Erratum: Optimal Design of a Population Pharmacodynamic Experiment for Ivabradine
Pharmaceutical Research ,
Feb 2003
S. B. Duffull , F. Mentré , L. Aarons
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Erratum: Optimal Design of a Population Pharmacodynamic Experiment for Ivabradine
Optimal Design of a Population Pharmacodynamic Experiment for Ivabradine
S. B. Duffull
F. Mentr e´
L. Aarons
TABLE I TABLE II The value of 2 should be 29.2 not 5.40 (last row).
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An error in the computation of standard errors for the fixed effect parameters for which the between-subject variability
was assumed to be log-normal has been identified. The error will affect: EmaxI, EC50I, EmaxS, EC50S, KeoI & KeoS. Standard
errors for these parameters (shown as CV%) should be multiplied by the value of the corresponding parameter. For example
for option 3 (column 5) the standard error of E0 remains unchanged but for EmaxI, it should be 4.95% computed as the product
of the value in the column and the value of the parameter (ie 0.064 × 77.4). The values of the fixed effect parameters are given
in Table I. The values of the standard errors of the between-subject variances are not affected. (...truncated)
This is a preview of a remote PDF: http://link.springer.com/content/pdf/10.1023%2FA%3A1022256111729.pdf
S. B. Duffull, F. Mentré, L. Aarons.
Erratum: Optimal Design of a Population Pharmacodynamic Experiment for Ivabradine ,
Pharmaceutical Research,
2003, pp. 333, Volume 20, Issue 2, DOI: 10.1023/A:1022256111729