Quantification of coronary enhancement - reproducibility of methods and feasibility of quantification in health and disease
Journal of Cardiovascular Magnetic Resonance ,
Jan 2013
Niharika Varma , Rene M Botnar , Andreas Indermuehle , Sarah A Peel , Gerald F Greil , Eike Nagel , Valentina O Puntmann
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Quantification of coronary enhancement - reproducibility of methods and feasibility of quantification in health and disease
Varma et al. Journal of Cardiovascular Magnetic
Resonance
Quantification of coronary enhancement - reproducibility of methods and feasibility of quantification in health and disease
Niharika Varma 0 2
Rene M Botnar 0 1
Andreas Indermuehle 0 1
Sarah A Peel 0 1
Gerald F Greil 0 2
Eike Nagel 0 2
Valentina O Puntmann 0 2
0 From 16th Annual SCMR Scientific Sessions San Francisco , CA, USA. 31 , USA
1 Department of Medical Physics and Bioengineering, Division of Imaging Sciences and Biomedical Engineering, King's College London , London , UK
2 Cardiovascular Imaging, King's College London , London , UK
Background Coronary enhancement (CE) imaging by magnetic resonance (MR) is a novel, non-invasive approach for visualization of contrast uptake within the coronary artery vessel wall. Quantification of CE may help to individualize subpopulations at risk for the benefit of early risk assessment and intervention. Here we sought to compare the reproducibility of several quantification methods and to investigate the feasibility to detect differences in healthy subjects and disease.
Methods
All imaging was performed with a 3T MRI scanner.
Targeted volume coronary imaging was performed using
double-oblique imaging planes parallel to either the left
and right coronary artery defined by a 3-point plan-scan
tool. A balanced steady state free precession sequence
(acquired in-plane resolution=1.25x1.25x3mm; TR/TE/
FA: 4.2ms/1.5ms/110°) was used for visualization of the
lumen. Subsequently, inversion-recovery T1 weighted 3D
gradient echo coronary imaging (TR/TE/FA: 6.1msec/1.9
msec/30°) was performed 40 minutes after administration
of 0.2 mmol/kg of gadobutrol. Three methods of
quantification M1-M3, were applied to the proximal coronary
artery of each subject’s dataset. M1 and M2 generated a
mean contrast to noise ratio (CNR) by using coronary
and aortic blood signal intensity (SI): M1 only included
the visually detectable enhancement in the wall of each
arterial segment whereas M2 included the complete
segment (lumen and wall) and derived an average SI per
segment (Figure 1). M3 was used to quantify a ‘total visually
detectable area’ of CE. Analysis was performed by two
independent observers for inter and intra-observer
reproducibility. We then tested the feasibility of these methods
to generate values in healthy subjects and those with
either coronary or systemic inflammatory disease.
Conclusions
Quantification of visualized CE in proximal coronary
segments using CNR and total area is feasible and
reproducible. Both methods are able to discern
significant differences between health and disease.
Funding
NIHR Biomedical Research Centre award (Atherosclerosis
theme).
doi:10.1186/1532-429X-15-S1-P84
Cite this article as: Varma et al.: Quantification of coronary
enhancement - reproducibility of methods and feasibility of
quantification in health and disease. Journal of Cardiovascular Magnetic
Resonance 2013 15(Suppl 1):P84. (...truncated)
This is a preview of a remote PDF: http://www.jcmr-online.com/content/pdf/1532-429X-15-S1-P84.pdf
Niharika Varma, Rene M Botnar, Andreas Indermuehle, Sarah A Peel, Gerald F Greil, Eike Nagel, Valentina O Puntmann.
Quantification of coronary enhancement - reproducibility of methods and feasibility of quantification in health and disease ,
Journal of Cardiovascular Magnetic Resonance,
2013, pp. P84, 15,