Pulmonary Therapy

http://link.springer.com/journal/41030

List of Papers (Total 48)

Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis: Experience from 92 Sites in an Open-Label US Expanded Access Program

Introduction In phase 3 clinical trials, pirfenidone significantly slowed disease progression with a well-defined and medically manageable safety profile in patients with idiopathic pulmonary fibrosis (IPF). This study examined safety events related to pirfenidone in patients with IPF in an expanded access program in the US. Methods The Expanded Access Program allowed patients with ...

A Network Meta-Analysis of Long-Acting Muscarinic Antagonist (LAMA) and Long-Acting β2-Agonist (LABA) Combinations in COPD

Introduction Comparative data on the efficacies of long-acting muscarinic antagonist (LAMA) and long-acting β2-agonist (LABA) combinations for the treatment of moderate-to-very-severe chronic obstructive pulmonary disease (COPD) are limited. The aim of this Bayesian network meta-analysis (NMA) is to assess the relative efficacies of available open combinations (delivered via ...

A Retrospective Study of the Effectiveness of the AeroChamber Plus® Flow-Vu® Antistatic Valved Holding Chamber for Asthma Control

Introduction Electrostatic charge in valved holding chambers (VHCs) may lead to inconsistent metered-dose inhaler (MDI) asthma drug delivery. We compared the AeroChamber Plus® Flow Vu® Antistatic Valved Holding Chamber (AC+FV AVHC) with non-antistatic control VHCs in terms of asthma exacerbations, resource use, and cost in an asthma population. Methods Patients included in an ...

Improving the Efficiency of Respiratory Drug Delivery: A Review of Current Treatment Trends and Future Strategies for Asthma and Chronic Obstructive Pulmonary Disease

Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous airway diseases associated with significant morbidity and mortality. Pharmacological treatment is delivered primarily through the inhalation route using various devices. Optimal disease control is highly dependent upon patient adherence. Both patients with asthma and COPD are prone to exacerbations leading to ...

Ipratropium/Salbutamol Comparator Versus Originator for Chronic Obstructive Pulmonary Disease Exacerbations: USA Observational Cohort Study Using the Clinformatics™ Health Claims Database

Introduction Affordable treatment alternatives are needed to prevent and treat chronic obstructive pulmonary disease (COPD) exacerbations and reduce the economic burden of COPD. This study evaluated whether the effectiveness of Steri-Neb™ (Teva Pharmaceuticals, Inc.), the comparator ipratropium/salbutamol (I/S) nebulizer solution, is non-inferior to DuoNeb® (Mylan Specialty L.P.), ...

A Review on the Safety and Efficacy of Inhaled Corticosteroids in the Management of Asthma

Asthma is a chronic inflammatory disease characterized by symptoms of cough, dyspnea, chest tightness, and wheeze. Inhaled corticosteroids (ICS) have been recommended as initial therapy in the treatment of persistent asthma in all guidelines, as they have been shown to reduce morbidity and mortality. However, high-dose regimens and long-term use of ICS may be associated with a ...

Impact of Inhalation Flow, Inhalation Volume and Critical Handling Errors on Delivered Budesonide/Formoterol Dose in Different Inhalers: An In Vitro Study

Introduction Inhaled drugs are essential for treatment of asthma and chronic obstructive pulmonary disease, but drug delivery via the respiratory tract is complex. Correct inhaler use is challenging as inhalers differ and inhaler technique errors are common. This in vitro study examined impact of inhalation flow, volume, and shaking of commonly used budesonide/formoterol (BUD/FORM) ...

Cohort Analysis of Exacerbation Rates in Adolescent and Adult Patients Initiating Inhaled Corticosteroids for Asthma: Different Dose–Response Profile by Particle Size

Introduction Targeting small airway inflammation could lead to improved clinical outcomes in asthma. Previous observational studies concluded that therapy with extrafine-particle [mass median aerodynamic diameter (MMAD) <2 µm] inhaled corticosteroids (ICS) is associated with similar or better odds of achieving asthma control at lower prescribed doses than fine-particle ICS (MMAD = ...

Aerosol Deposition of Inhaled Corticosteroids/Long-Acting β2-Agonists in the Peripheral Airways of Patients with Asthma Using Functional Respiratory Imaging, a Novel Imaging Technology

Introduction Drug deposition in the peripheral airways has been reported to differ between pressurized metered dose inhalers (pMDIs) and dry powder inhalers (DPIs). This study was conducted to determine the drug deposition fraction from three inhaled corticosteroids/long-acting β2-agonists (ICS/LABA) combination products for inhalation in the peripheral airways. Methods An airway ...

Inhaler Operability and Patient Satisfaction Regarding Genuair® and Respimat® Inhalers for Chronic Obstructive Pulmonary Disease: A Randomized Crossover Study

Introduction Tiotropium via the Respimat® device, once daily, is a common treatment for patients with chronic obstructive pulmonary disease (COPD). Aclidinium via the Genuair® device, twice daily, is an alternative option. However, there are few studies comparing the two devices. We evaluated inhaler operability, patient satisfaction, and patient preference between Genuair and ...

