Mortality in Children Aged 0-9 Years: A Nationwide Cohort Study from Three Nordic Countries
Mortality in Children Aged 0-9 Years: A Nationwide Cohort Study from Three Nordic Countries
Yongfu Yu 0 1
Guoyou Qin 0 1
Sven Cnattingius 0 1
Mika Gissler 0 1
Jørn Olsen 0 1
Naiqing Zhao 0 1
Jiong Li 0 1
0 1 Section for Epidemiology, Department of Public Health, Aarhus University , Aarhus , Denmark , 2 Department of Biostatistics, School of Public Health, Fudan University , Shanghai , China , 3 Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 4 Information Department, THL National Institute for Health and Welfare , Helsinki , Finland , 5 Department of Epidemiology, School of Public Health, University of California Los Angeles , Los Angeles , California, United States of America, 6 Department of Clinical Epidemiology, Aarhus University Hospital , Aarhus , Denmark
1 Editor: Eliseo A Eugenin, Rutgers University , UNITED STATES
Mortality in children under five years has been widely studied, whereas mortality at 5-9 years has received little attention. Using unique data from national registers in three Nordic countries, we aimed to characterize mortality directionality in children aged 0 to 9 years. The cohort study included all children born in Denmark from 1973 to 2008 (n = 2,433,758), Sweden from 1973 to 2006 (n = 3,400,212), and a random sample of 89.3% of children born in Finland from 1987 to 2007 (n = 1,272,083). Children were followed from 0 to 9 years, and cumulative mortality and mortality rates were compared by age, gender, cause of death, and calendar periods. Among the 7,105,962 children, there were 48,299 deaths during study period. From 1981-1985 to 2001-2005, all-cause mortality rates were reduced by between 34% and 62% at different ages. Overall mortality rate ratio between boys and girls decreased from 1.25 to 1.21 with the most prominent reduction in children aged 5-9 years (from 1.59 to 1.19). Neoplasms, diseases of the nervous system and transport accidents were the most frequent cause of death after the first year of life. These three leading causes of death declined by 42% (from 6.2 to 3.6 per 100,000 person years), 43% (from 3.7 to 2.1) and 62% (from 3.9 to 1.5) in boys, and 25% (from 4.1 to 3.1 per 100000 person years), 42% (from 3.4 to 1.9) and 63% (from 3.0 to 1.1) in girls, respectively. Mortality from neoplasms was the highest in each age except infants when comparing cause-specific mortality, and half of deaths from diseases of the nervous system occurred in infancy. Mortality rate due to transport accidents increased with age and was highest in boys aged 5-9 years.
Data Availability Statement: All data is kept by a
trusted third party, Statistics Denmark. Statistics
Denmark is the central authority on Danish statistics
with the mission to collect, compile and publish
statistics on the Danish society. By legislation,
researchers who want to get access to the data must
apply for permissions from both Statistics Denmark
and Danish Data Protection Agency. Only Danish
research environments are granted authorisation.
Foreign researchers can, however, get access to
micro data through an affiliation to a Danish
authorised environment. Access is given to
anonymised micro data, i.e. data at an individual
personal or corporate level.
Funding: This study was supported by a grant from
the European Commission’s Seventh Framework
Programme/European Research Council
(ERC-2010StG-260242-PROGEURO to JL) http://ec.europa.eu/
research/fp7/index_en.cfm. Data recruitment was
supported by grants from the Danish Medical
Research Council (project no. 09-072986 to JL) http://
ufm.dk/site/english/councils-commissionscommittees/scientific-research-councils/the-danishmedical-research-council, the Swedish Council for
Working Life and Social Research (Grant no.
20100092 to SC) http://www.forte.se/en/, the Nordic
Cancer Union (2013-78760 to JL) http://www.ncu.nu/.
The funders had no role in study design, data
collection and analysis, decision to publish, or
preparation of the manuscript.
Competing Interests: The authors have declared
that no competing interests exist.
Mortality rate in children aged 0–9 years has been decreasing with diminished difference
between genders over the past decades. Our results suggest the importance of further
research on mortality by causes of neoplasms, and causes of transport
accidents—especially in children aged 5–9 years.
