Eye and Vision

http://link.springer.com/journal/40662

List of Papers (Total 102)

Ex vivo testing of intact eye globes under inflation conditions to determine regional variation of mechanical stiffness

Background The eye globe exhibits significant regional variation of mechanical behaviour. The aim of this present study is to develop a new experimental technique for testing intact eye globes in a form that is representative of in vivo conditions, and therefore suitable for determining the material properties of the complete outer ocular tunic. Methods A test rig has been...

Tear biomarkers for keratoconus

Keratoconus is a progressive corneal thinning, ectatic condition, which affects vision. Recent advances in corneal topography measurements has helped advance proper diagnosis of this condition and increased research and clinical interests in the disease etiopathogenesis. Considerable progress has been achieved in understanding the progression of the disease and tear fluid has...

Standard manual capsulorhexis / Ultrasound phacoemulsification compared to femtosecond laser-assisted capsulorhexis and lens fragmentation in clear cornea small incision cataract surgery

Background Femtosecond-laser assisted clear cornea cataract surgery may hold promise in safer and more effective procedures. We decided to perform a comparative study to standard manual incision phacoemulsification surgery. Methods This is a single-center, single-intervention, and prospective comparative data evaluation of 133 consecutive cases subjected to cataract surgery...

Consideration of corneal biomechanics in the diagnosis and management of keratoconus: is it important?

Keratoconus is a bilateral, non-inflammatory, degenerative corneal disease. The occurrence and development of keratoconus is associated with corneal thinning and conical protrusion, which causes irregular astigmatism. With the disruption of the collagen organization, the cornea loses its shape and function resulting in progressive visual degradation. Currently, corneal topography...

Knowledge and attitudes toward corneal donation among Singaporean youth: a cross-sectional study

Background To assess the knowledge of Singaporean youth regarding corneal donation and gauge their willingness to donate their corneas. Methods We conducted a cross-sectional study among 500 students from five tertiary institutions in Singapore. All students answered self-administered questionnaires which included seven questions that tested knowledge and three questions that...

Genetics in Keratoconus: where are we?

Keratoconus (KC) is a non-inflammatory thinning and protrusion of the cornea in which the cornea assumes a conical shape. Complex etiology of this condition at present remains an enigma. Although environmental factors have been involved in KC pathogenesis, strong underlining genetic susceptibility has been proven. The lack of consistent findings among early genetic studies...

Effect of fibrin glue on corneal lamellar healing and how it correlates to biomechanical properties: biomechanical wavefront analysis and confocal study

Background To evaluate, using a rabbit model, the influence of the wound healing process at the flap edge on corneal biomechanics after sutured, glued, and non-augmented microkeratome flaps. Methods Unilateral 160 μm thick laser in situ keratomileusis (LASIK) flaps using a mechanical microkeratome were performed on the corneas of the left eyes of 36 rabbits. Animals were then...

Demographics, referral patterns and management of patients accessing the Welsh Eye Care Service

BackgroundThe Primary Eyecare Acute Referral Service (PEARS) and the Wales Eye Health Examination (WEHE) operate as enhanced optometry services for patients residing in Wales, enabling the examination of a patient presenting with an acute eye problem (PEARS) or the examination of patients at higher risk of eye disease (WEHE). The purpose of the study is to assess the demographics...

Assessment of refractive astigmatism and simulated therapeutic refractive surgery strategies in coma-like-aberrations-dominant corneal optics

Background The aim of the study is to raise the awareness of the influence of coma-like higher-order aberrations (HOAs) on power and orientation of refractive astigmatism (RA) and to explore how to account for that influence in the planning of topography-guided refractive surgery in eyes with coma-like-aberrations-dominant corneal optics. Methods Eleven eyes with coma-like...

The Italian Catquest-9SF cataract questionnaire: translation, validation and application

Background To validate the Catquest-9SF questionnaire in Italian, assess the change in visual disability with cataract surgery and determine the correlation between pre-operative Catquest-9SF scores and Lens Opacities Classification System (LOCS) III cataract grading. Methods Prospective, questionnaire validation study. The Catquest-9SF questionnaire was forward and back...

PACK-CXL: Corneal cross-linking in infectious keratitis

BackgroundCorneal cross-linking (CXL) using ultraviolet light-A (UV-A) and riboflavin is a technique developed in the 1990’s to treat corneal ectatic disorders such as keratoconus. It soon became the new gold standard in multiple countries around the world to halt the progression of this disorder, with good long-term outcomes in keratometry reading and visual acuity. The original...

Where does selective laser trabeculoplasty stand now? A review

BackgroundChronic treatment of glaucoma can present a challenge in patients who lack the means and/or the discipline to use daily glaucoma medication. We wondered if selective laser trabeculoplasty (SLT) could be a useful alternative.MethodsInclusion criteria: controlled trials comparing efficacy of SLT in adult patients with any form of open angle glaucoma or ocular hypertension...

