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The Berlin Treatment Algorithm: recommendations for tailored innovative therapeutic strategies for multiple sclerosis-related fatigue

More than 80% of multiple sclerosis (MS) patients suffer from fatigue. Despite this, there are few therapeutic options and evidence-based pharmacological treatments are lacking. The associated societal burden is substantial (MS fatigue is a major reason for part-time employment or early retirement), and at least one out of four MS patients view fatigue as the most burdensome ...

A comparison of intestinal microbiota in a population of low-risk infants exposed and not exposed to intrapartum antibiotics: The Baby & Microbiota of the Intestine cohort study protocol

Background The intestinal microbiota influences metabolic, nutritional, and immunologic processes and has been associated with a broad range of adverse health outcomes including asthma, obesity and Type 2 diabetes. Early life exposures may alter the course of gut microbial colonization leading to differences in metabolic and immune regulation throughout life. Although approximately ...

The use of polymeric and metallic geogrid on a full-scale MSE wall/embankment on hard foundation: a comparison of field data with simulation

A full-scale reinforced earth embankment was designed and constructed by the Department of Highways of Thailand on a hard foundation in Phitsanulok Province, Thailand. Two types of reinforcement were used in the embankment. One side was reinforced with polymeric reinforcement consisting of polyester (PET), polypropylene (PP) and high-density polyethylene (HDPE) and referred to as a ...

Identification of activated enhancers and linked transcription factors in breast, prostate, and kidney tumors by tracing enhancer networks using epigenetic traits

Background Although technological advances now allow increased tumor profiling, a detailed understanding of the mechanisms leading to the development of different cancers remains elusive. Our approach toward understanding the molecular events that lead to cancer is to characterize changes in transcriptional regulatory networks between normal and tumor tissue. Because enhancer ...

Silybin supplementation during HCV therapy with pegylated interferon-α plus ribavirin reduces depression and anxiety and increases work ability

Background Hepatitis C virus infection and interferon treatment are often associated with anxiety, depressive symptoms and poor health-related quality of life. To evaluate the Silybin-vitamin E-phospholipids complex effect on work ability and whether health related factors (anxiety and depression) were associated with work ability in subjects with chronic hepatitis C treated with ...

A vessel segmentation method for multi-modality angiographic images based on multi-scale filtering and statistical models

Background Accurate segmentation of blood vessels plays an important role in the computer-aided diagnosis and interventional treatment of vascular diseases. The statistical method is an important component of effective vessel segmentation; however, several limitations discourage the segmentation effect, i.e., dependence of the image modality, uneven contrast media, bias field, and ...

Parent–child associations for changes in diet, screen time, and physical activity across two decades in modernizing China: China Health and Nutrition Survey 1991–2009

Background While the household context is important for lifestyle behavior interventions, few studies have examined parent–child associations for diet and physical activity (PA) changes over time in a rapidly urbanizing country. We aimed to investigate changes in diet, screen time, and PA behaviors over time in children and their parents living in the same household, and examine ...

Modulating effects of exercise training regimen on skeletal muscle properties in female polo ponies

Background The match play patterns in equestrian polo are unique and require specific training programs to ensure sport performance. The effect of commonly used exercise training regimens on the adaptation of skeletal muscle is unclear. The present study investigated the modulating effects of the classic training regimen, comprised of aerobic exercise training with increasing ...

Transverse momentum dependent fragmenting jet functions with applications to quarkonium production

We introduce the transverse momentum dependent fragmenting jet function (TMDFJF), which appears in factorization theorems for cross sections for jets with an identified hadron. These are functions of z, the hadron’s longitudinal momentum fraction, and transverse momentum, p ⊥, relative to the jet axis. In the framework of Soft-Collinear Effective Theory (SCET) we derive the TMDFJF ...

