Global and regional estimates of cancer mortality and incidence by site: II. results for the global burden of disease 2000

BMC Cancer, Dec 2002

Background Mortality estimates alone are not sufficient to understand the true magnitude of cancer burden. We present the detailed estimates of mortality and incidence by site as the basis for the future estimation of cancer burden for the Global Burden of Disease 2000 study. Methods Age- and sex- specific mortality envelope for all malignancies by region was derived from the analysis of country life-tables and cause of death. We estimated the site-specific cancer mortality distributions from vital records and cancer survival model. The regional cancer mortality by site is estimated by disaggregating the regional cancer mortality envelope based on the mortality distribution. Estimated incidence-to-mortality rate ratios were used to back calculate the final cancer incidence estimates by site. Results In 2000, cancer accounted for over 7 million deaths (13% of total mortality) and there were more than 10 million new cancer cases world wide in 2000. More than 60% of cancer deaths and approximately half of new cases occurred in developing regions. Lung cancer was the most common cancers in the world, followed by cancers of stomach, liver, colon and rectum, and breast. There was a significant variations in the distribution of site-specific cancer mortality and incidence by region. Conclusions Despite a regional variation, the most common cancers are potentially preventable. Cancer burden estimation by taking into account both mortality and morbidity is an essential step to set research priorities and policy formulation. Also it can used for setting priorities when combined with data on costs of interventions against cancers.

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Global and regional estimates of cancer mortality and incidence by site: II. results for the global burden of disease 2000

