BMC Research Notes

http://link.springer.com/journal/13104

List of Papers (Total 5,550)

Quality of life in mucopolysaccharidoses: construction of a specific measure using the focus group technique

Objective To describe the perceptions of patients, their caregivers, and their healthcare providers to the development of a new specific instrument for assessment of the quality of life (QoL) in patients with mucopolysaccharidoses (MPS) using a qualitative focus group (FG) design. FGs were held in two Brazilian states (Rio Grande do Sul and Rio de Janeiro). Results Three versions ...

Examining human paragonimiasis as a differential diagnosis to tuberculosis in The Gambia

Objective Paragonimiasis is a foodborne trematode infection of the lungs caused by Paragonimus spp., presenting clinically with similar symptoms to active tuberculosis (TB). Worldwide, an estimated 20.7 million people are infected with paragonimiasis, but relatively little epidemiological data exists for Africa. Given a recently reported case, we sought to establish whether ...

Estimating the proportion of clinically diagnosed infectious and non-infectious animal diseases in Ganta Afeshum woreda, Eastern Tigray zone, Ethiopia

Objective This study was performed with the objective of identifying the proportion of emerging and endemic livestock diseases using cross sectional survey. Result A total of 285 clinically diseased animals were presented to a veterinary clinic and diagnosed tentatively based on history, clinical sign, and simple laboratory diagnostics and from the study, actinomycosis (15.83%), ...

Factors associated with poor treatment outcome of tuberculosis in Debre Tabor, northwest Ethiopia

Objective Directly observed treatment short course has been implemented as part of the national tuberculosis control program in Ethiopia. The strategy, as evidenced by different studies, has improved the survival and treatment success rate of tuberculosis patients. However, some patients failed to complete their treatments and the factors for this failure were not assessed in the ...

Measuring management’s perspective of data quality in Pakistan’s Tuberculosis control programme: a test-based approach to identify data quality dimensions

Background Data quality is core theme of programme’s performance assessment and many organizations do not have any data quality improvement strategy, wherein data quality dimensions and data quality assessment framework are important constituents. As there is limited published research about the data quality specifics that are relevant to the context of Pakistan’s Tuberculosis ...

Publication rate of abstracts presented at Japan Geriatrics Society Annual Meetings (2011–2012): a retrospective observational study

Objective We aimed to determine the publication rate of abstracts presented at Japan Geriatrics Society Annual Meetings. Publication rates were determined by searching for full-text publications up to September 2017 in the MEDLINE database. Factors associated with publication were determined. Results In total, 618 abstracts presented at Japan Geriatrics Society Annual Meetings ...

Infantile hypertrophic pyloric stenosis: a 4-year experience from two tertiary care centres in Cameroon

Objective This study aimed to describe the clinical characteristics of patients with infantile hypertrophic stenosis, management and its outcome in two tertiary care centres in Cameroon. Results A total of 21 patients were included from the two centres. The mean age at presentation was 5.2 ± 1.2 weeks, predominantly male with a male-to-female ratio of 4.25:1. The triad of vomiting, ...

Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis

Objective Sepsis is a condition associated with a dysregulated inflammatory response to infection with significant morbidity. Recent advances have elucidated the vital role that the short chain fatty acid glycoprotein receptor 43 (FFA2/GPR43) plays in inflammatory and immunomodulatory pathways. We hypothesized that elevated whole blood GPR43 RNA expression would be associated with ...

Morphometric characterisation of human tracheas: focus on cartilaginous ring variation

Purpose Details regarding tracheal anatomy are currently lacking, with existing literature focussing mainly on the cricoid-tracheal region or the carina. External gross anatomy and internal morphology throughout the entire trachea is important for normal physiological functioning and various clinical applications such as designs for tracheal implants or endotracheal devices. ...

Nonmedical prescription opioid use and illegal drug use: initiation trajectory and related risks among people who use illegal drugs in Vancouver, Canada

Objective We investigated the prevalence of and risk factors associated with initiating nonmedical prescription opioid use (NMPOU) before and after illegal drugs using data from two linked cohort studies of street youth and adults who use illegal drugs in Vancouver, Canada. All participants who attended a study visit between 2013 and 2016 were eligible for the primary analyses. ...

Treatment outcome of anti-angiogenesis through VEGF-pathway in the management of gastric cancer: a systematic review of phase II and III clinical trials

Objectives Advanced gastric cancer poses a therapeutic challenge worldwide. In randomised clinical trials, anti-VEGF has been reported as an essential agent for the treatment of advanced gastric cancer. This review aims at assessing the treatment outcome of anti-angiogenesis therapy through the VEGF pathway in the management of patients with advanced gastric cancer. Results During ...

The PHARMS (Patient Held Active Record of Medication Status) feasibility study: a research proposal

Objective Medication errors are a major source of preventable morbidity, mortality and cost and many occur at the times of hospital admission and discharge. Novel interventions (such as new methods of recording medication information and conducting medication reconciliation) are required to facilitate accurate transfer of medication information. With existing evidence supporting ...

