Canadian Journal of Gastroenterology and Hepatology

https://www.hindawi.com/journals/cjgh/

List of Papers (Total 335)

Clinical Experience with 5-Aminosalicylate Preparations in Inflammatory Bowel Disease - A Review

The efficacy of 5-ASA tablets is around 65 co 70% in patients with active ulcerative colitis, whereas the efficacy of the rectal preparations approach 100% when the treatment is for active distal disease. When there is more extensive left sided colonic disease, the efficacy of 5-ASA rectal preparations is not as high, but it is still much improved over that seen with oral 5-ASA...

Giardiasis in Endoscopy Patients: A Comparison of Diagnostic Techniques

The results of a study comparing techniques for diagnosis of giardiasis during endoscopy are presented. Methods of diagnosis included examination of duodenal biopsy impression smears, culture of both biopsies and aspirates, and examination of preserved aspirate. Giardiasis was diagnosed in three of 80 patients; in each case the impression smear was positive. Cultures of duodenal...

Esophageal Variceal Ligation

Endoscopic sclerotherapy is an effective method for treating and eradicating acutely bleeding varices in repeated sessions; however, it is not ideal because of numerous serious complications. Endoscopic variceal ligation, developed to circumvent some of the side effects of sclerotherapy, controls actively bleeding varices in about 90% of cases. Of 146 patients treated with...

Symptomatic Improvement of Gastroduodenal Crohn’s Disease with Omeprazole

Four patients with ileal Crohn’s disease presented with abdominal pain aggravated by food, a mean weight loss of 5.5 kg (range 4 to 7) and ulceration of the antrum and/or duodenum at gastroscnpy, without radiological features of mechanical obstruction . The endoscopic and histological appearance of the ulcers was consistent with Crohn's disease. Omeprazole 40 mg daily was...

The Social Toll of Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) – ulcerative colitis and Crohn’s disease – has become one the most important chronic digestive disorders found in the younger population. As a result of the nature of the illness, with remission and exacerbation of the inflammatory process, there has been increasing concern regarding the costs, both financial and social, of IBD. There have been...

Pain Management in Functional Gastrointestinal Disorders

Pain is a common feature in functional gastrointestinal disorders (FGID). An abnormally low visceral sensory threshold, as well as a number of central, spinal and peripheral pain-modulating abnormalities, have been proposed for this syndrome. Clinical aspects of pain associated with irritable esophagus, functional dyspepsia, biliary dysmotility, inflammatory bowel syndrome and...

Ileocolonic Schistosomiasis Resembling Crohn’s Disease

A case of ileocolonic schistosomiasis mimicking Crohn’s disease of the ileum is presented. Surgical resection of ileum was performed in a 40-year-old man because of intestinal obstruction with fistulas, which were diagnosed surgically and histologically as Crohn’s disease. It was only with tissue review six months later that the diagnosis of ileal schistosomiasis was made. The...

Failure of Ketoprofen and Interferon Combination Therapy to Improve Interferon-Resistant Chronic Hepatitis C

Preliminary reports suggest that patients with interferon (IFN)-resistant chronic hepatitis C respond better to a combination of IFN-α and nonsteroidal anti-inflammatory drugs than to IFN alone. The efficacy of IFN combined with ketoprofen in the treatment of patients with IFN-resistant chronic hepatitis C was evaluated. Seventeen patients, nonresponsive after at least six months...

Small Bowel Review - Part I

Significant advances have been made in the study of the small bowel. Part I of this two-part review of the small bowel examines carbohydrates, including brush border membrane hydrolysis and sugar transport; amino acids, dipeptides, proteins and food allergy, with a focus on glutamine, peptides and macromolecules, and nucleosides, nucleotides and polyamines; salt and water...

Selecting Candidates for Liver Transplantation: A Medical Ethics Perspective on the Microallocation of a Scarce and Rationed Resource

Liver transplantation has evolved over the past 35 years from an experimental procedure with high perioperative mortality to an accepted form of treatment with an approximate 85% one-year and 80% three-year patient survival rate. Following the success and acceptance of transplantation in the treatment of end-stage liver disease, there has been a progressive increase in the number...

Emergency Endoscopy

The need for emergency endoscopy is a matter of debate. The time interval for emergency procedures remains to be defined. Most authors propose a time span of 24 h as emergency time, while some define a period of 72 h (especially in acute pancreatitis). Several studies have shown a possible benefit for a select group of patients. Four main indications are established for emergency...

