Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

European Journal of Nutrition, Jan 2018

Purpose The purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postprandial endothelial dysfunction. Methods This was a single-blind, randomized, placebo-controlled, crossover-within-subject clinical trial. A total of 37 patients with borderline or stage 1 hypertension were randomized to two study groups. The participants consumed a test meal with a single intake of the test coffee. Subjects in the Study 1 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or coffee with a high content of chlorogenic acids and a high content of hydroxyhydroquinone with crossover. Subjects in the Study 2 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or placebo coffee with crossover. Endothelial function assessed by flow-mediated vasodilation and plasma concentration of 8-isoprostanes were measured at baseline and at 1 and 2 h after coffee intake. Results Compared with baseline values, single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone, but not coffee with a high content of chlorogenic acids and high content of hydroxyhydroquinone or placebo coffee, significantly improved postprandial flow-mediated vasodilation and decreased circulating 8-isoprostane levels. Conclusions These findings suggest that a single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone is effective for improving postprandial endothelial dysfunction. Clinical Trial Registration URL for Clinical Trial: https://upload.umin.ac.jp; Registration Number for Clinical Trial: UMIN000013283.

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Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

European Journal of Nutrition https://doi.org/10.1007/s00394 Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension Masato Kajikawa 0 1 2 4 5 6 7 Tatsuya Maruhashi 0 1 2 4 5 6 7 Takayuki Hidaka 0 1 2 4 5 6 7 Yukiko Nakano 0 1 2 4 5 6 7 Satoshi Kurisu 0 1 2 4 5 6 7 Takeshi Matsumoto 0 1 2 4 5 6 7 Yumiko Iwamoto 0 1 2 4 5 6 7 Shinji Kishimoto 0 1 2 4 5 6 7 Shogo Matsui 0 1 2 4 5 6 7 Yoshiki Aibara 0 1 2 4 5 6 7 Farina Mohamad Yusoff 0 1 2 4 5 6 7 Yasuki Kihara 0 1 2 4 5 6 7 Kazuaki Chayama 0 1 2 4 5 6 7 Chikara Goto 0 1 2 4 5 6 7 Kensuke Noma 0 1 2 4 5 6 7 Ayumu Nakashima 0 1 2 4 5 6 7 Takuya Watanabe 0 1 2 4 5 6 7 Hiroshi Tone 0 1 2 4 5 6 7 Masanobu Hibi 0 1 2 4 5 6 7 Noriko Osaki 0 1 2 4 5 6 7 Yoshihisa Katsuragi 0 1 2 4 5 6 7 Yukihito Higashi 0 1 2 4 5 6 7 0 Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine 1 Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima , Japan 2 Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital , Hiroshima , Japan 3 Yukihito Higashi 4 Health Care Food Research Laboratories, Kao Corporation , Tokyo , Japan 5 Department of Physical Therapy, Hiroshima International University , Hiroshima , Japan 6 Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima , Japan 7 (RIRBM), Hiroshima University , 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551 , Japan Purpose The purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postprandial endothelial dysfunction. Methods This was a single-blind, randomized, placebo-controlled, crossover-within-subject clinical trial. A total of 37 patients with borderline or stage 1 hypertension were randomized to two study groups. The participants consumed a test meal with a single intake of the test coffee. Subjects in the Study 1 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or coffee with a high content of chlorogenic acids and a high content of hydroxyhydroquinone with crossover. Subjects in the Study 2 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or placebo coffee with crossover. Endothelial function assessed by flow-mediated vasodilation and plasma concentration of 8-isoprostanes were measured at baseline and at 1 and 2 h after coffee intake. Results Compared with baseline values, single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone, but not coffee with a high content of chlorogenic acids and high content of hydroxyhydroquinone or placebo coffee, significantly improved postprandial flow-mediated vasodilation and decreased circulating 8-isoprostane levels. Conclusions These findings suggest that a single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone is effective for improving postprandial endothelial dysfunction. Clinical Trial Registration URL for Clinical Trial: https://upload.umin.ac.jp; Registration Number for Clinical Trial: UMIN000013283. Chlorogenic acids; Hydroxyhydroquinone; Atherosclerosis; Endothelial function Introduction Endothelial dysfunction occurs in the early stage of atherosclerosis and plays an important role in the development of atherosclerotic conditions, resulting in cardiovascular complications [ 1, 2 ]. Measurements of flow-mediated vasodilation (FMD) as an index of endothelium-dependent vasodilation in the brachial artery have been widely used in clinical research to evaluate endothelial function [ 3–6 ]. Endothelial dysfunction has been shown to be an independent predictor of cardiovascular events [ 7–10 ]. Postprandial hyperglycemia is associated with endothelial dysfunction and is a risk factor for cardiovascular events [ 11, 12 ]. Acute hyperglycemia induces oxidative stress, which is a key trigger of endothelial dysfunction by reducing nitric oxide (NO) bioavailability [ 11, 12 ]. Therefore, it is important to determine interventions that can restore endothelial function under the condition of postprandial hyperglycemia. Coffee is a popular beverage that is consumed worldwide. Coffee contains an abundance of polyphenols, which is the major source of dietary antioxidants [ 13, 14 ]. Drinking coffee is associated with lower risks of metabolic syndrome, diabetes, and coronary heart disease [ 15–19 ]. However, there have been conflicting results regarding the association between coffee drinking and risk of cardiovascular disease [ 19–23 ]. The effect o (...truncated)


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Masato Kajikawa, Tatsuya Maruhashi, Takayuki Hidaka, Yukiko Nakano, Satoshi Kurisu, Takeshi Matsumoto, Yumiko Iwamoto, Shinji Kishimoto, Shogo Matsui, Yoshiki Aibara, Farina Mohamad Yusoff, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Kensuke Noma, Ayumu Nakashima, Takuya Watanabe, Hiroshi Tone, Masanobu Hibi, Noriko Osaki, Yoshihisa Katsuragi, Yukihito Higashi. Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension, European Journal of Nutrition, 2018, pp. 1-8, DOI: 10.1007/s00394-018-1611-7