# SpringerPlus

## List of Papers (Total 4,582)

#### Review and results of a survey about biosimilars prescription and challenges in the Middle East and North Africa region

Background Only drafts of regulatory guidelines for the registration of biosimilars are available in Lebanon. We analyzed the results of a regional survey conducted in Lebanon to understand the impact of different parameters on the acceptance and future prescription of biosimilars. We also reviewed the current situation of biosimilars around the world. The study surveyed healthcare ...

#### Effect of chlorhexidine pretreatment on bacterial contamination at rhinoplasty field

Background This study investigated on bacterial contamination of the rhinoplasty field. The effect of preoperative chlorhexidine treatment on decreasing bacterial contamination in the rhinoplasty field is examined. Methods Thirty patients who underwent rhinoplasty were block randomized into a chlorhexidine, regular-soap, or control group comprising ten participants each. The ...

#### Molecular diagnostic markers of Tachysurus fulvidraco and Leiocassis longirostris and their hybrids

Background Bagridae is an important family of catfishes and has a high market demand. Recently, more cultivable Bagridae fishes are being exploited in China, and hybridization of some species has been carried out to achieve better growth performance, favorable sex ratios and better disease resistance. Yet, these hybrids have further increased the difficulties of taxonomy ...

#### Are the expected benefits of requirements reuse hampered by distance? An experiment

Background Software development processes are often performed by distributed teams which may be separated by great distances. Global software development (GSD) has undergone a significant growth in recent years. The challenges concerning GSD are especially relevant to requirements engineering (RE). Stakeholders need to share a common ground, but there are many difficulties as ...

#### Volumetric medical image compression using 3D listless embedded block partitioning

This paper presents a listless variant of a modified three-dimensional (3D)-block coding algorithm suitable for medical image compression. A higher degree of correlation is achieved by using a 3D hybrid transform. The 3D hybrid transform is performed by a wavelet transform in the spatial dimension and a Karhunen–Loueve transform in the spectral dimension. The 3D transformed ...

#### An EMG-based feature extraction method using a normalized weight vertical visibility algorithm for myopathy and neuropathy detection

Background Electromyography (EMG) signals recorded from healthy, myopathic, and amyotrophic lateral sclerosis (ALS) subjects are nonlinear, non-stationary, and similar in the time domain and the frequency domain. Therefore, it is difficult to classify these various statuses. Methods This study proposes an EMG-based feature extraction method based on a normalized weight vertical ...

#### Some isomorphic properties of m-polar fuzzy graphs with applications

The theory of graphs are very useful tool in solving the combinatorial problems in different areas of computer science and computational intelligence systems. In this paper, we present a frame work to handle m-polar fuzzy information by combining the theory of m-polar fuzzy sets with graphs. We introduce the notion of weak self complement m-polar fuzzy graphs and establish a ...

#### What makes it likeable? A study on the reactions to messages in a digital social network: the case of Facebook in Farsi

Background After a piece of information is put into a network, its fate depends on the behaviors of the nodes of the network; nodes that are equipped with the hardware and software of the age of information and are more powerful than any time in the past. This study suggests that a useful research for communication, marketing and advertising would be one that looks for patterns in ...

#### Ontology construction and application in practice case study of health tourism in Thailand

Ontology is one of the key components in semantic webs. It contains the core knowledge for an effective search. However, building ontology requires the carefully-collected knowledge which is very domain-sensitive. In this work, we present the practice of ontology construction for a case study of health tourism in Thailand. The whole process follows the METHONTOLOGY approach, which ...

#### Characterization of saliva microbiota’s functional feature based on metagenomic sequencing

Objective Saliva, a mixture of exocrinally secretive fluids, amounts to ~1.5 L daily and harbors numerous microbial inhabitants. However, except the organismal structure of saliva microbiota, the functional profile of saliva microbiota remain elusive. Methods Here we used metagenomic sequencing to experimentally reconstruct the global genomic profile of saliva by sequencing total ...