The global effort towards Millennium Development Goal 4 has led to reduced mortality rate in
children younger than 5 years, from 90 deaths per 1,000 live births in 1990 to 48 deaths in
2012. With the exception of Sub-Saharan Africa and Oceania, mortality has at least halved in
most regions [
]. As a consequence, an estimated additional 90 million children survived their
5th birthday during the past two decades, leading to an increase of population beyond 5 years
]. Mortality under five years has been widely studied, and the need to focus on the health and
development of adolescence has been emphasized by the United Nations [
]. In contrast,
health and mortality in children aged 5 to 9 years have been almost neglected, even with a
population of 600 million worldwide.
The scarcity of detailed data has been an obstacle to gain a basic understanding of mortality
directionality over time in age, gender, and cause of death among children from 0 to 9 years. In
previous childhood mortality studies, age-specific mortality rates are not known since children
aged 0–9 years are typically merged in even larger aggregated age-groups, like 0–14 years [
or 1 month to 15 years [
]. Based on unique data from national registers in three Nordic
countries, we aimed to characterize mortality in children aged 0 to 9 years, according to age,
calendar time, gender, and cause of death.
Materials and Methods
This population-based cohort study used nationwide data from Denmark, Sweden and
Finland. All live-born and new residents in these three Nordic countries were assigned a unique
civil personal identification number, which permits accurate individual information linkage
across different national registries [
]. We included all children born in Denmark from 1973 to
2008 (n = 2,433,758) and in Sweden from 1973 to 2006 (n = 3,400,212), and a random sample
of 89.3% of children born in Finland from 1987 to 2007 (n = 1,272,083) following strict data
protection rules in Finland, because the authorities in Finland do not allow to extract 100%
complete data from the targeted population. Follow-up started at birth and ended at one of the
following events, which ever came first: death, emigration, the day before the 10th birthday or
end of follow-up (The follow-up ended until December 31st 2009 in Denmark, December 31st
2008 in Sweden and December 31st 2010 in Finland). We excluded 91 children with no
information on gender.
The main outcomes of interest were all-cause mortality rate, age-, gender- and cause-specific
mortality rate, and type of death (natural death from diseases or medical conditions, unnatural
death from external causes of injuries and poisonings) mortality rate in children aged 0 to 9
years. We obtained information on cause of death from the Cause of Death Registers in the
three countries. The death statistics are based on individual data in death certificates and
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contains the date of death and cause of death of individuals. In Denmark, the International
Classification of Disease (ICD) 8th version was used to classify the cause of death before 1994
and ICD-10 was used since 1994; in Sweden, ICD-8 was used from 1973 to 1986, ICD-9 from
1987 to 1996 and ICD-10 was used since 1997; and in Finland, ICD-9 was used from 1987 to
1995 and ICD-10 was used since 1996. For Finnish data, we do not have detailed ICD Codes
and death by the underlying cause of death was divided into 54 main groups based on ICD
]. Type of death was separated into two categories: natural death from diseases or
medical conditions (ICD-8 codes 000–799, ICD-9 codes 000–799, and ICD-10 codes A00-R99), and
unnatural death from external causes of injuries and poisoning (ICD-8 codes E800-E999,
ICD9 codes E800-E999, andICD-10 codes V01-Y98). Natural death were classified into the
following main groups according to the ICD system: infections and parasitic diseases (ICD-8 and
ICD-9 codes 000–1399, ICD-10 codes A00–B999); neoplasms (ICD-8 and ICD-9 codes 140–
2389, ICD-10 codes C00–C999); endocrine, nutritional, and metabolic diseases (ICD-8 and
ICD-9 codes 240–2799, ICD-10 codes E00–E909); diseases of the nervous system and the sense
organs (ICD-8 and ICD-9 codes 320–389, ICD-10 codes G00–H95); diseases of the circulatory
system (ICD-8 and ICD-9 codes 410–414, 420–423,425–429, ICD-10 codes I20–I25, I30–I33,
I39–I52); diseases of the respiratory system (ICD-8 and ICD-9 codes 460–519, ICD-10 codes
J00–J99); diseases of the digestive system (ICD-8 and ICD-9 codes 520–579, 4442, ICD-10
codes K00–K93); certain conditions originating in the prenatal periods(ICD-8 and ICD-9
codes 760–779, ICD-10 codes P00–P96); congenital malformations (ICD-8 and ICD-9 codes
