Small differences in age and cataract surgery percentage have a potentially high effect on the corneal endothelial cell density

International Ophthalmology, Oct 2015

Yu Cheol Kim

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Small differences in age and cataract surgery percentage have a potentially high effect on the corneal endothelial cell density

Small differences in age and cataract surgery percentage have a potentially high effect on the corneal endothelial cell density Yu Cheol Kim 0 1 0 Y. C. Kim (&) Department of Ophthalmology, Dongsan Medical Center, Keimyung University School of Medicine , Daegu , Korea 1 To the Editor - I read with interest the article entitled ‘‘Differences in corneal parameters between normal tension glaucoma and primary open-angle glaucoma’’ by Lee et al. [1]. The study showed that the baseline characteristics such as age, anti-glaucoma medication, cataract surgery, and post-treatment intraocular pressure (IOP), which may affect endothelial cell density (ECD), were statistically similar in both their normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG) populations, and the mean corneal ECDs in NTG and POAG subjects were 2380 and 2530 cell/mm2, respectively. On the basis of these results, the authors reported a significant lower corneal ECD in NTG, compared to POAG subjects with similar baseline characteristics. However, I respectfully disagree. The difference of ECD in the 2 groups can be due to differences in age and pseudophakic/ phakic ratio in the groups, though not statistically significant. The mean ages of the NTG and POAG were 67.6 and 61.8, respectively, and the pseudophakic/phakic ratios were 0.2 and 0.1, respectively. ECD reduction every year was reported as 0.3–1 % and a recent study reported that the mean ECD difference between sixties and seventies age groups was 177 cells/mm2 [2]. Approximately, 150 cell/cm2 of ECD difference is presumed to be due to 5.8 years of age difference and twice pseudophakia/phakia ratio not due to NTG. Compliance with ethical standards Conflict of interest The author declares that there is no conflict of interests regarding the publication of this article. 1. Lee JW , Wong RL , Chan JC , Wong IY , Lai JS ( 2014 ) Differences in corneal parameters between normal tension glaucoma and primary open-angle glaucoma . Int Ophthalmol . doi:10.1007/s10792- 014 - 0020 -z 2. Galgauskas S , Norvydaite D , Krasauskaite D , Stech S , Asoklis RS ( 2013 ) Age-related changes in corneal thickness and endothelial characteristics . Clinical Interv Aging 8 : 1445 - 1450 . doi:10.2147/cia.s51693


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Yu Cheol Kim. Small differences in age and cataract surgery percentage have a potentially high effect on the corneal endothelial cell density, International Ophthalmology, 2015, 621, DOI: 10.1007/s10792-015-0114-2