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The first multidisciplinary aggregator of Open Access journals and papers. Keep on top of recent discoveries and never hit a paywall.

#### Perceived causes of stress among a group of western Canadian dental students

Objective The demanding nature of dental education, both academically and clinically, results in higher levels of perceived stress among its students. The aim of this study was to determine how dental students at the College of Dentistry, University of Saskatchewan perceived stress. During the 2013–2014 academic year, all students were asked to complete a modified dental ...

#### Self-microemulsifying drug delivery system and nanoemulsion for enhancing aqueous miscibility of Alpinia galanga oil

Alpinia galanga oil (AGO) possesses various activities but low aqueous solubility limits its application particularly in aquatic animals. AGO has powerful activity on fish anesthesia. Ethanol used for enhancing water miscible of AGO always shows severe side effects on fish. The present study explores the development of self-microemulsifying drug delivery systems (SMEDDS) and ...

#### Theoretical Investigations on the Influence of Artificially Altered Rock Mass Properties on Mechanical Excavation

This study presents a theoretical analysis of the influence of the rock mass rating on the cutting performance of roadheaders. Existing performance prediction models are assessed for their suitability for forecasting the influence of pre-damaging the rock mass with alternative methods like lasers or microwaves, prior to the mechanical excavation process. Finally, the RMCR model was ...

#### Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon

Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune responses in the pulmonary and intestinal mucosae are closely interrelated, and ...

#### Clinical outcomes in patients treated for coronary in-stent restenosis with drug-eluting balloons: Impact of high platelet reactivity

Background The impact of high platelet reactivity (HPR) on clinical outcomes after elective percutaneous coronary interventions (PCI) with drug-eluting balloons (DEB) due to in-stent restenosis (ISR) is unknown. Objective We sought to evaluate the prognostic importance of HPR together with conventional risk factors in patients treated with DEB. Methods Patients treated with DEB due ...

#### A Constitutional Critique on the Criminalization of Panhandling in Washington State

Individuals who have lost everything—their homes, jobs, and dignity—are often forced to live on the street. Those with no reasonable alternative can find themselves relying on the generosity of others just to survive. In response, citizens petition, legislatures enact, and officers enforce laws that criminalize signs of visible poverty. Municipalities have made considerable ...

#### Notch signaling and progenitor/ductular reaction in steatohepatitis

Background and objective Persistent hepatic progenitor cells (HPC) activation resulting in ductular reaction (DR) is responsible for pathologic liver repair in cholangiopathies. Also, HPC/DR expansion correlates with fibrosis in several chronic liver diseases, including steatohepatitis. Increasing evidence indicates Notch signaling as a key regulator of HPC/DR response in biliary ...

#### Study protocol: incentives for increased access to comprehensive family planning for urban youth using a benefits card in Uganda. A quasi-experimental study

The use of contraception is one of the most cost-effective public health interventions and has the potential to prevent about 30% of maternal and 10% of child deaths in developing countries. Voucher-based initiatives for family planning are an effective and viable means of increasing contraceptive use. In this paper, we present a protocol for a pilot study of a novel incentive, a ...

#### The fine-scale genetic structure and evolution of the Japanese population

The contemporary Japanese populations largely consist of three genetically distinct groups—Hondo, Ryukyu and Ainu. By principal-component analysis, while the three groups can be clearly separated, the Hondo people, comprising 99% of the Japanese, form one almost indistinguishable cluster. To understand fine-scale genetic structure, we applied powerful haplotype-based statistical ...

#### Elbow Joint Geometry in Bears (Ursidae, Carnivora): a Tool to Infer Paleobiology and Functional Adaptations of Quaternary Fossils

Bears are currently represented by eight species among Carnivora. Being all particularly large and generally plantigrade limits to certain extent their functional morphology so that inferences about their past diversification are difficult to achieve. We analyzed variation in bears’ elbow joint size and shape to reconstruct paleobiology of Quaternary fossil species. By using 2D ...

#### Non-perturbative reheating and Nnaturalness

We study models in which reheating happens only through non-perturbative processes. The energy transferred can be exponentially suppressed unless the inflaton is coupled to a particle with a parametrically small mass. Additionally, in some models a light scalar with a negative mass squared parameter leads to much more efficient reheating than one with a positive mass squared of the ...