740–759, ICD-10 codes Q00–Q99); sudden infant death syndrome (ICD-9 codes 798.0,
ICD10 codes R95), unknown or unspecified causes (ICD-8codes 795–796, and ICD-9 codes 798.1–
9,799 and ICD-10 codes R96-R99); and other diseases. Unnatural death were classified into the
following main groups: transport accidents(ICD-8 and ICD9 codes 800–848, ICD-10 codes
V01–V99); drowning (ICD-8 and ICD-9 codes 910, ICD-10 codes W65–W74); other external
cause (ICD-8 and ICD9 codes 849–900 except 910, ICD-10 codes W00-Y89 except
Follow-up time was counted by years and time at risk was calculated for each child. Mortality
rate was calculated by dividing the number of deaths by the person time at risk and expressed
as the number of deaths per 100,000 person-years (PY) at risk. Rate ratio was calculated to
compare the risk of death between different groups [
]. Cumulative mortality measured the
probability of death before a given age. Children aged 0–9 were categorized into ten groups at
one-year interval, while infant deaths (<1 year) were subdivided into neonatal (0–27
completed days) and post-neonatal (28–364 days) mortality. To analyze the change of mortality
over the period, the follow-up calendar time was grouped into seven periods (1973–1980,
1981–1985, 1986–1990, 1991–1995, 1996–2000, 2001–2005, and 2006–2010). Mortality was
estimated according to all-cause mortality, mortality by type of death (natural vs. unnatural
cause of death) and cause-specific mortality, stratified by age, gender and calendar period.
Other deaths were considered as competing events while calculating cause-specific mortality.
In order to compare with previous studies, we calculated all-cause mortality not only in each
age group but also in three aggregated age groups (<1 year, 1–4 and 5–9 years). Due to the
small numbers of death, mortality rate was only observed in the three aggregated age groups
when analyzing cause-specific mortality. As the death information during 1973–1980 and
2006–2010 was incomplete in five-year interval, we defined mortality in 1981–1985 as baseline
and 2001–2005 as current level to assess the degree of mortality change over time except for
special notice. As we did not have detailed ICD codes of Finland, only data from Denmark and
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Denmark, Sweden & Finland
Sweden were used when calculating some specific causes of death (Table 1). Analysis was
conducted in SAS software (SAS 9.2, SAS Institute Inc., Cary, North Carolina, USA).
A total of 7,105,962 children were followed up for 62,649,303 person-years. During the period,
147,658 children (2%) were censored due to emigration. A total of 48,299 deaths were
identified and 343 had no information on causes of death (0.67%). Certain conditions originating in
the prenatal periods, congenital malformations, sudden infant death syndrome, and unknown
or unspecified causes were the most important causes of death in infancy (Table 1 and S1A
Table). Although the majority of death by congenital malformations happened in infancy,
congenital malformations were still the important cause of death in children between 1 and 9
years. After 1 year of age, neoplasms, diseases of the nervous system and transport accidents
were the most frequent cause of death (Table 1 and S1A Table). Overall cumulative mortality
before 10 years was 696 (95% CI: 690–702) per 100,000, for boys 777 (95% CI: 767–786) per
100,000 and for girls 611 (95% CI: 602–619) per 100,000.
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Fig 1. Mortality rates in children aged 0–9 years over type of death and age (28d: 28–364 Days).
All-cause mortality rate in children aged 0–9 years decreased with age and differed slightly
between 5 and 9 years. The directionality was similar in both genders (Fig 1A). In the entire
study period, mortality rate before 10 years was 86.1 per 100,000 person years in boys and 67.7
per 100,000 person-years in girls, giving a rate ratio of boys to girls (RRm/f) of 1.27 (95% CI:
1.25–1.29). All-cause mortality rate was higher in boys than that in girls according to age, but
gender difference was more pronounced in children aged 5–9 years than that in younger
children (Fig 1B). In almost all ages between 5 and 9 years, RRm/f were greater than 1.30, whereas
in children younger than 5 years, all RRm/f were lower than 1.30. Regarding aggregated age
groups, mortality difference between genders was more pronounced in children aged 5–9 years
(RRm/f: 1.39, 95% CI: 1.31–1.49) compared to the other two aggregated age groups (<1 year,
1.27 [95% CI: 1.25–1.30]; 1 to 4 years, 1.21 [95% CI: 1.15–1.27]). Similar results were observed
for natural death from diseases or medical conditions and unnatural death from external causes
of injuries and poisonings (Fig 1C and 1D).
