Shift work is associated with metabolic syndrome in male steel workers-the role of resistin and WBC count-related metabolic derangements

Diabetology & Metabolic Syndrome, Oct 2017

There is increasing evidence linking a shift work schedule with various adverse health effects. The present study aimed to examine the relationship between shift work and the metabolic syndrome (MetS) in male steel workers, and also the possible mechanism of shift work-related metabolic derangements. A total of 1732 men aged 42 ± 8 years were enrolled in this cross-sectional study, including 862 day workers and 870 shift workers. Circulating levels of resistin were measured by ELISA using monoclonal specific antibodies. The shift workers had higher rates of MetS and its components (central obesity, hypertension, and hypertriglyceridemia) than the day workers. In multiple logistic regression analysis, shift work was independently associated with MetS. In further analysis, the shift workers had elevated circulating levels of resistin (13 ± 10 vs. 10 ± 7 ng/mL) and total white blood cell (WBC) count (6.865 ± 1.819 vs. 6.304 ± 1.547 109/L) than the day workers. In addition, both resistin level and total WBC count were significantly associated with shift work, MetS, and its components (body mass index, fasting glucose, triglyceride, and high-density lipoprotein-cholesterol levels), and plasma resistin levels were significantly associated with total WBC count (β = 0.34, p < 0.0001). Shift work was independently associated with MetS in male steel workers. Resistin and WBC count were associated with shift work-related metabolic derangements.

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Shift work is associated with metabolic syndrome in male steel workers-the role of resistin and WBC count-related metabolic derangements

Lu et al. Diabetol Metab Syndr Shift work is associated with metabolic syndrome in male steel workers-the role of resistin and WBC count-related metabolic derangements Yung‑Chuan Lu 3 4 Chao‑Ping Wang 2 4 Teng‑Hung Yu 2 IT‑ing Tsai 5 7 Wei‑Chin Hung 2 I‑Cheng Lu 0 6 Chia‑Chang Hsu 1 Wei‑Hua Tang 8 JerY‑iing Houng 9 Fu‑Mei Chung 2 Mei‑Chu Yen Jean 0 4 5 6 0 Department of Occupational Medicine, E‐ Da Hospital, I‐ Shou University , No. 1, Yi‐Da Rd, Jiau‐Shu Village, Yan‐Chao Township, Kaohsiung 82445 , Taiwan 1 Division of Gastroenterology and Hepatology, Department of Internal Medicine, E‐Da Hospital, I‐Shou University , Kaoh‐ siung 82445 , Taiwan 2 Division of Cardiology, E‐Da Hospital, I‐Shou University , Kaohsiung 82445 , Taiwan 3 Division of Endocrinologic, E‐Da Hospital, I‐Shou University , Kaohsi‐ ung 82445 , Taiwan 4 School of Medicine for International Students, I‐Shou University , Kaohsiung 82445 , Taiwan 5 Department of Nursing, I‐Shou University , Kaohsiung 82445 , Taiwan 6 Department of Occupational Medicine, E‐Da Hospital, I‐Shou University , No. 1, Yi‐Da Rd, Jiau‐Shu Village, Yan‐Chao Township, Kaohsiung 82445 , Taiwan 7 Department of Emergency, E‐Da Hospital, I‐Shou University , Kaohsiung 82445 , Taiwan 8 Division of Cardiology, Department of Internal Medicine, National Yang‐Ming University Hospital , Yilan , Taiwan 9 Department of Nutri‐ tion, Institute of Biotechnology and Chemical Engineering, I‐Shou University , Kaohsiung 82445 , Taiwan Aims: There is increasing evidence linking a shift work schedule with various adverse health effects. The present study aimed to examine the relationship between shift work and the metabolic syndrome (MetS) in male steel workers, and also the possible mechanism of shift work‑ related metabolic derangements. Methods: A total of 1732 men aged 42 ± 8 years were enrolled in this cross‑ sectional study, including 862 day workers and 870 shift workers. Circulating levels of resistin were measured by ELISA using monoclonal specific antibodies. Results: The shift workers had higher rates of MetS and its components (central obesity, hypertension, and hypertriglyceridemia) than the day workers. In multiple logistic regression analysis, shift work was independently associated with MetS. In further analysis, the shift workers had elevated circulating levels of resistin (13 ± 10 vs. 10 ± 7 ng/mL) and total white blood cell (WBC) count (6.865 ± 1.819 vs. 6.304 ± 1.547 109/L) than the day workers. In addition, both resistin level and total WBC count were significantly associated with shift work, MetS, and its components (body mass index, fasting glucose, triglyceride, and high‑ density lipoprotein‑ cholesterol levels), and plasma resistin levels were significantly associated with total WBC count (β = 0.34, p < 0.0001). Conclusion: Shift work was independently associated with MetS in male steel workers. Resistin and WBC count were associated with shift work‑ related metabolic derangements. Steel workers; Shift work; Metabolic syndrome; Body mass index; Fasting glucose; Triglyceride; High‑ density lipoprotein‑ cholesterol; Resistin; White blood cell count Background Shift work is defined that takes place on a schedule outside the traditional 9  a.m.–5  p.m.  day. It can involve evening or night shifts, early morning shifts, and rotating shifts [ 1 ]. Shift work is increasing worldwide, and as many as 20% of workers in industrialized nations are shift workers [ 2 ]. Shift work has been reported to disrupt the circadian rhythm, sleep and work-life balance, and to increase the risk of metabolic syndrome (MetS) [ 3 ], coronary heart disease [ 4 ], mental and behavioral disorders [ 5 ], and sleep disturbances [ 6 ]. The major function of the circadian system is internal cycling of physiological and metabolic events [ 7 ]. Many physiological processes display a day-night rhythms, and feeding behaviour, lipid and carbohydrate metabolism and blood pressure are subject to daily variations. The prevalence of MetS is increasing globally, including Taiwan. The components of MetS including dyslipidemia, dysglycemia, high blood pressure, and being overweight/obese tend to cluster together, and they are thought to be related to lifestyle habits including physical activity, nutrient intake, alcohol consumption, and smoking [ 8–11 ]. Few studies have examined the relationships between shift work and MetS taking into consideration the various factors associated with shift work that might lead to MetS. In addition, shift work may be responsible for increased body fatness and inflammatory markers, higher blood pressure levels, and chronic low-grade inflammation to play an important role in the development of MetS [ 3, 12–16 ]. The detrimental effects of shift work on MetS and the induction of inflammatory cytokines and associated factors raise the possibility that shift work may increase the risk of MetS. To clarify this hypothesis, we investigated the association betwe (...truncated)


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Yung-Chuan Lu, Chao-Ping Wang, Teng-Hung Yu, I-Ting Tsai, Wei-Chin Hung, I-Cheng Lu, Chia-Chang Hsu, Wei-Hua Tang, Jer-Yiing Houng, Fu-Mei Chung, Mei-Chu Yen Jean. Shift work is associated with metabolic syndrome in male steel workers-the role of resistin and WBC count-related metabolic derangements, Diabetology & Metabolic Syndrome, 2017, pp. 83, DOI: 10.1186/s13098-017-0283-4