Effects of asymmetric medical insurance subsidy on hospitals competition under non-price regulation

Background Poor medical care and high fees are two major problems in the world health care system. As a result, health care insurance system reform is a major issue in developing countries, such as China. Governments should take the effect of health care insurance system reform on the competition of hospitals into account when they practice a reform. This article aims to capture ...

Experience of the use of Ketamine to manage opioid withdrawal in an addicted woman: a case report

Background Opioids are good painkillers, but many patients treated with opioids as painkillers developed a secondary addiction. These patients need to stop misusing opioids, but the mild-to-severe clinical symptoms associated with opioid withdrawal risk increasing their existing pain. In such cases, ketamine, which is used by anaesthetists and pain physicians to reduce opioid ...

“GET-UP” study rationale and protocol: a cluster randomised controlled trial to evaluate the effects of reduced sitting on toddlers’ cognitive development

Background The educational and cognitive differences associated with low socioeconomic status begin early in life and tend to persist throughout life. Coupled with the finding that levels of sedentary time are negatively associated with cognitive development, and time spent active tends to be lower in disadvantaged circumstances, this highlights the need for interventions that ...

“Inverse signaling” of the transmembrane chemokine CXCL16 contributes to proliferative and anti-apoptotic effects in cultured human meningioma cells

Background Chemokines and their receptors play a decisive role in tumor progression and metastasis. We recently found a new signaling mechanism in malignant glioma cells mediated by transmembrane chemokines that we termed “inverse signaling”. According to this hypothesis, soluble (s)-CXCL16 binds to the surface-expressed transmembrane (tm) -CXCL16, and induces signaling and ...

Diabetes in young adult men: social and health-related correlates

Background Diabetes is a global public health issue. It is associated with significant disability, morbidity and mortality risks and substantial healthcare costs. Of great concern is the fact that its prevalence is rising, particularly amongst the young, while epidemiological data regarding the incidence, prevalence and complications of early-onset type 2 diabetes is noted to be ...

Concepts of madness in diverse settings: a qualitative study from the INTREPID project

Background In order to facilitate case identification of incident (untreated and recent onset) cases of psychosis and controls in three sites in India, Nigeria and Trinidad, we sought to understand how psychoses (or madness) were conceptualized locally. The evidence we gathered also contributes to a long history of research on concepts of madness in diverse settings. Methods We ...

Evidence of two distinct functionally specialized fibroblast lineages in breast stroma

Background The terminal duct lobular unit (TDLU) is the most dynamic structure in the human breast and the putative site of origin of human breast cancer. Although stromal cells contribute to a specialized microenvironment in many organs, this component remains largely understudied in the human breast. We here demonstrate the impact on epithelium of two lineages of breast stromal ...

The connected prescription for form factors in twistor space

We propose a connected prescription formula in twistor space for all tree-level form factors of the stress tensor multiplet operator in \( \mathcal{N} \) = 4 super Yang-Mills, which is a generalisation of the expression of Roiban, Spradlin and Volovich for superamplitudes. By introducing link variables, we show that our formula is identical to the recently proposed four-dimensional ...

‘I’ve Changed My Mind’, Mindfulness-Based Childbirth and Parenting (MBCP) for pregnant women with a high level of fear of childbirth and their partners: study protocol of the quasi-experimental controlled trial

Background Approximately 25 % of pregnant women suffer from a high level of Fear of Childbirth (FoC), as assessed by the Wijma Delivery Expectancy Questionnaire (W-DEQ-A, score ≥66). FoC negatively affects pregnant women’s mental health and adaptation to the perinatal period. Mindfulness-Based Childbirth and Parenting (MBCP) seems to be potentially effective in decreasing ...

A metal artifact reduction method for a dental CT based on adaptive local thresholding and prior image generation

Background Metal artifacts appearing as streaks and shadows often compromise readability of computed tomography (CT) images. Particularly in a dental CT in which high resolution imaging is crucial for precise preparation of dental implants or orthodontic devices, reduction of metal artifacts is very important. However, metal artifact reduction algorithms developed for a general ...

