Arterial Ischemic Stroke Prospective Study

Pediatric Neurology Briefs, Feb 2014

Investigators from Departments of Paediatric Neurology, Bristol Royal Hospital for Children, the Institute of Child Health, London, and other centers in the UK, conducted a prospective population-based study of 96 children aged 29 days to 16 years with radiologically confirmed arterial ischemic stroke (AIS) occurring over a 1-year period (July 2008 to June 2009) in southern England.

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Arterial Ischemic Stroke Prospective Study

References. VASCULAR DISORDERS ARTERIAL ISCHEMIC STROKE PROSPECTIVE STUDY 0 Investigators from Departments of Paediatric Neurology, Bristol Royal Hospital for Children, the Institute of Child Health , London , and other centers in the UK, conducted a prospective population-based study of 96 children aged 29 days to 16 years with radiologically confirmed arterial ischemic stroke (AIS) occurring over a 1-year period COMMENTARY. Diagnosis of Lambert-Eaton myasthenic syndrome. Usually diagnosed as a paraneoplastic disease affecting middle-aged adults with small-cell lung cancer, Lambert-Eaton myasthenic syndrome (LEMS) may occur as a primary autoimmune disorder in younger adults and rarely in children. Proximal muscle weakness, absent reflexes, normal serum creatine kinase, and autonomic dysfunction should prompt electrodiagnostic testing for LEMS. Low-amplitude compound muscle action potentials with >100% facilitation following 10 seconds of voluntary exercise or in response to high frequency repetitive motor nerve stimulation (when tolerated) is diagnostic. Serum titers of voltage-gated calcium channel receptor antibodies specific to LEMS will differentiate the disorder from myasthenia gravis [1][2]. Identification of LEMS will prompt a search for malignancy. (...truncated)


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J Millichap, John Millichap. Arterial Ischemic Stroke Prospective Study, Pediatric Neurology Briefs, 2014, pp. 13-13, Volume 28, Issue 2, DOI: 10.15844/pedneurbriefs-28-2-7