International Journal of Clinical Pharmacy

http://link.springer.com/journal/11096

List of Papers (Total 198)

Inhibition of cough reflex sensitivity by diphenhydramine during acute viral respiratory tract infection

Background: Currently available over-the-counter cough remedies historically have been criticized for lack of scientific evidence supporting their efficacy. Although the first-generation antihistamine diphenhydramine is classified as an antitussive by the United States Food and Drug Administration, to the authors’ knowledge it has never been shown to inhibit cough reflex...

Chronopharmacokinetics of once daily dosed aminoglycosides in hospitalized infectious patients

Background hospitalized patients with serious infections treated with aminoglycosides are at risk of developing nephrotoxicity. Previous clinical studies have shown that the pharmacokinetics of aminoglycosides in humans follow a circadian rhythm. Therefore, the time of administration could have important clinical implications with respect to the risk of developing aminoglycoside...

Exploring the opinions and experiences of patients with generic substitution: a representative study of Polish society

Background Generics have the potential to contain drug therapy costs; successful implementation of generic substitution policy largely depends on consumers’ willingness to choose generics. Objective This study aims to analyse the opinions, experiences and preferences of Polish patients towards generic medicines. Setting The study was performed in Poland. Method The survey was...

Out-of-range INR values and outcomes among new warfarin patients with non-valvular atrial fibrillation

Background Although efficacious in stroke prevention in non-valvular atrial fibrillation, many warfarin patients are sub-optimally managed. Objective To evaluate the association of international normalized ratio control and clinical outcomes among new warfarin patients with non-valvular atrial fibrillation. Setting Adult non-valvular atrial fibrillation patients (≥18 years...

Patient involvement in medication safety in hospital: an exploratory study

Background Medication errors are common in hospital inpatients. While many interventions have been proposed to address these problems, few have been shown to have significant benefits. A complementary approach is to facilitate greater involvement of patients with their inpatient medication. However, there is relatively little research in this area and it is not known which...

Attitudes towards conscientious objection among community pharmacists in Poland

Background The European Council Resolution 1763 (2010), “The right to conscientious objection in lawful medical care”, provoked a discussion among Polish pharmacists on the necessity for granting them the right to refuse to dispense medicinal products which invoke conscientious objection. Objective To explore attitudes of Polish pharmacists towards the conscience clause. Setting...

Weaning from intravenous prostanoids and normalization of hemodynamics by long-term imatinib therapy in severe idiopathic pulmonary arterial hypertension

Introduction Despite new treatment options targeted at its three main pathogenic pathways, prognosis of idiopathic pulmonary arterial hypertension has remained dismal, with 3-year survival rates around 70 %. Antiproliferative agents have emerged as a new therapeutic concept. However, they may exert their effects only after a prolonged period of time. Case description Herein we...

Cognitive memory screening and referral program in community pharmacies in the United States

Introduction 12 chain community pharmacy sites located in two geographic areas with the United States implemented easy-to-administer memory screening assessments for patients with risk factors of cognitive memory decline and referred at-risk patients to their physicians. Aim of the study To evaluate the impact of a pharmacy-based cognitive memory screening and referral program...

A method for calculating adherence to polypharmacy from dispensing data records

Background Several measures for calculating adherence to one medication from dispensing data records have been proposed, but the nomenclature is inconsistent and computations vary. The same measures, like the medication possession ratio (MPR), have been used for multiple medication regimens, and have tended to over- or under-estimate adherence rates. Objective To demonstrate the...

Adherence: the journey of medication taking, are we there yet?

Patient adherence to medications has been an issue challenging healthcare professionals for decades. Adherence rates, causes of non-adherence, barriers and enablers to medication taking, interventions to promote adherence, and the impact of non-adherence on health outcomes, have been extensively studied. In light of this, the area of adherence research has progressed conceptually...

Adherence to inhaled corticosteroids by asthmatic patients: measurement and modelling

Background Poor adherence to inhaled corticosteroids (ICS) is known as the main cause for therapeutic failure in asthma treatment and associated morbidity. To improve adherence, targetted and effective interventions need to be developed ideally based on using longitudinal follow-up of a large study cohort to establish patterns and influences on adherence. Objective To develop an...

Disease acceptance and adherence to imatinib in Taiwanese chronic myeloid leukaemia outpatients

Background The launch of imatinib has turned chronic myeloid leukaemia (CML) into a chronic illness due to the dramatic improvement in survival. Several recent studies have demonstrated that poor adherence to imatinib may hamper the therapeutic outcomes and result in increased medical expenditures, whilst research on exploring the reasons for non-adherence to imatinib is still...

Imatinib adherence associated clinical outcomes of chronic myeloid leukaemia treatment in Taiwan

Background Since the launch of imatinib, chronic myeloid leukaemia has become a chronic condition requiring costly long-term treatment. Emerging evidence from several short-term studies has raised concerns on the detrimental clinical outcomes and waste of resources associated with poor adherence to imatinib. Objective This study aims to evaluate the effects of long-term imatinib...

Community pharmacists’ interventions with electronic prescriptions in England: an exploratory study

Background Prescribing errors in primary care are problematic. The electronic prescription service (EPS) is an English electronic system linking prescribing, dispensing and reimbursement, designed to rectify some of the problems associated with paper-based prescribing. Objective To document the numbers and types of interventions made by community pharmacists and their staff using...

Linda J. Dodds: Drugs in use, case studies for pharmacists and prescribers

The book ‘Drugs in use’ focusses on clinical skills, and that is a very useful area for modern pharmacists, both in hospital as well as community. The book offers a very wide variety of speciality case histories in many different fields of pharmacotherapy, some applicable in a clinical setting, others in community. There have been at least 40 contributors who have brought...

Filgrastim therapy in a child with neutropenia induced by linezolid

We describe the case of a young child with multidrug-resistant tuberculosis, treated with linezolid. The child developed severe neutropenia after 5 months of treatment. Filgrastim was used, a drug that officially is not indicated for non-cytostatic drug-induced neutropenia. This allowed the fast recovery of the patient’s neutrophil-count. However, more experience with the off...