JNCI: Journal of the National Cancer Institute

https://academic.oup.com/jnci

List of Papers (Total 3,839)

Drugging the Cancers Addicted to DNA Repair

Defects in DNA repair can result in oncogenic genomic instability. Cancers occurring from DNA repair defects were once thought to be limited to rare inherited mutations (such as BRCA1 or 2). It now appears that a clinically significant fraction of cancers have acquired DNA repair defects. DNA repair pathways operate in related networks, and cancers arising from loss of one DNA...

Breast Cancer Risk and Progressive Histology in Serial Benign Biopsies

More than 1 million women per year in the United States with benign breast biopsies are known to be at elevated risk for breast cancer (BC), with risk stratified on histologic categories of epithelial proliferation. Here we assessed women who had serial benign biopsies over time and how changes in the histologic classification affected BC risk.

Evidence for a Mesothelial Origin of Body Cavity Effusion Lymphomas

Primary effusion lymphoma (PEL) is a Kaposi's sarcoma herpes virus (KSHV)–induced lymphoma that typically arises in body cavities of HIV-infected patients. PEL cells are often co-infected with Epstein-Barr virus (EBV). “PEL-like” lymphoma is a KSHV-unrelated lymphoma that arises in body cavities of HIV-negative patients. “PEL-like” lymphoma is sometimes EBV positive. The...

Local Treatment of Unresectable Colorectal Liver Metastases: Results of a Randomized Phase II Trial

Tumor ablation is often employed for unresectable colorectal liver metastases. However, no survival benefit hasever been demonstrated in prospective randomized studies. Here, we investigate the long-term benefits of such an aggressive approach.

The Role of Obesity, Type 2 Diabetes, and Metabolic Factors in Pancreatic Cancer: A Mendelian Randomization Study

Risk factors for pancreatic cancer include a cluster of metabolic conditions such as obesity, hypertension, dyslipidemia, insulin resistance, and type 2 diabetes. Given that these risk factors are correlated, separating out causal from confounded effects is challenging. Mendelian randomization (MR), or the use of genetic instrumental variables, may facilitate the identification...

Meta-Analysis of the Association Between Phosphodiesterase Inhibitors (PDE5Is) and Risk of Melanoma

The US Food and Drug Administration recently announced the need to evaluate the association between PDE5is and melanoma. We performed a meta-analysis on the association between PDE5i and melanoma using random effects models and examined whether it met Hill's criteria for causality. A systematic search of Medline, EMBASE, and the Cochrane Library from 1998 to 2016 identified three...