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Single chest tube drainage is superior to double chest tube drainage after lobectomy: a meta-analysis

Journal of Cardiothoracic Surgery, May 27, Dong Zhou, Xu-Feng Deng, Quan-Xing Liu, et al.

Background In this meta-analysis, we conducted a pooled analysis of clinical studies comparing the efficacy of single chest tube versus double chest tube after a lobectomy. Methods According to the recommendations of the Cochrane Collaboration, we established a rigorous study protocol. We performed a systematic electronic search of the PubMed, Embase, Cochrane Library and Web of ...

Encouraging impact following 2.5 years of reinforced malaria control interventions in a hyperendemic region of the Republic of Guinea

Malaria Journal, May 28, Amanda Tiffany, Faya Moundekeno, Alexis Traoré, et al.

Background Malaria is one of the principal causes of morbidity and mortality in the Republic of Guinea, particularly in the highly endemic regions. To assist in malaria control efforts, a multi-component malaria control intervention was implemented in the hyperendemic region of Guéckédou Prefecture. The coverage of the intervention and its impact on malaria parasite prevalence were ...

Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge

Journal of Neuroinflammation, May 27, Jennifer Parrott, Laney Redus, Jason O’Connor

Background Inflammation increases the risk of developing depression-related symptoms, and tryptophan metabolism is an important mediator of these behavior changes. Peripheral immune activation results in central up-regulation of pro-inflammatory cytokine expression, microglia activation, and the production of neurotoxic kynurenine metabolites. The neuroinflammatory and kynurenine ...

Engineering Escherichia coli for production of 4-hydroxymandelic acid using glucose–xylose mixture

Microbial Cell Factories, May 27, Fei-Fei Li, Ying Zhao, Bing-Zhi Li, et al.

Background 4-Hydroxymandelic acid (4-HMA) is a valuable aromatic fine chemical and widely used for production of pharmaceuticals and food additives. 4-HMA is conventionally synthesized by chemical condensation of glyoxylic acid with excessive phenol, and the process is environmentally unfriendly. Microbial cell factory would be an attractive approach for 4-HMA production from ...

Detection of Plasmodium using filter paper and nested PCR for patients with malaria in Sanliurfa, in Turkey

Malaria Journal, May 28, Nebiye Yentur Doni, Fadile Yildiz Zeyrek, Adnan Seyrek

Background The objective of this study to detect Plasmodium and a subspecies of Plasmodium using filter paper in malaria endemic province, Sanliurfa, in Turkey, compare the results of nested PCR (nPCR) with microscopy for the diagnosis of malaria and present the epidemiological data of malaria. Methods This study was carried out in malaria-endemic Sanliurfa between 2008 and 2011. ...

Intracellular delivery of messenger RNA by recombinant PP7 virus-like particles carrying low molecular weight protamine

BMC Biotechnology, May 28, Yanli Sun, Yanhua Sun, Ronglan Zhao, et al.

Background Cell-penetrating peptides (CPPs) have been widely used as carriers to transport different molecules into living cells, whereas messenger RNAs (mRNAs) have been utilized as target molecules for the prevention and treatment of various diseases. However, the instability of CPPs and mRNAs has limited their application. Bacteriophage PP7 virus-like particles (VLPs) may ...

Prognostic impact of high levels of circulating plasmacytoid dendritic cells in breast cancer

Journal of Translational Medicine, May 28, Jithendra Kini Bailur, Brigitte Gueckel, Graham Pawelec

Background Identifying immune markers in blood that are informative for breast cancer patient survival would not only be useful for prognosis but might also provide mechanistic insights into processes facilitating survival. Methods We phenotyped circulating plasmacytoid dendritic cells (pDCs), myeloid-derived suppressor cells (MDSCs) and regulatory T-cells in relation to T-cell ...

Safety and efficacy of vernakalant for the conversion of atrial fibrillation to sinus rhythm; a phase 3b randomized controlled trial

BMC Cardiovascular Disorders, May 28, Gregory Beatch, Brian Mangal

Background Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with significant health risks. One strategy to mitigate the risks associated with long-term AF is to convert AF to sinus rhythm (SR). This study assessed the efficacy and safety of vernakalant hydrochloride for the pharmacological conversion of AF to SR. Methods Patients with recent-onset ...

SLCO1B1*5 polymorphism (rs4149056) is associated with chemotherapy-induced amenorrhea in premenopausal women with breast cancer: a prospective cohort study

BMC Cancer, May 27, Toralf Reimer, Sarah Kempert, Bernd Gerber, et al.

Background Because inheritance is recognized as playing a role in age at menarche and natural menopause, the development of chemotherapy-induced amenorrhea (CIA) might depend on inherited genetic factors; however, studies that explore such a correlation are few and have received scant attention. Given the importance of this topic we conducted a comprehensive genotype study in young ...