Development of AhMITE1 markers through genome-wide analysis in peanut (Arachis hypogaea L.)

Objective In peanut, the DNA polymorphism is very low despite enormous phenotypic variations. This limits the use of genomics-assisted breeding to enhance peanut productivity. This study aimed to develop and validate new AhMITE1 and cleaved amplified polymorphic sequences (CAPS) markers. Results In total, 2957 new AhMITE1 markers were developed in addition to identifying 465 ...

Planning a sports training program using Adaptive Particle Swarm Optimization with emphasis on physiological constraints

Objective An effective training plan is an important factor in sports training to enhance athletic performance. A poorly considered training plan may result in injury to the athlete, and overtraining. Good training plans normally require expert input, which may have a cost too great for many athletes, particularly amateur athletes. The objectives of this research were to create a ...

The impact of salinity on mycorrhizal colonization of a rare legume, Galactia smallii, in South Florida pine rocklands

Objectives The success of restoration plantings depends on the capacity of transplanted individuals or seeds to establish and reproduce. It is increasingly recognized that restoration success depends quite heavily upon biotic interactions and belowground processes. Under stressful abiotic conditions, such as soils salinized by storm surge and sea level rise, symbiotic interactions ...

Spontaneous rhythms in a harbor seal pup calls

Objectives Timing and rhythm (i.e. temporal structure) are crucial, though historically neglected, dimensions of animal communication. When investigating these in non-human animals, it is often difficult to balance experimental control and ecological validity. Here I present the first step of an attempt to balance the two, focusing on the timing of vocal rhythms in a harbor seal ...

Sickness absence among municipal workers in a Brazilian municipality: a secondary data analysis

Background Sickness absence, work disability associated with illness or injury, is a major public health problem worldwide. Some studies have investigated determinants of sickness absence among workers with shorter job tenure, but have only focused on certain diagnostic groups. Although it is well established that job tenure has an inverse relationship with work injury rate, less ...

Cross-cultural survey development: The Colon Cancer Screening Behaviors Survey for South Asian populations

Objective The objective of this work was to develop a survey that considered cultural relevance and diversity of South Asian populations, with the aim of describing or predicting factors that influence colorectal cancer screening intention and adherence. The scientifically rigorous approach for survey development informed the final phase of an exploratory mixed method study. This ...

Can testing clinical significance reduce false positive rates in randomized controlled trials? A snap review

Objective The use of minimum clinically important difference in the hypothesis formulation for superiority trials is similar in principle to the concept of non-inferiority or equivalence trial. However, most clinical trials are analysed testing zero clinical difference. Since the minimum clinically important difference is pre-defined for power calculation, it is important to ...

Using incentives to recruit physicians into behavioral trials: lessons learned from four studies

Objective To describe lessons learned from the use of different strategies for recruiting physicians responsible for trauma triage, we summarize recruitment data from four behavioral trials run in the United States between 2010 and 2016. Results We ran a series of behavioral trials with the primary objective of understanding the influence of heuristics on physician decision making ...

Lack of CT scanner in a rural emergency department increases inter-facility transfers: a pilot study

Objective Rural emergency departments (EDs) are an important gateway to care for the 20% of Canadians who reside in rural areas. Less than 15% of Canadian rural EDs have access to a computed tomography (CT) scanner. We hypothesized that a significant proportion of inter-facility transfers from rural hospitals without CT scanners are for CT imaging. Our objective was to assess ...

Reduction of the contaminant fraction of DNA obtained from an ancient giant panda bone

Objective A key challenge in ancient DNA research is massive microbial DNA contamination from the deposition site which accumulates post mortem in the study organism’s remains. Two simple and cost-effective methods to enrich the relative endogenous fraction of DNA in ancient samples involve treatment of sample powder with either bleach or Proteinase K pre-digestion prior to DNA ...

Trends in Demographic and Health Survey data quality: an analysis of age heaping over time in 34 countries in Sub Saharan Africa between 1987 and 2015

Objective This paper evaluates one aspect of data quality within DHS surveys, the accuracy of age reporting as measured by age heaping. Other literature has explored this phenomenon, and this analysis build on previous work, expanding the analysis of the extent of age heaping across multiple countries, and across time. Results This paper makes a comparison of the magnitude of ...

Effects of a naturally occurring amino acid substitution in bovine PrP: a model for inherited prion disease in a natural host species

Objective The most common hereditary prion disease is human Creutzfeldt-Jakob disease (CJD), associated with a mutation in the prion gene resulting in a glutamic acid to lysine substitution at position 200 (E200K) in the prion protein. Models of E200K CJD in transgenic mice have proven interesting but have limitations including inconsistencies in disease presentation, requirement ...

Health-related quality of life for First Nations and Caucasian women in the First Nations Bone Health Study

Objective Studies about the health of Indigenous (i.e., original inhabitants) populations often focus on chronic diseases and risk behaviors, emphasizing physical aspects of health. Our objective was to test for differences in self-reported health-related quality of life (HRQOL), which provides a multidimensional and holistic perspective on health, between First Nations (one group ...