Quantification of left ventricular trabeculae using cardiac magnetic resonance imaging for the diagnosis of left ventricular non-compaction
Yeonu Choi
1
Yeon Hyeon Choe
0
Sung Mok Kim
0
Sang-Chol Lee
0
Sung-A Chang
0
From
th Annual SCMR Scientific Sessions Nice
France.
February
0
Cardiovascular Stroke Imaging Center, Samsung Medical Center, Sungkyunkwan University School of Medicine
,
Seoul
,
Korea (the Republic of
1
Sungkyunkwan Univerity School of Medicine
,
Seoul
,
Korea (the Republic of
-
Background
Left ventricular non-compaction (LVNC) is an
unclassified cardiomyopathy and there is no consensus in the
diagnosis of LVNC. The aims of this study were to
establish quantitative method to diagnose isolated
LVNC (INC) using cardiac magnetic resonance (CMR)
imaging and to suggest novel qualitative method to
diagnose isolated LVNC.
Methods
This retrospective study included 145 subjects with
moderate to severe trabeculation of LV myocardium [24
patients with isolated LVNC, 33 patients with non-isolated
LVNC, 30 patients with dilated cardiomyopathy (DCM)
with noncompaction, 27 patients with DCM and 31
healthy control subjects]. LVNC patients had to fulfill
Petersens CMR criteria. LV ejection fraction, global LV
volume, trabeculated LV volume, and number of segments
with late gadolinium enhancement were measured. And
most prominent noncompacted (NC), compacted (C),
normal mid-septum, normal mid-lateral wall and apical
trabeculation thickness on the end-diastolic frames of each
long-axis slice was also measured.
Results
Results In the patients with isolated LVNC, the
percentage of trabeculated LV volume was 1.4 times higher
(42.6 13.8) than in DCM (30.3 14.3, p<0.0001)
[YHC1], and 1.7 times higher than in controls (24.8
7.1, p<0.0001). However, there were no significant
differences between INC and DCMNC (47.1 17.3, p =
0.210). And a value of percentage of trabeculated LV
volume above 32% was predictive of isolated LVNC with
a specificity of 90.3% (CI, 74.2-98.0%) and sensitivity of
79.2% (CI, 57.8-92.9%). A value of NC/septum over 1.1
was considered predictive for isolated LVNC with a
specificity of 80.6% (CI, 62.5-92.5%) and sensitivity of 95.8%
(CI, 78.9-99.9%). And a value of apex/C above 3.1 was
considered predictive of isolated LVNC with a specificity
of 93.5% (CI, 78.6-99.2%) and sensitivity of 87.5% (CI,
67.6-97.3%).
Conclusions
As a quantitative approach, a trabeculated LV volume
above 32% of the total LV volume is diagnostic for
isolated LVNC with high sensitivity and specificity. And as
a qualitative approach, apex/C and NC/septum ratio
could be useful for supplemental diagnostic criteria.
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