5-Chloromethyl-8-quinolinol was condensed with 4-methyl piperazine in presence of sodium bicarbonate. The resulting 5-(4-methyl piper-azinylmethylene)-8-quinolinol (MPQ) was characterized by elemental analysis and spectral studies. The transition metal chelates viz Cu
The metal complexes of Ni(II), Cu(II), Zn(II) Cd(II) with organic ligands viz Hydrazine hydrate, 1,2-N,N'-Bisammonium thiocarbamoyl ethane and 1,4-N,N'-Bisammonium thiocarbamoyl benzene have been prepared. These ligands and metal complexes of dithiocarbamates were screened for their antimicrobial activity against various microbs.
Domperidone is an antiemetic and pantoprazole is an antiulcer drug. Simple, precise, rapid and selective simultaneous equation and Q- analysis UV spectrophotometric methods have been developed for the simultaneous determination of domperidone and pantoprazole from combined tablet dosage forms. The methods involve solving of simultaneous equations and Q-value analysis based on...
Multistep and one-pot conversion of aldehydes to nitriles were carried out conveniently with out solvent using KF/Al2O3, montmorillonite KSF and K10 as catalyst, under microwave irradiation. The reactions are completed within 6-8 min to give satisfactory yields. KF/Al2O3 was more effective catalyst both in multistep procedure and one-pot reaction.
Two new spectrophotometric methods are proposed for the determination of zidovudine(ZDV) in pharmaceuticals. The methods use chloramine-T (CAT) and two dyes, methylene blue and rhodamine-B, as reagents and are based on adding of a known excess of CAT to ZDV in hydrochloric acid medium followed by determination of residual oxidant by reacting with a fixed amount of either...
This paper deals with a fundamental review of preparation methods, characterizations, thermal and environmental stabilities and practical applications of polypyrrole (PPy) conducting electroactive polymers. In this article some of the most important factors affecting the electrical, electrochemical, thermal and environmental stabilities of polypyrrole conducting polymers have...
Five novel chalcones were synthesised by condensing 2-hydroxy-1-acetonaphthone with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation and another five novel chalcones were prepared by refluxing 3-acetyl coumarin with aldehydes in the presence of piperidine in ethanol. All these compounds were...
Two new sensitive spectrophotometric methods are proposed for the determination of raloxifene hydrochloride (RLX) using bromate-bromide mixture and two dyes, methyl orange and indigocarmine, as reagents. The methods entail the addition of a known excess of bromate-bromide mixture to RLX in hydrochloric acid medium followed by determination of residual bromine by reacting with a...
A number of imines derivatives have been synthesized, they were obtained by condensation of aromatic aldehyde derivatives with primary aromatic amine derivatives. Their structures have been characterised by IR, 1H NMR in addition to the elemental analysis. The biological activity of these imines (which are also known as Schiff bases) were examined against different type of...
2-Amino-6-(2-naphthalenyl)thiazolo[3,2-d]thiadiazole [1] was prepared by treatment of KCNS and Br2 on 2-Amino-4-(2-naphthalenyl) thiazole. This amine on facile condensation with aromatic aldehydes afford Schiff Base/anils/azomethines(2a-h). These anils on cyclocondensation reaction with chloro acetyl chloride and thio glycolic acid (i.e. mercapto acetic acid) afford 2...
Novel, rapid, highly sensitive and selective spectrophotometric method for the determination of traces of vanadium (V) in environmental and biological samples, pharmaceutical and steel samples was studied. The method is based on oxidation of 2,4- dinitro phenyl hydrazine(2,4-DNPH) by vanadium (V) followed by coupling reaction with N-(1-naphthalene-1-yl)ethane-1,2-diamine...
Various 2-phenyloxy-4,6-bisarylhydrazino-1,3,5-triazines(3a-f) were prepared by reaction of 2- phenyloxy -4,6-dichloro -1,3,5-triazine and various aryl hydrazine derivatives. All the 3a-f derivatives were characterized by elemental analysis and IR spectral studies. All the compounds were screened for microbial activity against gram-positive and gram-negative bacteria.
The textile effluents has been proved to impart adverse effects on humans, animals and plantation. The present study reveals that the impact of textile effluents on a protenious edible fresh water fish Mastacembelus Armatus by examining the changes in the ionic regulations of some selected tissues like liver , kidney and muscle before and after exposure to the Acid Blue 92 (CI.No...