Strengthening individual capacity in monitoring and evaluation of malaria control programmes to streamline M&E systems and enhance information use in malaria endemic countries

Malaria Journal, May 28, Ashley Garley, Erin Eckert, Ali Sie, et al.

Background Malaria control interventions in most endemic countries have intensified in recent years and so there is a need for a robust monitoring and evaluation (M&E) system to measure progress and achievements. Providing programme and M&E officers with the appropriate skills is a way to strengthen malaria’s M&E systems and enhance information use for programmes’ implementation. ...

Centrosome associated genes pattern for risk sub-stratification in multiple myeloma

Journal of Translational Medicine, May 28, Fedor Kryukov, Pavel Nemec, Lenka Radova, et al.

Background The genome of multiple myeloma (MM) cells is extremely unstable, characterized by a complex combination of structure and numerical abnormalities. It seems that there are several “myeloma subgroups” which differ in expression profile, clinical manifestations, prognoses and treatment response. In our previous work, the list of 35 candidate genes with a known role in ...

Retraction Note: Effects of replacing groundnut cake with rumen content supplemented with or without enzyme in the diet of weaner rabbits

Lipids in Health and Disease, May 27, A. Adeniji, S. Rumak, R. Oluwafemi

Automatic learning of pre-miRNAs from different species

BMC Bioinformatics, May 28, Ivani O. N. Lopes, Alexander Schliep, André de L. F. de Carvalho

Background Discovery of microRNAs (miRNAs) relies on predictive models for characteristic features from miRNA precursors (pre-miRNAs). The short length of miRNA genes and the lack of pronounced sequence features complicate this task. To accommodate the peculiarities of plant and animal miRNAs systems, tools for both systems have evolved differently. However, these tools are biased ...

Selection of oleaginous yeasts for fatty acid production

BMC Biotechnology, May 27, Dennis Lamers, Nick van Biezen, Dirk Martens, et al.

Background Oleaginous yeast species are an alternative for the production of lipids or triacylglycerides (TAGs). These yeasts are usually non-pathogenic and able to store TAGs ranging from 20 % to 70 % of their cell mass depending on culture conditions. TAGs originating from oleaginous yeasts can be used as the so-called second generation biofuels, which are based on non-food ...

Asymptomatic Plasmodium infections in 18 villages of southern Savannakhet Province, Lao PDR (Laos)

Malaria Journal, May 27, Koukeo Phommasone, Bipin Adhikari, Gisela Henriques, et al.

Background A large fraction of Plasmodium infections do not cause clinical signs and symptoms of disease and persist at densities in blood that are not detectable by microscopy or rapid diagnostic tests. These infections may be critical as a transmission reservoir in areas of low malaria endemicity. Understanding the epidemiology of these infections would be helpful for malaria ...

Proteomic analysis of short-term preload-induced eccentric cardiac hypertrophy

Journal of Translational Medicine, May 27, Belal Mohamed, Abdul Asif, Moritz Schnelle, et al.

Background Hemodynamic load leads to cardiac hypertrophy and heart failure. While afterload (pressure overload) induces concentric hypertrophy, elevation of preload (volume overload) yields eccentric hypertrophy and is associated with a better outcome. Here we analysed the proteomic pattern of mice subjected to short-term preload. Methods and Results Female FVB/N mice were ...

Geometrical and functional changes of left heart in adults with prehypertension and hypertension: a cross-sectional study from China

BMC Cardiovascular Disorders, May 28, Tan Li, Jun Yang, Xiaofan Guo, et al.

Background Studies regarding the association between prehypertension and the structual changes of left heart are scanty. However, which type of the geometrical change of left heart is predominated one in prehypertension and hypertension is controversial. It is therefore important to investigate geometrical and functional changes of left heart in adults with prehypertension and ...

Suresh C. Ameta and Rakshit Ameta (Eds.): Solar Energy Conversion and Storage. Photochemical Modes

Chromatographia, May 28, Ken Jones

Transition to practice: can rural interprofessional education make a difference? A cohort study

BMC Medical Education, May 28, Susan Pullon, Christine Wilson, Peter Gallagher, et al.

Background The transition from student to health practitioner at entry-to-practice is complex, requiring critical acquisition of collaborative practice skills. In rural communities where health need is multidimensional, there is potential for multiple intentional collaborative learning objectives to be met concurrently. A five-week, rurally-located, clinically-based ...

Comprehensive analyses of the annexin gene family in wheat

BMC Genomics, May 28, Lei Xu, Yimiao Tang, Shiqing Gao, et al.

Background Annexins are an evolutionarily conserved multigene family of calcium-dependent phospholipid binding proteins that play important roles in stress resistance and plant development. They have been relatively well characterized in model plants Arabidopsis (Arabidopsis thaliana) and rice (Oryza sativa), but nothing has been reported in hexaploid bread wheat (Triticum ...

