In Vitro Activity of Cefepime against Multidrug-Resistant Gram-Negative Bacilli, Viridans Group Streptococci and Streptococcus pneumoniae from a Cross-Canada Surveillance Study

Canadian Journal of Infectious Diseases and Medical Microbiology, Sep 2018

OBJECTIVE: To determine the in vitro activity of cefepime against multidrug-resistant Gram-negative bacilli and Gram-positive cocci obtained from an ongoing cross-Canada surveillance study.

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In Vitro Activity of Cefepime against Multidrug-Resistant Gram-Negative Bacilli, Viridans Group Streptococci and Streptococcus pneumoniae from a Cross-Canada Surveillance Study

Can J Infect Dis In vitro activity of cefepime against multidrug-resistant Gram-negative bacilli, viridans group streptococci and Streptococcus pneumoniae from a cross-Canada surveillance study Donald E Low FRCPC Joyce de Azavedo Canadian Bacterial Surveillance Network 0 Ross Davidson 0 Members of the Canadian Bacterial Surveillance Network include Allison McGeer MD FRCPC, Mount Sinai Hospital , Toronto , Ontario; Sylvia Pong-Porter RT, Mount Sinai Hospital , Toronto, Ontario; Andrew Simor MD FRCPC , Sunnybrook Health Science Centre, North York, Ontario; Samuel Matsumura BSc, Mount Sinai Hospital , Toronto, Ontario; Daryl J Hoban PhD , University of Manitoba , Winnipeg, Manitoba; George G Zhanel PharmD PhD , Health Sciences Centre , Winnipeg, Manitoba; Kevin Forward MD FRCPC , Queen Elizabeth II, Health Sciences Centre , Halifax, Nova Scotia; Lewis Abbott MD FRCPC , Queen Elizabeth Hospital , Charlottetown, Prince Edward Island; Joseph Blondeau PhD, District Health , St Paul's Hospital and the University of Saskatchewan, Saskatoon, Saskatchewan; Lilyanna Trpeski BSc, Mount Sinai Hospital , Toronto, Ontario; Gilles Murray MD FRCPC , Centre Hôpital Universitaire de Québec St Sacrement , Sainte-Foy, Quebec; Gurmeet Randhawa MD FRCP , Kelowna General Hospital , Kelowna, British Columbia; Godfrey Harding MD FRCPC , St Boniface General Hospital , Winnipeg, Manitoba; Donna Hinds MD FRCP , The Richmond Hospital , Richmond, British Columbia; Christiane Gaudreau MD FRCP , Centre hospitalier de l'université de Montréal , Montréal, Québec; R Roy MD FRCP , Vernon Jubilee Hospital , Vernon, British Columbia; D Groves PhD , St Joseph's Hospital , Hamilton, Ontario; Michel G Bergeron MD FRCPC , Centre Hospitalier de L'Université Laval , Sainte-Foy, Québec; Dan Gregson MD FRCP , St Joseph's Health Centre , London, Ontario; Peter Jessamine MD FRCP , Ottawa Civic Hospital and Ottawa General Hospital , Ottawa, Ontario; Pamela C Kibsey MD FRCP , Victoria General Hospital , Victoria, British Columbia; Robert Rennie PhD , University of Alberta Hospitals , Edmonton , Alberta; Pierre L Turgeon MD FRCP, Hôpital Sainte-Luc and Universitaire de Montréal , Montréal, Québec; P Leighton PhD , Dr Everett Chalmers Hospital , Fredericton, New Brunswick; Louise Thibault MD FRCP , Dr Georges L Dumont Hospital Moncton, New Brunswick; M Laverdiere MD FRCPC, Hôpital Maisonneuve-Rosemont , Montreal, Québec; Magdalena Kuhn MD FRCP , The Moncton Hospital , Moncton, New Brunswick; Roland Lewis PhD , Cape Breton Regional Hospital , Sydney, Nova Scotia; Karl Weiss MD FRCP, Hôpital Maisonneuve-Rosemont, Montréal, Québec; Phillipe Jutras MD FRCP , Centre hospitalier regional de Rimouski, Rimouski, Québec Department of Microbiology, Mount Sinai and Princess Margaret Hospitals, University of Toronto , Ontari 1X5. Telephone 416-586-4435, fax 416-586-8746, e-mail DE Low, J de Azavedo, Canadian Bacterial Surveillance Network, Ross Davidson. In vitro activity of cefepime against multidrug-resistant Gram-negative bacilli, viridans group streptococci and Streptococcus pneumoniae from a cross-Canada surveillance study. Can J Infect Dis 1999;10(2):122-127. OBJECTIVE: To determine the in vitro activity of cefepime against multidrug-resistant Gram-negative bacilli and Grampositive cocci obtained from an ongoing cross-Canada surveillance study. DESIGN: Clinical isolates of aerobic Gram-negative bacilli with inducible and constitutive chromosomally mediated cephalosporinases, viridans group streptococci and Streptococcus pneumoniae were collected from laboratories serving hospitals, nursing homes and physician offices in the community from across Canada during 1996 and 1997. Laboratories were asked to submit only clinically relevant nonduplicate isolates for susceptibility testing. In vitro antimicrobial susceptibility testing was carried out on all isolates of Gram-negative and viridans group streptococci. S pneumoniae were characterized as penicillin susceptible, intermediately resistant or highly resistant. Nonsusceptible isolates were defined as being intermediately or highly resistant (minimal inhibitory concentrations [MIC] greater than 0.06 mg/L). Only isolates of S pneumoniae that were nonsusceptible to penicillin were selected for further study. MICs were deter- - ORIGINAL ARTICLE 95 75 25 5 0 100 95 75 mined using a microbroth dilution technique according to the National Committee of Clinical Laboratory Standards. RESULTS: A total of 727 Gram-negative bacilli samples were collected. No resistance to cefepime was detected with Citrobacter freundii, Serratia marcescens, Morganella morganii and Enterobacter species. Of these strains, Enterobacter species and C freundii were the most resistant to ceftazidime, cefotaxime and ceftriaxone with MIC90S of 32 mg/L or greater and resistance rates of 6% or greater. Resistance rates of Pseudomonas aeruginosa and Acinetobacter species to cefepime were 4.8% and 3%, respectively. The two organisms h (...truncated)


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Donald E Low, Joyce de Azavedo, Canadian Bacterial Surveillance Network, Ross Davidson. In Vitro Activity of Cefepime against Multidrug-Resistant Gram-Negative Bacilli, Viridans Group Streptococci and Streptococcus pneumoniae from a Cross-Canada Surveillance Study, Canadian Journal of Infectious Diseases and Medical Microbiology, 10, DOI: 10.1155/1999/172031