Synthesis of some biologically active benzothiazolotriazine derivatives by microwave irradiation is reported. 2-Amino-6-substituted benzothiazoles 1 on treatment with benzaldehyde in anhydrous ethanol afforded 2-benzylidenoimino-6-substitutedbenzothiazoles 2 which underwent cyclisation with ammoniumthiocyanate in dioxane to give 2-phenyl benzothiazolo [3,2-α]-s-triazine-4-[3H...
The perovskite oxides GdCo1-xFexO3 (x = 0.10, 0.20) were prepared by chemical method. The dielectric behavior of compositions with x = 0.10 and 0.20 in the system GdCo1-xFexO3 was studied in the temperature range 300-500 K. It is observed that dielectric constant increases with increasing Fe2
A series of some new phenothiazine derivatives were synthesized with the objective for evaluation as antimicrobials. The title compounds were prepared by a five step synthesis scheme. 2-Amino-6-substituted benzothiazoles (1) on diazotization afford 6-substituted benzothiazolyl-2-diazonium chlorides (2). Reaction of 2 with cold solution of β-naphthol in dilute NaOH furnishes α-(2...
Two simple extractive Spectrophotometric methods are described for the determination of rosuvastatin calcium (RST) in pure form and in pharmaceutical formulations. These methods are based on the formation of ion association complexes of the RST with basic dyes safranin O (Method A) and methylene blue (Method B) in basic buffer of pH 9.8 followed by their extraction in chloroform...
2-[4-Hydroxy benz-1(propene-1-one)]Pyrrole II on treatment with phenyl thiourea, guanidine carbonate, urea and thiourea in alcoholic KOH yielded compounds III, IV, V, VI which on treatment with different aryl anilines gave compounds VII, VIII, IX, X which under goes cyclisation with sulphur and iodine to give 2-[4-(10H-substituted phenothiazine-3-yl)-6-pyrimidin-2-phenylthiol/-ol...
1,3,4-Oxadiazoles were associated with broad spectrum of biological activities including antituberculosis, anticonvulsant, anti-inflammatory, insecticidal, antifungal, analgesic and antitumor properties. Morpholine derivatives find their wide spectrum of antimicrobial activity and exhibit anthelmintic, bactericidal and insecticidal activity. Pyrimidine derivatives are also...
Three new simple, sensitive, rapid and economical spectrophotometric Methods (A, B and C) have been developed for the determination of Raloxifene Hydrochloride in pharmaceutical bulk and tablet dosage form. Method A is based on the formation of yellow colored chromogen with 0.1N Sodium hydroxide exhibiting maximum absorbance against the corresponding reagent blank. The method B...
A simple, general and efficient method has been developed for the conversion of aldehydes to 1,1-diacetates using acetic anhydride, a catalytic amount of non commercial Keggin heteropolyacid (H6 PalMo11O40) (1% mol) in solvent free conditions at room temperature. Aromatic and aliphatic, simple and conjugated aldehydes were protected with excellent yields.
The activated carbon (AC) was used for removal of As(III) and As(V) ions from aqueous solutions. Sorption experiments were conducted using both batch and column systems. The effect of some important parameters on sorption of these by AC was studied. It was found that among the different factors affecting sorption capacity and efficiency in removal of arsenic from aqueous...
One titrimetric and two spectrophotometric methods are presented for the assay of metaprolol tartrate (MPT) in bulk drug and in tablets. The methods employ N-bromosuccinimide (NBS) as the oxidimetric reagent and two dyes, methyl orange and indigo carmine as spectrophotometric reagents. In titrimetry, an acidified solution of MPT is treated with a known excess amount of NBS and...
Sulphur containing organic compounds decreases the corrosion rate by increasing the hydrogen over potential on zinc metal due to their electron donating groups. Their inhibiting effect was found to be associated with their adsorption on the active centers of the metal. The inhibition efficiencies of some aliphatic sulphides in ammonium chloride solution have been studied by...
Protease production by Aspergillus oryzae was optimized in shake-flask cultures using Box-Behnken experimental design. An empirical model was developed through response surface methodology to describe the relationship between tested variable (peptone, glucose, soyabeanmeal and pH). Maximum enzyme activity was attained with Peptone at 4 g∕L; temperature at 30 °C glucose at 6 g∕L...