Pediatric Neurology Briefs

http://www.pediatricneurologybriefs.com/
Pediatric Neurology Briefs is a peer-reviewed, Open Access (OA), continuing education service designed to expedite and facilitate the review of current scientific research and advances in child neurology and related subjects. The editors provide detailed monthly summaries of published articles, followed by commentaries based on their experience and corroborated by appropriate supplementary citations. Pediatric Neurology Briefs provides pediatric neurologists, neurologists, neurosurgeons, pediatricians, psychiatrists, psychologists, educators and other health professionals with a detailed reference guide to the diagnosis, etiology, pathology, treatment and prognosis of nervous diseases of infants, children and adolescents. Content is intended to be accessible to readers in any medical discipline.

List of Papers (Total 3,736)

Lacosamide in Pediatric Status Epilepticus

Investigators from Baylor College of Medicine studied the efficacy of lacosamide in pediatric status epilepticus (SE).

Understanding the Spectrum of SLC2A1-Associated Disorders

Investigators from the Danish Epilepsy Center the frequency of SLC2A1 mutations in a cohort of patients with different types of epilepsies.

Migraine, Celiac Disease and Intestinal Microbiota

Investigators from four European tertiary care hospitals (in Paris, France; Milan, Udine and Perugia, Italy) performed a case-control study of children and adolescents aged 6 to 17 years diagnosed with primary headaches in the emergency department by a pediatric neurologist using the validated ICHD-3 criteria.

Imaging of Glutamate Concentration in Sturge-Weber Syndrome

Investigators from Wayne State University studied a cohort of children with Sturge-Weber syndrome (SWS) and epilepsy using both glucose-based positron emission tomography (FDG-PET) to evaluate metabolic activity and proton magnetic resonance spectroscopic imaging (MRSI) to evaluate glutamate turnover.

Adult Stroke Screening Tool in Childhood Ischemic Stroke

Investigators from Nationwide Children's Hospital, Columbus, OH performed a retrospective study to determine whether the application of an adult stroke scale could discriminate between children with acute arterial ischemic stroke (AIS) and other causes of acute neurologic deficits.

Pediatric Neurology Briefs: Year in Review

Pediatric Neurology Briefs (PNB) has been published monthly since 1987 as a continuing education service designed to expedite and facilitate review of current medical literature concerning pediatric neurology.

Neurocognitive Functions and Behavior in Joubert Syndrome

Investigators from multiple Italian pediatric neurology and neurogenetics departments studied cognitive functions, behavior, and adaptive functioning in large cohort of 54 patients with Joubert syndrome (JS) as part of a prospective, multi-center study.

Ocular Manifestation of CACNA1A Pathogenic Variants

Investigators from The Children’s Hospital at Westmead in New South Wales; The Queensland University of Technology in Brisbane; Sydney Children’s Hospital in New South Wales and Laboratoire de Genetique in Paris investigated children with a proven heterozygous missense pathogenic variant in the CACNA1A gene.

Epileptic Encephalopathy Due to BRAT1 Pathogenic Variants

Investigators from Institut für Medizinische Genetik und Humangenetik have highlighted the role of compound heterozygous BRAT1 variants in two German brothers with variable presentations of intractable epilepsy, poor development, postnatal microcephaly, hypertonia, apnea, and infantile/childhood death.

Predicting and Preventing Epilepsy in Sturge-Weber Syndrome?

Investigators from the University of Montreal studied potential predictors of epilepsy in young patients with Sturge-Weber syndrome (SWS).

Biomarkers of Inflammation in Pediatric Arterial Ischemic Stroke

Investigators from Switzerland studied inflammatory markers in children and neonates with acute arterial ischemic stroke (AIS).

Crouch Gait in Dravet Syndrome

Investigators from Necker Enfants Malades Hospital, Sorbonne Paris Cite University, Raymond Poincare University, and Paris Descartes University studied motor neuron function in children with Dravet syndrome (DS).

The Burden of Pediatric Encephalitis in the United States

Investigators from the University of Maryland, University of Colorado, and Arkansas Children’s Hospital studied the epidemiology, management and resource utilization of children admitted to hospitals in the United States with encephalitis.

Pediatric Intracranial Hypertension

Investigators from the Ohio State University, Oregon Health and Science University and Rosalind Franklin School of Medicine examined the presenting manifestations, demographics and treatment strategies in children enrolled in the Intracranial Hypertension Registry (IHR).

Genetic Testing Requires NGS and Sanger Methodologies

Investigators from the EuroEPINOMICS rare epilepsy syndromes Dravet working group performed whole-exome sequencing on 31 trios that had been reported negative for SCN1A mutations by Sanger sequencing.

Risk of Remote Seizures After Perinatal Ischemic Stroke

Investigators from the University of California San Francisco and Kaiser Permanente Medical Centers in Oakland report outcome of perinatal arterial ischemic stroke (PAIS) in a population-based cohort, with particular attention to the incidence of seizures.

Utility of Double Inversion Recovery Sequences in MRI

Investigators from the Mayo Clinic, Rochester Minnesota investigated the utility of three-dimensional (3D) double inversion recovery (DIR) sequences in magnetic resonance imaging (MRI) detection of focal cortical dysplasia (FCD) in children and young adults with epilepsy.

Phenotypes of Dravet Syndrome

Researchers from the University of Washington in Seattle studied selective heterozygous and homozygous deletions of the voltage gated sodium channel (Nav1.1) in parvalbumin (PV) or somato-statin (SST) expressing interneurons.

ADHD, Methylphenidate, and Childhood Epilepsy

Investigators from the Department of Functional Neurology, Epileptology and Epilepsy Institute (IDEE), and the Lyon’s University Hospital examined the clinical determinants of ADHD severity in children with epilepsy (CWE) along with the response to treatment with methylphenidate (MPH).

Tuberous Sclerosis Complex: A Roadmap for Future Research

Investigators from the NINDS and the Tuberous Sclerosis Alliance sponsored a workshop in March 2015, which joined basic scientists and clinicians with expertise in various aspects of Tuberous Sclerosis Complex (TSC), in order to assess the current state of TSC research and to set future goals.

Arnold-Chiari with Myelomeningocele

The outcome of 19 infants with complications of Arnold-Chiari malformation and meningomyelocele was reviewed at the Depts.

Levetiracetam for Pediatric Posttraumatic Seizure Prophylaxis

Investigators from Nationwide Children's Hospital performed an observational cohort study of early post-traumatic seizures (EPTS) among 34 children with moderate to severe traumatic brain injury (TBI) who received levetiracetam (LEV) prophylaxis following admission to their pediatric intensive care unit.

Predicting Post-Concussion Symptom Risk in the ED

Investigators from The Pediatric Emergency Research Canada (PERC) Concussion Team developed a clinical risk score for predicting persistent post-concussion symptoms (PPCS) at 28 days post injury in a large cohort of children initially evaluated at the emergency department (ED) within 48 hours of injury.

Utility of Pediatric Nerve Biopsy in Tertiary Care Referral

Investigators from Mayo Clinic in Rochester, MN, report the utility of nerve biopsy as a diagnostic tool in their institution.

Guidelines for Corticosteroid use in Treatment of DMD

The guideline development subcommittee of the American Academy of Neurology has provided an update to the 2005 treatment guidelines for use of corticosteroids (CS) in Duchenne muscular dystrophy (DMD).