Insulin sensitivity and Lp(α) concentrations in normoglycemic offspring of type 2 diabetic parents

Lipids in Health and Disease, Oct 2003

Background Offspring of at least 1 parent with type 2 diabetes are more resistant to the insulin action, exhibit higher incidence of dyslipidemia and are more prone to cardiovascular diseases. The association between Lp(α) and coronary heart disease is well established. An association between Lp(α) concentration and insulin sensitivity was examined in this study. We investigated the serum LP(α) in 41 offspring of 41 families of type 2 diabetic subjects (group I) with normal glucose tolerance, compared to 49 offspring who their parents had no history of type 2 diabetes, matched for sex, age, BMI, WHR and blood pressure (group II). Serum Lp(α), triglycerides, insulin resistant index, HDL, LDL-cholesterol and insulin were measured. Results The offspring of type 2 diabetic subjects had higher fasting serum triglycerides (mean ± SD 199.3 ± 184.2 vs. 147.1 ± 67.9 ng/dl, p < 0.05) lower HDL-cholesterol (37.3 ± 9.0 vs. 44.6 ± 7.8, p < 0.001) and particularly higher Insulin resistance Index (HOMA-IR) (2.84 ± 1.39 vs. 1.67 ± 0.77, p < 0.001). They also had higher serum LP(α) concentration (15.4 ± 6.7 vs. 8.6 ± 6.0, p < 0.001). By simple linear analysis in the offspring of type 2 diabetic parents there was no correlation of Lp(α) concentration with insulin resistance index Homa-IR (r = 0,016 p = NS). Conclusions We conclude that serum LP(α) is significantly increased in offspring of type 2 diabetic subjects but was not related to insulin sensitivity.

A PDF file should load here. If you do not see its contents the file may be temporarily unavailable at the journal website or you do not have a PDF plug-in installed and enabled in your browser.

Alternatively, you can download the file locally and open with any standalone PDF reader:

http://www.lipidworld.com/content/pdf/1476-511X-2-8.pdf

Insulin sensitivity and Lp(α) concentrations in normoglycemic offspring of type 2 diabetic parents

Lipids in Health and Disease Insulin sensitivity and Lp() concentrations in normoglycemic offspring of type 2 diabetic parents Agathoklis Psyrogiannis 0 Ioannis Habeos 0 Venetsana Kyriazopoulou 0 0 Address: Division of Endocrinology and Diabetes, Department of Medicine, University of Patras Medical School , Patras , Greece Background: Offspring of at least 1 parent with type 2 diabetes are more resistant to the insulin action, exhibit higher incidence of dyslipidemia and are more prone to cardiovascular diseases. The association between Lp() and coronary heart disease is well established. An association between Lp() concentration and insulin sensitivity was examined in this study. We investigated the serum LP() in 41 offspring of 41 families of type 2 diabetic subjects (group I) with normal glucose tolerance, compared to 49 offspring who their parents had no history of type 2 diabetes, matched for sex, age, BMI, WHR and blood pressure (group II). Serum Lp(), triglycerides, insulin resistant index, HDL, LDL-cholesterol and insulin were measured. Results: The offspring of type 2 diabetic subjects had higher fasting serum triglycerides (mean SD 199.3 184.2 vs. 147.1 67.9 ng/dl, p < 0.05) lower HDL-cholesterol (37.3 9.0 vs. 44.6 7.8, p < 0.001) and particularly higher Insulin resistance Index (HOMA-IR) (2.84 1.39 vs. 1.67 0.77, p < 0.001). They also had higher serum LP() concentration (15.4 6.7 vs. 8.6 6.0, p < 0.001). By simple linear analysis in the offspring of type 2 diabetic parents there was no correlation of Lp() concentration with insulin resistance index Homa-IR (r = 0,016 p = NS). Conclusions: We conclude that serum LP() is significantly increased in offspring of type 2 diabetic subjects but was not related to insulin sensitivity. - Background Patients with type 2 diabetes mellitus are characterized by resistance to insulin-stimulated glucose uptake [1,2], dyslipidemia (especially increased triglyceride and decreased high-density lipoprotein (HDL) levels [3,4], hypertension [5] and coronary heart disease [6,7]. Lipoprotein () [Lp()], first described by Berg [8] in 1963, is a low density lipoprotein (LDL) like substance with a specific apoprotein, apoprotein () [apo ()], bound to apo- 100 by disulfide bridges [9,10]. Numerous studies have suggested that lipoprotein () concentrations may be an independent risk factor for coronary heart disease [1115]. However, the molecular mechanism by which Lp() might promote atherosclerosis has not been clarified. Triglyceride (mg/dl) Cholesterol (mg/dl) HDL-cholesterol (mg/dl) LDL-cholesterol (mg/dl) Lp() (mg/dl) The relationship of Lp() concentrations with insulin resistance remains controversial. Some studies have showed increase Lp() concentration in subjects with NIDDM [1618] whereas other studies have showed similar Lp() concentrations in type 2 diabetic subjects compared with normoglycemic subjects[19]. In other studies of nondiabetic subjects, insulin concentrations have not been associated with Lp() concentrations [20,21]. One study showed no elevated Lp() concentrations in normoglycemic insulin-resistant subjects [22]. In this report, we examine the association of Lp() concentrations to insulin sensitivity, calculated using the Homeostasis model Assessment (HOMA-IRI) in normoglycemic offspring of at least 1 parent with type 2 diabetes. Results The clinical characteristics of the study population are shown in Table 1 and the laboratory profile of the study population are shown in Table 2. The group of offspring with type 2 diabetes parents as well as the control group had a similar distribution of age, sex, BMI, WHR systolic and diastolic BP. As expected the mean fasting serum triglycerides, cholesterol, and LDL-cholesterol were significantly higher in group 1 compared to the control group. HDL-cholesterol was significantly lower in group 1 compared to the control group. The glucose and insulin concentrations in the fasting state and after an oral glucose challenge are shown in Table 3. The mean fasting glucose and insulin concentrations were significantly higher in group I compared to group 2: fasting glucose: 4.5 0.6 vs. 4.3 0.6 mmol/l (p < 0.05) fasting insulin: 14.0 6.4 vs. 8.6 3.2 U/ml (p < 0.005) Serum insulin concentration 30 min post glucose challenge was significantly higher in the offspring group 1 (122.2 94.3 vs. 81.7 51.6 U/ml, p < 0.005) as well at 60 min post glucose challenge (134.4 103.1 vs. 99.9 48.9 U/ml, p < 0.05) whereas there was no difference at 120 min. In the offspring of the diabetic parents the insulin resistance index was significantly higher compared to control group (2.84 1.39 vs. 1.67 0.77, p < 0.001). 22 (53.6%) of the 41 subjects of group 1, had HOMA-IR values > 2.5 indicating that they were insulin resistant [2329], compared to only 6 (12.2%) of the 49 subjects of group 2. Lp() concentration was significantly higher in group 1 compared to group 2 (15.4 6.7 vs. 8.6 6.0 ng/dl, p < 0.001). In (...truncated)


This is a preview of a remote PDF: http://www.lipidworld.com/content/pdf/1476-511X-2-8.pdf

Agathoklis Psyrogiannis, Ioannis Habeos, Venetsana Kyriazopoulou. Insulin sensitivity and Lp(α) concentrations in normoglycemic offspring of type 2 diabetic parents, Lipids in Health and Disease, 2003, pp. 8, 2, DOI: 10.1186/1476-511X-2-8