Annals of Biomedical Engineering

http://link.springer.com/journal/10439

List of Papers (Total 358)

Augmented Reality Based Navigation for Computer Assisted Hip Resurfacing: A Proof of Concept Study

Implantation accuracy has a great impact on the outcomes of hip resurfacing such as recovery of hip function. Computer assisted orthopedic surgery has demonstrated clear advantages for the patients, with improved placement accuracy and fewer outliers, but the intrusiveness, cost, and added complexity have limited its widespread adoption. To provide seamless computer assistance...

Stormram 4: An MR Safe Robotic System for Breast Biopsy

Suspicious lesions in the breast that are only visible on magnetic resonance imaging (MRI) need to be biopsied under MR guidance with high accuracy and efficiency for accurate diagnosis. The aim of this study is to present a novel robotic system, the Stormram 4, and to perform preclinical tests in an MRI environment. Excluding racks and needle, its dimensions are 72 × 51 × 40 mm...

The Effect of Heated CO2 Insufflation in Minimising Surgical Wound Contamination During Open Surgery

The primary source of infections in open surgeries has been found to be bacteria and viruses carried into the surgical wound on the surfaces of skin particles shed by patients and surgical staff. In open cardiac surgeries, insufflation of the wound with carbon dioxide is used to limit the quantity of air able to enter into the heart, avoiding air embolisms when the heart is...

Mechanical and Clinical Evaluation of a Shape Memory Alloy and Conventional Struts in a Flexible Scoliotic Brace

Smart materials have attracted considerable attention in the medical field. In particular, shape memory alloys (SMAs) are most commonly utilized for their superelasticity (SE) in orthopaedic treatment. In this study, the resin struts of a flexible brace for adolescent idiopathic scoliosis (AIS) are replaced with different conventional materials and an SMA. The corrective...

From Tension to Compression: Asymmetric Mechanical Behaviour of Trabecular Bone’s Organic Phase

Trabecular bone is a cellular composite material comprising primarily of mineral and organic phases with their content ratio known to change with age. Therefore, the contribution of bone constituents on bone’s mechanical behaviour, in tension and compression, at varying load levels and with changing porosity (which increases with age) is of great interest, but remains unknown. We...

Spatio-temporal Organization During Ventricular Fibrillation in the Human Heart

In this paper, we present a novel approach to quantify the spatio-temporal organization of electrical activation during human ventricular fibrillation (VF). We propose three different methods based on correlation analysis, graph theoretical measures and hierarchical clustering. Using the proposed approach, we quantified the level of spatio-temporal organization during three...

Robot-Assisted Fracture Surgery: Surgical Requirements and System Design

The design of medical devices is a complex and crucial process to ensure patient safety. It has been shown that improperly designed devices lead to errors and associated accidents and costs. A key element for a successful design is incorporating the views of the primary and secondary stakeholders early in the development process. They provide insights into current practice and...

Collagen Damage Location in Articular Cartilage Differs if Damage is Caused by Excessive Loading Magnitude or Rate

Collagen damage in articular cartilage is considered nearly irreversible and may be an early indication of cartilage degeneration. Surface fibrillation and internal collagen damage may both develop after overloading. This study hypothesizes that damage develops at these different locations, because the distribution of excessive strains varies with loading rate as a consequence of...

Biomechanical Characterisation of Bone-anchored Implant Systems for Amputation Limb Prostheses: A Systematic Review

Bone-anchored limb prostheses allow for the direct transfer of external loads from the prosthesis to the skeleton, eliminating the need for a socket and the associated problems of poor fit, discomfort, and limited range of movement. A percutaneous implant system for direct skeletal attachment of an external limb must provide a long-term, mechanically stable interface to the bone...

Correction to: Deformability of Human Mesenchymal Stem Cells Is Dependent on Vimentin Intermediate Filaments

This erratum is to correct the following: (1) in the Western Blotting subsection under the Materials and Methods section, the concentration of protein from each sample loaded into Criterion Tris–HCl gels was incorrectly stated as 155 µg of protein. The correct value is 9.7 µg; (2) in Fig. 1b, the bar graph showed incorrect values for semi-quantitation of Western blots. Figure 1...

