Facet joint syndrome: from diagnosis to interventional management
Insights into Imaging
pp 1–17 | Cite as
Facet joint syndrome: from diagnosis to interventional management
AuthorsAuthors and affiliations
Romain PerolatAdrian KastlerBenjamin NicotJean-Michel PellatFlorence TahonArnaud AttyeOlivier HeckKamel BoubagraSylvie GrandAlexandre Krainik
First Online: 08 August 2018
Received: 09 January 2018
Revised: 06 May 2018
Accepted: 24 May 2018
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Low back pain (LBP) is the most common pain syndrome, and is an enormous burden and cost generator for society. Lumbar facet joints (FJ) constitute a common source of pain, accounting for 15–45% of LBP. Facet joint degenerative osteoarthritis is the most frequent form of facet joint pain. History and physical examination may suggest but not confirm facet joint syndrome. Although imaging (radiographs, MRI, CT, SPECT) for back pain syndrome is very commonly performed, there are no effective correlations between clinical symptoms and degenerative spinal changes. Diagnostic positive facet joint block can indicate facet joints as the source of chronic spinal pain. These patients may benefit from specific interventions to eliminate facet joint pain such as neurolysis, by radiofrequency or cryoablation. The purpose of this review is to describe the anatomy, epidemiology, clinical presentation, and radiologic findings of facet joint syndrome. Specific interventional facet joint management will also be described in detail.
• Lumbar facet joints constitute a common source of pain accounting of 15–45%.
• Facet arthrosis is the most frequent form of facet pathology.
• There are no effective correlations between clinical symptoms, physical examination and degenerative spinal changes.
• Diagnostic positive facet joint block can indicate facet joints as the source of pain.
• After selection processing, patients may benefit from facet joint neurolysis, notably by radiofrequency or cryoablation.
KeywordsLow back pain Facet joint Block Neurolysis Radiofrequency Cryoablation
Low back pain
Medial branch of the dorsal rami
Magnetic resonance imaging
Superior articular process
Single-photon emission computed tomography
Chronic low back pain is one of the most common pain syndromes and represents an enormous burden and cost generator for society . Lumbar facet joints (FJs) constitute a common source of pain and remain a misunderstood, misdiagnosed and improperly treated pathology . Facet osteoarthritis is the most frequent form of facet pathology . Although imaging for back pain syndrome is very common (radiographs, MRI, CT, SPECT), there is no effective correlation between clinical symptoms and degenerative spinal changes , with some imaging findings that may, in specific cases, appear irrelevant to the clinical setting. Clinical facet joint syndrome is defined as a unilateral or bilateral back pain radiating to one or both buttocks, sides of the groin, and thighs, and stopping above the knee . However, in some cases, patients’ symptoms in the setting of low back pain may lack specificity, as facet joints may mimic the pain caused by herniated discs or compressed roots. History and physical examination may suggest, but not confirm FJs as the source of pain . A diagnostic positive facet joint block can indicate facet joints as the source of chronic spinal pain , but the rate of false positives remains high. After conservative management failure, these patients may benefit from articular steroid injections  and/or specific interventions to eliminate facet joint pain such as neurolysis . Radiologists play an important role in the management of back pain, as imaging of spinal disorders has become one of the keys to better patient management. Moreover, interventional radiology has become a keystone of facet joint management, as both a diagnostic and a therapeutic tool. Therefore, this review aims to provide the radiologist with specific information on facet joint epidemiology, anatomy and physiopathology, and its implication in chronic low back pain. Furthermore, the authors describe the essential knowledge of facet joint imaging modalities along with a detailed description of existing interventional management.
Chronic and recurrent pain has been defined as a specific health care problem and is considered a disease in its own right . A recent survey showed a high prevalence of chronic pain of moderate to severe intensity in adult Europeans, affecting the quality of their social and working lives and is therefore a major health care problem in Europe . Low back pain (LBP) is one of the most common pain syndromes and is an enormous burden and cost generator for society. The high health care costs may be attributed to multiple factors, including lack of an accurate diagnosis , imaging overuse, unwarranted surgery and working stoppages. LBP is responsible for functional limitations and causes difficulty in performing common daily life tasks, especially among the elderly . Therefore, LBP is the most expensive disease in industrialized countries, as has been reported in Germany at a total cost of 48.960 billion euros per year . In the USA, the prevalence of LBP is reportedly between 15 and 45% according to cross-sectional studies . Most spinal structures may be source of LBP, including intervertebral discs, FJs, sacroiliac joints and nerve roots, and may be accessible to diagnostic tests including imaging. Some disorders, particularly disc-related impairments, are reasonably easily diagnosed and lead to definitive treatments. However, discogenic LBP without disc herniation, lumbar FJ, and sacroiliac joint pain are difficult to diagnose with imaging only . The literature focuses on intervertebral discs as the source of LBP; however, FJ pain also seems to play a major role in generating LBP . Among LBP patients, there are wide discrepancies in the reported prevalence of FJ pain. Reviews implicate FJs as the primary pain generator in 10–15% of young adult patients with chronic LBP and higher in older populations (15% among injured workers, 40% in older population without pre-existing trauma, 45% in a more heterogeneous population) . Controlled diagnostic studies have shown a prevalence of lumbar FJ pain of 27–40% in patients with chronic LBP .
Anatomy of facet joints (FJs)
Each spinal segment consists of an intervertebral disc and posterior paired synovial joints (FJ) comprising a “three-joint complex”, where each component influences the other two, with degenerative changes in one joint affecting the biomechanics of the whole complex. FJs constitute the posterolateral articulation connecting the posterior arch between vertebral levels. They are a paired and diarthrodial joint and are the only synovial joints in the spine, with hyaline cartilage overlying subchondral bone, a synovial membrane and a joint capsule . The joint space presents capacity of 1–2 mL . Each joint comprises an anteriorly and laterally facing inferior articular process from the superior vertebral level and reciprocally a larger, posteriorly and medially facing concave superior, articular process from the inferior vertebral level. Morphological variations may occur within the lumbar spine, as lumbosacral transitional vertebra (defined as either sacralization of the lowest lumbar segment or lumbarization of the most superior sacral segment of the spine). They are common in the general population, with a reported prevalence of 4–30%, with varying morphology, ranging from broadened transverse processes to complete fusion (Castellvi classification) . Knowledge of such variations is essential to avoid an intervention at an incorrect level (see below). The axial morphology of the lumbar FJ from L3 to S1 has been shown to assume a gradually more coronal orientation compared to proximal lumbar levels, with a maximal transverse articular dimension to the distal end. The orientation of the lumbar FJ in the sagittal plane allows for a greater range of flexion motion and prevents gross rotatory instability . Facet joint tropism has been defined as an asymmetry between right and left FJ angles, with one joint having more of a sagittal orientation than the other. Some studies found a relationship among patients who had a symptomatic disc herniation or degenerative spondylolisthesis at L4–5 or L5–1 levels, and an increased severity of facet joint tropism . FJs play an important role in load transmission, providing a posterior load bearing helper, stabilizing the motion segment in flexion and extension. They are also involved in the mechanism of rotational kinematics by restricting the axial rotation . This is achieved through a collagenous tissue of the fibrous capsule layed in a transverse plane providing resistance to flexion motions . Because of their high level of mobility and the important forces influencing in the lumbar area, they can develop significant degenerative changes and be a potential source of pain . The capsule of the FJs, subchondral bone and synovium are richly innervated with nociceptive and autonomic nerve fibres . Substance P nerve fibres have been identified in subchondral bone in degenerative lumbar FJ . Inflammatory mediators such as prostaglandins and cytokines (IL6, TNFα) have been found in cases of degenerative disorders . This partly explains the origin of LBP in case of FJ degeneration. Bogduk et al.  were the first to describe three ramifications of the dorsal branch (medial, intermediate and lateral branch) of the spinal nerve, which spread within the dorsal muscles (Fig. 1). From L1 to L4 segments, each lumbar FJ is innervated by the medial branch of the dorsal rami (MBDR). It emerges from the inter-transversal ligament. This branch crosses the superior margin of the medial termination of the transverse process, passing through the caudal root of the superior articulate process (SAP) one level below (i.e. the MBDR of L4 level passes around the SAP of L5). At this level the nerve runs downwards, and is fixed by the mamillo-accessory ligament (MAL). It then enters the multifidus muscle . Intermediate and lateral branches emerge from the dorsal ramus, they run caudally and laterally and enter respectively the longissimus and iliocostalis muscles. Each joint is innervated by a dual supply from the medial branch at the same level and the level above  with ascending and descending branches. The L5 segment has a different distribution of the branches, which should be considered in FJ denervation . First of all, the dorsal ramus is longer; it emerges dorsally and in the inferior region on top of the sacrum wing, along the groove formed between the ala of the sacrum at the root of the S1 SAP, and runs near the inferior portion of the articular process. The nerve then ramifies in an intermediate and a medial branch. There is no lateral branch; the MBDR lies caudally to the process, running into a fibrous tissue equivalent to the MAL, with communicating branches with the S1 dorsal ramus. Four factors were described for an anatomical structure to be deemed a cause of back pain: a nerve supply to the structure, the ability of the structure to cause pain similar to that seen clinically in normal volunteers, the structure’s susceptibility to painful diseases or injuries and demonstration that the structure can be a source of pain in patients using diagnostic techniques of known reliability and validity . Owing to this definition, lumbar FJ may be implicated in generating low back pain due to their nerve supply, especially in cases of capsular stretching . The fact that pain can originate in the FJ is widely accepted in the literature and is supported by investigations employing articular joint blocks . Meanwhile, some patients may have variations or aberrant innervation of FJ, which may explain false-negative medial branch blocks . Despite technical success, those considerations should be taken into account in patient selection and in FJ denervation procedures. (See below).