Assessment of risk factors for cerebral oxygen desaturation during neonatal and infant general anesthesia: an observational, prospective study

Background Cerebral oxygen saturation (rSO 2 c) decrease from baseline greater than 20 % during infant cardiac surgery was associated with postoperative neurologic changes and neurodevelopmental impairment at 1 year of age. So far, there is no sufficient evidence to support the routine monitoring of rSO 2 c during general surgical procedures in children. We aimed to find out the ...

A randomized, controlled trial evaluating the efficacy of an online intervention targeting vitamin D intake, knowledge and status among young adults

Background Vitamin D plays a key role in bone health. Consuming adequate vitamin D during young adulthood is important due to the development of peak bone mass; however, many Canadian young adults do not meet vitamin D recommendations. This study aimed to improve knowledge, perceptions, dietary intake and blood concentrations of vitamin D among a sample of young adults. Methods ...

Facilitators and barriers of breastfeeding late preterm infants according to mothers’ experiences

Background Late preterm infants account for the majority of preterm births. They are at an increased risk of neonatal mortality and morbidity and are less likely to initiate breastfeeding and to be exclusively breastfed at discharge compared to infants born at term. The aim of this study was to identify the facilitators and barriers to breastfeeding during hospital stays according ...

A regularity criterion for the generalized Hall-MHD system

This paper proves a regularity criterion for the 3D generalized Hall-MHD system. MSC: 35Q35, 35B65, 76D05.

Th 17 responses are not altered by natural exposure to seasonal allergens in pollen-sensitive patients

Background Allergic rhinitis affects 10–30 % of the global population and this number is likely to increase in the forthcoming years. Moreover, it commonly co-exists with allergic asthma as a chronic allergic respiratory syndrome. While the involvement of Th 2 cells in allergy is well understood, alterations of pro-inflammatory Th 17 responses remain poorly characterized. The aim ...

Primary psychosis and Borna disease virus infection in Lithuania: a case control study

Background The hypothesis that microbial infections may be linked to mental disorders has long been addressed for Borna disease virus (BDV), but clinical and epidemiological evidence remained inconsistent due to non-conformities in detection methods. BDV circulating immune complexes (CIC) were shown to exceed the prevalence of serum antibodies alone and to comparably screen for ...

The Australian longitudinal study on male health-methods

Background The Australian Longitudinal Study on Male Health (Ten to Men) was established in 2011 to build the evidence base on male health to inform policy and program development. Methods Ten to Men is a national longitudinal study with a stratified multi-stage cluster random sample design and oversampling in rural and regional areas. Household recruitment was conducted from ...

The NUTs and Bolts of squashed holography

We evaluate the partition function of the free O(N ) model on a two-parameter family of squashed three spheres. We also find new solutions of general relativity with negative cosmological constant and the same double squashed boundary geometry and analyse their thermodynamic properties. Remarkably, both systems exhibit a qualitatively similar behaviour over the entire configuration ...

Hybrid Numerical Solution of Mixed Convection Boundary Layer Flow of Nanofluid Along an Inclined Plate with Prescribed Surface Fluxes

The present paper contains a numerical study using hybrid approach on mixed convective boundary layer flow of a nanofluid past an inclined plate embedded in a porous medium. The inclined plate is maintained at uniform and constant heat, mass and nanoparticle fluxes, and the behavior of the porous medium is described by the Darcy’s model. The model considered for nanofluids ...

Does the Incredible Years Teacher Classroom Management Training programme have positive effects for young children exhibiting severe externalizing problems in school?: a quasi-experimental pre-post study

Background Young children exhibiting severe externalizing problems in school are at risk of developing several poor outcomes. School-based intervention programs have been found to be effective for students with different problems, including those with behavioral problems, emotional distress, or social problems. The present study investigated whether the IY-TCM programme, as a ...

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