Tolbutamide stimulates Ca2+ influx in islet cells without reducing k+ conductance

Diabetologia, Jul 1980

W. J. Malaisse, A. R. Carpinelli, A. Herchuelz

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Tolbutamide stimulates Ca2+ influx in islet cells without reducing k+ conductance

0 T I M E , rain 1 Dr. W. J. Malaisse Laboratory of Experimental Medicine Brussels University Medical School 115 , Boulevard de Waterloo B-1000 Brussels , Belgium Fig. l . Effect of tolbutamide (100 ~tg/ml) upon S6Rb and 45Ca fractional outflow rate (F.O.R.) and insulin release from rat islets perifused in the presence of glucose 8.3 mmol/1. Mean values (_+ SEM) for S6Rb and 45Ca F.O.R. refer to the same 6 individual experiments, insulin release being measured in only 4 of these 6 experiments - 1~ E 2 - 4 9 3 . 6 3 . 2 2 - 8 1.e 2.4 2 . 0 d ~ o 1.2 z ~ . .=,.-0.4 L T o l b u t a m i d e S t i m u l a t e s C a 2+ I n f l u x in I s l e t C e l l s w i t h o u t R e d u c i n g K § C o n d u c t a n c e I Glucose ( 8 . 3 raM) Tolbutamide (,100 p g / m l ) t I 1 T n : 6 1. Henquin JC ( 1980 ) Tolbutamide stimulation and inhibition of insulin release: studies of the underlying ionic mechanisms in isolated rat islets . Diabetologia 18 : 151 - 160 2. Boschero AC , Malaisse WJ ( 1979 ) Stimulus-secretion coupling of glucose-induced insulin release . XXIX. Regulation of 86Rb+ efflux from pancreatic islets . Am J Physiol 236: E 139-E 146 3. Herchuelz A , Couturier E , Malaisse WJ ( 1980 ) Regulation of calcium fluxes in pancreatic islets. Glucose-induced calciumcalcium exchange . Am J Physiol 2 3 8 : E 9 7 - E 1 0 3 4. Malaisse WJ , Devis G , Hutton JC , Somers G ( 1977 ) Effect of insulinotropic agents on Ca 2+ translocation in an artificial system (abstract) . Diabetes 26 : 407 5. Anjaneyulu R , Anjaneyulu K , Couturier E , Malaisse WJ (in press) Opposite effects of hypoglycemic and hyperglycemic sulfonamides upon ionophore-mediated calcium transport . Biochem Pharmacol


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W. J. Malaisse, A. R. Carpinelli, A. Herchuelz. Tolbutamide stimulates Ca2+ influx in islet cells without reducing k+ conductance, Diabetologia, 1980, 85-85, DOI: 10.1007/BF00258318