Fecal microbiota transplantation for severe clostridium difficile infection after left ventricular assist device implantation: a case control study and concise review on the local and regional therapies

BMC Infectious Diseases, May 27, Zeina Berro, Righab Hamdan, Israa Dandache, et al.

Background We report herein a case of fecal microbiota transplantation (FMT) used for severe Clostridium difficile infection for a 65-year-old Lebanese man who underwent left ventricular assist device implantation. To the best of our knowledge this is the first case report from Lebanon and the region presenting such technique. Case presentation The patient experienced diarrhea and ...

The transcriptome of metamorphosing flatfish

BMC Genomics, May 27, Ricardo Alves, Ana Gomes, Kurt Stueber, et al.

Background Flatfish metamorphosis denotes the extraordinary transformation of a symmetric pelagic larva into an asymmetric benthic juvenile. Metamorphosis in vertebrates is driven by thyroid hormones (THs), but how they orchestrate the cellular, morphological and functional modifications associated with maturation to juvenile/adult states in flatfish is an enigma. Since THs act via ...

‘It just has to click’: Internists’ views of: what constitutes productive interactions with chronically ill patients

BMC Health Services Research, May 27, N. Kromme, C. Ahaus, R. Gans, et al.

Background According to the Chronic Care Model, productive interactions are crucial to patient outcomes. Despite productive interactions being at the heart of the Model, however, it is unclear what constitutes such an interaction. The aim of this study was to gain a better understanding of physician views of productive interactions with the chronically ill. Method We conducted a ...

Vision and hearing impairments, cognitive impairment and mortality among long-term care recipients: a population-based cohort study

BMC Geriatrics, May 27, Kazuko Mitoku, Naoko Masaki, Yukiko Ogata, et al.

Background Vision and hearing impairments among elders are common, and cognitive impairment is a concern. This study assessed the association of vision and hearing impairments with cognitive impairment and mortality among long-term care recipients. Methods Data of 1754 adults aged 65 or older were included in analysis from the Gujo City Long-Term Care Insurance Database in Japan ...

Fluorescence activated cell sorting followed by small RNA sequencing reveals stable microRNA expression during cell cycle progression

BMC Genomics, May 27, Vince Grolmusz, Eszter Tóth, Kornélia Baghy, et al.

Background Previously, drug-based synchronization procedures were used for characterizing the cell cycle dependent transcriptional program. However, these synchronization methods result in growth imbalance and alteration of the cell cycle machinery. DNA content-based fluorescence activated cell sorting (FACS) is able to sort the different cell cycle phases without perturbing the ...

Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied to drug repositioning and drug mode of action discovery

BMC Genomics, May 27, Zhilong Jia, Ying Liu, Naiyang Guan, et al.

Background Drug repositioning, finding new indications for existing drugs, has gained much recent attention as a potentially efficient and economical strategy for accelerating new therapies into the clinic. Although improvement in the sensitivity of computational drug repositioning methods has identified numerous credible repositioning opportunities, few have been progressed. ...

Cluster randomised trial of a tailored intervention to improve the management of overweight and obesity in primary care in England

Implementation Science, May 27, Jane Goodfellow, Shona Agarwal, Fawn Harrad, et al.

Background Tailoring is a frequent component of approaches for implementing clinical practice guidelines, although evidence on how to maximise the effectiveness of tailoring is limited. In England, overweight and obesity are common, and national guidelines have been produced by the National Institute for Health and Care Excellence. However, the guidelines are not routinely followed ...

Beyond the “Choosing wisely”: a possible attempt

Italian Journal of Pediatrics, May 28, Roberto Bernardini, Giampaolo Ricci, Francesca Cipriani, et al.

Since the fundamental principles of the medical profession were clearly defined in a physician charter in 2002, special considerations have been expressed about the adequate distribution of health care resources taking in account the individual patient needs to optimize the health care service. The correct application of procedures represents a key point in order to reach the ...

Validation of the American version of the CareGiver Oncology Quality of Life (CarGOQoL) questionnaire

Health and Quality of Life Outcomes, May 28, Sarah Kaveney, Karine Baumstarck, Patricia Minaya-Flores, et al.

Background The CareGiver Oncology Quality of Life (CarGOQoL) questionnaire, a 29-item, multidimensional, self-administered questionnaire, was validated using a large French sample. We reported the linguistic validation process and the metric validity of the English version of CarGOQoL in the United- States. Methods The translation process consisted of 3 consecutive steps: ...

The ecstasy and the agony of the altmetric score

Scientometrics, May 28, Christian Gumpenberger, Wolfgang Glänzel, Juan Gorraiz

Altmetrics have gained momentum and are meant to overcome the shortcomings of citation-based metrics. In this regard some light is shed on the dangers associated with the new “all-in-one” indicator altmetric score.

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