Journal of Chemistry

https://www.hindawi.com/journals/jchem/

List of Papers (Total 1,346)

QSAR Studies of 6-Amino Uracil Base Analogues: A Thymidine Phosphorylase Inhibitor in Cancer Therapy

A novel series of 6-amino uracil base analogue were synthesized. QSAR study was used to relate the selective nonsubstrate inhibitory activity of 6-amino uracil base analogue with various physicochemical descriptors. Stepwise multiple regression analysis was performed to find out the correlation between various physicochemical descriptors and biological activity of the compounds...

Kinetics and Mechanism of Oxidation of L-proline by Trivalent Copper: A free radical intervention and decarboxylation

The kinetics of oxidation of L-proline by diperiodatocuprate(III) (DPC) in aqueous alkaline medium at a constant ionic strength of 0.10 mol dm-3 was studied spectrophotometrically. The reaction between DPC and L-proline in alkaline medium exhibits 2:1 stoichiometry (DPC: L-Proline). The reaction is of first order in [DPC], less than unit order in [L-proline] and [alkali...

Standardization Study of Antifertility Drug - Pippalyadiyoga

The present paper deals with the standardization study of pippalyadiyoga powder. It is used as a long acting contraceptive. The standardization of compound drug has been achieved by physico-chemical analysis and high performance liquid chromatography (HPLC) fingerprint studies. Quantitative evaluation of borax in pippalyadiyoga showed 19.08% as sodium borate. RP-HPLC was...

The Effect of Deposition Rate on Electrical, Optical and Structural Properties of ITO Thin Films

Indium tin oxide (ITO) thin films have been prepared using the reactive evaporation technique on glass substrates in an oxygen atmosphere. It is found that the deposition rate plays prominent role in controlling the electrical and optical properties of the ITO thin films. Resistivity, electrical conductivity, activation energy, optical transmission and band gap energy were...

Spectrophotometric Determination of Ziprasidone in Pharmaceutical Formulations

A simple and reproducible spectrophotometric method has been developed for the determination of Ziprasidone hydrochloride monohydrate (ZPS) in bulk and in dosage forms. The method is based on the extraction of the drugs into organic layer of the dye TPooo in presence of 0.1 N hydrochloric acid and the absorbances were measured at 490 nm. Results indicate that the proposed method...

Microwave Assisted Synthesis of Some Biologically Active Benzothiazolotriazine Derivatives

Synthesis of some biologically active benzothiazolotriazine derivatives by microwave irradiation is reported. 2-Amino-6-substituted benzothiazoles 1 on treatment with benzaldehyde in anhydrous ethanol afforded 2-benzylidenoimino-6-substitutedbenzothiazoles 2 which underwent cyclisation with ammoniumthiocyanate in dioxane to give 2-phenyl benzothiazolo [3,2-α]-s-triazine-4-[3H...

Synthesis and Antibiotic Activity of Mebendazole Derivatives of Pharmacological Interest

Mebendazole is a well known anti-helimintic and belongs to the benzimidazole group of medicines. In order to achieve better medicinal results, i.e. enhanced activity and low toxicity, structural modifications are made in the existing drugs. Some 5-benzoyl-N-[1-(alkoxyphthalimido) benzimidazol-2-yl] carbamic acid methyl ester (3a-c) and 5-benzoyl-N-[1-(2,3-bis oxyphthalimido...

Assessment of Ground Water Quality in and around Gobichettipalayam Town Erode District, Tamilnadu

Ground water samples collected from different localities in and around Gobichettipalayam town, Erode District, Tamil Nadu were analyzed for their physico- chemical characteristics. This analysis result was compared with the WHO & ICMR standards of drinking water quality parameters with the following water quality parameters namely pH, Electrical conductivity, CN-, Cl-, SO42-, Na

in vitro Antioxidant Activity and Total Polyphenolic Content of Cyperus rotundus Rhizomes

In this study, Antioxidant activity of Cyperus rotundus rhizomes extract (CRRE) was evaluveted in a series of in vitro assay involving free radicals and reactive oxygen species and IC50 values were determined. CRRE exhibited its scavenging effect in concentration dependent manner on superoxide anion radicals, hydroxyl radicals, nitric oxide radical, hydrogen peroxide, and...

