Clinical Relevance of the Pharmacokinetic Interactions of Azole Antifungal Drugs with Other Coadministered Agents
Clinical Infectious Diseases ,
May 2009
There are currently a number of licensed azole antifungal drugs; however; only 4 (namely, fluconazole, itraconazole, posaconazole, and voriconazole) are used frequently in a clinical setting for prophylaxis or treatment of systemic fungal infections. In this article, we review the pharmacokinetic interactions of these azole antifungal drugs with other coadministered agents. We describe these (2-way) interactions and the extent to which metabolic pathways and/or other supposed mechanisms are involved in these interactions. This article provides an overview of all published drug-drug interactions in humans (either healthy volunteers or patients), and on the basis of these findings, we have developed recommendations for managing the specific interactions.
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Clinical Relevance of the Pharmacokinetic Interactions of Azole Antifungal Drugs with Other Coadministered Agents
Roger J. M. Bru ggemann
(
[email protected] )
1
4
Jan-Willem C. Alffenaar
3
Nicole M. A. Blijlevens
4
Eliane M. Billaud
2
Jos G. W. Kosterink
3
Paul E. Verweij
0
4
David M. Burger
1
4
0
Medical Microbiology, Radboud University Nijmegen Medical Centre
1
Departments of Clinical Pharmacy
2
Department of Pharmacology, University Medical Center
, l'Hopital Europeen Georges Pompidou,
Universite Paris Descartes
,
Paris, France
3
Department of Hospital and Clinical Pharmacy, University Medical Centre Groningen
, Groningen,
The Netherlands
4
Nijmegen Institute for Infection, Inflammation and Immunology
,
Nijmegen
There are currently a number of licensed azole antifungal drugs; however; only 4 (namely, fluconazole, itraconazole, posaconazole, and voriconazole) are used frequently in a clinical setting for prophylaxis or treatment of systemic fungal infections. In this article, we review the pharmacokinetic interactions of these azole antifungal drugs with other coadministered agents. We describe these (2-way) interactions and the extent to which metabolic pathways and/or other supposed mechanisms are involved in these interactions. This article provides an overview of all published drug-drug interactions in humans (either healthy volunteers or patients), and on the basis of these findings, we have developed recommendations for managing the specific interactions.
-
METHODS
PHARMACOKINETICS OF AZOLE ANTIFUNGAL
DRUGS
Drug Absorption
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This is a preview of a remote PDF: https://cid.oxfordjournals.org/content/48/10/1441.full.pdf
Roger J. M. Brüggemann, Jan-Willem C. Alffenaar, Nicole M. A. Blijlevens, Eliane M. Billaud, Jos G. W. Kosterink, Paul E. Verweij, David M. Burger, Louis D. Saravolatz.
Clinical Relevance of the Pharmacokinetic Interactions of Azole Antifungal Drugs with Other Coadministered Agents ,
Clinical Infectious Diseases,
2009, pp. 1441-1458, 48/10, DOI: 10.1086/598327