Editorial: special issue introduction

Clinical & Experimental Metastasis, Apr 2017

Jonathan P. Sleeman

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Editorial: special issue introduction

Clin Exp Metastasis Editorial: special issue introduction 0 Institut für Toxikologie und Genetik, Karlsruhe Institute for Technology (KIT) , Campus Nord, Postfach 3640, 76021 Karlsruhe , Germany 1 Medical Faculty Mannheim, Centre for Biomedicine and Medical Technology Mannheim (CBTM), University of Heidelberg , TRIDOMUS-Gebäude Haus C, Ludolf-Krehl-Str. 13 - 17, 68167 Mannheim , Germany 2 Jonathan P. Sleeman This special issue marks several important milestones for the Metastasis Research Society (MRS) and its journal Clinical & Experimental Metastasis. First, the special issue is dedicated to Prof. Sue Eccles, long-serving Editorin-Chief of the journal who retired at the end of 2016. On behalf of the society and the journal, we wish to express our gratitude to Sue for her hard work for the journal over the years, and hope that she can now enjoy a well-earned retirement. Sue looks back over her career and offers advice to the next generation of metastasis researchers in an interview with Kate Bankaitis in this issue [1]. In addition to the retirement of Prof. Eccles, there has been a further generation change in the editorial line up, as two other Editor-in-Chiefs also stepped down during 2016. We want to take this opportunity to thank Prof. Robin Anderson who rotated off as Editor-in-Chief at the end of 2016 for her outstanding efforts on behalf of Clinical & Experimental Metastasis over many years, and wish her well for the additional responsibilities she has taken on board at her home institute. We also recognize the valuable contribution of Prof. Tatsuro Irimura who retired from his Editor-in-Chief position mid 2016. I would also like to take this opportunity to thank the members of the Editorial Board of Clinical & Experimental Metastasis who have provided invaluable support for Vol.:(011233456789) - the journal through their voluntary efforts, particularly those who will be rotating off the board in 2016. Several Editorial Board members have also supported Clinical & Experimental Metastasis by publishing excellent research in the journal during the last couple of years. For example, Ingunn Holen’s research interests lie in understanding how the bone marrow microenvironment regulates the survival and outgrowth of tumor cells that disseminate to the bone [ 2, 3 ]. To study tumor cell interactions with the bone microenvironment, she has recently developed a novel humanized model of bone metastases, in which tumor cells are seeded in viable subchaodral bone discs from humans [4]. These discs can be cultivated in vitro for several weeks, or implanted into experimental animals, allowing tumor cell-bone interactions to be investigated. She has also developed other in  vivo models of bone metastasis, that have allowed the effects of Zolendronic acid and oestrogen on tumour cell dissemination and growth to be determined [ 5 ]. Andrea Mastro, another Editorial Board member, also investigates metastasis to the bone, in particular regulation by the immune system and nutrition, and the interaction of disseminated tumor cells with osteoblasts [ 6, 7 ]. She recently used a novel three-dimensional co-culture system to investigate mechanisms leading to release of dormancy in the bone marrow microenvironment, and found evidence that inflammatory cytokines involved in bone repair and turnover can activate latent disseminated breast cancer cells [8]. CEM Board Member Barbara Fingleton investigates how MMPs and the Th2 cytokines IL4 and IL13 and their receptors regulate malignant progression of breast and colon cancers [ 9, 10 ]. Her recent review on IL4/IL4R as a target for metastasis disease provides a valuable resource for colleagues in the field [11]. This special issue focuses on the 16th Biennial International Conference of the MRS that took place in Chengdu, 1. Bankaitis KV ( 2017 ) A reflection and a look forward with Dr. Sue Eccles, retired Editor-in-Chief of Clinical and Experimental Metastasis . Clin Exp Metastasis. doi:10.1007/ s10585-017-9841-2 2. Holen I ( 2016 ) The bone microenvironment: multiple players involved in cancer progression . J Bone Oncol 5 : 87 - 89 . doi: 10 .1016/j.jbo. 2016 . 05 .004 3. Holen I , Lefley DV , Francis SE , Rennicks S , Bradbury S , Coleman RE , Ottewell P ( 2016 ) IL-1 drives breast cancer growth and bone metastasis in  vivo . Oncotarget 7 : 75571 - 75584 . doi: 10 .18632/oncotarget.12289 4. Holen I , Nutter F , Wilkinson JM , Evans CA , Avgoustou P , Ottewell PD ( 2015 ) Human breast cancer bone metastasis in  vitro and in  vivo: a novel 3D model system for studies of tumour cell-bone cell interactions . Clin Exp Metastasis . 32 : 689 - 702 . doi: 10 .1007/s10585-015-9737-y 5. Holen I , Walker M , Nutter F , Fowles A , Evans CA , Eaton CL , Ottewell PD ( 2016 ) Oestrogen receptor positive breast cancer metastasis to bone: inhibition by targeting the bone microenvironment in vivo . Clin Exp Metastasis 33 : 211 - 224 . doi: 10 .1007/ s10585-015-9770-x 6. Chen YC , Prabhu KS , Das A , Mastro AM ( 2013 ) Dietary selenium supplementation modifies breast tumor growth and metastasis . Int J Cancer 133 : 2054 - 2064 . doi: 10 .1002/ijc.28224 7. Jackson W , Sosnoski DM , Ohanessian SE , Chandler P , Mobley AW , Meisel KD , Mastro AM ( 2017 ) The role of megakaryocytes in breast cancer metastasis to bone . Cancer Res. doi:10 .1158/ 0008 - 5472 .CAN- 16 -1084 8. Sosnoski DM , Norgard RJ , Grove CD , Foster SJ , Mastro AM ( 2015 ) Dormancy and growth of metastatic breast cancer cells in a bone-like microenvironment . Clin Exp Metastasis 32 : 335 - 344 . doi: 10 .1007/s10585-015-9710-9 9. Bates AL , Pickup MW , Hallett MA , Dozier EA , Thomas S , Fingleton B ( 2015 ) Stromal matrix metalloproteinase 2 regulates collagen expression and promotes the outgrowth of experimental metastases . J Pathol 235 : 773 - 783 . doi: 10 .1002/path.4493 10. Venmar KT , Carter KJ , Hwang DG , Dozier EA , Fingleton B ( 2014 ) IL4 receptor ILR4alpha regulates metastatic colonization by mammary tumors through multiple signaling pathways . Cancer Res 74 : 4329 - 4340 . doi: 10 .1158/ 0008 - 5472 .CAN- 14 -0093 11. Bankaitis KV , Fingleton B ( 2015 ) Targeting IL4/IL4R for the treatment of epithelial cancer metastasis . Clin Exp Metastasis 32 : 847 - 856 . doi: 10 .1007/s10585-015-9747-9 12. Bankaitis K , Borriello L , Cox T , Lynch C , Zijlstra A , Fingleton B , Guzvic M , Anderson R , Neman J ( 2017 ) Meeting report : Metastasis Research Society-Chinese Tumor Metastasis Society joint conference on metastasis. Clin Exp Metastasis. doi:10.1007/s10585-017-9842-1 13. Sleeman JP ( 2017 ) 16th Biennial Congress of the Metastasis Research Society . Clin Exp Metastasis. doi:10.1007/ s10585-017-9843-0


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Jonathan P. Sleeman. Editorial: special issue introduction, Clinical & Experimental Metastasis, 2017, 197-198, DOI: 10.1007/s10585-017-9845-y