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Innervation of facet joints (L3–4, L4–5 levels). Vr: ventral ramus. Dr: Dorsal ramus. m: medial branch. i: intermediate branch. l: lateral branch a: ascending branch. d: descending branch. Posterior (a) and posterolateral (b) view of the lumbar spine
Etiologies of facet joints
Degenerative process (Fig. 2)
Facet joint degenerative osteoarthritis is the most frequent form of FJ pain, intimately tied to degeneration of the intervertebral discs. Like in all synovial lined joints, osteoarthritis is a continuum between loss of joint space, narrowing, loss of synovial fluid and loss of cartilage and bony overgrowth. High-grade cartilage necrosis arises quite rapidly in FJ. Inflammation generated by degeneration of FJs and surrounding tissues is believed to be a cause of local pain. Prevalence of degenerative FJ is debated in the literature. In a study on 647 cadaveric lumbar spine, Eubanks et al. found that degenerative changes are universal findings with a highest prevalence in L4-L5 spinal level . Evidence of osteoarthritis may be found in early life, with more than one half of adults younger than 30 years and 100% after 60 years, highly suggestive of the major role played by FJs in back pain in the elderly population. In another study, Kalichman et al. showed a high prevalence of FJ osteoarthritis in a community-based population (59.6% of males and 6.7% of females) which increases with age and reaches 89.2% in individuals over 60 years old . Risk factors for lumbar FJ osteoarthritis include: age, sex, spinal level (L4-L5), facet orientation (sagittally oriented) and associated background of intervertebral disc degeneration. This last factor may is often related to the amount of heavy work done before the age of 20. However, the association between degenerative changes in the lumbar FJs and symptomatic low back pain remains unclear and subject of an ongoing debate . Synovial FJ cysts are also associated with radicular pain mimic rather than FJ pain. Indeed, in advanced FJ osteoarthritis, a synovial cyst may appear by a herniation of the synovium through the facet capsule. In contrast to primary facet osteoarthritis, which most often results in low back pain, synovial cysts characteristically cause radiculopathy or symptomatic spinal stenosis by nerve root impingement, particularly in the lateral recesses . Lumbar FJ cysts is associated with higher rates of arthritis and coronally orientated FJ . Lumbar spinal canal or foraminal stenosis may result from degenerative changes in the posterior lumbar spine structures, such as bony proliferation of the FJ themselves (and/or associated with ligamentum flavum thickening) .
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Degenerative facet joint osteoarthritis (FJOA): Sagittal (a) and axial (b, c) CT views. Hypertrophy of the posterior articular process (black arrow). Joint space narrowing (thin white arrow). Joint capsule calcification (arrow head) and vacuum phenomenon (white arrow)
Spondylolisthesis (Fig. 3)
Degenerative spondylolisthesis is the displacement of one vertebra to another in the sagittal plane, which is related in the majority of cases to FJ osteoarthritis and failure of the motion segment. It occurs as a result of subluxation of the FJs, related to an important and progressive loss of cartilage and articular remodelling, with segmental instability causing capsule tension . Spondylolisthesis most often occurs at the L4–5 level, which is predominantly affected by osteoarthritis . In younger populations (30–40 years old), spondylolisthesis can be due to congenital abnormalities, acute or stress-related fractures or isthmic spondylolisthesis. As opposed to its degenerative counterpart, L5–1 is the most affected level, and related instability seems to be more frequent .
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Isthmic lysis. a: Axial CT view at L4–5 level; b: axial CT view at L5-S1 level c: X-ray sagittal view at L5-S1 level; d: sagittal CT view L4–5 level
Septic facet arthritis (Fig. 4)
Septic arthritis is a rare entity , which can show similar radiologic findings with more inflammation and a more aggressive signs. It can be secondary to disc or vertebral infection (spondylodiscitis). An isolated form should raise suspicion of tuberculosis or iatrogenic cause. One case of septic arthritis due to Kingella kingae has been described .
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Septic facet joint arthritis. Axial (a) and coronal (b) T2 STIR views. Intra-articular effusion (white arrow) and articular process bone edema (white star). Unilateral signs should raise suspicion of a septic cause
Rheumatoid arthritis and ankylosing spondylitis, which are seronegative spondyloarthropathies, may also involve the lumbar FJs, as FJs are synovial joints .
Clinical presentation and pain patterns
FJ as a source of LBP was first described by Goldthwaite in 1911 , and Ghormhley who used the term “facet syndrome” to describe a symptom originating from the FJ . It was initially described as lumbosacral pain with or without sciatica in 1933. Ten years later, Badgley et al. suggested FJ as the source of up to 80% of back pain . Facet syndrome included local pain and pseudo radicular radiation with variability of the distribution of referral patterns of pain . Most authors tried to classify the distribution of FJ pain provoked by an infiltration  or electrical stimulation . The majority of these studies have not found reliable referral patterns of FJ pain. As suggested by Cohen, this may be explained by the fact that stimulation does not reproduce physiological conditions . FJ pain may be referred distally into the lower limb, thereby mimicking sciatica. “Pseudo-radicular” lumbar pain typically radiates uni- or bilaterally to the buttock and the trochanteric region (from the L4 and L5 levels), the groin and the thighs (from L2 to L5), ending above the knee, without neurological deficits (Fig. 5). However, radiating pain may reach the foot, mimicking sciatic pain, especially in cases of osteophytes or synovial cysts. Claudication is possible. Pain is usually worse in the morning, during periods of inactivity, and following stress exercise, lumbar spine extension or rotary trunk motions, is provoked by standing or sitting positions, and may be elicited on FJ palpation . Pain radiation can be subdivided into primary, secondary and least commonly painful areas as previously described by Barlocher et al. . Abdominal and pelvic pain have also been described . Differential diagnoses include true sciatica, hip pathology (hip osteoarthritis or greater trochanteric bursitis) or sacroiliac impairment. However, lumbar FJ syndrome seems not to be a reliable clinical diagnosis , and a specific etiology of back pain can be diagnosed in only about 15% of patients with certainty based on clinical examination alone . The results of studies investigating the FJ as the source of a patient’s symptoms suggest that the currently available tests have limited or no diagnostic validity. Moreover, history and physical examination may suggest but not confirm FJ as the source of pain .