When taking length of follow-up time into account, all-cause mortality rates in children
aged 0–9 years decreased with calendar periods for a given age, and dropped with age for a
given calendar period (Table 2). Compared to the period of 1981–1985, mortality rates in the
period of 2001–2005 were decreased by more than 40% in most age groups, ranging from a
decline of 34% to 62%. The reduction in infant mortality was 52%, and the reductions in
neonatal and post-neonatal mortality were 47% and 62%, respectively. An estimate of 87.0% of
death due to congenital malformations, 92.8% of death due to unknown or unspecified causes
and 99.3% of death due to certain conditions originating in the prenatal periods and happened
in infancy. From 1981–1985 to 2001–2005, mortality rate due to certain conditions originating
in the prenatal periods, unknown or unspecified causes and congenital malformations
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decreased by 33%, 94% and 58% (34%, 95% and 59% in boys, 31%, 93% and 56% in girls),
respectively. Because the ICD codes of sudden infant death syndrome began from 1987 in our
database, we used the mortality rate in 1991–1995 as baseline to assess mortality change over
time. Mortality rate due to sudden infant death syndrome (SIDS) decreased by 47% (54% in
boys, 35% in girls) from 1991–1995 to 2001–2005. It should be noted that infant mortality rate,
accounting for 70% of the total deaths, still remained dramatically higher than other
agerelated mortality rates (1–9 years) during the recent years of 2006–2010 (Table 2). Both natural
death and unnatural death had similar results (S2 Table and S3 Table). In both genders, we
found a similar pattern of all-cause mortality rates over calendar periods and age (Fig 2; S1B
Table). During 1981–1985, boys had higher mortality rates than girls in all age groups;
mortality rates in boys and girls were 97.45 and 77.94 per 100,000 person years, respectively. Mortality
rates in boys were higher than in girls, but the gender difference in mortality rate began to
decrease in 1996–2000. During 2001–2005, mortality rates in boys and girls were 48.38 and
39.97 per 100,000 person years, respectively. RRm/f in children less than 10 years decreased
from 1.25 (95% CI: 0.93–1.68) to 1.21 (95% CI: 0.80–1.84) with the most prominent reduction
in children aged 5–9 years (from 1.59 [95% CI: 0.83–3.06] to 1.18 [95% CI: 0.5–2.78]).
However, statistically significant gender differences were only observed in children under 1 year
with RRm/f of 1.21 (95% CI: 1.09–1.35) in 1981–1985 and 1.22 (95% CI: 1.04–1.43) in 2001–
2005 (S4 Table).
Mortality due to neoplasms
Neoplasm was the most frequent cause of death after 1 year of age and cumulative mortality
before 10 years was 39 (95% CI: 37–40) per 100,000, with boys of 42 (95%CI: 40–45) per
100,000 and girls of 35 (95%CI: 33–37) per 100,000. Both genders had higher mortality at 0–27
days than in other ages (Fig 3A). Boys had lower mortality than girls with a RRm/f of 0.92 (95%
CI: 0.75–1.13) before 1 year of age. After 1 year of age, boys had higher mortality rate than girls
with the RRm/f from 1.04 to 1.60. We found no obvious change in patterns of mortality rate
among age-groups. When taking length of time into consideration, mortality rate decreased by
42% in boys and 25% in girls. Mortality rate showed an overall downward directionality with
calendar periods in aggregated age-groups with obvious fluctuations among calendar periods
(Fig 4A; S5 Table). Particularly, boys less than 1 year and girls aged 1–4 years reached the
second peak in 2001–2005. During 1981–1985, boys had higher mortality rate than girls. Mortality
rate was 6.18 per 100,000 person years in boys and 4.13 per 100,000 person years in girls.