#### Effect of radiotherapy on activity and concentration of serum paraoxonase-1 in breast cancer patients

Paraoxonase-1 (PON1) is an intra-cellular antioxidant enzyme found also in the circulation associated with high-density lipoproteins. The activity of this enzyme has been shown to be decreased in breast cancer (BC) patients. The aims of our study were to investigate the changes produced by radiotherapy (RT) on activity and concentration of serum PON1 in BC patients, and to evaluate ...

#### Relations for product moments and covariances of kth records from discrete distributions

The aim of this paper is to establish recurrence relations satisfied by product moments and covariances of kth records arising from discrete distributions. They will be evaluated for geometric underlying distribution. Then we use these results to obtain formulas for correlation coefficients of geometric kth records. We consider all three known types of kth records: strong, ...

#### LHC Run I bounds on minimal lepton flavour violation in Type-III see-saw: a case study

In minimal lepton flavour violation Type-III see-saw models the flavour structure of the couplings of the triplet fermions to the Standard Model leptons can be reconstructed from the neutrino mass matrix and lepton number violation is very suppressed. Here, we explore the possibility of imposing bounds on this class of models with results of existing LHC searches and we quantify ...

#### Measuring Sound Speed in Gas Mixtures Using a Photoacoustic Generator

We present a new method which allows us to percentage distinction of gas composition with a fast response time. This system uses the speed of sound in a resonant cell along with temperature to determine the gas mixture composition. The gas mixtures contain two gases with an unknown combination. In our experiment, the acoustic waves were excited inside the acoustic longitudinal ...

#### The Greenland shark Somniosus microcephalus—Hemoglobins and ligand-binding properties

A large amount of data is currently available on the adaptive mechanisms of polar bony fish hemoglobins, but structural information on those of cartilaginous species is scarce. This study presents the first characterisation of the hemoglobin system of one of the longest-living vertebrate species (392 ± 120 years), the Arctic shark Somniosus microcephalus. Three major hemoglobins ...

#### The Case of Local Administration in Turkey Within the Perspective of Participatory Democracy

Today, democracy and local governments are emerging as concepts that are handled together. There is widespread belief that local governments, which meet the socioeconomic and cultural needs of the individuals in the local community and provide public goods and services at the local level, are the basic institutions of democratic organization. With Turkey becoming the candidate ...

#### Phylogenetic analysis of the core histone doublet and DNA topo II genes of Marseilleviridae: evidence of proto-eukaryotic provenance

While the genomes of eukaryotes and Archaea both encode the histone-fold domain, only eukaryotes encode the core histone paralogs H2A, H2B, H3, and H4. With DNA, these core histones assemble into the nucleosomal octamer underlying eukaryotic chromatin. Importantly, core histones for H2A and H3 are maintained as neofunctionalized paralogs adapted for general bulk chromatin ...

#### Systematic review of randomized controlled trials in the treatment of dry eye disease in Sjogren syndrome

Primary Sjögren’s syndrome is an autoimmune disease characterized by dry eye and dry mouth. We systematically reviewed all the randomized controlled clinical trials published in the last 15 years that included ocular outcomes. We found 22 trials involving 9 topical, 10 oral, 2 intravenous and 1 subcutaneous modalities of treatment. Fluoromethalone eye drops over 8 weeks were more ...

#### Classification of compactified su(N c ) gauge theories with fermions in all representations

We classify su(N c ) gauge theories on ${\mathrm{\mathbb{R}}}^3\times {\mathbb{S}}^1$ with massless fermions in higher representations obeying periodic boundary conditions along ${\mathbb{S}}^1$. In particular, we single out the class of theories that is asymptotically free and weakly coupled in the infrared, and therefore, is amenable to semi-classical treatment. Our study ...

#### Insights into soybean transcriptome reconfiguration under hypoxic stress: Functional, regulatory, structural, and compositional characterization

Soybean (Glycine max) is one of the major crops worldwide and flooding stress affects the production and expansion of cultivated areas. Oxygen is essential for mitochondrial aerobic respiration to supply the energy demand of plant cells. Because oxygen diffusion in water is 10,000 times lower than in air, partial (hypoxic) or total (anoxic) oxygen deficiency is important component ...

#### Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping

The thiopurine drugs 6-mercaptopurine (6-MP) and azathiopurine (AZA) are widely used to treat inflammatory bowel disease. However, the incidence of adverse reactions is high, particularly in Asia, and the mechanisms of toxicity in Asian populations remain unclear. Thiopurine S-methyltransferase (TPMT) is a well-known enzyme that inactivates AZA or 6-MP through methylation and is ...