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The first multidisciplinary aggregator of Open Access journals and papers. Keep on top of recent discoveries and never hit a paywall.

#### Effect of tree logging on reproductive performance in Blue Tits (Cyanistes caeruleus)

Journal of Ornithology, Sep 22,

For birds, habitat quality is largely determined by local vegetation, and reproductive performance can therefore be negatively influenced by anthropogenic activities. A tree logging event enabled us to examine the effect of removing trees of different maturities and types on the reproductive performance of Blue Tits (Cyanistes caeruleus). Against expectations, only the logging of ...

#### Unification of gauge couplings in radiative neutrino mass models

Journal of High Energy Physics, Sep 01,

We investigate the possibility of gauge coupling unification in various radiative neutrino mass models, which generate neutrino masses at one- and/or two-loop level. Renormalization group running of gauge couplings is performed analytically and numerically at one- and two-loop order, respectively. We study three representative classes of radiative neutrino mass models: (I) minimal ...

#### In vitro evaluation of physiologically relevant concentrations of teriflunomide on activation and proliferation of primary rodent microglia

Journal of Neuroinflammation, Sep 22,

Background Teriflunomide, an inhibitor of dihydroorotate dehydrogenase, is thought to ameliorate multiple sclerosis by reducing activation-induced proliferation of lymphocytes, which is highly dependent on de novo pyrimidine synthesis. Nevertheless, its immunomodulatory effects on resident glial cells in the central nervous system are only poorly understood. Methods In this study, ...

#### Inorganic and Organic Solution-Processed Thin Film Devices

Thin films and thin film devices have a ubiquitous presence in numerous conventional and emerging technologies. This is because of the recent advances in nanotechnology, the development of functional and smart materials, conducting polymers, molecular semiconductors, carbon nanotubes, and graphene, and the employment of unique properties of thin films and ultrathin films, such as ...

#### Therapie der schweren COPD mit nur einem Hub täglich

Pneumo News, Sep 01, de

#### Expressions of VEGF-A and VEGFR-2 in placentae from GDM pregnancies

Reproductive Biology and Endocrinology, Sep 20, Qian Meng, Li Shao, Xiucui Luo, et al.

Background Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy, and has important health implications for mother and child. Changes in the fetoplacental vessels may predict those in the vasculature of the developing fetus, as these have been implicated in the pathogenesis of human GDM. This study aimed to determine the differences in the ...

#### miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain

Journal of Neuroinflammation, Sep 20,

Background Accumulating evidence indicates that neuropathic pain is a neuro-immune disorder with enhanced activation of the immune system. Recent data provided proof that neuropathic pain patients exhibit increased numbers of immunosuppressive regulatory T cells (Tregs), which may represent an endogenous attempt to limit inflammation and to reduce pain levels. We here investigate ...

#### Environmental and lifestyle risk factors of breast cancer in Malta—a retrospective case-control study

Aim and Background Environmental exposures are known to play a role in the development of cancer, including breast cancer. There are known associations of breast cancer with environmental factors such as sunlight exposure, diet and exercise and alcohol consumption as well as physiological factors. This study examines the prevalence of risk factors for breast cancer related to ...

#### Identification of environmental stressors and validation of light preference as a measure of anxiety in larval zebrafish

BMC Neuroscience, Sep 15, Yiming Bai, Harrison Liu, Bo Huang, et al.

Background Larval zebrafish, with a simple and transparent vertebrate brain composed of ~100 K neurons, is well suited for deciphering entire neural circuit activity underlying behavior. Moreover, their small body size (~4–5 mm in length) is compatible with 96-well plates, making larval zebrafish amenable to high content screening. Despite these attractive features, there is a ...

#### Reserve and Reserve-building activities research: key challenges and future directions

Background The concept of Cognitive Reserve has great appeal and has led to an interesting and important body of research. We believe, however, that it is unnecessarily limited by ‘habits’ of measurement, nomenclature, and intra-disciplinary thinking. Main body A broader, more comprehensive way of conceptualizing Reserve is proposed that invokes a broader measurement approach, ...

#### Leptogenesis parametrized by lepton mass matrices

The conventional seesaw-leptogenesis can simultaneously explain the suppression of neutrino masses and the generation of cosmic baryon asymmetry, but usually it cannot predict an unambiguous relation between these two sectors. In this work we shall demonstrate a novel left–right symmetric scenario, motivated to solve the strong CP problem by parity symmetry, where the present ...

#### DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer

Genome Biology, Sep 15, Nnennaya Kanu, Maria Cerone, Gerald Goh, et al.

Background The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer types. Although many studies have documented the downstream effects of APOBEC3 activity through next-generation sequencing, less is known about their upstream regulation. In this study, we sought to identify a molecular basis for APOBEC3 expression and activation. Results HER2 ...

#### Demystifying the mechanistic and functional aspects of p21 gene activation with double-stranded RNAs in human cancer cells

Journal of Experimental & Clinical Cancer Research, Sep 17, Huan-Lei Wu, Sen-Mao Li, Jia Hu, et al.