During 2001–2005, boys still had higher mortality than girls except for children aged 1–4 years.
Mortality rates in boys and girls were 3.57 and 3.11 per 100,000 person years, respectively.
RRm/f in children less than 10 years decreased from 1.49 (95%CI: 1.22–1.83) to 1.15 (95%CI:
0.94–1.41) with a reduction in children aged 5–9 years from 1.71 (95%CI: 1.27–2.27) to 1.24
(95%CI: 0.91–1.69) (S4 Table). Leukemia (31.9%), brain and other central nervous system
(CNS) tumours (31.6%) were the most common cause of death by neoplasms in children
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Fig 2. All-cause mortality rates in children aged 0–9 years over calendar periods and age.
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Fig 3. Mortality rates of the three most frequent causes in children aged 0–9 years over age and
gender (28d: 28–364 Days).
before 10 years. Mortality rate due to leukemia, brain and CNS tumours decreased by 50%
(66% in boys, 23% in girls), and 36% (38% in boys, 34% in girls) from 1981–1985 to 2001–
Mortality due to diseases of the nervous system
Disease of the nervous system was the most frequent cause of death in children of both 1 year
and 1–9 years of age and cumulative mortality before 10 years was 27 (95%CI: 25–28) per
100,000, with boys of 29 (95%CI: 27–31) per 100,000 and girls of 25 (95%CI: 23–26) per
100,000. The highest risk was obtained among children younger than 1 year and 52% of deaths
occurred before 1 year of age. Mortality rates decreased with age in the early ages and kept
relatively stable after 3 years of age (Fig 3B). Boys had a slightly higher overall mortality risk than
girls (RRm/f: 1.18, 95%CI: 1.07–1.29), but a pronounced gender difference was not observed in
9 / 17
Fig 4. Mortality rates of the three most frequent causes in children aged 0–9 years over calendar
periods, aggregated age groups and gender.
separated age groups. When taking length of follow-up time into account, mortality in children
less than 1 year had declined remarkably. In contrast, the decline in mortality rate after 1 year
of age was modest. At 5–9 years of age, mortality rate remained quite stable around 1.00 per
100,000 person years across the entire follow-up period.
In most calendar periods, mortality rates in boys were slightly higher than that in girls (Fig
4B; S6 Table). During 1981–1985, boys had higher mortality rate than girls, except for infant
mortality. Mortality rate was 3.70 per 100,000 person years in boys and 3.36 per 100,000 person
years in girls, giving a RRm/f of 1.10(95%CI: 0.87–1.40). Infant mortality rate (<1 year)
decreased dramatically over calendar periods, and from 1 year of age mortality rate was
relatively stable across calendar periods (Fig 4B). During 2001–2005, boys had higher mortality
rate than girls except for children aged 5–9 years (S4 Table). Mortality rate was 2.11 per
100,000 person years in boys and 1.93 per 100,000 person years in girls, giving a RRm/f of 1.09
10 / 17
Among the diseases of the nervous system, meningitis is the first leading cause of death
(28.5%), followed by cerebral palsy (12.7%) in children before 10 years. More than 64% of
deaths by meningitis and 44% of deaths by cerebral palsy occurred in infancy. Mortality rate
due to meningitis and cerebral palsy in children under 10 years decreased by 65% (68% in
boys, 20% in girls), and 68% (76% in boys, 60% in girls) from 1981–1985 to 2001–2005.
