Cigarette Smoking Is Associated With Low Glomerular Filtration Rate in Male Patients With Type 2 Diabetes: Response to Saito et al.

Diabetes Care, Mar 2007

Salvatore De Cosmo, Olga Lamacchia, Loreto Gesualdo, Vincenzo Trischitta, Mauro Cignarelli

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Cigarette Smoking Is Associated With Low Glomerular Filtration Rate in Male Patients With Type 2 Diabetes: Response to Saito et al.

Response to Saito et al. 0 Unit of Nephrology, Department of Molecular Medicine, University of Foggia , Foggia , Italy; and the 1 Unit of Endocrinology and Metabolic Diseases, Department of Medical Sci- ences, University of Foggia , Foggia , Italy; the 2 Unit of Endocrinology, the Scientific In- stitute Casa Sollievo della Sofferenza , San Giovanni Rotondo, Foggia , Italy; the 3 Depart- ment of Clinical Sciences, University of Rome La Sapienza , Rome , Italy. MD, Unit of Endocrinology and Metabolic Diseases, Department of Medical Sciences, University of Fog- gia , via Luigi Pinto, 71100 Foggia , Italy - W interest and comments regarding e thank Saito et al. (1) for their our recent article (2). They suggest that the absence of positive correlation between the number of cigarettes smoked per day and severity of nephropathy, as expressed by low glomular filtration rate, might be due to the exclusion of ex-smokers in the analysis. This is possible, given the fact that some studies (3,4) (though not all [5]) including ex-smokers have found the above-mentioned correlation. In fact, both options (i.e., ex-smokers being either included or excluded) have their own rationale (3 6). In our specific context, we decided to design a study aimed at investigating the role of current smoking in modulating the risk of having low glomular filtration rate. Including exsmokers could weaken the result obtained and conceal the role played by exposure to tobacco smoke on oxidative stress, as we have shown. However, we do acknowledge that the alternative approach, including ex-smokers, would have been equally appropriate if aimed at also determining the effect of previous smoking habit. SALVATORE DE COSMO, MD1 OLGA LAMACCHIA, MD2 LORETO GESUALDO, MD3 VINCENZO TRISCHITTA, MD1,4 MAURO CIGNARELLI, MD2 (...truncated)


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Salvatore De Cosmo, Olga Lamacchia, Loreto Gesualdo, Vincenzo Trischitta, Mauro Cignarelli. Cigarette Smoking Is Associated With Low Glomerular Filtration Rate in Male Patients With Type 2 Diabetes: Response to Saito et al., Diabetes Care, 2007, pp. e3-e3, 30/3, DOI: 10.2337/dc06-2420