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Facet joint pain radiation. Posterior aspect of lower limb. Blue: from most frequent (dark blue), to less frequent (light blue) radiating pain areas. Dark blue: pain limited to lower back. Intermediate blue: radiating pain to the posterior aspect of the buttocks. Light blue: radiating pain to the posterior aspect of the lower limbs, may extend lower than the knee level. Green: anterior aspect of lower limb possible radiation areas. a anterior aspect of the lower limb (green). b posterior aspect of the lower limb etc
Imaging findings (Table 1)
X-ray imaging: Radiographs and computed tomography (CT)
The initial radiographic assessment of patients presenting with lumbar facet-mediated pain includes AP, lateral, and oblique views . Oblique radiographs are the best projections for assessing FJs of the lumbar spine because of their oblique position (“Scottie dog”). Lateral films, however, may provide useful information from the isthmus profile such as the pars interarticularis defect. Because of its ability to provide cross-sectional images and to provide a higher contrast between bony structures, CT improves anatomic evaluation of the FJs and is the preferred method for imaging FJ osteoarthritis . However, standard radiographs can also show pathological changes especially in severe disease. Degeneration is characterized by joint space narrowing, sclerosis, subchondral sclerosis and erosions, cartilage thinning, calcification of the joint capsule, hypertrophy of articular processes and of the ligamentum flavum causing impingement of the foramina and osteophytes. Secondary signs include vacuum joint phenomenon (intra-articular gas), joint effusion and associated degenerative spondylolisthesis. Synovial and subchondral cysts can extend posterior to the FJ but also anterior in the spinal cord or neuroforamen. Kalichman et al. showed 24% of X-rays FJOA before 40 years and 89% in the 60–69 years population, but once again with no correlation between abnormal morphology on radiologic findings and back pain .
Main imaging findings in various imaging modalities
AP, lateral (isthmus profile) and oblique views (“Scottie dog”)
Highest contrast between bony structures and adjacent soft tissue
Active synovial inflammation,
Adjacent bone edema
Fat saturation technique ± Gadolinium injection
99mTc labelled bisphosphonates
Hyperemia associated with bone remodelling
Joint space narrowing
Subchondral sclerosis and erosions
Calcification of the joint capsule
Hypertrophy of articular processes
Vacuum joint phenomenon joint effusion
Facet joint effusion
Subchondral bone edema
Enhancement of the FJ rim (synovitis)
Wraparound bumper osteophyte formation
Increased uptake (nonspecific)
Associated possible degenerative changes:
Degeneration of the intervertebral discs
Ligamentum flavum thickening
Degenerative spondylolisthesis (L4-L5 level)
Isthmic spondylolisthesis (L5-S1 level)
Facet joints cysts (coronally orientated FJ)
Lumbar spinal canal or foraminal stenosis
Neural structure impingement
AP antero posterior, CT computed tomography, MRI magnetic resonance imaging, SPECT single photon emission tomography
Magnetic resonance imaging (MRI) (Fig. 6)
MRI is a noninvasive and nonionizing modality that provides excellent soft tissue resolution. The role of MRI in the evaluation of FJ degeneration is not proven. Osteoarthritis may be present in both symptomatic and asymptomatic patients (from 8 to 14%) [47, 48]. Superior sensitivity of MRI compared to CT imaging is controversial . CT and MRI are equally useful in demonstrating morphological changes in FJ. One of the two examinations is thus sufficient for assessing degenerative changes . MRI, however, clearly presents advantages of better assessing the immediate consequences of FJ degeneration, such as surrounding neural structure impingement . Chronic degenerative osteoarthritis processes in these structures involve active synovial inflammation or adjacent bone edema, which can be detected using MRI with a fat saturation technique . Exaggerated fluid in the facets and FJ synovial cysts seen on axial MRI seems to be significantly suggestive of spondylolisthesis and its instability, but is not specific of FJ origin of pain . Recent studies using fat-suppressed MRI sequences have demonstrated that subchondral bone edema is present in the lumbar FJ articular processes in 14 to 41% of patients with back pain [53, 54]. Enhancement of the FJ rim after gadolinium administration will establish a diagnosis of synovitis. Fujiwara et al. proposed a four-grade classification from 1 to 4 : grade 1, normal; grade 2, joint space narrowing or mild osteophyte; grade 3, sclerosis or moderate osteophyte; and grade 4, marked osteophyte. They additionally described the wraparound bumper osteophyte formations which provides an additional stabilizing effect in segmental degenerative disease. An important observation from the Fujiwara study is that MRI tends to underestimate the severity of osteoarthritis of the FJs as compared to CT. The fluid-sensitive sequences on MRI are generally preferred over CT for imaging FJ effusions and juxta-facet cysts; however, they are less sensitive in depicting the joints’ bony cortices and are less accurate in quantifying the amount of sclerosis present. An additional limitation of MRI is that it cannot accurately measure cartilage thinning secondary to the partial volume effect and chemical-shift artefact inherent in this type of imaging. CT is better able to demonstrate the degenerative changes of the FJs because of the high contrast between bony structures and the surrounding soft tissues . However, some authors suggest that TSE T2 fat saturation sequences and, when indicated, gadolinium administration with T1 fat saturation sequences enhance the sensitivity and diagnostic specificity of MR scans. In particular, gadolinium will disclose the active inflammatory stage of a degenerative process thereby identifying new therapeutic targets for percutaneous treatment .
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MRI imaging of facet joints. Active synovial inflammation and intra articular edema: axial and sagittal T2 STIR views (a, b) and T2 sagittal view (c). T2 STIR and T1 gado axial views (d, e): articular process bone edema
Single-photon emission computed tomography (SPECT)
The detection of FJ inflammation may be more useful than morphological imaging of the joint itself. Radionuclide bone scintigraphy, using 99mTc labelled bisphosphonates, show increased osteoblastic activity along with synovial changes secondary to inflammation or hyperemia associated with bone remodelling (Fig. 7). It has been shown that patients present better improvement after FJ injection in case of positive SPECT findings .
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SPECT imaging of FJ. Hyperfixation on bone scintigraphy located on FJ capsule inflammation (white arrow)
Imaging classification of facet joint osteoarthritis
Two classifications of FJ degeneration are recommended for clinical use. Radiographically, Pathria’s classification classifies FJ arthropathy as well: Facets with joint space narrowing are classified as grade 1, facets with narrowing and sclerosis or hypertrophy as grade 2, and facets with severe degenerative disease encompassing narrowing, sclerosis, and osteophytes as grade 3 . Standard radiographs (Meyerding or Taillard classification)  also evaluate motion-related abnormalities in flexion or extension, and assess instability in cases of spondylolisthesis, thanks to dynamic studies. In the setting of degenerative spondylolisthesis, a weight-bearing lateral flexion-extension radiograph is most effective for grading spondylolisthesis and may be needed in addition to MRI and CT imaging. Anteroposterior translation of more than a few millimetres is suggestive of lumbar spine instability in the sagittal plane, which in the appropriate clinical setting may require surgical arthrodesis. In addition to Pathria’s classification, Weishaupt’s grading scheme, based on the agreement between MRI and CT imaging, has been proposed. Facets were again graded from 0 to 3 depending on the degree of joint space narrowing, hypertrophy, sclerosis, and osteophyte formation. The authors recommended against the routine use of CT imaging in the presence of an adequate MRI scan . Fujiwara et al. is credited with developing the standard MRI-based classification system for lumbar FJ osteoarthritis. An additional grading system for foramen stenosis, caused by disc and FJ degeneration can be used as well, based on the depiction of the foraminal components: nerve, vessels and fat . First stage, the non stenotic stage: no modifications depicted. Second stage corresponds to stenosis without evidence of root compression. Third stage, compression of the spinal nerve in the intervertebral foramen caused by either intervertebral disc, flaval ligament or osseous stenosis. In this stage, the content of the foramen is not well identified. A grading scale has also been proposed for lumbar canal stenosis as follows : A) cerebro-spinal fluid (CSF) is clearly visible inside the thecal sac, but its distribution is inhomogeneous. B) Some CSF is still present, giving a grainy appearance to the thecal sac. The rootlets occupy the whole of the dural sac, but they can still be individualized. C) the dural sac demonstrates a homogeneous grey signal with no CSF. No rootlets can be recognized. D) In addition to no rootlets being recognizable, there is no epidural fat posteriorly.
There is currently no consensus on how best to evaluate lumbar FJ osteoarthritis with imaging. It has been reported that in clinical practice, imaging findings of degenerative abnormalities (including radiographs, MRI, CT, SPECT) have been assumed to be associated with nonspecific low back pain . Radiographic changes secondary to osteoarthritis are equally reported among symptomatic and asymptomatic patients. Radiological investigations report a poor correlation between clinical symptoms and degenerative spinal changes . Therefore, the role of FJ imaging in patient with LBP is still debated. The interest of imaging often lies in its ability to rule out differential diagnosis, commonly referred to as “red flag indications”, rather than to prove a symptomatic condition. Red flag indications are intended to represent the potential for life or limb threatening conditions (suspicion of aortic aneurysm or dissection, neoplasm, infection, cauda equina syndrome, fracture, motor weakness). Advanced diagnostic imaging of the symptomatic level is appropriate and/or work-up for a non-spinal source of spine pain .