Mortality due to transport accidents
Transport accidents was the most frequent cause of death after 1 year of age and cumulative
mortality before 10 years was 22 (95% CI: 21–23) per 100,000, with boys of 26 (95% CI: 24–28)
per 100,000 and girls of 18 (95% CI: 17–20) per 100,000. Mortality rate in boys increased with
age while those in girls differed slightly between ages (Fig 3C). Boys had higher mortality rate
than girls in all age groups and calendar periods except for children aged 1–4 year in 2001–
2005 (Fig 4C; S4 Table and S7 Table). During 1981–1985, mortality rates in boys and girls were
3.85 and 2.98 per 100,000 person years, respectively. Mortality rates decreased with calendar
periods in four aggregated age groups. However, among girls mortality showed early growth
and later decline from 1986–1990 onwards. During 2001–2005, mortality rates in boys and
girls were 1.47 and 1.10 per 100,000 person years, respectively. RRm/f in children less than 10
years increased from 1.29 (95%CI: 1.01–1.65) to 1.34 (95%CI: 0.96–1.87) with a large increase
in age group of 5–9 years from 1.50 (95%CI: 1.08–2.09) to 1.75 (95%CI: 1.08–2.85). Compared
with the other three groups (including boys aged 1–4 years, girls aged 1–4 years and girls aged
5–9 years), boys aged 5–9 years had higher mortality rate in all calendar period. Because of the
very small number of deaths before 1 year of age in both genders, mortality rate in infancy was
not compared with those in other age groups.
This study presents an overview of mortality directionality in children aged 0–9 years in
combined data of three Nordic countries. In this study, which to our knowledge is the first study
examining mortality over age at 1-year interval, we found that overall mortality rates decreased
with age before 5 years and were relatively stable between 5 and 9 years. Mortality rate in boys
was higher than that in girls at each age and the gender differences were more pronounced in
children between the ages of 5–9 years. From 1981–1985 to 2001–2005, all-cause mortality
rates were reduced by between 34% and 62% at different ages. Mortality rate ratio between
boys and girls aged 0–9 years decreased with a pronounced decline in aged 5–9 years. Mortality
in infancy (<1 year) making up 70% of the total deaths, still greatly exceeded that of all other
ages in the recent years of 2006–2010. Most of death in infancy was caused by certain
conditions originating in the prenatal periods, congenital malformations, sudden infant death
syndrome, and unknown or unspecified causes. After 1 year of year, neoplasms were the most
frequent cause of death, followed by diseases of the nervous system and transport accidents.
These three most important causes of death declined over time, both in boys and girls.
Mortality from neoplasms was the highest in each age group except for infants among the three
leading causes of death, and half of deaths from diseases of the nervous system occurred in infancy.
Mortality due to transport accidents increased with age and boys aged 5–9 years had higher
risk compared to boys and girls in any other age groups.
Our finding of a reduction in mortality in children aged 0–9 years in the past decades is
consistent with previous studies from high-income countries [
]. Unlike previous studies [
], we had individual level data to compute person years and mortality rate in our study
11 / 17
can be expressed as deaths per 100,000 person years. We found that mortality rate decreased
with age and was relatively stable between 5 to 9 years. Boys had higher mortality than girls at
each age and the difference between genders was more pronounced between 5 to 9 years.
Infant mortality rate has decreased by more than 50% from 1981–1985 to 2001–2005. Preterm
birth complications are the leading cause of death in neonates and the second common cause
of death in children younger than 5 years[
]. Surviving preterm infants are at increased
longterm risk of neurodevelopmental impairments and respiratory and gastrointestinal
]. Interventions, advances in technologies and the collaborative efforts of obstetricians
and neonatologists have not only increased the survival rate of preterm infants and
prematurity-related neonatal morbidity, but may possibly also have decreased the risk in later life [
]. Studies in Finland and Sweden also showed that advancing neonatal intensive care is
associated with decreased death of extremely premature infants [
]. The national Guidelines
for Perinatal Care in the USA recommend that all infants <32 weeks gestation and infants
with very low birth weight are born in subspecialty perinatal centers. As infants still have much
higher mortality risk than other ages, special attention and continued effort should be focused
on better survival of preterm births. The reduction in mortality from congenital malformation
is consistent with the result from the previous study in Canada, which might be the results of
improved prenatal diagnose with subsequent termination of affected pregnancies and
improved surgical repair . The decrease in mortality from sudden infant death syndrome
might be due in part to diagnostic shift and better ascertainment of deaths previously registered
as sudden infant death syndrome[
]. SIDS cannot be prevented completely but a better
understanding of the circumstances and events associated with sleep-related infant deaths may
help reduce the risks for SIDS and other sleep-related causes of infant death.
