Digestive Diseases and Sciences

http://link.springer.com/journal/10620

List of Papers (Total 685)

Long-Term Clinical Outcomes After Switching from Remicade® to Biosimilar CT-P13 in Inflammatory Bowel Disease

Background Limited data are available on long-term clinical outcomes regarding the switch from Remicade® to the infliximab biosimilar CT-P13 in inflammatory bowel disease (IBD) patients. Aims To investigate long-term efficacy, safety, pharmacokinetic profile, and immunogenicity. Methods We performed a single-center prospective observational cohort study following an elective switch ...

Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway

Genetic investigations have provided unique insight into the mechanism of chronic pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central pathogenic factor. Mutations in the PRSS1, SPINK1, and CTRC genes promote increased activation of trypsinogen to trypsin by stimulation of autoactivation or by impairing protective trypsinogen degradation ...

The Gastroenterology Fellowship Match: A Decade Later

Following a period of uncertainty and disorganization, the gastroenterology (GI) national leadership decided to reinstitute the fellowship match (the Match) under the auspices of the National Residency Matching Program (NRMP) in 2006. Although it has now been a decade since the rebirth of the Match, there have been limited data published regarding progress made. In this piece, we ...