Association and linkage analyses of RGS4 polymorphisms in schizophrenia
Human Molecular Genetics ,
Jul 2003
Kodavali V. Chowdari , Karoly Mirnics , Prachi Semwal , Joel Wood , Elizabeth Lawrence , Triptish Bhatia , Smita N. Deshpande , B.K. Thelma , Robert E. Ferrell , Frank A. Middleton , et al.
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Association and linkage analyses of RGS4 polymorphisms in schizophrenia
Kodavali V. Chowdari
Karoly Mirnics
Prachi Semwal
Joel Wood
Elizabeth Lawrence
Triptish Bhatia
Smita N. Deshpande
B.K. Thelma
Robert E. Ferrell
Frank A. Middleton
Bernie Devlin
Pat Levitt
David A. Lewis
Vishwajit L. Nimgaonkar
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The original manuscript reported on association and linkage
between polymorphisms of the RGS4 gene and schizophrenia.
The primary analyses suggested association and linkage with
schizophrenia. Secondary analyses using a sample of patients
with bipolar I disorder (BD1) suggested significant overall
differences in estimated RGS4 haplotype frequency between
the BD1 cases and two groups of population based controls.
We recently noted a data entry error restricted to genotypes
for SNP7 among the BD1 cases and their parents. The
corrections presented below have no bearing on the original
reported associations with schizophrenia. They clarify a
puzzling variation noted earlier between the BD1 and
schizophrenia samples.
Unlike the prior results, the revised genotypes now show no
significant haplotype frequency differences between the BD1
cases and either group of controls. The initial and the revised
haplotype distributions are provided (Table 2R, available
online at http://www.pitt.edu/~nimga/research/RGS4).
Unchanged values for the population based controls, listed in
Table 2 in the original paper are also presented for comparison.
Due to the revisions, the estimates for linkage disequilibrium
with other RGS4 SNPs are now larger (see revised data, Table
3R online at http://www.pitt.edu/~nimga/research/RGS4). Our
estimates for transmission distortion in the BD1 sample using
TRANSMIT software are lower (w2 12.94, 10 df,
P 0.2269). However, the overall probability for biased
parental transmission of haplotypes bearing SNPs 1, 4, 7 and
18 among the family-based schizophrenia and the bipolar
samples continues to be significant (P 0.0033).
The authors regret this error.
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Kodavali V. Chowdari, Karoly Mirnics, Prachi Semwal, Joel Wood, Elizabeth Lawrence, Triptish Bhatia, Smita N. Deshpande, B.K. Thelma, Robert E. Ferrell, Frank A. Middleton, Bernie Devlin, Pat Levitt, David A. Lewis, Vishwajit L. Nimgaonkar.
Association and linkage analyses of RGS4 polymorphisms in schizophrenia ,
Human Molecular Genetics,
2003, pp. 1781-1781, 12/14, DOI: 10.1093/hmg/ddg171