Global and regional estimates of cancer mortality and incidence by site: II. results for the global burden of disease 2000
BMC Cancer
Global and regional estimates of cancer mortality and incidence by site: II. results for the global burden of disease 2000
Kenji Shibuya 2
Colin D Mathers 2
Cynthia Boschi-Pinto 1
Alan D Lopez 2
Christopher JL Murray 0
0 Executive Director, Evidence and Information for Policy, World Health Organization , Geneva , Switzerland
1 Family and Community Health/ Child and Adolescent Health and Development, World Health Organization , Geneva , Switzerland
2 Global Program on Evidence for Health Policy, World Health Organization , Geneva , Switzerland
Background: Mortality estimates alone are not sufficient to understand the true magnitude of cancer burden. We present the detailed estimates of mortality and incidence by site as the basis for the future estimation of cancer burden for the Global Burden of Disease 2000 study. Methods: Age- and sex- specific mortality envelope for all malignancies by region was derived from the analysis of country life-tables and cause of death. We estimated the site-specific cancer mortality distributions from vital records and cancer survival model. The regional cancer mortality by site is estimated by disaggregating the regional cancer mortality envelope based on the mortality distribution. Estimated incidence-to-mortality rate ratios were used to back calculate the final cancer incidence estimates by site. Results: In 2000, cancer accounted for over 7 million deaths (13% of total mortality) and there were more than 10 million new cancer cases world wide in 2000. More than 60% of cancer deaths and approximately half of new cases occurred in developing regions. Lung cancer was the most common cancers in the world, followed by cancers of stomach, liver, colon and rectum, and breast. There was a significant variations in the distribution of site-specific cancer mortality and incidence by region. Conclusions: Despite a regional variation, the most common cancers are potentially preventable. Cancer burden estimation by taking into account both mortality and morbidity is an essential step to set research priorities and policy formulation. Also it can used for setting priorities when combined with data on costs of interventions against cancers.
-
WHO region
Mortality
stratum
Sub region
WHO Member States
AMRO
AMRO
AMRO
EMRO
EMRO
EURO
EURO
EURO
EURO
SEARO
SEARO
WPRO
WPRO
WPRO WPRO D E
AmrA
AmrB
AmrD
EmrB
EmrD
EurA
EurB2
EurC
SearB
SearD
WprA
WprB1
WprB2
WprB3
Discussion
AfrD
AfrE
AmrA
AmrB
AmrD
EmrB
EmrD
EurA
EurB
EurC
SearB
SearD
WprA
WprB
World
AfrD
AfrE
AmrA
AmrB
AmrD
EmrB
EmrD
EurA
EurB1
EurB2
EurC
SearB
SearD
WprA
WprB1
WprB2
WprB3
World
AfrD
AfrE
AmrA
AmrB
AmrD
EmrB
EmrD
EurA
965.1
1,386.4
1,612.8
1,074.1
895.3
1,354.4
688.6
540.6
1,109.9
Age-group
Number of deaths (000s)
462.1 1,503.0
26.3 59.2
33.1 65.0
23.1 102.4
31.7 86.4
6.4 14.8
8.0 19.2
10.6 17.8
31.3 154.1
16.6 59.3
4.3 7.9
28.4 114.2
30.9 90.0
65.1 189.0
7.7 49.6
128.2 451.6
9.5 21.4
0.6 1.2
548.2
667.6
798.9
581.8
463.9
593.4
374.6
305.6
570.4
Subregion
Category I:
Complete vital statistics
(95%+ coverage)
Category II:
Incomplete vital
statistics
Category III:
Sample registration and
surveillance systems
Category IV:
Child mortality
estimated from
surveys and censuses
Category V: No
recent data on child
or adult mortality
Number of
countries
1,702.1
2,799.0
2,932.2
1,901.0
1,773.8
2,827.8
1,182.8
716.3
2,089.7
116.5
81.4
89.1
203.1
90.7
102.3
55.8
50.5
259.6
EurB1
EurB2
EurC
SearB
SearD
WprA
WprB1
WprB2
WprB3
World
AfrD
AfrE
AmrA
AmrB
AmrD
EmrB
EmrD
EurA
EurB1
EurB2
EurC
SearB
SearD
WprA
WprB1
WprB2
WprB3
World
AfrD
AfrE
AmrA
AmrB
AmrD
EmrB
EmrD
EurA
EurB1
EurB2
EurC
SearB
SearD
WprA
WprB1
WprB2
WprB3
47.1
41.5
51.3
36.7
24.9
25.9
38.1
31.7
47.8
226.3
172.8
266.1
192.9
124.6
153.3
218.2
152.4
173.4
Age-group
Number of deaths (000s)
228.3 844.8
14.3 29.2
20.3 33.3
10.5 54.0
12.4 41.4
2.2 5.4
3.0 10.0
5.1 9.0
15.2 90.1
8.7 37.2
2.0 4.4
13.8 70.1
11.8 45.4
31.0 88.4
3.4 29.2
69.7 285.7
4.6 11.4
0.2 0.6
694.5
697.7
824.4
689.9
546.5
583.7
461.9
385.5
762.6
847.1
598.0
1,001.0
569.2
516.9
668.2
796.0
431.4
329.5
602.5
450.4
656.0
442.1
448.9
471.8
617.6
312.2
280.3
874.0
584.6
911.4
679.3
681.4
927.3
1,080.7
525.6
378.4
1,264.5
1,607.5
1,866.5
1,353.3
1,139.1
1,505.9
904.8
704.1
1,576.8
1,225.6
772.0
1,453.4
905.5
792.8
1,387.3
1,372.3
784.9
476.3
1,325.3
550.4
1,012.8
1,109.6
1,499.2
1,907.7
1,435.2
1,540.4
1,162.9
2,095.6
3,446.7
4,078.5
2,286.9
2,145.2
3,264.8
1,444.8
1,014.3
2,711.7
1,657.4
676.4
1,541.1
1,264.7
1,419.2
2,603.3
1,729.7
2,303.2
1,404.1
153.5
68.4
205.4
76.2
64.9
222.6
130.0
59.7
49.1
128.2
83.9
93.5
213.1
94.5
93.6
62.1
54.8
295.6
183.0
75.0
242.3
82.0
64.8
270.5
151.1
68.1
46.7
World
AfrD
AfrE
AmrA
AmrB
AmrD
EmrB
EmrD
EurA
EurB1
EurB2
EurC
SearB
SearD
WprA
WprB1
WprB2
WprB3
Age-group
Number of deaths (000s)
233.8 658.2
12.0 30.0
12.8 31.7
12.6 48.4
19.3 45.0
4.2 9.4
5.0 9.2
5.5 8.8
16.2 64.0
7.9 22.1
2.3 3.6
14.6 44.1
19.1 44.6
34.2 100.6
4.3 20.4
58.5 165.9
5.0 9.9
0.4 0 (...truncated)