First-line therapy consists in conservative multimodal management such as pain medication (acetaminophen, nonsteroidal anti-inflammatory drugs, muscle relaxants, antidepressants), physiotherapy, acupuncture, and, if necessary, psychotherapy .
As mentioned above, because radio-clinical correlation is not reliable in patients with LBP, the diagnostic and therapeutic role of interventional procedures targeting the FJ have been reported in chronic spinal pain in patients who have failed conservative management . Whatever the technique used, it has been shown that the physician’s attitude seems to affect the clinical outcome of a procedure by a hetero-suggestion phenomenon, with better results . Imaging guidance has shown to both to increase technical and clinical efficacy and reduce potential complications . Common complications of FJ procedures include: hemorrhagic, infectious complications, and vasovagal syncope .
Because no clinical features or diagnostic imaging studies can determine whether an FJ is painful or not, controlled blocks are the only reliable tool in the diagnosis of FJ pain as a cause of LBP . Diagnostic blocks of nervous structures that are suspected to generate pain can be performed to evaluate the role of the target structure in the painful syndrome . However, several debates exist on the technique and the definition of the performed block:
The degree of the relief that should occur
Bogduk defined specific criteria for an optimal selection as an anatomically accurate block under guidance with ideally complete relief of pain following an MBDR block. Manchikanti et al. defined at least an 80% reduction of pain and the ability to perform previously painful movements . More liberal criteria have also been reported, such as greater than 50% relief of pain .
The target of the block (Fig. 8)
The first results comparing intra-articular and medial branch block have reported similar outcomes [67, 68]. However, a recent review showed higher evidence in short- and long-term relief with medial branch blocks versus intra-articular blocks . Moreover, intra-articular blocks appear less anatomically accurate and have not been validated as predictive of response to any form of treatment . Medial branch block also seem to present higher specificity to select patients for medial branch neurolysis . Moreover, it seems technically easier to perform using anatomic landmarks , than intra-articular injections, providing the use of MDBR block in patient selection before denervation procedures .
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Medial branch block under CT guidance. a: L4–5 level; b: L5-S1 level. c, d: Diffusion of contrast media prior to anesthetic injection confirming optimal needle tip placement (white arrows). Needle tip at the target point at injection should be placed at the middle of the base of the transverse process at its junction with the superior process at the L4–5 level. An analogous target point should be used at the L5-S1 level midway between the upper end and middle of the ala of the sacrum (white stars). Vr: ventral ramus. Dr: Dorsal ramus. m: medial branch. i: intermediate branch. l: lateral branch
The number of blocks and the levels which should be targeted
A definitive diagnosis of FJ mediated pain may require blocks at two separate sessions. When performing a single-level block only, there is a high false-positive rate (30–45%). Some authors have therefore advocated the performance of repeated blocks . Cohen et al. showed a success rate of lumbar FJ radiofrequency (RF) denervation patients of 39% after a single block and 64% after a double block . Because of the dual nerve supply of FJs, at the same level and the level above, diagnostic blocks should be performed with a minimum of two levels to block a single joint .
Diagnostic blocks commonly include local anesthesia (lidocaine and/or bupivacaine) with or without steroids injections . Some find an advantage of adding steroid injection  (see below).
In the majority of the reported studies, FJ injection include long acting corticosteroids (anti-inflammatory and antiedematous effect, immunosuppressive action and inhibition of neural transmission within the C fibres) and local anesthetics . FJ can be infiltrated with intra-articular, periarticular and medial branch injections. Due to the presence of inflammatory mediators into and around degenerative FJ, short- to intermediate-term pain relief should occur after steroids injections. However, discrepancies persist in the literature about the efficacy of steroids for FJ pain . Although intra-articular injections (with or without steroids) have traditionally been used in the diagnosis of FJ pain, a controlled trial by Lilius et al. reported no outcome differences between intra- and periarticular injections . European guidelines do not recommend the use of intra-articular steroids in management of chronic LBP .
The ideal candidate for FJ denervation is a patient who underwent medial branch infiltration with significant pain relief after failure of conservative management. Because of the dual nerve supply of a given FJ, electrodes or cryoprobes should be placed at two subsequent levels . Nerve fibres can either be destroyed by physical means: heat (radiofrequency) or cold (cryoneurolysis), or by chemical means (alcohol/phenol). The main characteristics of these techniques are described in Table 2. Lumbar medial branch neurolysis achieves relief of pain, improvement in disability, and reduction of the need for analgesics . Whatever the technique used, neurolysis does not allow definite pain relief. The destroyed nerve will eventually regenerate, and in consequence, recurrence of pain may occur. The procedure can be repeated . Currently, the two most widely reported techniques are radiofrequency (RF) and cryoneurolysis (CN). In both techniques, before injection of local anesthetics and thermal lesions, electrical stimulation monitoring should be performed to ensure safety in performing thermal denervation . Currently, ISIS recommends a maximum of two FJ denervation per year . Although RF techniques have been described in detail with a possibly longer effect than CN, in our experience it may appear as a slightly more challenging technique.
Main characteristics of the denervation procedure
Tissular heating by friction
T > 45 C°
Decompression of CO2 or N20
T > −20 C°
Possibly longer effect
Technique described in more detail
Wider range of needles available
Less tissue damage
Technically easier (bigger lesion)
More tissue damage
Technically more challenging
Duration of effectiveness less assessed
Larger probes and coaxial needles
Not widely used in this indication
Physical neurolysisRadiofrequency ablation (RFA) (Fig. 9)
RF consists in the placement of electrodes under imaging guidance, delivering a sinusoidal current (400–500 kHz). Regions crossed by the current undergo an ionic agitation which leads, through particle friction, to tissular heating. The sought purpose is to expose nerve cells to a temperature > 45 °C causing an irreversible cellular denaturation . A wide temperature range (70–90 °C) has been reported in the literature with good results . Another possibility is the use of pulsed RF (application of RF energy with pulsed time cycles at temperatures not exceeding 42 °C). The rationale for the use of pulsed RF is to avoid any potential inadvertent damage to adjacent nerve roots as well as possible secondary spinal instability due to muscle denervation . However, the use of this technique appears to be less effective in the long term . Therefore, pulsed RF does not appear as a substitute for conventional thermal lumbar medial branch neurotomy .
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Facet joint radiofrequency ablation. a: Radiofrequency ablation at the right L5-S1 level. Appropriate electrode placement (white arrow) parallel to the target nerve (white star) in order to achieve denervation along a substantial segment of the targeted nerve. b: 22G Radiofrequency needle showing uninsulated tip
Bogduck et al. underlined the importance of patient selection and the use of a properly performed technique . Appropriate technique is described in the ISIS guidelines  where emphasis is made on the electrode placement: parallel to the target nerve in order to achieve denervation along a substantial length of the targeted nerve . These considerations seem more important to take into account with the RF technique than with CN, where circumferential lesions are less extensive than with cryoprobe . RF probes produce transverse lesions around the electrodes, but little lesioning at the needle tip. Perpendicular placement may miss the targeted nerve . Moreover, operators should not rely on single placement of the electrode, and multiple placements may be required in order to cover all possible variations of the nerve .
In a prospective study, Dreyfuss et al. showed that under these conditions some 60% of patients could expect at least a 90% reduction in pain, and 87% could expect at least 60% reduction lasting 12 months . In Kessinger et al.’s study, conducted in patients with minor degenerative spondylolisthesis, 60% of patients sustained at least 80% pain relief lasting at least 12 months; 80% sustained at least 60% relief . Several controlled studies confirmed this trend [69, 84, 85, 86, 87], with a mean decrease of 2–3 points on a visual analogue scale vs control groups. RF complications are uncommon (1% incidence), of limited duration and minor in nature . Potential side effects include painful cutaneous dysesthesias or hyperesthesia increased pain due to neuritis, neuroma formation, and deafferentation pain. Unintentional damage to a spinal nerve causing a motor deficit, is also a complication . Sensory and motor stimulation during the procedure may help to avoid this complication .
Cryoneurolysis (CN) (or Cryoneuroablation or Cryoanalgesia) (Fig. 10)
Cryoneurolysis is an application of cold to the nerve to cause its denaturation. The physical principles relies on the Joule–Thompson effect, which is based on a rapid decompression of gas (either N2O or CO2) at the extremity of the probe, capable of delivering ice-cold temperatures of up to −70 °C . At the tip of the needle, an ice ball is created in the surrounding tissues. It induces a conduction block, similar to the effect of local anesthetics (all nerves fibres stop conducting at −20 C°). Long-term pain relief from nerve freezing is obtained because of the vascular damage caused by ice crystals to the vasa vasorum, which causes endo-neural edema and cell death.
