INCREASED RADIORESISTANCE TO LETHAL DOSES OF GAMMA RAYS IN MICE AND RATS AFTER EXPOSURE TO MICROWAVE RADIATION EMITTED BY A GSM MOBILE PHONE SIMULATOR

Dose-Response: An International Journal, Dec 2013

The aim of this study was to investigate the effect of pre-irradiation with microwaves on the induction of radioadaptive response. In the 1st phase of the study, 110 male mice were divided into 8 groups. The animals in these groups were exposed/sham-exposed to microwave, low dose rate gamma or both for 5 days. On day six, the animals were exposed to a lethal dose (LD). In the 2nd phase, 30 male rats were divided into 2 groups of 15 animals. The 1st group received microwave exposure. The 2nd group (controls) received the same LD but there was no treatment before the LD. On day 5, all animals were whole-body irradiated with the LD. Statistically significant differences between the survival rate of the mice only exposed to lethal dose of gamma radiation before irradiation with a lethal dose of gamma radiation with those of the animals pre-exposed to either microwave (p=0.02), low dose rate gamma (p=0.001) or both of these physical adapting doses (p=0.003) were observed. Likewise, a statistically significant difference between survival rates of the rats in control and test groups was observed. Altogether, these experiments showed that exposure to microwave radiation may induce a significant survival adaptive response.

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INCREASED RADIORESISTANCE TO LETHAL DOSES OF GAMMA RAYS IN MICE AND RATS AFTER EXPOSURE TO MICROWAVE RADIATION EMITTED BY A GSM MOBILE PHONE SIMULATOR

Dose-Response: An International Journal INCRE A SED RADIORESISTANCE TO LETHAL DOSES OF GAMMA RAYS IN MICE AND RATS AFTER EXPOSURE TO MICROWAVE RADIATION EMITTED BY A GSM MOBILE PHONE SIMUL ATOR SMJ Mortazavi 0 1 MA Mosleh-Shirazi 0 1 AR Tavassoli 0 1 M Taheri 0 1 AR Mehdizadeh 0 1 Iran Blood Transfusion Organization, Shiraz, Iran 0 Shiraz University of Medical Sciences , Shiraz , Iran 1 Medical Physics & Medical Engineering Department , The Head , The Center for Research on Radiological Sciences , The Head , Medical Physics & Medical Engineering Department, School of Medicine , Zand Street , Shiraz University of Medical Sciences 2 98-711-2289113; Home Page: Recommended Citation - See next page for additional authors Follow this and additional works at: https://scholarworks.umass.edu/dose_response INCREASED RADIORESISTANCE TO LETHAL DOSES OF GAMMA RAYS IN MICE AND RATS AFTER EXPOSURE TO MICROWAVE RADIATION EMITTED BY A GSM MOBILE PHONE SIMULATOR Authors SMJ Mortazavi, MA Mosleh-Shirazi, AR Tavassoli, M Taheri, AR Mehdizadeh, SAS Namazi, A Jamali, R Ghalandari, S Bonyadi, M Haghani, and M Shafie INCREASED RADIORESISTANCE TO LETHAL DOSES OF GAMMA RAYS IN MICE AND RATS AFTER EXPOSURE TO MICROWAVE RADIATION EMITTED BY A GSM MOBILE PHONE SIMULATOR Mortazavi SMJ1,2, Mosleh-Shirazi MA3, Tavassoli AR4,Taheri M5, Mehdizadeh AR6, Namazi SAS7, Jamali A7, Ghalandari R7, Bonyadi S7, Haghani M2 and Shafie M7 1Professor of Medical Physics, Radiobiology & Radiation Protection Department, School of Allied Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; 2The Center for Research in Radiological Sciences, School of Allied Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; 3Assistant Professor of Medical Physics, Physics Unit, Radiotherapy Department, and Center for Research in Medical Physics and Biomedical Engineering, Shiraz University of Medical Sciences, Shiraz, Iran; 4Assistant Professor of Pathology, Iran Blood Transfusion Organization, Shiraz, Iran; 5Lecturer of Microbiology, Laboratory Sciences Department, School of Allied Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; 6Assistant Professor of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; 7Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran The aim of this study was to investigate the effect of pre-irradiation with microwaves on the induction of radioadaptive response. In the 1st phase of the study, 110 male mice were divided into 8 groups. The animals in these groups were exposed/sham-exposed to microwave, low dose rate gamma or both for 5 days. On day six, the animals were exposed to a lethal dose (LD). In the 2nd phase, 30 male rats were divided into 2 groups of 15 animals. The 1st group received microwave exposure. The 2nd group (controls) received the same LD but there was no treatment before the LD. On day 5, all animals were whole-body irradiated with the LD. Statistically significant differences between the survival rate of the mice only exposed to lethal dose of gamma radiation before irradiation with a lethal dose of gamma radiation with those of the animals pre-exposed to either microwave (p=0.02), low dose rate gamma (p=0.001) or both of these physical adapting doses (p=0.003) were observed. Likewise, a statistically significant difference between survival rates of the rats in control and test groups was observed. Altogether, these experiments showed that exposure to microwave radiation may induce a significant survival adaptive response. Mortazavi SMJ and others INTRODUCTION Radioadaptive response or radiation-induced adaptive response is defined as the acquisition of radiation resistance against irradiation with a high radiation dose in cultured cells or organisms that had been pretreated with a priming low radiation dose. The priming low radiation dose is usually called “adapting dose” or “conditioning dose” while the high radiation dose is called “challenge dose”. The induction of radioadaptive response was first reported by Olivieri et al. (1984) who showed that the frequency of chromatid aberrations were down to 50% less than expected after exposure to 1.5 Gy of x-rays. Many articles have demonstrated radioadaptive response in plant cells (Cortes et al. 1990) , insects (Fritz-Niggli and Schaeppi-Buechi 1991) , Chinese hamster V79 cells (Ikushima 1987, 1989a, 1989b) , cultured human lymphocytes (Shadley and Wolff 1987; Wolff et al. 1988; Sankaranarayanan et al. 1989; Shadley and Wiencke 1989; Ghiassi-nejad et al. 2002) , embryonic and HeLa cells (Ishii and Watanabe 1996) , occupationally exposed persons (Barquinero et al. 1995; Gourabi and Mozdarani 1998) , cultured animal lymphocytes (Wojcik and Tuschl 1990), and in vivo studies on laboratory animals (Bosi and Olivieri 1989; Cai and Liu 1990; Liu et al. 1992; Farooqi and Kesavan 1993) . However, there are reports indicating lack of radi (...truncated)


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SMJ Mortazavi, MA Mosleh-Shirazi, AR Tavassoli, M Taheri, AR Mehdizadeh, SAS Namazi, A Jamali, R Ghalandari, S Bonyadi, M Haghani, M Shafie. INCREASED RADIORESISTANCE TO LETHAL DOSES OF GAMMA RAYS IN MICE AND RATS AFTER EXPOSURE TO MICROWAVE RADIATION EMITTED BY A GSM MOBILE PHONE SIMULATOR, Dose-Response: An International Journal, 2013, Volume 11, Issue 2,