A Robotic Flexible Drill and Its Navigation System for Total Hip Arthroplasty

This paper presents a robotic flexible drill and its navigation system for total hip arthroplasty (THA). The new robotic system provides an unprecedented and unique capability to perform curved femoral milling under the guidance of a multimodality navigation system. The robotic system consists of three components. Firstly, a flexible drill manipulator comprises multiple rigid...

Cell Migration in 1D and 2D Nanofiber Microenvironments

Understanding how cells migrate in fibrous environments is important in wound healing, immune function, and cancer progression. A key question is how fiber orientation and network geometry influence cell movement. Here we describe a quantitative, modeling-based approach toward identifying the mechanisms by which cells migrate in fibrous geometries having well controlled...

Using a Teaching Intervention and Calibrated Peer Review™ Diagnostics to Improve Visual Communication Skills

Rice University’s bioengineering department incorporates written, oral, and visual communication instruction into its undergraduate curriculum to aid student learning and to prepare students to communicate their knowledge and discoveries precisely and persuasively. In a tissue culture lab course, we used a self- and peer-review tool called Calibrated Peer Review™ (CPR) to...

Role of Re-entry Tears on the Dynamics of Type B Dissection Flap

Mortality during follow-up after acute Type B aortic dissection is substantial with aortic expansion observed in over 59% of the patients. Lumen pressure differential is considered a prime contributing factor for aortic dilation after propagation. The objective of the study was to evaluate the relationship between changes in vessel geometry with and without lumen pressure...

Correction to: Impact Performance of Modern Football Helmets

This erratum is to correct headings listing the impact location and speed in Figs. 5 and 6. The following provides corrected Figs. 5 and 6. The data is unchanged. The authors apologize for any inconvenience this might have caused.

Knee Implant Loosening Detection: A Vibration Analysis Investigation

Knee implant loosening is mainly caused by the weakness of the prosthesis-bone interface and is the main reason for surgical revisions. However, pre-operative diagnosis is difficult due to lack of accurate tests. In this study, we developed a vibration-based system to detect the loosening of the tibial implant of an instrumented knee prosthesis. The proposed system includes an...

Simultaneous Measurement of Contraction and Calcium Transients in Stem Cell Derived Cardiomyocytes

Induced pluripotent stem cell derived cardiomyocytes (iPSC-CM) provide a powerful platform for disease modeling and drug development in vitro. Traditionally, electrophysiological methods or fluorescent dyes (e.g. calcium) have been used in their functional characterization. Recently, video microscopy has enabled non-invasive analysis of CM contractile motion. Simultaneous...

Importance of Consistent Datasets in Musculoskeletal Modelling: A Study of the Hand and Wrist

Hand musculoskeletal models provide a valuable insight into the loads withstood by the upper limb; however, their development remains challenging because there are few datasets describing both the musculoskeletal geometry and muscle morphology from the elbow to the finger tips. Clinical imaging, optical motion capture and microscopy were used to create a dataset from a single...

Investigation of Shape with Patients Suffering from Unilateral Lymphoedema

This study investigates the use of a 3D depth sensing camera for analysing the shape of lymphoedematous arms, and seeks to identify suitable metrics for monitoring lymphoedema clinically. A fast, simple protocol was developed for scanning upper limb lymphoedema, after which a robust data pre- and post-processing framework was built that consistently and quickly identifies arm...

Ranges of Injury Risk Associated with Impact from Unmanned Aircraft Systems

Regulations have allowed for increased unmanned aircraft systems (UAS) operations over the last decade, yet operations over people are still not permitted. The objective of this study was to estimate the range of injury risks to humans due to UAS impact. Three commercially-available UAS models that varied in mass (1.2–11 kg) were evaluated to estimate the range of risk associated...

Image-Guided Surgical Robotic System for Percutaneous Reduction of Joint Fractures

Complex joint fractures often require an open surgical procedure, which is associated with extensive soft tissue damages and longer hospitalization and rehabilitation time. Percutaneous techniques can potentially mitigate these risks but their application to joint fractures is limited by the current sub-optimal 2D intra-operative imaging (fluoroscopy) and by the high forces...