Canadian Journal of Infectious Diseases and Medical Microbiology

https://www.hindawi.com/journals/cjidmm/

List of Papers (Total 51)

Newer Clinical Strategies for Combining Interferon and Cytotoxic Agents Against Solid Tumours and Hematological Malignancies

The role of interferons in the treatment of cancer continues to evolve. Despite limited single agent activity against solid tumours, interferons now appear to have an important role as modulators of the activity of a variety of cytotoxic drugs. Clinical benefits have been observed for combinations of interferons and alkylating agents against low grade lymphomas, interferons and...

The Laboratory Diagnosis of Syphilis

Syphilis has several clinical manifestations, making laboratory testing a very important aspect of diagnosis. In North America, many unsuspected cases are discovered by laboratory testing. The etiological agent, Treponema pallidum, cannot be cultured, and there is no single optimal alternative test. Serological testing is the most frequently used approach in the laboratory...

Prevention of Foodborne Listeriosis

Listeria monocytogenes is a Gram-positive, rod-shaped bacterium which, although recognized in the medical literature as an opportunistic pathogen for the past 60 years, has only recently gained prominence as an important foodborne pathogen. Factors which make this organism unique among foodborne pathogens include its ability both to survive in foods under a variety of adverse...

Comparative Antifungal Activity of Cilofungin (LY121019) against Candida Species, Including Evaluation of Susceptibility Testing Method

The in vitro activity of cilofungin against 100 Candida species was compared with 5-flucytosine. amphotericin B and ketoconazole by two laboratories independently and in a blinded fashion using a macrotitre dilution broth method in saam-f medium. Cilofungin showed good in vitro activity against Candida albicans. Candida tropicalis and Candida glabrata (90% minimal inhibitory...

Biological Response Modifiers in Combination with Antivirals against Experimentally-Induced Virus Infections

Biological response modifiers (BRMs) have particular promise when used in combination with more standard antiviral agents for treatment of viral diseases. Reported here are a series of studies which have used two BRMs in combination with the antiviral drug, ribavirin (l-β-o-ribofuranosyl-1,2,4-triazole-3-carboxamide) in treatment of experimentally-induced phlebovirus (Punta Toro...

Laboratory Diagnosis of HIV Infection

The laboratory diagnosis of HIV infection has progressed greatly since the introduction of the commercially prepared, HIV antibody assay in 1985. However, the antibody assay remains the gold standard since the sensitivity and specificity of properly performed tests exceed 99%. Recent progress in diagnostic test development includes the availabilily of reliable HIV p-24 antigen...

Comparative Activity of Cefepime with Several Antimicrobials against Aerobic Gram-Negative and Gram-Positive Organisms Isolated from Patients across Canada in 1993

To compare the activity of cefepime, a fourth-generation cephalosporin, with several available antimicrobials, in vitro susceptibility studies were carried out on bacteria commonly associated with various infections, including sepsis. Ten tertiary care hospital laboratories in six provinces provided 1276 clinically relevant isolates of aerobic Gram-negative bacilli and Gram...

Sequential Antibiotic Therapy: Effective Cost Management and Patient Care

The escalating costs associated with antimicrobial chemotherapy have become of increasing concern to physicians, pharmacists and patients alike. A number of strategies have been developed to address this problem. This article focuses specifically on sequential antibiotic therapy (sat), which is the strategy of converting patients from intravenous to oral medication regardless of...

Chlamydia Infection in Street Youth: Need for More Aggressive Screening Programs

OBJECTIVES: To determine, first, the sexual practices among street youth in the Ottawa-Carleton, Ontario region; second, the percentage of street youth who report previous sexually transmitted disease (STD) screening; and third, the rate of previous infection with Chlamydia trachomatis in this population.

Evaluation of Routine Enteric Pathogens in Hospitalized Patients: A Canadian Perspective

Diarrhea is a frequently encountered problem in hospitalized patients. Since nosocomial spread of routine enteric pathogens such as Salmonella species, Shigella species, Campylobacter species and Escherichia coli O:157 H:7 seldom occurs, testing for these organisms in patients hospitalized for longer than three days has been questioned. The goal of this study was to determine the...

Disseminated Nocardia Otitidiscaviarum in a Patient with AIDS

A case of disseminated infection due to Nocardia otitidiscaviarum is described in a Caucasian man infected with the human immunodeficiency virus. The patient presented with no previous AIDS-defining conditions, a CD4 lymphocyte count of 206 cells/mm3 and enlarging intra-abdominal and chest wall abscesses with bilateral pulmonary infiltrates. Aggressive surgical debridement and...

The Antibiotic Puzzle: Guidelines for the Family Physician

Choosing the most appropriate antibiotic for the treatment of common infections is becoming increasingly complex. New drugs and new classes of antibiotics are being developed and made available, and emerging resistance and pharmacoeconomics play important roles. The Canadian healthcare system presents a unique challenge for prescribing physicians because pharmacoeconomic...

Current Antibiotic Treatment and Outcome for Lower Respiratory Tract Infections

A number of national guidelines have been published to aid the antimicrobial management of community-acquired pneumonia. However, data on prescriptions for lower respiratory tract infection (LRTI) indicate considerable variation in the choice of first-line and subsequent therapy at national and local levels. Outcomes research in LRTI, whether based on clinical, economic or...

Diagnosis and Analysis of a Recent Case of Human Rabies in Canada

BACKGROUND: On September 30, 2000, staff at the Canadian Food Inspection Agency's Centre of Expertise for Rabies, located at the Animal Diseases Research Institute in Ottawa, Ontario, diagnosed rabies in a child from Quebec. This was the first case of rabies in a human in Canada in 15 years and in 36 years in the province of Quebec. After spending a week in intensive care in a...