Applications of Recombinant DNA Technology in Gastrointestinal Medicine and Hepatology: Basic Paradigms of Molecular Cell Biology. Part C: Protein Synthesis and Post-Translational Processing in Eukaryotic Cells

The translation of mRNA constitutes the first step in the synthesis of a functional protein. The polypeptide chain is subsequently folded into the appropriate three-dimensional configuration and undergoes a variety of processing steps before being converted into its active form. These processing steps are intimately related to the cellular events that occur in the endoplasmic...

Meeting Review – Helicobacter pylori: Basic Mechanisms to Clinical Cure 2000

The meeting Helicobacter pylori: Basic Mechanisms to Clinical Cure 2000, held in Bermuda from March 26 to 29, 2000, gathered physicians and scientists from all corners of the world. State-of-the-art reviews and the most recent developments in the field were presented. This article summarizes the highlights of this meeting, including important scientific and clinical developments.

Nutrition and Gastric Cancer

The reasons for the worldwide decline in stomach cancer incidence and mortality rates are not fully understood, but dietary changes are clearly implicated. While the possible mechanisms of gastric carcinogenesis and the impact of Helicobacter pylori eradication remain open to debate, at least two practical recommendations – to increase fruit and vegetable intake, and to reduce...

Nutrition of Liver Transplant Patients

Good cooperation between the hepatologist, surgeon and anesthesiologist is required to determine the appropriate perioperative nutritional management for the liver transplant patient. For preoperative risk stratification, nutritional assessment according to resting energy expenditure by indirect calorimetry, and body cell mass by bioelectrical impedence analysis, may be superior...

Solitary Rectal Ulcer Syndrome Presenting with Rectal Prolapse, Severe Mucorrhea and Eroded Polypoid Hyperplasia: Case Report and Review of the Literature

A case of solitary rectal ulcer syndrome in a 36-year-old woman presenting with severe, persistent mucorrhea and eroded polypoid hyperplasia as the predominant clinical features, who was ultimately noted to have symptoms of rectal prolapse, is presented. Endoscopically, she had multiple (50 to 60) small, whitish polypoid lesions in the rectum that were initially misinterpreted as...

Plexiform Neurofibroma of the Submandibular Salivary Gland in a Child

Plexiform neurofibromas in major salivary glands are rarely described. In the literature, most reported tumours have been present in the parotid gland region. A three-year-old boy with a family history of neurofibromatosis presented with a rapidly growing left submandibular mass. The clinical diagnosis was that of a neurofibroma rather than a primary salivery gland tumour...

Nonalcoholic Fatty Liver Disease in Patients Investigated for Elevated Liver Enzymes

Nonalcoholic fatty liver disease (NAFLD) is a common diagnosis among patients referred to gastroenterology and hepatology clinics for the evaluation of elevated liver enzymes. The diagnosis of NAFLD is supported by blood work to exclude other liver diseases, and by ultrasound evidence of fat in the liver in patients without a significant history of alcohol intake. The gold...

Prognostic Indicators in Acute Pancreatitis

Several approaches have been used in an attempt to predict the severity and prognosis of attacks of acute pancreatitis. The Ranson and Glasgow criteria include a variety of simple laboratory parameters that are measured on admission and again within 48 h. They are the most widely used indices in clinical practice. The Acute Physiological and Chronic Health Evaluation II system is...

Helicobacter pylori and the Prevention of Gastric Cancer

BACKGROUND: Helicobacter pylori is an important cause of stomach cancer that infects a substantial proportion of the Canadian adult population. H pylori can be detected by noninvasive tests and effectively eradicated by medical treatment. Screening for and treatment of H pylori may represent a significant opportunity for preventive oncology.

The Canadian Association of Gastroenterology Education Committee Report

I am pleased to provide an update regarding the activities and future directions of the Canadian Association of Gastroenterology (CAG) Education Committee. The mandate of the CAG Education Committee is to facilitate, develop and promote excellence as it pertains to educational initiatives for the Canadian gastroenterology community. Professional education has long remained a...

Primary Biliary Cirrhosis in A Patient with Turner Syndrome

An increased prevalence of X chromosome monosomy has recently been demonstrated in patients with primary biliary cirrhosis (PBC). Chronic cholestasis of unknown etiology is a common clinical feature in patients with Turner syndrome who reach the fourth and fifth decades of life. A 37-year-old patient with Turner syndrome who presented with clinical and biochemical features of...