Background The recently identified phenomenon of double-stranded RNA (dsRNA)-mediated gene activation (RNAa) has been studied extensively, as it is present in humans, mice, and Caenorhabditis elegans, suggesting that dsRNA-mediated RNAa is an evolutionarily conserved mechanism. Previous studies have shown that dsP21-322 can induce tumor suppressor gene p21 expression in several ...

#### Visual representation and characterization of three-dimensional hydrofracturing cracks within heterogeneous rock through 3D printing and transparent models

The heterogeneity of unconventional reservoir rock tremendously affects its hydrofracturing behavior. A visual representation and accurate characterization of the three-dimensional (3D) growth and distribution of hydrofracturing cracks within heterogeneous rocks is of particular use to the design and implementation of hydrofracturing stimulation of unconventional reservoirs. ...

#### Prevalence of tuberculosis and associated risk factors in the Central Prison of Mbuji-Mayi, Democratic Republic of Congo

Background Tuberculosis still remains a major public health concern in several provinces of the Democratic Republic of Congo, especially in prison settings. The present study aimed at determining tuberculosis (TB) prevalence and associated risk factors in inmates of the Mbuji-Mayi Central Prison. Methods This cross-sectional study was performed over a 6-month period (January to ...

#### A folk theorem with codes of conduct and communication

We study self-referential games in which players have the ability to commit to a code of conduct—a complete description of how they play and their opponents should play. Each player receives a private signal about each others’ code of conduct and their codes of conduct specify how to react to these signals. When only some players receive informative signals, players are allowed to ...

#### Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis

Respiratory Research, Sep 22,

The activity of cysteine cathepsin B increased markedly in lung homogenates and in bronchoalveolar lavage fluids (BALF) of the mouse model of bleomycin-induced lung fibrosis after 14 days of challenge. In contrast the level of the cysteine cathepsin inhibitor cystatin C was unaffected in BALF of wild-type and cathepsin B-deficient mice. Therefore, murine cystatin C is not a ...

#### MutS regulates access of the error-prone DNA polymerase Pol IV to replication sites: a novel mechanism for maintaining replication fidelity

Nucleic Acids Research, Sep 19,

Translesion DNA polymerases (Pol) function in the bypass of template lesions to relieve stalled replication forks but also display potentially deleterious mutagenic phenotypes that contribute to antibiotic resistance in bacteria and lead to human disease. Effective activity of these enzymes requires association with ring-shaped processivity factors, which dictate their access to ...

#### Florida child care center directors’ intention to implement oral health promotion practices in licensed child care centers

BMC Oral Health, Sep 22, Ajay Joshi, Romer Ocanto, Robin Jacobs, et al.

Background To determine the factors associated with child care center directors’ (CCCDs) intention to implement oral health promotion practices (OHPPs) in licensed childcare centers (CCCs) within the next year, and their self-perceived barriers in successfully implementing those practices. Methods For this cross-sectional study, a pretested 45-item online survey was sent to 5142 ...

#### Rapid urine-based screening for tuberculosis to reduce AIDS-related mortality in hospitalized patients in Africa (the STAMP trial): study protocol for a randomised controlled trial

BMC Infectious Diseases, Sep 22,

Background HIV-associated tuberculosis (TB) co-infection remains an enormous burden to international public health. Post-mortem studies have highlighted the high proportion of HIV-positive adults admitted to hospital with TB. Determine TB-LAM and Xpert MTB/RIF assays can substantially increase diagnostic yield of TB within one day of hospital admission. However, it remains unclear ...

CME, Sep 01, rb

#### Can Machines Create Art?

As machines take over more tasks previously done by humans, artistic creation is also considered as a candidate to be automated. But, can machines create art? This paper offers a conceptual framework for a philosophical discussion of this question regarding the status of machine art and machine creativity. It breaks the main question down in three sub-questions, and then analyses ...

#### Tests of Sunspot Number Sequences: 4. Discontinuities Around 1946 in Various Sunspot Number and Sunspot-Group-Number Reconstructions

Solar Physics, Sep 19,

We use five test data series to search for, and quantify, putative discontinuities around 1946 in five different annual-mean sunspot-number or sunspot-group-number data sequences. The data series tested are the original and new versions of the Wolf/Zürich/International sunspot number composite [$R_{\text{ISNv1}}$ and $R_{\text{ISNv2}}$] (respectively Clette et al. in Adv. Space ...

#### The Effect of Mechanochemical Treatment of the Cellulose on Characteristics of Nanocellulose Films

Nanoscale Research Letters, Sep 20,

The development of the nanomaterials with the advanced functional characteristics is a challenging task because of the growing demand in the market of the optoelectronic devices, biodegradable plastics, and materials for energy saving and energy storage. Nanocellulose is comprised of the nanosized cellulose particles, properties of which depend on characteristics of plant raw ...

#### Biosynthesis of catechol melanin from glycerol employing metabolically engineered Escherichia coli

Background Melanins comprise a chemically-diverse group of polymeric pigments whose function is related to protection against physical and chemical stress factors. These polymers have current and potential applications in the chemical, medical, electronics and materials industries. The biotechnological production of melanins offers the possibility of obtaining these pigments in ...