Synthesis, Physical Characterization and Biological Activity of Some Schiff Base Complexes

Structural modification of organic molecule has considerable biological relevance. Further, coordination of a biomolecules to the metal ions significantly alters the effectiveness of the biomolecules. In view of the antimicrobial activity ligand [bis-(2-aminobenzaldehyde)] malonoyl dihydrazone], metal complexes with Cu(II), Ni(II), Zn(II) and oxovanadium(IV) have been synthesized...

Kinetics and Mechanism of Oxidation of L-Cystine by Hexacyanoferrate(III) in Alkaline Medium

Kinetics of oxidation of L-cystine by hexacyanoferrate(III) was studied in alkaline medium at 30 °C. The reaction was followed spectrophotometrically at λmax = 420 nm. The reaction was found to be first order dependence each on [HCF(III)] and [cystine]. It was found that the rate of the reaction increases with increase in [OH-]. The oxidation product of the reaction was found to...

Vibrational Dynamics of the Diterpene-Neoandrographolide

A complete normal coordinate analysis was performed for neoandrographolide in terms of the calculation by using Wilson’s G-F matrix method and Urey Bradley force field. Andrographis paniculata has been reported for its potent hepatoprotective. Andrographis paniculata has been reported to have antisecretory (antidiarrhoeal), immunostimulant, antimalarial, antifilarial activity. It...

Preparation of Biodiesel through Transesterification of Animal Oil and AlcoholUnder the Catalysis of SO42- / TiO2

Biodiesel was obtained through transesterification of animal oil and ethanol under the catalysis of SO42- / TiO2 We have inspected the activation of SO42- / TiO2prepared under different dipping vitriol concentration,baking activation temperature. The optimum conditions to prepare SO42- / TiO2are; dipping vitriol concentration of TiCl4 hydrolysis product is 1.5 mol / L, baking...

A Comparative Study of the Corrosion Inhibitive Properties of Pyrimidine Derivatives for Mild Steel

The influence of pyrimidine derivatives on the corrosion inhibition of mild steel in 1 M H2SO4 was studied using weight loss and electrochemical techniques. These compounds act as good corrosion inhibitors even at low concentration and the inhibition efficiency increased with the increase in inhibition concentration. The corrosion rates have been determined at various...

Effect of Various Additives on Photocatalytic Degradation of 4-Nitrophenol

The photocatalytic degradation of 4-nitrophenol (4-NP) assisted by titanium dioxide (TiO2) was investigated in aqueous suspension under irradiation by UV light. The effect of different supporting materials mixed physically with TiO2on the photocatalytic degradation of 4-NP has been studied. TiO2 with all supports exhibits good degradation efficiency of 4-NP and was better than...

A Facile Microwave Assisted One-pot Strategy for the Synthesis of Bis-hexahydroquinazolin-5(6H)-ones

A facile microwave assisted one-pot synthetic protocol has been devised for the synthesis of 3,3'-(alkanediyl) bis (1-phenyl-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-ones (2a-c), 3,3'-(1,4-phenylene) bis (1-phenyl-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one (2d),3,3'-(alkanediyl) bis (7,7-dimethyl-1-phenyl-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-ones (2e-g) and 3,3'-(1,4-phenylene) bis...

Liquid Chromatographic Method for Determination of Nisoldipine from Pharmaceutical Samples

A simple and specific high performance thin layer chromatographic method was developed and validated for the determination of nisoldipine from tablet dosage form. The method was carried out at 320 nm after extraction of drug in methanol. The method uses aluminum plates pre-coated with silica gel 60F-254 as stationary phase and cyclohexane-ethyl acetate-toluene (3:3:4, v/v/v) as...

