68Ga-DOTANOC PET/CT for the detection of a mesenchymal tumor causing oncogenic osteomalacia

European Journal of Nuclear Medicine and Molecular Imaging, Mar 2008

Christian von Falck, Thomas Rodt, Herbert Rosenthal, Florian Länger, Thomas Goesling, Wolfram H. Knapp, Michael Galanski

A PDF file should load here. If you do not see its contents the file may be temporarily unavailable at the journal website or you do not have a PDF plug-in installed and enabled in your browser.

Alternatively, you can download the file locally and open with any standalone PDF reader:

https://link.springer.com/content/pdf/10.1007%2Fs00259-008-0755-8.pdf

68Ga-DOTANOC PET/CT for the detection of a mesenchymal tumor causing oncogenic osteomalacia

Eur J Nucl Med Mol Imaging 68Ga-DOTANOC PET/CT for the detection of a mesenchymal tumor causing oncogenic osteomalacia Christian von Falck 0 1 2 3 Thomas Rodt 0 1 2 3 Herbert Rosenthal 0 1 2 3 Florian Länger 0 1 2 3 Thomas Goesling 0 1 2 3 Wolfram H. Knapp 0 1 2 3 Michael Galanski 0 1 2 3 0 T. Goesling Department of Trauma Surgery, Hannover Medical School , Hannover , Germany 1 F. Länger Institute of Pathology, Hannover Medical School , Hannover , Germany 2 C. von Falck ( 3 W. H. Knapp Department of Nuclear Medicine, Hannover Medical School , Hannover , Germany - A 54-year-old female patient had presented with clinical features of hyperphosphaturia, hypophosphatemia and osteomalacia. These findings were suggestive of oncogenic osteomalacia, a rare paraneoplastic disorder that is usually associated with a phosphaturic mesenchymal tumor [ 1 ]. Conventional morphologic imaging including whole-body computed tomography (CT) failed to localise the primary tumor. The patient underwent additional positron emission tomography (PET)/CT using 68Ga-DOTANOC, a highly sensitive and specific tracer for imaging of somatostatin receptor overexpression, which has recently proven potential in oncogenic osteomalacia [ 2, 3 ]. Abnormal focal tracer uptake was seen in the right distal femur (A). Using image fusion and three-dimensional volume-rendering techniques, the localisation of the suspected primary tumor was clearly visualised (B). Notably, no morphologic correlative was observed in the corresponding low-dose CT (C). Based on the PET/CT findings, the patient underwent segmental resection and compound osteosynthesis of the distal femur. The hematoxylin and eosin-stained section (D) demonstrated randomly organised spindle cells with slight cellular and nuclear atypia and a sparse intercellular matrix. Immunohistochemistry was negative for myogenic, neural, vascular and epithelial markers. These histopathologic findings were consistent with the diagnosis of a benign phosphaturic, mesenchymal tumor. 1. Edmister KA , Sundaram M. Oncogenic osteomalacia . Semin Musculoskelet Radiol 2002 ; 6 : 191 - 6 . 2. Hesse E , Moessinger E , Rosenthal H , et al. Oncogenic osteomalacia: exact tumor localization by co-registration of positron emission and computed tomography . J Bone Miner Res 2007 ; 22 : 158 - 62 . 3. Hesse E , Rosenthal H , Bastian L . Radiofrequency ablation of a tumor causing oncogenic osteomalacia . N Engl J Med 2007 ; 357 : 422 - 44 . (...truncated)


This is a preview of a remote PDF: https://link.springer.com/content/pdf/10.1007%2Fs00259-008-0755-8.pdf

Christian von Falck, Thomas Rodt, Herbert Rosenthal, Florian Länger, Thomas Goesling, Wolfram H. Knapp, Michael Galanski. 68Ga-DOTANOC PET/CT for the detection of a mesenchymal tumor causing oncogenic osteomalacia, European Journal of Nuclear Medicine and Molecular Imaging, 2008, pp. 1034-1034, Volume 35, Issue 5, DOI: 10.1007/s00259-008-0755-8