INCREASED RADIORESISTANCE TO LETHAL DOSES OF GAMMA RAYS IN MICE AND RATS AFTER EXPOSURE TO MICROWAVE RADIATION EMITTED BY A GSM MOBILE PHONE SIMULATOR
Dose-Response: An International Journal
INCRE A SED RADIORESISTANCE TO LETHAL DOSES OF GAMMA RAYS IN MICE AND RATS AFTER EXPOSURE TO MICROWAVE RADIATION EMITTED BY A GSM MOBILE PHONE SIMUL ATOR
SMJ Mortazavi 0 1
MA Mosleh-Shirazi 0 1
AR Tavassoli 0 1
M Taheri 0 1
AR Mehdizadeh 0 1
Iran Blood Transfusion Organization, Shiraz, Iran
0 Shiraz University of Medical Sciences , Shiraz , Iran
1 Medical Physics & Medical Engineering Department , The Head , The Center for Research on Radiological Sciences , The Head , Medical Physics & Medical Engineering Department, School of Medicine , Zand Street , Shiraz University of Medical Sciences
2 98-711-2289113; Home Page:
Recommended Citation
-
See next page for additional authors
Follow this and additional works at: https://scholarworks.umass.edu/dose_response
INCREASED RADIORESISTANCE TO LETHAL DOSES OF
GAMMA RAYS IN MICE AND RATS AFTER EXPOSURE TO
MICROWAVE RADIATION EMITTED BY A GSM MOBILE
PHONE SIMULATOR
Authors
SMJ Mortazavi, MA Mosleh-Shirazi, AR Tavassoli, M Taheri, AR Mehdizadeh, SAS Namazi, A Jamali, R
Ghalandari, S Bonyadi, M Haghani, and M Shafie
INCREASED RADIORESISTANCE TO LETHAL DOSES OF GAMMA RAYS IN
MICE AND RATS AFTER EXPOSURE TO MICROWAVE RADIATION EMITTED
BY A GSM MOBILE PHONE SIMULATOR
Mortazavi SMJ1,2, Mosleh-Shirazi MA3, Tavassoli AR4,Taheri M5,
Mehdizadeh AR6, Namazi SAS7, Jamali A7, Ghalandari R7, Bonyadi S7,
Haghani M2 and Shafie M7 1Professor of Medical Physics, Radiobiology &
Radiation Protection Department, School of Allied Medical Sciences, Shiraz
University of Medical Sciences, Shiraz, Iran; 2The Center for Research in
Radiological Sciences, School of Allied Medical Sciences, Shiraz University of
Medical Sciences, Shiraz, Iran; 3Assistant Professor of Medical Physics, Physics Unit,
Radiotherapy Department, and Center for Research in Medical Physics and
Biomedical Engineering, Shiraz University of Medical Sciences, Shiraz, Iran;
4Assistant Professor of Pathology, Iran Blood Transfusion Organization, Shiraz,
Iran; 5Lecturer of Microbiology, Laboratory Sciences Department, School of Allied
Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; 6Assistant
Professor of Medical Physics, School of Medicine, Shiraz University of Medical
Sciences, Shiraz, Iran; 7Student Research Committee, Shiraz University of Medical
Sciences, Shiraz, Iran
The aim of this study was to investigate the effect of pre-irradiation with microwaves
on the induction of radioadaptive response. In the 1st phase of the study, 110 male mice
were divided into 8 groups. The animals in these groups were exposed/sham-exposed to
microwave, low dose rate gamma or both for 5 days. On day six, the animals were exposed
to a lethal dose (LD). In the 2nd phase, 30 male rats were divided into 2 groups of 15
animals. The 1st group received microwave exposure. The 2nd group (controls) received the
same LD but there was no treatment before the LD. On day 5, all animals were whole-body
irradiated with the LD. Statistically significant differences between the survival rate of the
mice only exposed to lethal dose of gamma radiation before irradiation with a lethal dose
of gamma radiation with those of the animals pre-exposed to either microwave (p=0.02),
low dose rate gamma (p=0.001) or both of these physical adapting doses (p=0.003) were
observed. Likewise, a statistically significant difference between survival rates of the rats in
control and test groups was observed. Altogether, these experiments showed that exposure
to microwave radiation may induce a significant survival adaptive response.
Mortazavi SMJ and others
INTRODUCTION
Radioadaptive response or radiation-induced adaptive response is
defined as the acquisition of radiation resistance against irradiation with
a high radiation dose in cultured cells or organisms that had been
pretreated with a priming low radiation dose. The priming low radiation
dose is usually called “adapting dose” or “conditioning dose” while the
high radiation dose is called “challenge dose”. The induction of
radioadaptive response was first reported by
Olivieri et al. (1984)
who showed that
the frequency of chromatid aberrations were down to 50% less than
expected after exposure to 1.5 Gy of x-rays. Many articles have
demonstrated radioadaptive response in plant cells
(Cortes et al. 1990)
, insects
(Fritz-Niggli and Schaeppi-Buechi 1991)
, Chinese hamster V79 cells
(Ikushima 1987, 1989a, 1989b)
, cultured human lymphocytes
(Shadley
and Wolff 1987; Wolff et al. 1988; Sankaranarayanan et al. 1989; Shadley
and Wiencke 1989; Ghiassi-nejad et al. 2002)
, embryonic and HeLa cells
(Ishii and Watanabe 1996)
, occupationally exposed persons
(Barquinero
et al. 1995; Gourabi and Mozdarani 1998)
, cultured animal lymphocytes
(Wojcik and Tuschl 1990), and in vivo studies on laboratory animals
(Bosi
and Olivieri 1989; Cai and Liu 1990; Liu et al. 1992; Farooqi and Kesavan
1993)
. However, there are reports indicating lack of radi (...truncated)