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Facet joint cryoneurolysis. CT-guided cryoablation at the right L5-S1 level. a: Anatomically accurate cryoprobe (white arrow) placement with the target midway between the upper end and middle of the ala of the sacrum (white star). b: 3D reconstruction showing the same cryoprobe placement. Cryoprobe needle tip (c): ice-ball formation at the cryoprobe tip (Joule–Thompson effect) (d)
As with RFA, the success of cryoneurolysis is dependent on patient selection and accurate probe placement, which should follow the same guidelines described by the ISIS. The extent and duration of the effect is therefore a function of the degree of cold obtained and the length of cold application . In contrast to RFA, a tangential approach of the probe is not essential . Minimal, if any, sedation should be used, as the patient must be conscious to respond to sensory and motor stimulation . Moreover, intra-procedural pain in CN appears to be tolerable .
Lloyd proposed CN as superior to chemical neurolysis . However, CN technique has been described as less accurate than RF. The lasting effect compared to RF also seems unclear. No studies comparing CN and RFA in FJ pain management are available to date. Three recent prospective studies [42, 92, 93] showed a reduction of pain at 6 weeks and 3 and 6 months, with a 50% pain decrease. A recent retrospective study by Wölter et al. in 2011 confirmed this trend . Advantages of CN include less tissue damage, less risk of neuroma or neuritis, and a larger denervation area at the needle tip [91, 94].
This technique requires the administration of a chemical agent able to destroy neural structures (protein denaturation)  involved in the perception of pain to promote long lasting analgesia. The size of the lesions varies according to the concentration, and therefore the quantity. The two neurolytic agents most widely used in the treatment of chronic pain are phenol and alcohol, producing a block that lasts 3–6 months . Major drawbacks with the use of these agents include: necrosis of surrounding tissue, neuritis, and uncontrolled diffusion (83). Furthermore, these powerful neurolytic agents may induce sequelae in the axonal membrane, which might explain cases of painful paresthesia observed several months following a neurolytic block: this is known to be deafferentation pain sequelae . These techniques are also associated with neuroma formation .
The neurolytic effects of ethyl alcohol at a concentration greater than 50% are well known, but higher concentrations (95–100%) are required for nerve destruction to be permanent . Alcohol is extremely irritating to both neural structures and surrounding tissues, causing pain, burns, and local hypersensitivity. Alcohol neurolysis usually causes severe, intense pain, which quickly disappears. Alcohol is associated with a higher rate of neuritis than phenol .
As with alcohol, neurolysis depends on the concentration used: the efficacy of 3% phenol in saline is comparable to that of 40% alcohol. Phenol is responsible for a transient local anesthetic effect (between 5 and 20 weeks). Aqueous phenol is easy to use, with a low potential of diffusion, and does not cause violent pain on injection .
Facet joint denervation: How to do it?Selection processing
The following criteria should be noted prior to the procedure: history of back pain surgery, description and radiation of pain, mean duration of pain, pain intensity on a numerical pain scale (0–10). Despite the lack of specificity, a physical examination should be performed. Prior imaging studies should be analysed and red flags should be ruled out.
As physical and neurologic examination do not identify symptomatic FJs, and structural findings of FJ osteoarthritis on imaging are not predictive of FJ pain origin, FJs targeted for blocks are chosen based on a combination of clinical and imaging data. Indeed, FJ level can be deduced by comparing the patient’s pain to FJ pain referral maps, T2WI MRI hyperintensity, gadolinium enhancement or increased uptake on SPECT, which may help to identify painful joints.
This procedure can be done under fluoroscopic or CT guidance. Our practice is to use CT guidance and medial branch block. The patient is placed in prone position. An initial, non-enhanced planning CT is performed from the subsequent level in order to determine target and the safest needle pathways. The skin entry point is marked, and a local skin scrub is performed. Needle progression (22G) is performed on axial view under CT guidance (oblique view in case of fluoroscopic guidance) until the needle tip artefact is located at the defined target (at the same level and the level above). The tip of the needle should be placed in the angle formed by the transverse process and at the neck of the medial aspect of the superior articular process in case of L1–4 level or midway between the upper end and middle of the ala of the sacrum at L5–1 level. Diluted iodinated contrast is injected (1 mL) in order to control accurate needle positioning. A mixture of fast and slow acting anesthetic (1 mL mixture of lidocaine hydrochloride 1%, and of ropivacaine hydrochloride 2 mg/mL). Patients are then asked to report pain relief in the following 12 h, both by self-reported improvement (percentage of pain decrease) and VAS score.
As with block tests, this procedure can be done under fluoroscopic or CT guidance. A 22G cannula (RFA) or a 12G insertion cannula (cryoneurolysis) is inserted as previously described (Fig. 11). The stimulation mode is the crucial step: a sensitive stimulation (frequency 50-100 Hz) is first performed, which should produce a tingling sensation in the painful area. Motor stimulation (frequency 2-5 Hz) is then performed and should not provoke leg muscle contraction. Caution is necessary in the case of sedation, as the stimulation threshold is biased by the neuroleptanalgesia. In the case of RFA, one to three cycles (90 s) between 70 and 90 °C may be performed, with slight needle repositioning between each cycle. Local anesthesia may be needed in case of pain during the heating process. A steroid injection may be added to avoid secondary neuritis. In the case of cryoneurolysis local anesthesia is generally not necessary. One to two cycles may performed.
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Photographs of the coaxial needles: for cryodenervation (a, d) and radiofrequency (b, c), highlighting the difference in diameter 12G vs 22G (e)
All patients should be followed up by physicians in the interventional radiology unit to assess the efficacy and possible complications with the same criteria. Because of a high false-positive rate, in cases of primary block test failure, this test should be repeated before any denervation procedure. Repeated infiltrations may be proposed in case of contraindications or refusal of denervation procedure. Neurolysis may also be repeated.
The results of FJ blocks to predict lumbar surgical outcomes and surgical therapies including arthrodesis for degenerative FJ disorders are discouraging . There is no convincing evidence to support any surgical intervention for FJ degenerative pain. In case of spondylolisthesis, pain relief may be obtained with arthrodesis when interventional management fails, but there are currently no guidelines available. In most cases, non-operative treatment should be attempted before surgical management. Some suggest that the optimal surgical management is a decompressive lumbar laminectomy in patients with grade I or II. On occasion, for those with foraminal/far lateral pathology at the level of the listhesis, patients may require additional non-instrumented or instrumented lumbar fusions . Although there currently is no consensus, FJ neurolysis may be used as a therapeutic tool in cases of surgical management failure on low back pain relief.
Other interventional treatments
Other more recent techniques or imaging guidance have been described in the literature, but will need further assessment. Wu et al. recently compared the effectiveness and safety between autologous platelet-rich plasma (PRP) and local anesthesia/corticosteroid in intra-articular injection for the treatment of FJ syndrome. They showed that prone autologous PRP presented a superior efficacy with longer duration . An observational retrospective study of 86 patients by Kirchner et al. confirmed this trend .
Iwatsuki et al. performed laser radiation of the dorsal surface of the facet capsule in 21 patients and reported greater than 70% pain relief for at least 1 year in 81% (17 patients) . Feasibility and safety of MRI-guided focused ultrasound ablation of the lumbar medial branch nerve has been shown in a swine model and thermal necrosis was confirmed .
Because chronic low back pain of facet joint pain origin represents a major health care problem, diagnosis and management of such a high prevalent condition as facet joint syndrome is a major socioeconomic burden. Because of the ability of facet joint pathology to mimic spine root compression, the low specificity of FJ syndrome and inefficient use of lumbar imaging, it appears as a misunderstood, misdiagnosed and improperly treated pathology. Facet joint-related anatomical, clinical and radiologic knowledge is essential for successful facet joint syndrome management. Diagnostic blocks are a keystone of facet syndrome diagnosis. If diagnostic blocks of the nerves that supply specific facet joints relieve the patient’s pain, denervation procedure lesioning of the same nerves can be offered to provide prolonged benefit. The role of the radiologist is essential in the management of these patients, and radiologists should embrace all aspects of facet joint pain management, from diagnosis—enabled by high-performance modalities available—to interventional management. The radiologist can therefore play an active role in the difficult task of alleviating patients’ chronic low back pain of facet joint origin.
