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ocean mass change is referred to as “closing the ocean-mass budget”17. In the last few years, several studies have attempted to close the ocean mass or sea-level budget on both global2–4,11,21–25 and ... observations from GRACE and altimetry4,21,24,25. Commonly, these studies show that the global sea level or ocean-mass budget closes from 2005 to 2015, when GRACE was operating nominally27 and the autonomous Argo
tomographic images of the plumbing system. The location and estimation of stored magma volumes provide constraints on deep recharging processes and on the estimation of the magma budget entering/leaving the ... system. Obtaining consistent budget estimates is crucial to understanding if the replenishment of fresh magma within the stagnation levels occurs continuously or with episodic batches. One of the most
-analyses and randomized clinical trials (RCTs). One-way and probabilistic sensitivity analysis were performed to assess model uncertainty. Budget impact analysis of 5 years of treatment under the DRd triplet ... ratio (ICUR) and cost effectiveness ratio (ICER) were $956/QALY and $472/LYG respectively. The budget impact analysis indicates that adding Daratumumab to Lenalidomide and dexamethasone regimen, in the
temperature by emanating an equatorward teleconnection wave train. The overlay of the tropical thermal conditions and extra-tropical forcings largely aggravated the severity of the “YRV drought and IB flood”. ... by emanating an equatorward teleconnection wave train. The overlay of the tropical thermal conditions and extra-tropical forcings largely aggravated the severity of the “YRV drought and IB flood
the global water budget, TCs enhance moisture transport from evaporative regions and precipitation over sink regions, leading to predominantly anomalous positive surface freshwater flux areas over the ... freshwater flux during the TCs from 1980 to 2018 and the grid-to-grid trend in the surface freshwater flux budget. Although the Lagrangian approach neglects liquid water and ice content in the atmosphere, the
kinetics with a genome-informed trait-based dynamic energy budget model to predict emergent life-history traits and trade-offs in soil bacteria. When applied to a plant microbiome system, the model ... long-standing assumption that living roots budget model (DEBmicroTrait; Fig. 1 and Supplementary Table 1). select for fast-growing r-strategists that compete for a small set of This model integrates
remained cost-effective. The budget impact analysis of enzalutamide in the health system during 5 years was estimated at $6,362,127. At current prices, adding enzalutamide to pharmaceutical lists represents ... dependence of prostate cancer on the androgen receptor pathway was identified, an incentive was provided to develop targeted therapies for extra-gonadal androgen signaling [10]. For mCRPC patients, taxane
Cornelia de Lange Syndrome (CdLS) is a rare genetic disorder characterized by a range of physical, cognitive, and behavioral abnormalities. This study aimed to perform a comprehensive review of the ... underscore the need for comprehensive genetic testing to enhance the diagnosis and management of CdLS patients. Cornelia de Lange Syndrome (CdLS); Whole exome sequencing; Novel variant; NIPBL gene; SMC1A gene
bodies; budget funds; financial resources; state property - JEL M41: H72 1. Introduction Formulation of the problem. Market transformations in Ukraine significantly affected the work of public sector ... threatens the national security of Ukraine in the financial sphere. The main reasons for this situation are the low level of executive discipline and significant deficiencies budget process" [3, p. 33]. In
security, increased the level and severity of criminal offenses. Non-targeted use of budget funds, in particular, spending from the budget or providing loans from the budget without the established budget ... dependent on such organizations, which, in turn, use state policy to concealing the essence of one’s activity. This article deals with the issue of misuse of budget funds, in particular, making expenditures
Primary Sjögren's syndrome (pSS) is an autoimmune condition that causes harm to exocrine glands and also has extra-glandular manifestations (EGM). pSS patients with EGM have a worse prognosis than ... [ 1, 2 ], but approximately 40% of patients may have extra-glandular manifestations (EGM) [3]. These EGM can affect different areas of the body, such as joints, skin, lungs, kidneys, and nervous system
encompassing the range of mutations that can arise in AML remains an unmet need. The bromo- and extra-terminal domain (BET) family of proteins represents an attractive therapeutic target in AML due to their ... patients, rapid disease progression at time of relapse, and evolution of resistance to current targeted therapeutics [ 3, 4 ]. Bromodomain and extra-terminal domain (BET) family proteins, including BRD2
bodies; budget funds; financial resources; state property - JEL M41: H72 1. Introduction Formulation of the problem. Market transformations in Ukraine significantly affected the work of public sector ... threatens the national security of Ukraine in the financial sphere. The main reasons for this situation are the low level of executive discipline and significant deficiencies budget process" [3, p. 33]. In
bodies; budget funds; financial resources; state property - JEL M41: H72 1. Introduction Formulation of the problem. Market transformations in Ukraine significantly affected the work of public sector ... threatens the national security of Ukraine in the financial sphere. The main reasons for this situation are the low level of executive discipline and significant deficiencies budget process" [3, p. 33]. In
study was optimized in terms of the number of participating sites. Excess sites ranged from 2 to 39. Excess costs associated with extra sites ranged from $17K to $330K with a median excess cost of $96K ... of $96K. Excess costs were, on average, 7% of the total study budget. Sensitivity analyses demonstrated that studies with higher overhead costs require more sites to complete the study as quickly as
Arctic hydrological cycle has important global implications through modifying deep ocean circulation via fresh water fluxes. However, attribution of the observed changes in Arctic moisture budget ... Arctic moisture budget We first compare long-term trends in precipitation, evaporation, and moisture transport to the Arctic using eight CMIP6 models that provide individual forcing simulations (Table 1
in Communications Earth & Environment, have shown how the changing influence of three of the most uncertain aspects of the methane budget-anthropogenic emissions, wetlands and chemical loss-have ... role in determining the global OH budget. High NOX/low CO conditions favour OH production, and so increasing NOX and decreasing CO concentrations during the 2000s contributed to the CH4 growth hiatus at