BMC Cancer Global and regional estimates of cancer mortality and incidence by site: II. results for the global burden of disease 2000 Kenji Shibuya 2 Colin D Mathers 2 Cynthia Boschi-Pinto 1 Alan D Lopez 2 Christopher JL Murray 0 0 Executive Director, Evidence and Information for Policy, World Health Organization , Geneva , Switzerland 1 Family and Community Health/ Child and Adolescent Health and Development, World Health Organization , Geneva , Switzerland 2 Global Program on Evidence for Health Policy, World Health Organization , Geneva , Switzerland Background: Mortality estimates alone are not sufficient to understand the true magnitude of cancer burden. We present the detailed estimates of mortality and incidence by site as the basis for the future estimation of cancer burden for the Global Burden of Disease 2000 study. Methods: Age- and sex- specific mortality envelope for all malignancies by region was derived from the analysis of country life-tables and cause of death. We estimated the site-specific cancer mortality distributions from vital records and cancer survival model. The regional cancer mortality by site is estimated by disaggregating the regional cancer mortality envelope based on the mortality distribution. Estimated incidence-to-mortality rate ratios were used to back calculate the final cancer incidence estimates by site. Results: In 2000, cancer accounted for over 7 million deaths (13% of total mortality) and there were more than 10 million new cancer cases world wide in 2000. More than 60% of cancer deaths and approximately half of new cases occurred in developing regions. Lung cancer was the most common cancers in the world, followed by cancers of stomach, liver, colon and rectum, and breast. There was a significant variations in the distribution of site-specific cancer mortality and incidence by region. Conclusions: Despite a regional variation, the most common cancers are potentially preventable. Cancer burden estimation by taking into account both mortality and morbidity is an essential step to set research priorities and policy formulation. Also it can used for setting priorities when combined with data on costs of interventions against cancers. - WHO region Mortality stratum Sub region WHO Member States AMRO AMRO AMRO EMRO EMRO EURO EURO EURO EURO SEARO SEARO WPRO WPRO WPRO WPRO D E AmrA AmrB AmrD EmrB EmrD EurA EurB2 EurC SearB SearD WprA WprB1 WprB2 WprB3 Discussion AfrD AfrE AmrA AmrB AmrD EmrB EmrD EurA EurB EurC SearB SearD WprA WprB World AfrD AfrE AmrA AmrB AmrD EmrB EmrD EurA EurB1 EurB2 EurC SearB SearD WprA WprB1 WprB2 WprB3 World AfrD AfrE AmrA AmrB AmrD EmrB EmrD EurA 965.1 1,386.4 1,612.8 1,074.1 895.3 1,354.4 688.6 540.6 1,109.9 Age-group Number of deaths (000s) 462.1 1,503.0 26.3 59.2 33.1 65.0 23.1 102.4 31.7 86.4 6.4 14.8 8.0 19.2 10.6 17.8 31.3 154.1 16.6 59.3 4.3 7.9 28.4 114.2 30.9 90.0 65.1 189.0 7.7 49.6 128.2 451.6 9.5 21.4 0.6 1.2 548.2 667.6 798.9 581.8 463.9 593.4 374.6 305.6 570.4 Subregion Category I: Complete vital statistics (95%+ coverage) Category II: Incomplete vital statistics Category III: Sample registration and surveillance systems Category IV: Child mortality estimated from surveys and censuses Category V: No recent data on child or adult mortality Number of countries 1,702.1 2,799.0 2,932.2 1,901.0 1,773.8 2,827.8 1,182.8 716.3 2,089.7 116.5 81.4 89.1 203.1 90.7 102.3 55.8 50.5 259.6 EurB1 EurB2 EurC SearB SearD WprA WprB1 WprB2 WprB3 World AfrD AfrE AmrA AmrB AmrD EmrB EmrD EurA EurB1 EurB2 EurC SearB SearD WprA WprB1 WprB2 WprB3 World AfrD AfrE AmrA AmrB AmrD EmrB EmrD EurA EurB1 EurB2 EurC SearB SearD WprA WprB1 WprB2 WprB3 47.1 41.5 51.3 36.7 24.9 25.9 38.1 31.7 47.8 226.3 172.8 266.1 192.9 124.6 153.3 218.2 152.4 173.4 Age-group Number of deaths (000s) 228.3 844.8 14.3 29.2 20.3 33.3 10.5 54.0 12.4 41.4 2.2 5.4 3.0 10.0 5.1 9.0 15.2 90.1 8.7 37.2 2.0 4.4 13.8 70.1 11.8 45.4 31.0 88.4 3.4 29.2 69.7 285.7 4.6 11.4 0.2 0.6 694.5 697.7 824.4 689.9 546.5 583.7 461.9 385.5 762.6 847.1 598.0 1,001.0 569.2 516.9 668.2 796.0 431.4 329.5 602.5 450.4 656.0 442.1 448.9 471.8 617.6 312.2 280.3 874.0 584.6 911.4 679.3 681.4 927.3 1,080.7 525.6 378.4 1,264.5 1,607.5 1,866.5 1,353.3 1,139.1 1,505.9 904.8 704.1 1,576.8 1,225.6 772.0 1,453.4 905.5 792.8 1,387.3 1,372.3 784.9 476.3 1,325.3 550.4 1,012.8 1,109.6 1,499.2 1,907.7 1,435.2 1,540.4 1,162.9 2,095.6 3,446.7 4,078.5 2,286.9 2,145.2 3,264.8 1,444.8 1,014.3 2,711.7 1,657.4 676.4 1,541.1 1,264.7 1,419.2 2,603.3 1,729.7 2,303.2 1,404.1 153.5 68.4 205.4 76.2 64.9 222.6 130.0 59.7 49.1 128.2 83.9 93.5 213.1 94.5 93.6 62.1 54.8 295.6 183.0 75.0 242.3 82.0 64.8 270.5 151.1 68.1 46.7 World AfrD AfrE AmrA AmrB AmrD EmrB EmrD EurA EurB1 EurB2 EurC SearB SearD WprA WprB1 WprB2 WprB3 Age-group Number of deaths (000s) 233.8 658.2 12.0 30.0 12.8 31.7 12.6 48.4 19.3 45.0 4.2 9.4 5.0 9.2 5.5 8.8 16.2 64.0 7.9 22.1 2.3 3.6 14.6 44.1 19.1 44.6 34.2 100.6 4.3 20.4 58.5 165.9 5.0 9.9 0.4 0 (...truncated)


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Kenji Shibuya, Colin D Mathers, Cynthia Boschi-Pinto, Alan D Lopez, Christopher JL Murray. Global and regional estimates of cancer mortality and incidence by site: II. results for the global burden of disease 2000, BMC Cancer, 2002, pp. 37, 2, DOI: 10.1186/1471-2407-2-37