Erratum: Optimal Design of a Population Pharmacodynamic Experiment for Ivabradine

Pharmaceutical Research, Feb 2003

S. B. Duffull, F. Mentré, L. Aarons

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Erratum: Optimal Design of a Population Pharmacodynamic Experiment for Ivabradine

Optimal Design of a Population Pharmacodynamic Experiment for Ivabradine S. B. Duffull F. Mentr e´ L. Aarons TABLE I TABLE II The value of 2 should be 29.2 not 5.40 (last row). - An error in the computation of standard errors for the fixed effect parameters for which the between-subject variability was assumed to be log-normal has been identified. The error will affect: EmaxI, EC50I, EmaxS, EC50S, KeoI & KeoS. Standard errors for these parameters (shown as CV%) should be multiplied by the value of the corresponding parameter. For example for option 3 (column 5) the standard error of E0 remains unchanged but for EmaxI, it should be 4.95% computed as the product of the value in the column and the value of the parameter (ie 0.064 × 77.4). The values of the fixed effect parameters are given in Table I. The values of the standard errors of the between-subject variances are not affected. (...truncated)


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S. B. Duffull, F. Mentré, L. Aarons. Erratum: Optimal Design of a Population Pharmacodynamic Experiment for Ivabradine, Pharmaceutical Research, 2003, pp. 333, Volume 20, Issue 2, DOI: 10.1023/A:1022256111729