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Advances in ovarian cancer therapy

Epithelial ovarian cancer is typically diagnosed at an advanced stage. Current state-of-the-art surgery and chemotherapy result in the high incidence of complete remissions; however, the recurrence rate is also high. For most patients, the disease eventually becomes a continuum of symptom-free periods and recurrence episodes. Different targeted treatment approaches and biological ...

Variation in angler distribution and catch rates of stocked rainbow trout in a small reservoir

We investigated the spatial and temporal relationship of catch rates and angler party location for two days following a publicly announced put-and-take stocking of rainbow trout (Oncorhynchus mykiss). Catch rates declined with time since stocking and distance from stocking. We hypothesized that opportunity for high catch rates would cause anglers to fish near the stocking location ...

Dynamic cellular complexity of anoxygenic phototrophic sulfur bacteria in the chemocline of meromictic Lake Cadagno

The meromictic Lake Cadagno is characterized by a compact chemocline with high concentrations of anoxygenic phototrophic purple sulfur bacteria (PSB) and green sulfur bacteria (GSB). The co-occurrence of phylogenetically distant bacterial groups such as PSB and GSB in the same ecological niche, makes the chemocline of Lake Cadagno an ideal system for studying the conditions and ...

Characterization of Mycosphaerellaceae species associated with citrus greasy spot in Panama and Spain

Greasy spot of citrus, caused by Zasmidium citri-griseum (= Mycosphaerella citri), is widely distributed in the Caribbean Basin, inducing leaf spots, premature defoliation, and yield loss. Greasy spot-like symptoms were frequently observed in humid citrus-growing regions in Panama as well as in semi-arid areas in Spain, but disease aetiology was unknown. Citrus-growing areas in ...

Psychosociale problematiek bij kinderen met diabetes

In de diabeteszorg voor kinderen ligt de focus nog te vaak alleen op het fysieke aspect van de ziekte. Voor een gunstig beloop van de diabetes door de jaren heen is er meer aandacht nodig voor de psychosociale aspecten, aldus pedagoog Minke Eilander in haar proefschrift.

Eye-Tracking Based Attention Bias Modification (ET-ABM) Facilitates Disengagement from Negative Stimuli in Dysphoric Individuals

To address shortcomings of purely reaction-time based attention bias modification (ABM) paradigms, a novel eye-tracking based ABM training (ET-ABM) was developed. This training targets the late disengagement from negative stimuli and the lack of attention for positive information, which are characteristics of depression. In the present study, 75 dysphoric students (BDI ≥ 9) were ...

Task demands affect spatial reference frame weighting during tactile localization in sighted and congenitally blind adults

Task demands modulate tactile localization in sighted humans, presumably through weight adjustments in the spatial integration of anatomical, skin-based, and external, posture-based information. In contrast, previous studies have suggested that congenitally blind humans, by default, refrain from automatic spatial integration and localize touch using only skin-based information. ...

Adaptation and validation of the Spanish version of the ORTO-15 questionnaire for the diagnosis of orthorexia nervosa

The aim of this study was the validation and analysis of the psychometric properties of a Spanish translation of the ORTO-15 questionnaire; an instrument designed to assess orthorexia nervosa behavior. Four hundred and fifty-four Spanish university students (65% women) aged between 18 and 51 years (M = 21.48 ± 0.31) completed the Spanish version of ORTO-15 and the Eating Disorders ...

Accuracies of univariate and multivariate genomic prediction models in African cassava

Genomic selection (GS) promises to accelerate genetic gain in plant breeding programs especially for crop species such as cassava that have long breeding cycles. Practically, to implement GS in cassava breeding, it is necessary to evaluate different GS models and to develop suitable models for an optimized breeding pipeline. In this paper, we compared (1) prediction accuracies from ...

A New Universal Bundle Theory

Universal Bundle Theory (UBT) holds that objects are fundamentally identical with bundles of universals. Universals are multiply instantiable properties. One popular objection to UBT concerns the possibility of distinct indiscernibles. There are mainly two replies in the literature, corresponding to two representative UBTs, which I shall call the Identity-View and the ...

Sex-specific role of education on the associations of socioeconomic status indicators with obesity risk: A population-based study in South Korea

Background No study of obesity risk for people in developed countries has conducted a multi-dimensional analysis of the association of socioeconomic status with obesity. In this paper, we investigated if education functions as either a confounder or an effect modifier in the association of another socioeconomic status indicator with obesity. Methods This cross-sectional study ...

A natural boundary element method for the Sobolev equation in the 2D unbounded domain

In this article, we devote ourselves to establishing a natural boundary element (NBE) method for the Sobolev equation in the 2D unbounded domain. To this end, we first constitute the time semi-discretized super-convergence format for the Sobolev equation by means of the Newmark method. Then, using the principle of natural boundary reduction, we establish a fully discretized NBE ...

Pyrometallurgical Treatment of Apatite Concentrate with the Objective of Rare Earth Element Recovery: Part II

Apatite, Ca5(PO4)3F, is a useful raw material for the production of both elemental phosphorus and phosphoric acid, and the mine tailings present at Luossavaara-Kiirunavaara AB (LKAB) in Kiruna, Sweden, represent a significant potential European source of apatite if upgraded to a concentrate. In the present study, pilot apatite concentrate made from the LKAB tailings has been ...

