Stem Cell Research & Therapy

http://link.springer.com/journal/13287

List of Papers (Total 1,333)

Dental pulp stem cells used to deliver the anticancer drug paclitaxel

BackgroundUnderstanding stem cell behavior as a delivery tool in cancer therapy is essential for evaluating their future clinical potential. Previous in-vivo studies proved the use of mesenchymal stem cells (MSCs) for local delivery of the commonest anticancer drug, paclitaxel (PTX). Dental pulp is a relatively abundant noninvasive source of MSCs. We assess dental pulp stem cells...

Impact of bone marrow mesenchymal stem cell immunomodulation on the osteogenic effects of laponite

BackgroundWith the development of osteoimmunology and bone tissue engineering (BTE), it has been recognized that the immunomodulatory properties of bone biomaterials have considerable impact in determining their fate after implantation. In this regard, the polarization of macrophages secondary to biomaterials is postulated to play a crucial role in modulating their osteogenesis...

Transcriptional activator DOT1L putatively regulates human embryonic stem cell differentiation into the cardiac lineage

BackgroundCommitment of pluripotent stem cells into differentiated cells and associated gene expression necessitate specific epigenetic mechanisms that modify the DNA and corresponding histone proteins to render the chromatin in an open or closed state. This in turn dictates the associated genetic machinery, including transcription factors, acknowledging the cellular signals...

Efficacy and long-term longitudinal follow-up of bone marrow mesenchymal cell transplantation therapy in a diabetic patient with recurrent lower limb bullosis diabeticorum

Bullosis diabeticorum is a rare presentation of cutaneous manifestation most commonly affecting the lower limbs in patients with diabetes. The appearance, often as insidious as its resolution, is characterized by tense blisters on the skin surfaces of the lower limbs and the feet. The cause still remains unclear, but it may relate to microangiopathy and neuropathy. In this report...

The need to revisit the definition of mesenchymal and adult stem cells based on their functional attributes

A debate is ongoing about the ‘stem cell’ status of mesenchymal stem cells (MSCs). This can easily be resolved based on the definition of a stem cell. ‘True’ stem cells are expected to undergo asymmetric cell divisions (ACD) whereby they divide to self-renew and give rise to a slightly bigger, differentiated cell. However, MSCs like any other adult tissue-specific stem cells...

Stem cell properties of human clonal salivary gland stem cells are enhanced by three-dimensional priming culture in nanofibrous microwells

BackgroundThree-dimensional (3D) cultures recapitulate the microenvironment of tissue-resident stem cells and enable them to modulate their properties. We determined whether salivary gland-resident stem cells (SGSCs) are primed by a 3D spheroid culture prior to treating irradiation-induced salivary hypofunction using in-vitro coculture and in-vivo transplant models.Methods3D...