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Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D (2006) Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain 10(4):287–333CrossRefPubMedGoogle Scholar
Manchikanti L, Hirsch JA, Falco FJ, Boswell MV (2016) Management of lumbar zygapophysial (facet) joint pain. World J Orthop 7(5):315–337CrossRefPubMedPubMedCentralGoogle Scholar
Kalichman L, Li L, Kim DH et al (2008) Facet joint osteoarthritis and low back pain in the community-based population. Spine (Phila Pa 1976) 33(23):2560–2565CrossRefGoogle Scholar
Kalichman L, Kim DH, Li L, Guermazi A, Hunter DJ (2010) Computed tomography-evaluated features of spinal degeneration: prevalence, intercorrelation, and association with self-reported low back pain. Spine J 10(3):200–208CrossRefPubMedGoogle Scholar
Manchikanti L, Singh V, Pampati V et al (2001) Evaluation of the relative contributions of various structures in chronic low back pain. Pain Physician 4(4):308–316PubMedGoogle Scholar
Hancock MJ, Maher CG, Latimer J et al (2007) Systematic review of tests to identify the disc, SIJ or facet joint as the source of low back pain. Eur Spine J 16(10):1539–1550CrossRefPubMedPubMedCentralGoogle Scholar
Falco FJ, Manchikanti L, Datta S et al (2012) An update of the systematic assessment of the diagnostic accuracy of lumbar facet joint nerve blocks. Pain Physician 15(6):E869–E907PubMedGoogle Scholar
Cohen SP, Raja SN (2007) Pathogenesis, diagnosis, and treatment of lumbar zygapophysial (facet) joint pain. Anesthesiology 106(3):591–614CrossRefPubMedGoogle Scholar
Bogduk N, Dreyfuss P, Govind J (2009) A narrative review of lumbar medial branch neurotomy for the treatment of back pain. Pain Med 10(6):1035–1045CrossRefPubMedGoogle Scholar
Declaration on Pain – EFIC. [En ligne]. Available via: http://www.europeanpainfederation.eu/about-efic/efic-declaration-on-pain/. Accessed: 8 February 2017
Edmond SL, Felson DT (2003) Function and back symptoms in older adults. J Am Geriatr Soc 51(12):1702–1709CrossRefPubMedGoogle Scholar
Wenig CM, Schmidt CO, Kohlmann T, Schweikert B (2009) Costs of back pain in Germany. Eur J Pain 13(3):280–286CrossRefPubMedGoogle Scholar
Manchikanti L, Manchikanti KN, Cash KA, Singh V, Giordano J (2008) Age-related prevalence of facet-joint involvement in chronic neck and low back pain. Pain Physician 11(1):67–75PubMedGoogle Scholar
Saravanakumar K, Harvey A (2008) Lumbar zygapophyseal (facet) joint pain. Rev Pain 2(1):8–13CrossRefPubMedPubMedCentralGoogle Scholar
Datta S, Lee M, Falco FJ, Bryce DA, Hayek SM (2009) Systematic assessment of diagnostic accuracy and therapeutic utility of lumbar facet joint interventions. Pain Physician 12(2):437–460PubMedGoogle Scholar
Yahia LH, Garzon S (1993) Structure on the capsular ligaments of the facet joints. Ann Anat 175(2):185–188CrossRefPubMedGoogle Scholar
Konin GP, Walz DM (2010) Lumbosacral transitional vertebrae: classification, imaging findings, and clinical relevance. AJNR Am J Neuroradiol 31(10):1778–1786CrossRefPubMedGoogle Scholar
Varlotta GP, Lefkowitz TR, Schweitzer M et al (2011) The lumbar facet joint: a review of current knowledge: part 1: anatomy, biomechanics and grading. Skeletal Radiol 40(1):13–23CrossRefPubMedGoogle Scholar
Gao T, Lai Q, Zhou S et al (2017) Correlation between facet tropism and lumbar degenerative disease: a retrospective analysis. BMC Musculoskelet Disord 18:483CrossRefPubMedPubMedCentralGoogle Scholar
Adams MA, Hutton WC (1983) The mechanical function of the lumbar apophyseal joints. Spine (Phila Pa 1976) 8(3):327–330CrossRefGoogle Scholar
Borenstein D (2004) Does osteoarthritis of the lumbar spine cause chronic low back pain? Curr Pain Headache Rep 8(6):512–517CrossRefPubMedGoogle Scholar
Cavanaugh JM, Ozaktay AC, Yamashita HT, King AI (1996) Lumbar facet pain: biomechanics, neuroanatomy and neurophysiology. J Biomech 29(9):1117–1129CrossRefPubMedGoogle Scholar
Beaman DN, Graziano GP, Glover RA, Wojtys EM, Chang V (1993) Substance P innervation of lumbar spine facet joints. Spine (Phila Pa 1976) 18(8):1044–1049CrossRefGoogle Scholar
Igarashi A, Kikuchi S, Konno S, Olmarker K (2004) Inflammatory cytokines released from the facet joint tissue in degenerative lumbar spinal disorders. Spine (Phila Pa 1976) 29(19):2091–2095CrossRefGoogle Scholar
Bogduk N, Wilson AS, Tynan W (1982) The human lumbar dorsal rami. J Anat 134(Pt 2):383–397PubMedPubMedCentralGoogle Scholar
Lau P, Mercer S, Govind J, Bogduk N (2004) The surgical anatomy of lumbar medial branch neurotomy (facet denervation). Pain Med 5(3):289–298CrossRefPubMedGoogle Scholar
Clinical anatomy of the lumbar spine and sacrum- NLMCatalog - NCBI. [En ligne]. Available via: https://www.ncbi.nlm.nih.gov/nlmcatalog/9801582. Accessed: 31 January 2017
Bogduk N (1997) Clinical anatomy of the lumbar spine and sacrum, 3rd edn. Churchill Livingstone, EdinburghGoogle Scholar
Eubanks JD, Lee MJ, Cassinelli E, Ahn NU (2007) Prevalence of lumbar facet arthrosis and its relationship to age, sex, and race: an anatomic study of cadaveric specimens. Spine (Phila Pa 1976) 32(19):2058–2062CrossRefGoogle Scholar
Chazen JL, Leeman K, Singh JR, Schweitzer A (2017) Percutaneous CT-guided facet joint synovial cyst rupture: success with refractory cases and technical considerations. Clin Imaging 49:7–11CrossRefPubMedGoogle Scholar
Ening G, Kowoll A, Stricker I, Schmieder K, Brenke C (2015) Lumbar juxta-facet joint cysts in association with facet joint orientation, −tropism and -arthritis: a case-control study. Clin Neurol Neurosurg 139:278–281CrossRefPubMedGoogle Scholar
Yoshiiwa T, Miyazaki M, Notani N, Ishihara T, Kawano M, Tsumura H (2016) Analysis of the relationship between ligamentum Flavum thickening and lumbar segmental instability, disc degeneration, and facet joint osteoarthritis in lumbar spinal stenosis. Asian Spine J 10(6):1132–1140CrossRefPubMedPubMedCentralGoogle Scholar
Kalichman L, Hunter DJ (2008) Diagnosis and conservative management of degenerative lumbar spondylolisthesis. Eur Spine J 17(3):327–335CrossRefPubMedGoogle Scholar
Sun Y, Wang H, Yang D et al (2016) Characterization of radiographic features of consecutive lumbar spondylolisthesis. Medicine (Baltimore) 95(46):e5323CrossRefGoogle Scholar
Rajeev A, Choudhry N, Shaikh M, Newby M (2016) Lumbar facet joint septic arthritis presenting atypically as acute abdomen - a case report and review of the literature. Int J Surg Case Rep 25:243–245CrossRefPubMedPubMedCentralGoogle Scholar
Le Hanneur M, Vidal C, Mallet C, Mazda K, Ilharreborde B (2016) Unusual case of paediatric septic arthritis of the lumbar facet joints due to Kingella kingae. Orthop Traumatol Surg Res OTSR 102(7):959–961CrossRefPubMedGoogle Scholar
Goldthwait JE (1911) The lumbosacral articulation: an explanation of many cases of lumbago, sciatica, and paraplegia. Boston Med Surg J 164:365–372CrossRefGoogle Scholar
Ghormley RK (1933) Low back pain with special reference to the articular facets, with presentation of an operative procedure. JAMA 101:773Google Scholar
