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Normative Transmission and Necessary Means

This paper focuses on the interaction of reasons and argues that reasons for an action may transmit to the necessary means of that action. Analyzing exactly how this phenomenon may be captured by principles governing normative transmission has proved an intricate task in recent years. In this paper, I assess three formulations focusing on normative transmission and necessary...

Mineral licks as environmental reservoirs of chronic wasting disease prions

Chronic wasting disease (CWD) is a fatal neurodegenerative disease of deer, elk, moose, and reindeer (cervids) caused by misfolded prion proteins. The disease has been reported across North America and recently discovered in northern Europe. Transmission of CWD in wild cervid populations can occur through environmental routes, but limited ability to detect prions in environmental...

mCRC: Differenzialtherapie nach Primarius-Lokalisation

Seit einigen Jahren wird diskutiert, dass die Seitigkeit und der Mutationsstatus des kolorektalen Primärtumors prognostisch und prädiktiv bedeutsam sind. Wie aber die individuell „richtige“ Therapieentscheidung treffen?

Remote monitoring of vibrational information in spider webs

Spiders are fascinating model species to study information-acquisition strategies, with the web acting as an extension of the animal’s body. Here, we compare the strategies of two orb-weaving spiders that acquire information through vibrations transmitted and filtered in the web. Whereas Araneus diadematus monitors web vibration directly on the web, Zygiella x-notata uses a...

Rapid Microbial Community Changes During Initial Stages of Pine Litter Decomposition

Plant litter decomposition is a process enabling biogeochemical cycles closing in ecosystems, and decomposition in forests constitutes the largest part of this process taking place in terrestrial biomes. Microbial communities during litter decomposition were studied mainly with low-throughput techniques not allowing detailed insight, particularly into coniferous litter, as it is...

Metal cofactor modulated folding and target recognition of HIV-1 NCp7

The HIV-1 nucleocapsid 7 (NCp7) plays crucial roles in multiple stages of HIV-1 life cycle, and its biological functions rely on the binding of zinc ions. Understanding the molecular mechanism of how the zinc ions modulate the conformational dynamics and functions of the NCp7 is essential for the drug development and HIV-1 treatment. In this work, using a structure-based coarse...

MicroDAIMON study: Microcirculatory DAIly MONitoring in critically ill patients: a prospective observational study

BackgroundUntil now, the prognostic value of microcirculatory alterations in critically ill patients has been mainly evaluated in highly selected subgroups. Aim of this study is to monitor the microcirculation daily in mixed group of Intensive Care Unit (ICU)-patients and to establish the association between (the evolution of) microcirculatory alterations and outcome.MethodsThis...

Recent advances in steroidal saponins biosynthesis and in vitro production

Main conclusionSteroidal saponins exhibited numerous pharmacological activities due to the modification of their backbone by different cytochrome P450s (P450) and UDP glycosyltransferases (UGTs). Plant-derived steroidal saponins are not sufficient for utilizing them for commercial purpose so in vitro production of saponin by tissue culture, root culture, embryo culture, etc, is...

Physical defence of the wild cucumber Echinocystis lobata in an invasive range changing seed removal by rodents

Invasive alien plant species in a new location usually lose their native enemies, but new interactions with local herbivores can also significantly influence their population dynamics. Seed predators have a strong effect on the seed banks, seedling recruitment, and establishment of a plant population. A given plant’s effective defence of its seeds from seed predators ensures its...

From \( \mathcal{N}=4 \) Galilean superparticle to three-dimensional non-relativistic \( \mathcal{N}=4 \) superfields

Abstract We consider the general \( \mathcal{N}=4 \), d = 3 Galilean superalgebra with arbitrary central charges and study its dynamical realizations. Using the nonlinear realization techniques, we introduce a class of actions for \( \mathcal{N}=4 \) three-dimensional non-relativistic superparticle, such that they are linear in the central charge Maurer-Cartan one-forms. As a...

Combining R gene and quantitative resistance increases effectiveness of cultivar resistance against Leptosphaeria maculans in Brassica napus in different environments

Using cultivar resistance against pathogens is one of the most economical and environmentally friendly methods for control of crop diseases. However, cultivar resistance can be easily rendered ineffective due to changes in pathogen populations or environments. To test the hypothesis that combining R gene-mediated resistance and quantitative resistance (QR) in one cultivar can...

