JNCI: Journal of the National Cancer Institute


List of Papers (Total 2,514)

Relationship Between Sunlight Exposure and a Key Genetic Alteration in Basal Cell Carcinoma

Basal cell carcinoma (BCC) of the skin is the most common cancer in humans. Epidemiologic studies implicate sunlight exposure as one risk factor, but the limited association between BCCs and UVB radiation (i.e., UV radiation of a wavelength of 280–320 nm) suggests that additional factors must be involved. At the molecular level, not much is known about the role of specific...

γ-Glutamyl Transpeptidase Mediation of Tumor Glutathione Utilization In Vivo

Glutathione is a tripeptide used by cells to protect against oxidative and free radical damage. It may also be involved in biochemical mechanisms that cause some tumors to become resistant to anticancer drugs. γ-Glutamyl transpeptidase (GGTP) is a membrane-bound enzyme that cleaves extracellular glutathione, providing cells with amino acids necessary for intracellular synthesis...