The Respimat® Development Story: Patient-Centered Innovation

The Respimat® Soft Mist™ Inhaler represents a unique delivery system for respiratory medications, using an innovative concept with major technological advancements made during prototype development. The Respimat® concept was driven by the intent to solve problems associated with existing inhaler devices for patient use. The following core aims were achieved: (1) avoiding ...

Idiopathic Pulmonary Arterial Hypertension in Children: A Review

Pediatric pulmonary hypertension (PH) is a heterogeneous disorder that leads to significant morbidity and mortality if left untreated. The Nice WHO classification from 2013 classifies PH into five groups: broadly, Group I pulmonary arterial hypertension (PAH), which includes idiopathic PAH, PAH associated with congenital heart disease and others; Group II comprises post-capillary ...

Effect of Nebulizer Designs on Aerosol Delivery During Non-Invasive Mechanical Ventilation: A Modeling Study of In Vitro Data

Introduction Nebulizers used to deliver aerosol during non-invasive mechanical ventilation (NIV) have many types, each type has many different designs. This study aimed to determine the effect of nebulizer deign on aerosol delivery in NIV. Methods Different designs of jet nebulizer (JN) and vibrating mesh nebulizer (VMN) were tested by placing 1 ml of salbutamol in a nebulizer ...

Empyema Thoracis Caused by Drug-Resistant Staphylococcus aureus in an Adult Female: A Case Report

Introduction Empyema thoracis, which is the collection of pus in the pleural cavity, has been experiencing an increase in incidence rate in both adults and children. When present, it is most often a complication of some cases of pneumonia, but a proportion may result from iatrogenic causes or develop without pneumonia. It, therefore, constitutes a significant management challenge. ...

Treatment Satisfaction During Routine Treatment with the SQ®-Standardised Grass Allergy Immunotherapy Tablet: A Non-interventional Observational Study

Introduction Therapy with the SQ®-standardised grass sublingual immunotherapy (SLIT)-tablet has been shown to be efficacious and well-tolerated in a large clinical development programme. The objective of this study was to investigate patients’ satisfaction with treatment by the SQ® grass SLIT-tablet during routine application. Methods In the setting of a non-interventional, ...

Validation of a New Portable Exhaled Nitric Oxide Analyzer, NIOX VERO®: Randomized Studies in Asthma

Introduction Fractional exhaled nitric oxide (FeNO) is a non-invasive marker of airway inflammation, and a new portable analyzer (NIOX VERO®) is now available. Our studies aimed to assess the agreement of measurements between NIOX VERO® and a reference device (NIOX MINO®) and assess the reproducibility of NIOX VERO®. Methods Paired FeNO readings were obtained from 112 subjects from ...

Riociguat in PAH and CTEPH: Strategies for Patient Management

Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are subtypes of pulmonary hypertension—a rare, life-threatening condition defined by chronically elevated pulmonary artery pressure. Treatment goals include improving patient functioning, symptom management, and delaying disease progression. Traditional therapies have focused on affected ...

A Real-World Study of 30-Day Exacerbation Outcomes in Chronic Obstructive Pulmonary Disease (COPD) Patients Managed with Aerobika OPEP

Introduction Oscillating positive expiratory pressure (OPEP) devices may reduce chronic symptoms in patients with obstructive pulmonary disease (COPD); however, no real-world studies have been performed to evaluate the benefits of these devices. The objective of this study was to measure the rate of early (30-day) moderate-to-severe exacerbations and related costs in COPD patients ...

Successful Fractional Exhaled Nitric Oxide Measurements with NIOX VERO using 6- and 10-s Exhalation Modes in Children with Asthma Aged 4–10 Years: A Randomized Study

Introduction Fractional exhaled nitric oxide (FeNO) is a valuable tool for measuring allergic airway inflammation in children with asthma, particularly in those for whom other tests are difficult to perform. The use of a 6-s exhalation time (6-s mode) rather than 10 s (10-s mode) used for adults is in line with current recommendations, making FeNO a feasible option for younger ...

Budesonide/Formoterol Easyhaler®: Performance Under Simulated Real-Life Conditions

Introduction We compared in vitro drug delivery characteristics of two budesonide/formoterol dry powder inhalers, the Bufomix Easyhaler® and the budesonide/formoterol Turbuhaler®, at different patient air flow rates, and to test dose delivery from the Easyhaler in stressed conditions exposed to moisture, dropping, vibration and freezing/thawing. Methods A total of 36 inhalers from ...

3D Printing and Personalized Airway Stents

In recent years, the 3D printing industry has undergone rapid development. Clinicians and researchers have begun to apply this technology in procedural planning, tissue engineering, and device manufacturing. Rapid prototyping and additive manufacturing techniques in the healthcare field have already yielded very exciting results and point to a bright future involving these ...

Indacaterol/Glycopyrronium Combination for COPD

In all current guidelines and recommendations of the management of COPD, inhaled bronchodilators are the pillar of therapy at each stage of the disease. Dual bronchodilation with long-acting muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA) is always more effective than the LAMA or LABA alone in terms of the improvement in trough FEV1, and transitional dyspnea index and ...