Note of clarification of data in the paper titled X-ray repair cross-complementing group 1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population

Tumor Biology, Feb 2015

Haiyan Yang, Ruo Feng, Haiyu Wang, Yadong Wang

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Note of clarification of data in the paper titled X-ray repair cross-complementing group 1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population

Note of clarification of data in the paper titled X-ray repair cross-complementing group 1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population Haiyan Yang 0 1 2 Ruo Feng 0 1 2 Haiyu Wang 0 1 2 Yadong Wang 0 1 2 0 R. Feng Department of Histology and Embryology, School of Basic Medicine, Zhengzhou University , Zhengzhou 450001 , People's Republic of China 1 H. Yang Department of Epidemiology, School of Public Health, Zhengzhou University , Zhengzhou 450001 , People's Republic of China 2 We read with great interest the paper titled X-ray repair cross- complementing group 1 Arg194Trp polymorphism is associ- ated with increased risk of lung cancer in Chinese Han popu- lation published in Tumor Biol. 2013, 34: 2611-2615 [1]. Wu et al. performed a meta-analysis to investigate the association between X-ray repair cross-complementing group 1 (XRCC1) Arg194Trp polymorphism and lung cancer risk in Chinese Han population on the basis of 12 case-control studies with 4385 cases and 4545 controls. The authors found that XRCC1 Arg194Trp polymorphism was associated with increased risk of lung cancer in Chinese Han population under three main models (allele contrast model , odds ratio (OR)= 1.12, 95 % confidence interval (CI) 1.00-1.26, P = 0.049; homozygote model, OR = 1.27, 95 % CI 1.09-1.48, P = 0.003; recessive model, OR = 1.26, 95 % CI 1.09-1.46, P = 0.003) when all eligible studies were pooled into meta-analysis. It is an inter- esting study 3 ) Department of Toxicology, Henan Center for Disease Control and Prevention , No. 105 of South Nongye Road, Zhengzhou 450016 , People's Republic of China - Nevertheless, a careful examination of the data provided by Wu et al. (Fig. 1 in the original text) [1] revealed two key issues that are worth noticing. Firstly, one overlapping paper [2] was not properly excluded from Wu et al.s study [1]. Secondly, four eligible papers [36] published before 2013 were not included in Wu et al.s study [1]. Therefore, the conclusions by Wu et al. [1] are not entirely reliable. In order to obtain a precise estimation of the relationship between XRCC1 Arg194Trp polymorphism and lung cancer risk in Chinese population, a meta-analysis was re-conducted on the basis of a total of 16 studies with 4591 cases and 4899 controls, which may provide comprehensive evidence for the association of XRCC1 Arg194Trp polymorphism with lung cancer risk in Chinese population. Table 1 listed the general information of selected studies. Table 2 listed the summary odds ratios of the association between XRCC1 Arg194Trp polymorphism and lung cancer risk in Chinese population. Overall, we observed an increased lung cancer risk in Chinese population among subjects carrying XRCC1 194 Trp/Trp genotype (OR = 1.26, 95 % CI 1.091.46) comparing with Arg/ Arg genotype carriers in total population (Fig. 1a). We did not observe any association of Arg/Trp vs. Arg/Arg and Trp/Trp + Arg/Trp vs. Arg/Arg polymorphisms with lung cancer risk in Chinese population (OR = 1.05, 95 % CI 0.901.22 and OR = 1.12, 95 % CI 0.951.31, respectively) (Fig. 1b, c). In the subgroup analysis by a source of control, we observed an increased risk of XRCC1 194 Trp/Trp vs. Arg/Arg polymorphism for lung cancer in a healthy subject-based study (OR = 1.34, 95 % CI 1.13 1.59) (Table 2); we did not observe any association between XRCC1 Arg194Trp polymorphism and lung cancer risk in additional subgroup analyses (Table 2). Limiting Fig. 1 Forest plots for the association between XRCC1 Arg194Trp polymorphism and lung cancer risk in Chinese population (a Trp/Trp vs. Arg/ Arg, b Arg/Trp vs. Arg/Arg, c Arg/Trp+Trp/Trp vs. Arg/Arg) the analysis to the studies with controls in agreement with Hardy-Weinberg equilibrium (HWE), we did not observe any association between XRCC1 Arg194Trp polymorphism and lung cancer risk (Table 2). Characteristics of selected papers HWE Hardy-Weinberg equilibrium Source of control Number of case Number of control Publication bias was assessed by funnel plots. The shape of funnel plots seemed to be approximately symmetrical (Fig. 2ac). The results from Eggers test and Beggs test signified that publication biases might have few effects on this current meta-analysis (Table 2). Sensitivity analyses were performed to identify the effects of the individual dataset on the summary estimates by sequentially removing each study. The summary effects were not modified when the studies were homogenous for Arg/Trp vs. Arg/Arg and Trp/Trp+Arg/Trp vs. Arg/Arg polymorphisms among total Case/control Heterogeneity test Summary OR (95 % CI) Hypothesis test df Total Trp/Trp vs. Arg/Arg 2776/2950 Arg/Trp vs. Arg/Arg 4130/4495 Trp/Trp+Arg/Trp vs. Arg/Arg 4591/4899 Stratification by HWE Yes Trp/Trp vs. Arg/Arg 2418/2531 Arg/Trp vs. Arg/Arg 3677/3950 Trp/Trp+Arg/Trp vs. Arg/Arg 4058/4302 Stratification by source of control Healthy subject-based control Trp/Trp vs. Arg/Arg 1997/2204 Arg/Trp vs. Arg/Arg 2 (...truncated)


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Haiyan Yang, Ruo Feng, Haiyu Wang, Yadong Wang. Note of clarification of data in the paper titled X-ray repair cross-complementing group 1 Arg194Trp polymorphism is associated with increased risk of lung cancer in Chinese Han population, Tumor Biology, 2015, pp. 2229-2233, Volume 36, Issue 4, DOI: 10.1007/s13277-015-3201-0