resolve this problem because they contain rich evolutionary information. To comprehend the plastid phylogenomics of all ten Pinaceous genera, we sequenced the plastomes of two previously unavailable genera, Pseudolarix amabilis (122,234 bp) and Tsuga chinensis ...

Return to Sport After Operative Management of Osteochondritis Dissecans of the Capitellum: A Systematic Review and Meta-analysis

Orthopaedic Journal of Sports Medicine, Jun 01, Robert W. Westermann, Kyle J. Hancock, Joseph A. Buckwalter, et al.

Background: Capitellar osteochondritis dissecans (OCD) is commonly managed surgically in symptomatic adolesent throwers and gymnasts. Little is known about the impact that surgical technique has on return to sport.

Strategic Planning for a Data-Driven, Shared-Access Research Enterprise: Virginia Tech Research Data Assessment and Landscape Study

College & Research Libraries, Jun 29, Yi Shen

The data landscape study at Virginia Tech addresses the changing modes of faculty scholarship and supports the development of a user-centric data infrastructure, management, and curation system. The study investigates faculty researchers’ current practices in organizing, describing, and preserving data and the emerging needs for services and education. The results demonstrate the ...

Major Chromosomal Rearrangements Distinguish Willow and Poplar After the Ancestral “Salicoid” Genome Duplication

Genome Biology and Evolution, Jun 01, Jing Hou, Ning Ye, Zhongyuan Dong, et al.

Populus (poplar) and Salix (willow) are sister genera in the Salicaceae family. In both lineages extant species are predominantly diploid. Genome analysis previously revealed that the two lineages originated from a common tetraploid ancestor. In this study, we conducted a syntenic comparison of the corresponding 19 chromosome members of the poplar and willow genomes. Our ...

Apropiación educativa de la cultura en los medios: ciudadanía digital / Educational appropriation of culture in the media: digital citizenship

RELATEC: Latin American Journal of Educational Technology, Jun 27, Elvira Molina Fernández, José Miguel Gutiérrez Pequeño (Coords.)

Este monográfico recoge reflexiones teóricas, experiencias aplicadas e investigaciones que muestran formas diferentes de estar en los medios, de ser y de hacer ciudadanía digital. Contribuciones desde la Red Universitaria de Investigación e Innovación Educativa. Cambios Sociales y Retos para la Educación en la Era Digital (REUNID+D) a través de un proyecto financiado por el ...

The Spirit of Invention

MTZ worldwide, Jun 27, Dipl.-Journ. (FH) Martin Westerhoff

Safety Evaluation of CNS Administered Biologics—Study Design, Data Interpretation, and Translation to the Clinic

Toxicological Sciences, Jun 27, Brian R. Vuillemenot, Sven Korte, Teresa L. Wright, et al.

Many central nervous system (CNS) diseases are inadequately treated by systemically administered therapies due to the blood brain barrier (BBB), which prevents achieving adequate drug concentrations at sites of action. Due to the increasing prevalence of neurodegenerative diseases and the inability of most systemically administered therapies to cross the BBB, direct CNS delivery ...

Beta-blockers in septic shock to optimize hemodynamics? Yes

Intensive Care Medicine, Jun 27, Daniel A. Reuter, James A. Russell, Armand Mekontso Dessap

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues

Toxicological Sciences, Jun 27, Stephanie M. Ravenscroft, Amy Pointon, Awel W. Williams, et al.

The immature phenotype of stem cell derived cardiomyocytes is a significant barrier to their use in translational medicine and pre-clinical in vitro drug toxicity and pharmacological analysis. Here we have assessed the contribution of non-myocyte cells on the contractile function of co-cultured human embryonic stem cell derived cardiomyocytes (hESC-CMs) in spheroid microtissue ...

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