Eye and Vision reviewer acknowledgement 2015

The editors of Eye and Vision would like to thank all our reviewers who have contributed to the journal in volume 2 (2015).

The use of intracorneal ring segments in keratoconus

Keratoconus is a corneal degeneration that usually appears during puberty and may seriously deteriorate the quality of life of the patients. This corneal disease is today the first indication of corneal transplantation in young patients. Until the last decade of the XX century, keratoplasty procedures were the only alternative to treat this pathological condition. In the...

Assessing progression of keratoconus: novel tomographic determinants

Several methods have been described in the literature to both evaluate and document progression in keratoconus, but there is no consistent or clear definition of ectasia progression. The authors describe how modern corneal tomography, including both anterior and posterior elevation and pachymetric data can be used to screen for ectatic progression, and how software programs such...

High intercorneal symmetry in corneal biomechanical metrics

BackgroudTo evaluate the symmetry of corneal biomechanical metrics, measured using an ocular response analyzer (ORA) and self-built corneal inflation test platform, in bilateral rabbit corneas and to investigate their relationship with physical intraocular pressure (IOPp).MethodsTwenty fresh enucleated eyes from ten rabbits were used for ex vivo whole ocular globe inflation. IOP...

Higher incidence of steroid-induced ocular hypertension in keratoconus

Background To compare intraocular pressure (IOP) changes following topical dexamethasone administration for 1 month in keratoconic versus normal eyes. Methods This is a retrospective, single-center, non-randomized case series evaluation of 350 eyes. Two groups were formed: normal/control Group A (nA =73), eyes that underwent excimer laser photorefractive keratectomy; and...

Corneal topography in keratoconus: state of the art

The morphological characterization of the cornea using corneal topographers is a widespread clinical practice that is essential for the diagnosis of keratoconus. The current state of this non-invasive exploratory technique has evolved with the possibility of achieving a great number of measuring points of both anterior and posterior corneal surfaces, which is possible due to the...

Wavefront-optimized surface retreatments of refractive error following previous laser refractive surgery: a retrospective study

BackgroundRetreatments are sometimes necessary to correct residual or induced refractive errors following refractive surgery. Many different combinations of primary treatment methods and retreatment techniques have been studied, however, few studies have investigated wavefront-optimized (WFO) technology for retreatment following primary refractive surgery. This study aimed to...

Corneal surgery in keratoconus: which type, which technique, which outcomes?

Keratoconus is a disease characterized by progressive thinning, bulging, and distortion of the cornea. Advanced cases usually present with loss of vision due to high irregular astigmatism. A majority of these cases require surgical intervention. This review provides an update on the current treatment modalities of corneal surgery available for the management of advanced corneal...

In pursuit of objective dry eye screening clinical techniques

Dry eye is a multifactorial, progressive, and chronic disease of the tears and ocular surface. The disease is multi-factorial and has intermittent symptoms. Discomfort, visual disturbance, tear film instability with potential damage to the ocular surface, and increased tear film osmolarity are known associates. Dry eye is a common clinical problem for eye-care providers worldwide...

Safety and efficacy of VisuMax® circle patterns for flap creation and enhancement following small incision lenticule extraction

Background The purpose of this case series is to evaluate the safety and efficacy of VisuMax® Circle patterns in eyes that have undergone small incision lenticule extraction, thus creating a flap to perform an enhancement procedure or residual lenticule extraction. Methods This prospective, single center, case study series evaluated the use of a VisuMax® Circle pattern to create...

Collagen cross-linking: when and how? A review of the state of the art of the technique and new perspectives

Since the late 1990s corneal crosslinking (CXL) has been proposed as a new possibility to stop progression of keratoconus or secondary corneal ectasia, with the promising aim to prevent progressive visual loss due to the evolution of the pathology and to delay or avoid invasive surgical procedures such as corneal transplantation. The possibility of strengthening corneal tissue by...

In vivo study of corneal responses to increased intraocular pressure loading

Background The cornea is responsible for two-thirds of the eye's refractive power which is a function of the shape and refractive index. The aim of this present study is to examine human eyes in vivo for corneal shape changes in response to short-term elevation in intraocular pressure. Methods Videokeratographic and tonometric assessments at baseline were compared with the same...

Development and validation of a novel PCR-RFLP based method for the detection of 3 primary mitochondrial mutations in Leber's hereditary optic neuropathy patients

BackgroundLeber’s Hereditary Optic Neuropathy (LHON; MIM 535000) is one of the most commonly inherited optic neuropathies and it results in significant visual morbidity among young adults with a peak age of onset between the ages of 15–30. The worldwide incidence of LHON is approximately 1 in 31,000. 95 % of LHON patients will have one of 3 primary mitochondrial mutations, G3460A...