Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs

Diabetologia, Oct 1982

D. P. Mikhailidis, J. Y. Jeremy, P. Dandona

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Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs

Diabetologia Contractile Activity and Prostacyclin Generation in Isolated Coronary Arteries from Diabetic D o g s Dear Sir 0 1 0 Dr. P. D a n d o n a Metabolic Unit Department of Chemical Pathology Royal Free Hospital Pond Street London NW3 2QG U K 1 Responsible for the text: Prof. A. G. Cudworth, Department of Diabetes, Medical Unit , King George V Building (5th Floor), St. Bartholomew's Hospital , London EC1A 7BE, England Responsible for advertisements: E. Liickermann, B. Sehultz, Kurfiirstendamm 237, D-1000 Berlin 15. Springer-Verlag Berlin Heidelberg New York Printed in Germany by aprinta, Wemding Copyright 9 Springer-Verlag GmbH & Co. KG , Berlin Heidelberg 1982 , USA - ent fashion. For example, in our experiments in vitro, clinically unacceptable plasma glucose concentrations (15-30 mmol/1) were stimulatory, whereas high concentrations of ketone bodies had no effect on PGI2 synthesis [ 8 ]. Non-esterified fatty acids, as mentioned above, were markedly inhibitory. Clearly, the relationship of diabetes mellitus with prostaglandin metabolism and vascular abnormalities requires further investigation. Yours sincerely, D. P. Mikhailidis, J. Y. Jeremy and P. D a n d o n a 1. Sterin-Borda L , Borda ES , Gimeno MF , Lazzari MA , del Castillo E , Gimeno AL ( 1982 ) Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs . Diabetologia 22 : 56 - 59 2. Hamilton G , Rosza I , Hutton R , Chow FPR , D a n d o n a P , Hobbs K E F ( 1981 ) Portal vein prostacyclin activity in experimental portal hypertension in rats . Clin Sci 60 : 327 - 329 3. D a n d o n a P , James IM , Newbury PA , Woollard ML , Beckett A G ( 1978 ) Cerebral blood flow in diabetes mellitus: evidence of abnormal cerebrovascular reactivity . Br Med J 2:325 326 4. Dandona P , James IM , Woolard ML , Newbury P , Beckett AG ( 1979 ) Instability of cerebral blood flow in insulin-dependent diabetics . Lancet 2 : 1203 - 1206 5. Ewald U , Tuvemot T , Rooth G ( 1981 ) Early reduction of vascular reactivity in diabetic children detected by transcutaneous oxygen electrode . Lancet 1 : 1287 - 1288 6. Dandona P , James IM , Beckett AG ( 1980 ) Vascular reactivity in diabetes . Lancet 2 : 694 7. Gcorgiadis E , Dandona P , Hughes R , Morris R , Woolard ML , Beckett AG , James IM ( 1981 ) Cerebral blood flow in patients with diabetic feet . Diabetologia 21 : 274 (Abstract) 8. Jeremy JY , Mikhailidis DP , Dandona P ( 1982 ) Simulating the diabetic environment modifies prostacyclin synthesis in vitro in the rat . Diabetologia 22 : 388 (Abstract) 9. Mikhailidis DP , Mikhailidis AM , Dandona P ( 1982 ) The effect of human plasma proteins on the stabilisation of the platelet antiaggregatory activity of prostacyclin . Ann Clin Biochem (in press) 10. Mikhailidis DP , Mikhailidis AM , Dandona P ( 1981 ) Plasma nonesterified fatty acid levels and atherogenesis in diabetes mellitus . Diabetologia 21 : 499 - 500 11. Sterin-Borda L , Gimeno M , Borda E , del Castillo E , Gimeno AL ( 1981 ) Prostacyclin (PGI2) and U-46619 stimulate coronary arteries from diabetic dogs and their action is influenced by inhibitors of prostaglandin biosynthesis . Prostaglandins 22 : 267 - 278


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D. P. Mikhailidis, J. Y. Jeremy, P. Dandona. Contractile activity and prostacyclin generation in isolated coronary arteries from diabetic dogs, Diabetologia, 1982, 380-380, DOI: 10.1007/BF00253750