In reply

Journal of Anesthesia, Feb 2018

Takaya Nishida, Takahiro Mihara, Koui Ka

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In reply

V In reply Takaya Nishida 0 1 2 Takahiro Mihara 0 1 2 Koui Ka 0 1 2 To the Editor: 0 1 2 0 Department of Anesthesiology, Kanagawa Children's Medical Center , 2-138-4, Mutsukawa, Minami-ku, Yokohama 232-8555 , Japan 1 Department of Anaesthesiology and Critical Care Medicine, Yokohama City University Graduate School of Medicine , 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004 , Japan 2 Department of Anaesthesiology, Kanagawa Children's Medical Centre , Mutsukawa 2-138-4, Minami-ku, Yokohama 232-8555 , Japan 3 Takahiro Mihara We would like to thank the readers of this journal for their comments on our article “Predictors for incidence of increased time spent in hospital after ambulatory surgery in children: a retrospective cohort study” [1]. We received three questions in the comments section; below are our answers: 1. We agree with the comment suggesting that conducting sensitivity analyses will be important for determining the validity of our results. We defined the cut-off time point for a prolonged hospital stay as 8 h from the end of anesthesia until discharge. We discussed the reason for selecting this cut-off point in our article [1] as follows: “This was because ambulatory surgeries were always scheduled for morning in our institution. The expected time of the end of anesthesia was between 9 and 11 a.m.; therefore, 8 h, not 6 h, after the end of anesthesia would fall outside of daytime working hours.” We have performed sensitivity analyses with cut-off points of either 7 or 9 h; these cut-off points would be meaningful because 7 or 9 h after the end of anesthesia would also fall outside of daytime working hours. With respect to the intraoperative fluid volume, similar results were obtained [odds ratio (95% confidence interval; CI): 0.82 (0.69-0.99) and 0.62 (0.44-0.88) for cut-off points of 7 and 9 h, respectively]. Regarding the caudal block, the trend in the results was consistent [odds ratio (CI): 0.71 (0.40-1.25) and 0.29 (0.10-0.89) for cut-off points of 7 and 9 h, respectively] but the 95% CI became wider when the cut-off time was 7 h. We argue that the consistent results of these sensitivity analyses support the validity of our results. 2. At our hospital, the attending nurse and anesthesiologist independently assessed all patients using a PADSS instrument. Therefore, we think that the bias introduced by unstandardized discharge criteria was minimal. 3. We agree with the comment that the discharge time was very different from that in other studies. As discussed in our article, clinical variations between institutions, such as the surgery type, indications for ambulatory surgery, or discharge criteria, may preclude the application of our results to other institutions. Therefore, our results should be considered as hypothesis-generative findings, and future studies will be needed to investigate whether the potentially modifiable factors in our study, such as intraoperative fluid volume or the type of regional block, could prevent unnecessary extended hospitalization periods and admissions for pediatric patients. - Compliance with ethical standards Conflict of interest The author(s) declare that they have no competing interests. 1. Nishida T , Mihara T , Ka K. Predictors for incidence of increased time spent in hospital after ambulatory surgery in children: a retrospective cohort study . J Anesth . 2017 . https://doi.org/10.1007/ s00540-017-2437-9. (...truncated)


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Takaya Nishida, Takahiro Mihara, Koui Ka. In reply, Journal of Anesthesia, 2018, pp. 310-310, Volume 32, Issue 2, DOI: 10.1007/s00540-018-2473-0