Badgley CE (1941) The articular facets in relation to low back pain and sciatic radiation. J Bone Joint Surg Am 23:481–496Google Scholar
Fukui S, Ohseto K, Shiotani M, Ohno K, Karasawa H, Naganuma Y (1997) Distribution of referred pain from the lumbar zygapophyseal joints and dorsal rami. Clin J Pain 13(4):303–307CrossRefPubMedGoogle Scholar
Windsor RE, King FJ, Roman SJ et al (2002) Electrical stimulation induced lumbar medial branch referral patterns. Pain Physician 5(4):347–353PubMedGoogle Scholar
Bärlocher CB, Krauss JK, Seiler RW (2002) Kryorhizotomy: an alternative technique for lumbar medial branch rhizotomy in lumbar facet syndrome. J Neurosurg 98(1 Suppl):14–20Google Scholar
Piraccini E, Calli M, Corso RM, Byrne H, Maitan S (2017) Abdominal and pelvic pain: an uncommon sign in lumbar facet joint syndrome. Minerva Anestesiol 83(1):104–105PubMedGoogle Scholar
Jackson RP (1992) The facet syndrome. Myth or reality? Clin Orthop Relat Res 279:110–121Google Scholar
Manchikanti L, Boswell MV, Singh V, Pampati V, Damron KS, Beyer CD (2004) Prevalence of facet joint pain in chronic spinal pain of cervical, thoracic, and lumbar regions. BMC Musculoskelet Disord 5(15)Google Scholar
Schwarzer AC, Wang SC, O’Driscoll D, Harrington T, Bogduk N, Laurent R (1995) The ability of computed tomography to identify a painful zygapophysial joint in patients with chronic low back pain. Spine (Phila Pa 1976) 20(8):907–912CrossRefGoogle Scholar
Weishaupt D, Zanetti M, Hodler J, Boos N (1998) MR imaging of the lumbar spine: prevalence of intervertebral disk extrusion and sequestration, nerve root compression, end plate abnormalities, and osteoarthritis of the facet joints in asymptomatic volunteers. Radiology 209(3):661–666CrossRefPubMedGoogle Scholar
Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS (1994) Magnetic resonance imaging of the lumbar spine in people without back pain. N Engl J Med 331(2):69–73CrossRefPubMedGoogle Scholar
Weishaupt D, Zanetti M, Boos N, Hodler J (1999) MR imaging and CT in osteoarthritis of the lumbar facet joints. Skeletal Radiol 28(4):215–219CrossRefPubMedGoogle Scholar
Clarençon F, Law-Ye B, Bienvenot P, Cormier É, Chiras J (2016) The Degenerative Spine. Magn Reson Imaging Clin N Am 24(3):495–513CrossRefPubMedGoogle Scholar
D’Aprile P, Tarantino A, Lorusso V, Brindicci D (2006) Fat saturation technique and gadolinium in MRI of lumbar spinal degenerative disease. Neuroradiol J 19(5):654–671CrossRefPubMedGoogle Scholar
Schinnerer KA, Katz LD, Grauer JN (2008) MR findings of exaggerated fluid in facet joints predicts instability. J Spinal Disord Tech 21(7):468–472CrossRefPubMedGoogle Scholar
Suri P, Miyakoshi A, Hunter DJ et al (2011) Does lumbar spinal degeneration begin with the anterior structures? A study of the observed epidemiology in a community-based population. BMC Musculoskelet Disord 12:202CrossRefPubMedPubMedCentralGoogle Scholar
Lakadamyali H, Tarhan NC, Ergun T, Cakir B, Agildere AM (2008) STIR sequence for depiction of degenerative changes in posterior stabilizing elements in patients with lower back pain. AJR Am J Roentgenol 191(4):973–979CrossRefPubMedGoogle Scholar
Fujiwara A, Tamai K, Yamato M et al (1999) The relationship between facet joint osteoarthritis and disc degeneration of the lumbar spine: an MRI study. Eur Spine J 8(5):396–401CrossRefPubMedPubMedCentralGoogle Scholar
Pneumaticos SG, Chatziioannou SN, Hipp JA, Moore WH, Esses SI (2006) Low back pain: prediction of short-termoutcome of facet joint injection with bone scintigraphy. Radiology 238(2):693–698CrossRefPubMedGoogle Scholar
Pathria M, Sartoris DJ, Resnick D (1987) Osteoarthritis of the facet joints: accuracy of oblique radiographic measurement. Radiology 164:227–230CrossRefPubMedGoogle Scholar
Splendiani A, Ferrari F, Barile A, Masciocchi C, Gallucci M (2014) Occult neural foraminal stenosis caused by association between disc degeneration and facet joint osteoarthritis: demonstration with dedicated upright MRI system. Radiol Med 119(3):164–174CrossRefPubMedGoogle Scholar
Schizas C, Theumann N, Burn A et al (2010) Qualitative grading of severity of lumbar spinal stenosis based on the morphology of the dural sac on magnetic resonance images. Spine (Phila Pa 1976) 35(21):1919–1924CrossRefGoogle Scholar
Hofmann UK, Keller RL, Walter C, Mittag F (2017) Predictability of the effects of facet joint infiltration in the degenerate lumbar spine when assessing MRI scans. J Orthop Surg Res 12Google Scholar
Lateef H, Patel D (2009) What is the role of imaging in acute low back pain? Curr Rev Musculoskelet Med 2(2):69–73CrossRefPubMedPubMedCentralGoogle Scholar
Filippiadis DK, Kelekis A (2015) A review of percutaneous techniques for low back pain and neuralgia: current trends in epidural infiltrations, intervertebral disk and facet joint therapies. Br J Radiol 20150357Google Scholar
Middendorp M, Kollias K, Ackermann H et al (2016) Does therapist’s attitude affect clinical outcome of lumbar facet joint injections? World J Radiol 8(6):628–634CrossRefPubMedPubMedCentralGoogle Scholar
Manchikanti L, Boswell MV, Singh V et al (2009) Comprehensive evidence-based guidelines for interventional techniques in the management of chronic spinal pain. Pain Physician 12(4):699–802PubMedGoogle Scholar
Velickovic M, Ballhause TM (2016) Delayed onset of a spinal epidural hematoma after facet joint injection. SAGE Open Med Case Rep 4Google Scholar
Manchikanti L, Manchikanti KN, Manchukonda R et al (2007) Evaluation of lumbar facet joint nerve blocks in the management of chronic low back pain: preliminary report of a randomized, double-blind controlled trial: clinical trial NCT00355914. Pain Physician 10(3):425–440PubMedGoogle Scholar
Dreyfuss PH, Dreyer SJ, Herring SA (1995) Lumbar zygapophysial (facet) joint injections. Spine (Phila Pa 1976) 20(18):2040–2047CrossRefGoogle Scholar
Dreyer SJ, Dreyfuss H (1996) Low back pain and the zygapophysial (facet) joints. Arch Phys Med Rehabil 77(3):290–300CrossRefPubMedGoogle Scholar
van Wijk RMAW, Geurts JW, Wynne HJ et al (2005) Radiofrequency denervation of lumbar facet joints in the treatment of chronic low back pain: a randomized, double-blind, sham lesion-controlled trial. Clin J Pain 21(4):335–344CrossRefPubMedGoogle Scholar
Taguchi T, Kawai S, Oda H, Kaneko K (2000) Anatomic basis for selective nervi-spinales infiltration in the treatment of articular back pain. J Neuroradiol 27(1):25–29PubMedGoogle Scholar
Manchukonda R, Manchikanti KN, Cash KA, Pampati V, Manchikanti L (2007) Facet joint pain in chronic spinal pain: an evaluation of prevalence and false-positive rate of diagnostic blocks. J Spinal Disord Tech 20(7):539–545CrossRefPubMedGoogle Scholar
Cohen SP, Williams KA, Kurihara C et al (2010) Multicenter, randomized, comparative cost-effectiveness study comparing 0, 1, and 2 diagnostic medial branch (facet joint nerve) block treatment paradigms before lumbar facet radiofrequency denervation. Anesthesiology 113(2):395–405CrossRefPubMedGoogle Scholar
Lilius G, Laasonen EM, Myllynen P, Harilainen A, Grönlund G (1989) Lumbar facet joint syndrome. A randomised clinical trial. J Bone Joint Surg Br 71(4):681–684CrossRefPubMedGoogle Scholar
