SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model

Critical Care, Nov 2013

Maryse A Wiewel, Anne van der Meer, Jonathan Haddad, Eric W Jacobson, George P Vlasuk, Tom van der Poll

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SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model

0 P3 Heparin-binding protein improves prediction of severe sepsis in the emergency department Adam Linder 1 Örebro University Hospital , Örebro , Sweden 2 P2 Acute kidney injury decreases long-term survival over a 10-year observation period Adam Linder 3 Cooper University Hospital , Camden, NJ , USA 4 Skåne University Hospital , Lund , Sweden 5 P1 Validation of a novel surveillance paradigm for ventilator-associated events Peter MC Klein Klouwenberg 6 , Bertil Christensson 7 Linköping University Hospital , Linköping , Sweden Critical Care 2013, 17(Suppl 4):P3; doi:10.1186/cc12904 8 Skåne University Hospital , Malmö , Sweden 9 P5 Passive immunotherapy of extended peritonitis as abdominal sepsis prevention Olexandr Butyrsky 10 , Viktor Starosek Department of Surgical Diseases, Crimean State Medical University , Simferopol, Ukraine Critical Care 2013, 17(Suppl 4):P5; doi:10.1186/cc12906 11 Department of Hygiene, Crimean State Medical University , Simferopol, Ukraine Critical Care 2013, 17(Suppl 4):P6; doi:10.1186/cc12907 12 Department of Surgical Diseases, Crimean State Medical University , Simferopol , Ukraine 13 P6 Efficacy of specific immunotherapy of abdominal sepsis Olexandr Butyrsky 14 Hackensack University Medical Center , Hackensack, NJ, USA Critical Care 2013, 17(Suppl 4):P7; doi:10.1186/cc12908 15 Section of Critical Care Medicine, University of Toronto , ON , Canada 16 Laurentian University , Sudbury, ON , Canada 17 Rush University , Chicago, IL , USA 18 Sirtris, A GSK Company , Cambridge, MA, USA Critical Care 2013, 17(Suppl 4):P8; doi:10.1186/cc12909 19 Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam , the Netherlands 20 P8 SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model Maryse A Wiewel 21 Armauer Hansen Research Institute , Addis Ababa , Ethiopia 22 Department of Public Health Officer, Jigjiga University , Jigjiga , Ethiopia 23 Department of Medical Laboratory Science, College of Health Science, Addis Ababa University , Ethiopia 24 P11 Bacteriological profile and antimicrobial sensitivity pattern of blood culture isolates among septicemia-suspected children at Tikur Anbessa Specialized Hospital and Yekatit 12 Hospital , Addis Ababa , Ethiopia Adugna Negussie 25 Tikur Anbessa Specialized Hospital, Department of Pediatrics , Addis Ababa, Ethiopia Critical Care 2013, 17(Suppl 4):P11; doi:10.1186/cc12911 26 Division of Allergy and Clinical Imunology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia , Jakarta , Indonesia 27 Division of Respirology and Critical Care, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia , Jakarta, Indonesia Critical Care 2013, 17(Suppl 4):P15; doi:10.1186/cc12915 28 Clinical Hospital, Federal University of Uberlândia , Brazil Critical Care 2013, 17(Suppl 4):P16; doi:10.1186/cc12916 29 Biomedical Sciences Institute, Federal University of Uberlândia , Brazil 30 Genetics and Biochemistry Institute, Federal University of Uberlândia , Brazil 31 P16 Is Strongyloides stercoralis a risk factor for sepsis severity? Patrícia Terra Alves 32 P18 Clinical manifestations, etiology and outcome of sepsis in pediatric patients admitted to the ICU Taís C São Pedro 33 , André M Morcillo, Emilio CE Baracat Department of Pediatrics, State University of Campinas, UNICAMP , Campinas, SP, Brazil Critical Care 2013, 17(Suppl 4):P18; doi:10.1186/cc12918 34 School of Medical Sciences, Rio de Janeiro State Federal University , Rio de Janeiro, Brazil Critical Care 2013, 17(Suppl 4):P19; doi:10.1186/cc12919 35 State University , Rio de Janeiro , Brazil 36 Central Laboratory, Pedro Ernesto University Hospital, Rio de Janeiro State University , Rio de Janeiro , Brazil 37 Bacteriology, Pedro Ernesto University Hospital, Rio de Janeiro State University , Rio de Janeiro , Brazil 38 School of Medical Sciences, Rio de Janeiro State University , Rio de Janeiro , Brazil 39 Pharmacy, Pedro Ernesto University Hospital, Rio de Janeiro State University , Rio de Janeiro , Brazil 40 Research Department of Emergency Medicine, Beth Israel Deaconess Medical Center , Boston, MA , USA 41 P24 Increasing number of organ dysfunctions is an excellent predictor of in-hospital mortality in emergency department patients with suspected infection: an internal and external prospective validation study Marie K Jessen 42 Research Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA, USA Critical Care 2013, 17(Suppl 4):P24; doi:10.1186/cc12924 43 Research Center for Emergency Medicine, Aarhus University Hospital , Aarhus , Denmark 44 P23 Prediction of bacteremia in emergency department patients with suspected infection: an external validation of a clinical decision rule Marie K Jessen 45 Department of Clinical Microbiology, Aalborg University Hospital, Aarhus University Hospital , Aalborg, Denmark Critical C (...truncated)


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Maryse A Wiewel, Anne van der Meer, Jonathan Haddad, Eric W Jacobson, George P Vlasuk, Tom van der Poll. SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model, Critical Care, 2013, pp. P8, 17,