International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
Heather J. Cordell 8
Younghun Han 9
George F. Mells 10
Yafang Li 9
Gideon M. Hirschfield 11
Casey S. Greene 12
Gang Xie 13
Brian D. Juran 14
Dakai Zhu 9
David C. Qian 9
James A.B. Floyd 15 16
Katherine I. Morley 15 17
Daniele Prati 0
Ana Lleo 1
Daniele Cusi 2 3
Canadian-US PBC Consortium
Italian PBC Genetics Study Group
UK-PBC Consortium
M. Eric Gershwin 4
Carl A. Anderson 15
Konstantinos N. Lazaridis 14
Pietro Invernizzi 1 4
Michael F. Seldin 4
Richard N. Sandford 10
Christopher I. Amos 9
Katherine A. Siminovitch 5 6 7 13
0 Department of Transfusion Medicine and Hematology, Ospedale Alessandro Manzoni , Lecco 23900 , Italy
1 Center for Autoimmune Liver Diseases, IRCCS Instituto Clinico Humanitas , 20089 Rozzano , Italy
2 Universita` degli Studi di Milano , Milan 20129 , Italy
3 Istituto di Tecnologie Biomediche Consiglio Nazionale delle Ricerche , Via Fratelli Cervi, 93, 20090 Segrate, Milan , Italy
4 University of California - Davis , Davis, California 95616 , USA
5 Department of Medicine, University of Toronto , Toronto, Ontario , Canada M5G 1X5
6 Department of Immunology, University of Toronto , Toronto, Ontario , Canada M5G 1X5
7 Department of Molecular Genetics, University of Toronto
8 Institute of Genetic Medicine, Newcastle University , Newcastle upon Tyne NE1 3BZ , UK
9 Center for Genomic Medicine, Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College , Lebanon, New Hampshire 03755 , USA
10 Academic Department of Medical Genetics, Cambridge University , Cambridge CB2 0QQ , UK
11 Centre for Liver Research and NIHR Biomedical Research Unit, University of Birmingham , Birmingham B15 2TT , UK
12 Department of Genetics, Institute for Quantitative Biomedical Sciences, Geisel School of Medicine, Dartmouth College , Hanover, New Hampshire 03755 , USA
13 Mount Sinai Hospital, Lunenfeld-Tanenbaum Research Institute and Toronto General Research Institute , Toronto, Ontario M5G 1X5 , Canada
14 Center for Basic Research in Digestive Diseases, Mayo Clinic , Rochester, Minnesota 55905 , USA
15 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus , Hinxton CB10 1SA , UK
16 William Harvey Research Institute, Queen Mary University of London , London EC1M 6BQ , UK
17 Institute of Psychiatry, Psychology & Neuroscience, Kings College London , London SE5 8AF , UK
18 Abertawe Bro Morgannwg University Health Board, Morriston Hospital , Heol Maes Eglwys, Morriston, Swansea SA6 6NL , UK
19 Betsi Cadwaladr University Health Board, Llandudno General Hospital , Hospital Road, Llandudno LL30 1LB , UK
20 Abertawe Bro Morgannwg University Health Board, Singleton Hospital , Sketty Lane, Sketty, Swansea SA2 8QA , UK
21 Betsi Cadwaladr University Health Board, Wrexham Maelor Hospital , Croesnewydd Road, Wrexham LL13 7TD , UK
22 Abertawe Bro Morgannwg University Health Board, Neath Port Talbot Hospital , Baglan Way, Port Talbot SA12 7BX , UK
23 Abertawe Bro Morgannwg University Health Board, Princess of Wales Hospital , Coity Road, Bridgend CF31 1RQ , UK
24 Blackpool Teaching Hospitals NHS Foundation Trusts, Blackpool Victoria Hospital , Whinney Heys Road, Blackpool FY3 8NR , UK
25 Bolton NHS Foundation Trust, Royal Bolton Hospital , Minerva Road, Farnworth, Bolton BL4 0JR , UK
26 Aintree University Hospitals NHS Foundation Trust, Aintree University Hospital , Longmoor Lane, Liverpool L9 7AL , UK
27 Bradford Teaching Hospitals NHS Foundation Trust, Bradford Royal Infirmary , Duckworth Lane, Bradford BD9 6RJ , UK
28 Airedale NHS Foundation Trust, Airedale General Hospital , Skipton Road, Steeton, Keighley BD20 6TD , UK
29 Brighton and Sussex University Hospitals NHS Trust, Princess Royal Hospital , Lewes Road, Haywards Heath RH16 4EX , UK
30 Aneurin Bevan University Health Board, Nevill Hall Hospital , Brecon Road, Abergavenny NP7 7EG , UK
31 Brighton and Sussex University Hospitals NHS Trust, Royal Sussex County Hospital , Eastern Road, Brighton BN2 5BE , UK
32 Aneurin Bevan University Health Board, Royal Gwent Hospital , Cardiff Road, Newport NP20 2UB , UK
33 Buckinghamshire Healthcare NHS Trust, Amersham Hospital , Whielden Street, Amersham HP7 0JD , UK
34 Aneurin Bevan University Health Board, Ysbyty Ystrad Fawr , Ystrad Fawr Way, Ystrad Mynach, Hengoed CF82 7EP , UK
35 Buckinghamshire Healthcare NHS Trust, Stoke Mandeville Hospital , Mandeville Road, Aylesbury HP21 8AL , UK
36 Ashford & St Peter's Hospitals NHS Foundation Trust, Ashford Hospital , London Road, Ashford TW15 3AA , UK
37 Buckinghamshire Healthcare NHS Trust, Wycombe Hospital , Queen Alexandra Road, High Wycombe HP11 2TT , UK
38 Ashford & St Peter's Hospitals NHS Foundation Trust, St Peter's Hospital , Guildford Road, Chertsey KT16 0PZ , UK
39 Burton Hospitals NHS Foundation Trust, Queen's Hospital , Belvedere Road, Burton upon Trent DE13 0RB , UK
40 Barking, Havering and Redbridge University Hosp (...truncated)