Airaksinen O, Brox JI, Cedraschi C et al (2006) Chapter 4. European guidelines for the management of chronic non-specific low back pain. Eur Spine J 15:S192–S300CrossRefPubMedPubMedCentralGoogle Scholar
Trescot AM (2003) Cryoanalgesia in interventional pain management. Pain Physician 6(3):345–360PubMedGoogle Scholar
International Spine Intervention Society (2004) Lumbar medial neurotomy. In: Bogduk N (ed) Practice guidelines for spinal diagnostic and treatment procedures. International Spinal Intervention Society, San Francisco, pp 188–218Google Scholar
Dreyfuss P, Halbrook B, Pauza K, Joshi A, McLarty J, Bogduk N (2000) Efficacy and validity of radiofrequency neurotomy for chronic lumbar zygapophysial joint pain. Spine (Phila Pa 1976) 25(10):1270–1277CrossRefGoogle Scholar
Costandi S, Garcia-Jacques M, Dews T et al (2016) Optimal temperature for radiofrequency ablation of lumbar medial branches for treatment of facet-mediated back pain. Pain Pract 16(8):961–968Google Scholar
Mikeladze G, Espinal R, Finnegan R, Routon J, Martin D (2003) Pulsed radiofrequency application in treatment of chronic zygapophyseal joint pain. Spine J 3(5):360–362CrossRefPubMedGoogle Scholar
Bogduk N, Macintosh J, Marsland A (1987) Technical limitations to the efficacy of radiofrequency neurotomy for spinal pain. Neurosurgery 20(4):529–535CrossRefPubMedGoogle Scholar
International Spine Intervention Society (2004) Lumbar medial branch blocks. In: Bogduk N (ed) Practice guidelines for spinal diagnostic and treatment procedures. International Spinal Intervention Society, San Francisco, pp 47–65Google Scholar
Mattmüller R (2002) Radiofrequenzläsion und Kryoläsion. In: Hankemeier U, Hildebrandt J (eds) Neurodestruktive Verfahren in der Schmerztherapie. Springer, Berlin, pp 19–32Google Scholar
Klessinger S (2012) Radiofrequency neurotomy for treatment of low back pain in patients with minor degenerative spondylolisthesis. Pain Physician 15(1):E71–E78PubMedGoogle Scholar
Gallagher J, Petriccione di Valdo PL, Wedley JR et al (1994) Radiofrequency facet joint denervation in the treatment of low back pain: a prospective controlled doubleblind study to assess its efficacy. Pain Clinic 7:193–198Google Scholar
Nath S, Nath CA, Pettersson K (2008) Percutaneous lumbar zygapophysial (facet) joint neurotomy using radiofrequency current, in the management of chronic low back pain: a randomized double-blind trial. Spine (Phila Pa 1976) 33(12):1291–1297 discussion 1298 CrossRefGoogle Scholar
van Kleef M, Barendse GA, Kessels A, Voets HM, Weber WE, de Lange S (1999) Randomized trial of radiofrequency lumbar facet denervation for chronic low back pain. Spine (Phila Pa 1976) 24(18):1937–1942CrossRefGoogle Scholar
Leclaire R, Fortin L, Lambert R, Bergeron YM, Rossignol M (2001) Radiofrequency facet joint denervation in the treatment of low back pain: a placebo-controlled clinical trial to assess efficacy. Spine (Phila Pa 1976) 26(13):1411–1416 discussion 1417 CrossRefGoogle Scholar
Kornick C, Kramarich SS, Lamer TJ, Todd Sitzman B (2004) Complications of lumbar facet radiofrequency denervation. Spine (Phila Pa 1976) 29(12):1352–1354CrossRefGoogle Scholar
Pacetti M, Fiaschi GS, Gennaro S (2016) Percutaneous radiofrequency thermocoagulation of dorsal ramus branches as a treatment of Blumbar facet syndrome^ how I do it. Acta Neurochir (Wien) 158(5):995–998CrossRefGoogle Scholar
Lloyd JW, Barnard JD, Glynn CJ (1976) Cryoanalgesia. A new approach to pain relief. Lancet 2(7992):932–934CrossRefPubMedGoogle Scholar
Wolter T, Deininger M, Hubbe U, Mohadjer M, Knoeller S (2011) Cryoneurolysis for zygapophyseal joint pain: a retrospective analysis of 117 interventions. Acta Neurochir (Wien) 153(5):1011–1019CrossRefGoogle Scholar
Staender M, Maerz U, Tonn JC, Steude U (2005) Computerized tomography-guided kryorhizotomy in 76 patients with lumbar facet joint syndrome. J Neurosurg Spine 3(6):444–449CrossRefPubMedGoogle Scholar
Birkenmaier C, Veihelmann A, Trouillier H et al (2007) Percutaneous cryodenervation of lumbar facet joints: a prospective clinical trial. Int Orthop 31(4):525–530CrossRefPubMedGoogle Scholar
Wolter T, Bozhkov Y, Knoeller SM (2017) An in vitro analysis of the size and shape of cryolesions for facet joint denervation. Clin Neurol Neurosurg 153:87–92CrossRefPubMedGoogle Scholar
Kastler A, Cadel G, Comte A et al (2014) Alcohol percutaneous neurolysis of the sphenopalatine ganglion in the management of refractory craniofacial pain. Neuroradiology 56(7):589–596CrossRefPubMedGoogle Scholar
Molloy R, Benzon H (2008) Neurolytic blocking agents: uses and complications. In: Raj’s practical management of pain. Mosby Elsevier, Philadelphia, pp 839–850CrossRefGoogle Scholar
Jain S, Gupta R (2007) Neural blockade with neurolytic agents. In: Textbook of pain management. 1st ed, ed. Waldman. Elsevier, PhiladelphiaGoogle Scholar
Evans PJ, Lloyd JW, Jack TM (1981) Cryoanalgesia for intractable perineal pain. J R Soc Med 74(11):804–809CrossRefPubMedPubMedCentralGoogle Scholar
Koyyalagunta D, Engle MP, Yu J, Feng L, Novy DM (2016) The effectiveness of alcohol versus phenol based splanchnic nerve neurolysis for the treatment of intra-abdominal cancer pain. Pain Physician 19(4):281–292PubMedGoogle Scholar
Raj PP (2004) Visceral pain. Agri 16:7–20PubMedGoogle Scholar
Epstein NE, Hollingsworth RD (2017) Nursing review of diagnosis and treatment of lumbar degenerative spondylolisthesis. Surg Neurol Int 8Google Scholar
Wu J, Zhou J, Zhang J et al (2017) A Prospective Study Comparing Platelet-Rich Plasma and Local Anesthetic (LA)/Corticosteroid in Intra-Articular Injection for the Treatment of Lumbar Facet Joint Syndrome. Pain Pract 17(7):914–924Google Scholar
Kirchner F, Anitua E (2016) Intradiscal and intra-articular facet infiltrations with plasma rich in growth factors reduce pain in patients with chronic low back pain. J Craniovertebr Junction Spine 7(4):250–256PubMedPubMedCentralGoogle Scholar
Iwatsuki K, Yoshimine T, Awazu K (2007) Alternative denervation using laser irradiation in lumbar facet syndrome. Lasers Surg Med 39(3):225–229CrossRefPubMedGoogle Scholar
Kaye EA, Monette S, Srimathveeravalli G, Maybody M, Solomon SB, Gulati A (2016) MRI-guided focused ultrasound ablation of lumbar medial branch nerve: feasibility and safety study in a swine model. Int J Hyperthermia 32(7):786–794CrossRefPubMedPubMedCentralGoogle Scholar
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Authors and Affiliations
Romain Perolat12Email authorAdrian Kastler1Benjamin Nicot3Jean-Michel Pellat4Florence Tahon1Arnaud Attye1Olivier Heck1Kamel Boubagra1Sylvie Grand1Alexandre Krainik11.Clinique Universitaire de NeuroradiologieCentre Hospitalier Universitaire A MichallonGrenobleFrance2.Clinique Universitaire de Radiologie et Imagerie MédicaleCentre Hospitalier UniversitaireGrenoble Cedex 9France3.Service de NeurochirurgieCentre Hospitalier Universitaire A. MichallonGrenobleFrance4.Centre d’évaluation et du traitement de la douleurGroupe hospitalier mutualisteGrenobleFrance