Our data showed that boys had higher mortality than girls in the total study period, which was
in line with the results from the studies in Nordic countries and from the UK [
10, 11, 22, 23
Few studies have reported mortality difference between genders over time in children and
limited studies focused on these differences by country, parental education or age [
data showed that gender mortality differences in children decreased with time in three Nordic
countries. Generally, there is currently no accepted explanation for why female mortality is
lower than male [
]. Gender differences in mortality could be influenced by biological,
genetic, social, cultural, environmental and behavioral factors [
], which need further
investigation for preventive measures.
Mortality due to neoplasms
Mortality rate due to neoplasms in both genders decreased dramatically with time. The ACCIS
project in Europe [
] reported that 5-year survival in children (0–14 years) with cancer has
improved remarkably since the 1970s. Surveillance research from American Cancer Society
] reported death rates for all childhood cancers (0–14 years) decreased steadily from 1975 to
2010, and mortality rates are lower in girls than in boys in US. In our study, the difference of
neoplasms mortality between genders was reduced with time. Over recent decades, survival
from childhood cancer has improved dramatically because of improvements in chemotherapy
and radiation treatment protocols, better diagnosis, and risk classification and improved
supportive care [
]. In Nordic countries, some specific programs may explain the reduction of
mortality in children. The Nordic Society of Paediatric Haematology and Oncology (NOPHO)
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started a registration in five Nordic countries in 1981 to create uniform diagnostic, treatment,
and clinical follow-up procedures for childhood cancers [
]. In addition, the Nordic Cancer
Union, a collaborative body for cancer societies in the Nordic countries, has a wide range of
cooperative activities to provide more effective prevention of cancer and to advance the
diagnostic procedures and treatment strategies for cancer patients. As a corollary of these
initiatives, the Nordic cooperation has led to a gradual improvement in the treatment and prognosis
of childhood cancers. For acute lymphoblastic leukemia, the most common cancer in children,
the overall event-free survival at 5 years has increased from 57% in the early 1980s to 78%
during the 1990s in five Nordic countries [
]. For children with acute myeloid leukaemia, the
5-year event-free survival and overall survival increased from 29% and 38% in July 1984, to
48% and 65% in December 2001, respectively [
]. The report from National Cancer Institute
] suggested that changes in diagnostic and improvement in treatment procedures since the
mid-1970s have resulted in improved survival rates for patients with brain tumours. Our
studies also showed that mortality rate by brain and other central nervous system tumours
decreased over the past years. Although our study demonstrated mortality by neoplasms had
an overall decreased directionality with calendar periods, the obvious peaks were observed in
boys less than 1 year and girls between 1 and 4 years in 2001–2005.
Mortality due to diseases of the nervous system
Our study showed that half of death due to diseases of the nervous system occurred in infancy
(<1 year). Over calendar period, mortality rates were decreased by 43% in boys and 42% in
girls. Holt et al [
] previously reported that neonatal meningitis in England and Wales
appeared to be falling. The progress can mainly be ascribed to successful vaccination
programmes (against Haemophilus influenzae type B, Streptococcus pneumonia and N.
meningitis), advances in diagnosis and treatment [
]. The conjugated Haemophilus influenzae
type B vaccine, which was administered routinely to all infants in Denmark in 1993, in Sweden
in 1992 and in Finland in 1990, may explain the sharp decrease in mortality rate in infancy
from 1991–1995 to 1996–2000 [
]. A US study [
] reported a decreased hospitalization
for pneumococcal meningitis among children 0–4 years after implementation of routine
childhood vaccination with a 7-valent pneumococcal conjugate vaccine (PCV7). PCV7 has been
included in the childhood vaccination programme since 2007 in Denmark [
] and since 2008
] in Sweden, which corresponded with the timing of the decrease from 2001–2005 to 2006–
2010. A cohort study in North Carolina showed that mortality of very low birth weight infants
by cerebral palsy decreased from 36.8% to 13.8% from 1982–1984 to 1992–1994 and the better
survival may be owing to improvements in obstetric care [
Mortality due to transport accidents
We observed that mortality due to transport accident was higher in boys than in girls at each
age. In boys, mortality rates increased with age, reaching a relatively high level at 7 to 9 years.