Pseudoaneurysma der bulbären Harnröhre nach traumatischer Katheterisierung

We present a case of heavy intermittent urethral bleeding in a 57-year-old man after traumatic catheterization caused by an urethral pseudoaneurysm. The source of bleeding could be detected by angiography and a superselective embolization was performed.

Utility of serum Aspergillus-galactomannan antigen to evaluate the risk of severe acute exacerbation in chronic obstructive pulmonary disease

Background Recent studies have shown that the microbiome, namely Aspergillus species, play a previously unrecognized role in both stable and exacerbated chronic obstructive pulmonary disease (COPD). Galactomannan is a major component of the Aspergillus cell wall that has been widely used as a diagnostic marker. Objectives To explore whether serum levels of Aspergillus...

Glucocorticoid-Induced Metabolic Disturbances Are Exacerbated in Obese Male Mice

The purpose of this study was to determine the effects of glucocorticoid-induced metabolic dysfunction in the presence of diet-induced obesity. C57BL/6J adult male lean and diet-induced obese mice were given dexamethasone, and levels of hepatic steatosis, insulin resistance, and lipolysis were determined. Obese mice given dexamethasone had significant, synergistic effects on...

Similar Intrapatient Blood Glucose Variability with LY2963016 and Lantus® Insulin Glargine in Patients with Type 1 (T1D) or Type 2 Diabetes, Including a Japanese T1D Subpopulation

IntroductionLY2963016 insulin glargine (LY IGlar) and Lantus® (IGlar), both with identical primary amino acid sequences, were compared in two phase 3 studies for intrapatient blood glucose variability.MethodsELEMENT-1 was a 52-week study in patients with type 1 diabetes (T1D), which included Japanese patients, and ELEMENT-2 was a 24-week study in non-Japanese patients with type 2...

Positive equilibria of weakly reversible power law kinetic systems with linear independent interactions

In this paper, we extend our study of power law kinetic systems whose kinetic order vectors (which we call “interactions”) are reactant-determined (i.e. reactions with the same reactant complex have identical vectors) and are linear independent per linkage class. In particular, we consider PL-TLK systems, i.e. such whose T-matrix (the matrix with the interactions as columns...

Petrophysical logs contribute in appraising productive sands of Lower Goru Formation, Kadanwari concession, Pakistan

The interpretation of petrophysical logs unveil the reservoir traits and augment an intuition of hydrocarbon (gas) bearing zones. This study focused on interpretation of petrophysical signatures (encountered in Kadanwari-01, 03, 10 and 11) of Lower Goru Formation (LGF). LGF composed of shoreface sands and near shelf shale, deposited in Cretaceous age in middle and lower Indus...

Exploring the Tensions in Organizational Theories

Today’s organizations cannot survive through the application of old theories which are considered obsolete. However, some of these ‘old theories’ still maintain their relevance in the operation of businesses today. The complexity and dynamism of the world have introduced more tensions in organizational theories as some of the theories were introduced with the intention of...

Global and local DNA (meta)barcoding reveal new biogeography patterns in tintinnid ciliates

Tintinnid ciliates are suitable models to study the diversity and biogeography of microbial plankton. In addition to morphological data accumulated over two centuries, most known families and common genera have been linked to DNA sequences in relatively recent barcoding efforts. This backbone of morphologically identified sequences is used here to classify environmental sequences...

The cosmological nature of the dark Universe

This paper deals with the cancellation mechanism, which identifies the energy density of space-time expansion in an empty universe with the zero-point energy density and avoids the scale discrepancy with the observed energy density (cosmological constant problem). Using an intrinsic degree of freedom which describes the coupling of a variable cosmological term \(\varLambda...

Explaining job polarisation in Spain from a task perspective

This paper presents new evidence on the evolution of job polarisation in Spain between 1994 and 2014. After showing the U-shaped relationship between employment share growth and job’s percentile in the wage distribution, I use the task approach to investigate the main determinants behind job polarisation. Using the European Working Condition Survey I analyse in detail the task...

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