#### Phenolics profile and anti-proliferative activity of Cyphomandra Betacea fruit in breast and liver cancer cells

Background Cyphomandra betacea (C. betacea) belongs to the Solanaceae family. This study was aimed to evaluate the anti-proliferative of C.betacea crude extract against selected cancer cell lines (breast and liver cancer) and to identify the polyphenolics profile (phenolic acids and flavonoids) of C. betacea fruits. Anti-proliferative effect of the extracts was examined using MTT ...

#### Influence of particle size on non-Darcy seepage of water and sediment in fractured rock

Surface water, groundwater and sand can flow into mine goaf through the fractured rock, which often leads to water inrush and quicksand movement. It is important to study the mechanical properties of water and sand in excavations sites under different conditions and the influencing factors of the water and sand seepage system. The viscosity of water–sand mixtures under different ...

#### Effect of various anticoagulants on the bioanalysis of drugs in rat blood: implication for pharmacokinetic studies of anticancer drugs

Background Pharmacokinetic studies are vital in development and optimization of drugs. While blood samples can be collected either in EDTA, heparin or citrate containing tubes for the estimation of drug levels in plasma, EDTA tubes are more commonly used. The purpose of this study was to evaluate the effects of anticoagulants on bioanalysis of drugs. Six drugs used extensively in ...

#### Molecular cloning, polymorphism, and functional activity of the bovine and water buffalo Mx2 gene promoter region

Background Bovine Mx2 gene sequences were already reported, but further information about the gene properties is not yet available. The objective of the current study was to elucidate the structural properties of the bovine Mx2 gene mainly the promoter region and its possible functional role. If available, such information would help in assessing the functional properties of the ...

#### Correlations of microRNA-124a and microRNA-30d with clinicopathological features of breast cancer patients with type 2 diabetes mellitus

This study intends to investigate the correlations of miR-124a and miR-30d with clinicopathological features of breast cancer (BC) patients with type 2 diabetes mellitus (T2DM). A total of 72 BC patients with T2DM (diabetic group) and 144 BC patients without T2DM (non-diabetic group) were enrolled in this study. Blood glucose was detected by glucose oxidase methods. Glycosylated ...

#### Diagnosis and treatment of spontaneous intracranial hypotension due to cerebrospinal fluid leakage

Introduction Spontaneous intracranial hypotension is one of the causes of a postural headache in young people. In this study, the diagnosis and treatment results of a case of intracranial hypotension headache due to spinal cerebrospinal fluid leakage were reported. Up to now, there is not absolutely effective treatment for intracranial hypotension headache. Case description A ...

#### Critical evaluation of reverse engineering tool Imagix 4D!

Introduction The comprehension of legacy codes is difficult to understand. Various commercial reengineering tools are available that have unique working styles, and are equipped with their inherent capabilities and shortcomings. The focus of the available tools is in visualizing static behavior not the dynamic one. Therefore, it is difficult for people who work in software product ...

#### Surface topological differences of phage infected uropathogenic Escherichia coli (UPEC) strains, revealed by atomic force microscopy

Background Atomic force microscopy (AFM) is an advance microscopic technique that provides three dimensional structures of cell surfaces with high resolution. In the present study AFM was used for comparative analysis of surface topology of phage infected and uninfected Uropathogenic Escherichia coli (UPEC) cells. Two UPEC strains NE and HN were isolated from urine samples of ...

#### Twelfth degree spline with application to quadrature

In this paper existence and uniqueness of twelfth degree spline is proved with application to quadrature. This formula is in the class of splines of degree 12 and continuity order $C^{12}$ that matches the derivatives up to order 6 at the knots of a uniform partition. Some mistakes in the literature are pointed out and corrected. Numerical examples are given to illustrate the ...

#### Rice grain nutritional traits and their enhancement using relevant genes and QTLs through advanced approaches

Background Rice breeding program needs to focus on development of nutrient dense rice for value addition and helping in reducing malnutrition. Mineral and vitamin deficiency related problems are common in the majority of the population and more specific to developing countries as their staple food is rice. Results Genes and QTLs are recently known for the nutritional quality of ...