In contrast, mortality rates in girls remained quite stable. A study from 50 countries [
identified transport injuries as the dominant causes of injury-related deaths in children aged 1–9
years. The study also reported an early increase and later decline, which were probably
associated with the introduction of road safety measures. We also observed this pattern in girls but
not in boys. The data from Scotland [
] reported that road-traffic injuries were the leading
causes of injury death in children aged 5–9 years despite declining mortality rates from 2002 to
2006, but the difference between genders was not provided. A probable explanation is that
children aged 8 to 14 are often easily distracted and therefore more prone to traffic accidents [
As boys are more likely to engage in risky behaviours than girls, their propensity towards
risk13 / 17
taking behaviours makes boys have a higher likelihood of being involved in fatal traffic
accidents than girls [
]. When taking length of follow-up time into account, mortality rate has
decreased by almost 62% in boys and 63% in girls from 1981–1985 to 2001–2005. Our results
are in line with the study examining childhood deaths and injuries among children aged 0–14
years in Finland . Our study showed that mortality reduction of transport accidents
exceeded that of the other two causes of death (neoplasms and disease of the nervous system),
for both boys and girls. Dedicated education campaigns to road safety, improved traffic safety
and mandatory use of safety belt, and child restraints may play an important role in such a
mortality reduction [
]. Also, improvement in trauma care may also contribute to the
]. Our findings suggest the effectiveness of those preventive measures and may further
reduce deaths due to preventable causes.
Strengths and limitations
Our study has a number of strengths. We combined nationwide data from three Nordic
countries in which have complete individual level register data on population and their deaths. The
individual level data over two decades permitted us to examine mortality directionality across a
different time periods as well as major groups of cause of death. Even with the small number of
death in children aged from 1 to 9 years, especially from 5 to 9 years, the combined data from
the three countries still provides the possibility to examine the mortality over age in 1- year
Our findings should also be interpreted in the light of limitations. First, we cannot rule out
the possibility that changes in long-term directionality in cause-specific mortality are related to
coding changes between and within ICD revisions [
]. Second, the total number of death was
relatively small in some age groups, and our study may not have enough statistical power to
detect gender differences between within age groups.
We observed decreased mortality in children at 0–9 years in the three Nordic countries during
the past decades. Mortality rates showed overall downward directionality with age and calendar
time, and suggests further possibilities for improving survival in children. Infants, particularly
in neonates, have much higher mortality than children aged 1–9 years. Mortality rate in boys
was higher than in girls and gender difference on mortality declined with calendar time.
Although advances in treatment have improved the survival rate of children with cancer,
neoplasms is still the most frequent cause of death in children aged 1–9 years in the three Nordic
countries and mortality was the highest in each age group except for infants. Mortality due to
transport accidents, one of the most common causes of death in children, increased with age
and was highest in boys aged 5–9 years. Our results suggest the importance of further study on
mortality by causes of neoplasms, and causes of transport accidents—especially in children
aged 5–9 years.
The data collection was approved by the Data Protection Agency and Research Ethics
Committee of the Central Region in Denmark, the Research Ethics Committee (EPN) at Karolinska
Institute in Sweden, the National Institute for Health and Welfare (THL) in Finland and
Statistics Finland. No informed consent from participants is required as the register-based study is
based on secondary data for which participants’ information was anonymized and
14 / 17
S1 Table. A) The number of deaths by causes of death. B) All-cause mortality rate by age,
gender and calendar period.
S2 Table. Mortality rate due to natural death by age, gender and calendar period.
S3 Table. Mortality rate due to unnatural death by age, gender and calendar period.
S4 Table. Mortality rate ration of boys to girls between 1981–1995 and 2001–2005.
S5 Table. Mortality rate due to neoplasms by age, gender and calendar period.
S6 Table. Mortality rate due to diseases of the nervous system by age, gender and calendar
S7 Table. Mortality rate due to diseases of transport accidents by age, gender and calendar
Conceived and designed the experiments: YFY JL. Performed the experiments: YFY GYQ SC
MG JO NQZ JL. Analyzed the data: YFY. Contributed reagents/materials/analysis tools: YFY
GYQ SC MG JO NQZ JL. Wrote the paper: YFY GYQ SC MG JO NQZ JL.
15 / 17
16 / 17
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