Syntheses and Reactions of 4′-[(ω-Bromoalkyl)oxy]-and 4′,4′′′-(Polymethylenedoxy)-bis Substituted Chalcones

Base catalyzed condensation of 4-hydroxyacetophenone (1) with several aldehydes resulted 4′-hydroxychalcones (2a-c). Reaction of α,ω -dibromoalkanes (3, n=2, 4 & 6) with (2a-c) in equimolar ratio resulted a mixture of 4′-[(ω-bromoalkyl)oxy]- substituted chalcones (4a-i) and 4′,4′′′-(polymethylenedioxy)-bis substituted chalcones (5a-i) separated by ethanol as soluble (4a-i) and...

Crystalline and Molecular Structure of Hexaaqua-1,3-diammoniumpropane Cobalt(II) Nitrate, Co(H2O) 6 [C3H12N2] (NO3)4

Chemical preparation and x-ray characterization of a new compound hexaaqua-1,3-diammoniumpropane cobalt(II) nitrate, Co(H2O) 6 [C3H12N2] (NO3)4 are reported. This mixed organo-mineral compound crystallizes in the orthorhombic system with Cmcm space group. The unit cell dimensions are: a = 10.795(7), b = 11.969(4), c = 14.685(5) Å, Z = 4 and V = 1897.5(12) Å3. The structure was...

Selective Extraction and Bulk Liquid Membrane Transport of Cu(II) from Aqueous Nitrate Solution in the Presence of Zn(II), Ni(II) and Mn(II) Cations Using Benzoyl Acetone

The competitive metal ion extraction and transport of Cu(II), Ni(II), Zn(II) and Mn(II) with benzoyl acetone and EDTA was studied. In the experiments the ligand was dissolved in chloroform and the pH and time of extraction or transport were varied. Also the rate of shaking and ligand concentration on the efficiency of extraction and transport was studied. The results revealed...

Synthesis and X-Ray Single Crystal Structures of Cadmiym(II) Complexes: CdCl2[CS(NHCH3)2]2 and CdCl2(CS(NH2)NHC6H5)4-Single Source Precursors to CdS Nanoparticles

Two new cadmium(II) complexes CdCl2[CS(NHCH3)2]2 (1) and CdCl2(CS(NH2)NHC6H5)4 (2) have been synthesized and characterized by spectroscopic and x-ray crystallographic methods. Both compounds are monomers in the solid state with the four and six coordinate and their coordination geometries based on distorted tetrahedron and distorted octahedron respectively. The thiourea ligands...

The Preparation and Characterization of Chitosan / Poly (Vinyl Alcohol) Blended Films

In this study, chitosan and PVA were blended at different proportions (considering chitosan as the main component) in solution forms. The chemical structure and the morphology of the obtained blend films were investigated using FTIR and field emission scanning electron microscope (FESEM). The thermal stability of the blend films were also studied using thermal gravimetric...

Amperometric Determination of Bismuth Using Gallacetophenone Phenylhydrazone with the Structural Elucidation of Complex

Gallacetophenone phenylhydrazone (GPPH) has been used as an analytical reagent for amperometric determination of bismuth. Bismuth is quantitatively determined by GPPH at pH 3.0-6.0. After studying the polarographic behaviour of GPPH and bismuth(III) at dropping mercury electrode (DME), applied potential was fixed at -0.4v vs. saturated calomel electrode (SCE). The method was...

Antibacterial Activity of Quaternary Ammonium Salt from Diethylaminoethyl Methacrylate

A quaternary ammonium salt was synthesized from diethylaminoethyl methacrylate (DEAEMA) by quaternization with hexadecyl bromide. The resultant compound (Am-h) was characterized by FTIR and NMR spectroscopy. Its bactericidal activity was evaluated by determining minimum inhibitory concentration (MIC) values and inhibitory zone diameter against gram positive bacteria...

A New Cross-Shaped Graphite Furnace with Ballast Body for Reduction of Interferences in Atomic Absorption Spectrometry

A new crossed graphite furnace for atomic absorption spectrometry (GFAAS) was designed and installed in heated graphite atomizer (HGA500) combined with Perkin-Elmer spectrometer (AAS1100). The Tungsten ballast body was inserted inside one part of the crossed furnace in a way perpendicular to light path. The analyzed sample was injected manually on the ballast body inside the...