Schlafbruxismus und schlafbezogene Atmungsstörungen

Erholsamer Schlaf ist lebensnotwendig für körperliche Integrität und seelische Gesundheit. Schlafbruxismus (SB) und schlafbezogene Atmungsstörungen (SBAS), wie obstruktive Schlafapnoe, sind Störungen im Schlaf, denen der Zahnarzt in der Praxis aufgrund steigender Prävalenz häufiger begegnet. Während reiner SB mit Okklusionsschienen behandelt wird, muss ein Umdenken stattfinden, ...

Role of cis-trans proline isomerization in the function of pathogenic enterobacterial Periplasmic Binding Proteins

Periplasmic Binding Proteins (PBPs) trap nutrients for their internalization into bacteria by ABC transporters. Ligand binding triggers PBP closure by bringing its two domains together like a Venus flytrap. The atomic determinants that control PBP opening and closure for nutrient capture and release are not known, although it is proposed that opening and ligand release occur while ...

Sodium bicarbonate supplementation improves severe-intensity intermittent exercise under moderate acute hypoxic conditions

Acute moderate hypoxic exposure can substantially impair exercise performance, which occurs with a concurrent exacerbated rise in hydrogen cation (H+) production. The purpose of this study was therefore, to alleviate this acidic stress through sodium bicarbonate (NaHCO3) supplementation and determine the corresponding effects on severe-intensity intermittent exercise performance. ...

Changes in multimodality functional imaging parameters early during chemoradiation predict treatment response in patients with locally advanced head and neck cancer

Objective To assess the optimal timing and predictive value of early intra-treatment changes in multimodality functional and molecular imaging (FMI) parameters as biomarkers for clinical remission in patients receiving chemoradiation for head and neck squamous cell carcinoma (HNSCC). Methods Thirty-five patients with stage III-IVb (AJCC 7th edition) HNSCC prospectively underwent ...

Exotic Eucalyptus leaves are preferred over tougher native species but affect the growth and survival of shredders in an Atlantic Forest stream (Brazil)

We evaluated the effect of leaves of native and exotic tree species on the feeding activity and performance of the larvae of Triplectides gracilis, a typical caddisfly shredder in Atlantic Forest streams. Leaves of four native species that differ in chemistry and toughness (Hoffmannia dusenii, Miconia chartacea, Myrcia lineata and Styrax pohlii) and the exotic Eucalyptus globulus ...

From Molecules to Life: Quantifying the Complexity of Chemical and Biological Systems in the Universe

Life is a complex phenomenon and much research has been devoted to both understanding its origins from prebiotic chemistry and discovering life beyond Earth. Yet, it has remained elusive how to quantify this complexity and how to compare chemical and biological units on one common scale. Here, a mathematical description of molecular complexity was applied allowing to quantitatively ...

Patient–ventilator asynchrony during conventional mechanical ventilation in children

Background We aimed (1) to describe the characteristics of patient–ventilator asynchrony in a population of critically ill children, (2) to describe the risk factors associated with patient–ventilator asynchrony, and (3) to evaluate the association between patient–ventilator asynchrony and ventilator-free days at day 28. Methods In this single-center prospective study, consecutive ...

Effect of Arsenic Exposure on NRF2-KEAP1 Pathway and Epigenetic Modification

Arsenic (As) is a known toxic element and carcinogen. Transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2) controls cellular adaptation to oxidants and electrophiles by inducing antioxidant genes in response to redox stress. To explore associations between As level and NRF2-regulated cytoprotective genes expression, an observational study was conducted in a ...

Immunogenicity of rotavirus vaccine (RotarixTM) in infants with environmental enteric dysfunction

Introduction Deployment of rotavirus vaccines has contributed to significant declines in diarrheal morbidity and mortality globally. Unfortunately, vaccine performance in low-middle income countries (LMICs) is generally lower than in developed countries. The cause for this has been associated with several host and maternal factors including poor water sanitation and hygiene (WASH) ...

Psychosocial Needs of Children in Foster Care and the Impact of Sexual Abuse

Children in family foster care, especially those who have experienced sexual abuse, require a safe and nurturing environment in which their psychosocial needs are met. However, there is limited knowledge on how youth prioritize various needs and what impact previous experiences have on these needs. In this study, we asked youth (formerly) in family foster care to indicate their ...

From microwatt to gigabit: challenges of modern radio design

On the brink of introducing the fifth generation (5G) of cellular networks, the art of radio-frequency (RF) integrated circuit design has never seen such a wide spread of diverging requirements: On the one hand, ubiquitous sensor networks are mandating power budgets in the order of micro-watt. They should be constructed as energy-autonomous, wireless, low-cost sensor nodes. This ...

The spectrosome of occupational health problems

Given the increased prevalence of cancer, respiratory diseases, and reproductive disorders, for which multifactorial origins are strongly suspected, the impact of the environment on the population represents a substantial public health challenge. Surveillance systems have become an essential public health decision-making tool. Networks have been constructed to facilitate the ...

Mild endoplasmic reticulum stress ameliorates lipopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization

Neuroinflammation, which ultimately leads to neuronal loss, is considered to play a crucial role in numerous neurodegenerative diseases. The neuroinflammatory process is characterized by the activation of glial cells such as microglia. Endoplasmic reticulum (ER) stress is commonly associated with impairments in neuronal function and cognition, but its relationship and role in ...

A fast indirect method to compute functions of genomic relationships concerning genotyped and ungenotyped individuals, for diversity management

Pedigree-based management of genetic diversity in populations, e.g., using optimal contributions, involves computation of the $${\mathbf{Ax}}$$ Ax type yielding elements (relationships) or functions (usually averages) of relationship matrices. For pedigree-based relationships $${\mathbf{A}}$$ A , a very efficient method exists. When all the individuals of interest are genotyped, ...

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