Granulomatous diseases of the breast and axilla: radiological findings with pathological correlation

Insights into Imaging, Feb 2018

Jeffery E. Illman, Simone B. Terra, Allison J. Clapp, Katie N. Hunt, Robert T. Fazzio, Sejal S. Shah, Katrina N. Glazebrook

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Granulomatous diseases of the breast and axilla: radiological findings with pathological correlation

Insights Imaging Granulomatous diseases of the breast and axilla: radiological findings with pathological correlation Jeffery E. Illman 0 1 Simone B. Terra 0 1 Allison J. Clapp 0 1 Katie N. Hunt 0 1 Robert T. Fazzio 0 1 Sejal S. Shah 0 1 Katrina N. Glazebrook 0 1 0 Sanford Broadway Clinic , Fargo, ND , USA 1 Department of Laboratory Medicine and Pathology, Mayo Clinic , Rochester, MN , USA 2 Katrina N. Glazebrook Objectives This article reviews our experience and describes the literature findings of granulomatous diseases of the breast and axilla. Methods After approval of the Institutional Review Board was obtained, the surgical pathological records from January 2000 to January 2017 were searched for the keyword granulomatous. Clinical, imaging and histology findings were reviewed by both a fellowship-trained radiologist and a breastimaging consultant radiologist, reviewing 127 patients (age range, 32-86 years; 126 women and 1 man). Results Most common causes of granulomatous lesions of the breast and axilla included silicone granulomas 33% (n = 42), fat necrosis 29% (n = 37) and suture granulomas 11% (n = 14). In 16% (n = 20), no cause could be found and clinical history was consistent with idiopathic granulomatous mastitis. Other granulomatous aetiologies included granulomatous infections, sarcoidosis and Sjögren's syndrome. Causes of axillary granulomatous disease were similar to the breast; however, a case of cat-scratch disease was found that only involved the axillary lymph nodes. They can have a variable appearance on imaging and may mimic malignancy with irregular masses seen on mammography, ultrasound and magnetic resonance imaging. Fistulas to the skin and nipple retraction can suggest chronicity and a granulomatous aetiology. Breast; Granulomatous mastitis; Mammography; MRI; Ultrasonography - Department of Radiology, Mayo Clinic, Rochester, MN, USA Introduction With Institutional Review Board approval, a search of the surgical pathology records of approximately 17,000 breast biopsies performed at our institution from 1 January 2000 to 1 January 2017 yielded 127 patients (age range, 32– 86 years; 126 women and 1 men) with granulomatous disease of the breast, and their imaging results were available for review by both a fellowship-trained radiologist and breast-imaging consultant radiologist. The search found records of 42 silicone granulomas, 37 fat necrosis, 20 idiopathic granulomatous mastitis, 14 suture granulomas, 1 Corynebacterium, 1 Mycobacterium fortuitum infection, 2 sarcoidosis and 1 Sjögren’s syndrome. Additionally, nine cases of granulomatous lymphadenitis where found: six of which were secondary to granulomatous causes involving the breast (for example, silicone granuloma), one was idiopathic and one patient was diagnosed with cat-scratch disease. A granuloma is the human immune system’s way of Bwalling off^ an offending impurity, be it a foreign body, chronic infection or necrotic fat. A granuloma (Fig. 1) is an organised group of macrophages (mononuclear cells within tissue) associated with a variable amount of lymphocytes. The outer layer of the granuloma consists of lymphocytes, fibroblasts and vessels. Granulomas may also contain additional cells such as neutrophils, eosinophils and fibroblasts, which can provide a clue to the aetiology of the granuloma. Central necrosis may also help determine the cause of the granuloma; infectious granulomas tend to have central necrosis, termed necrotising granulomas (Fig. 1). Central necrosis with a cheese-like appearance has been termed caseating necrosis and is a feature of Mycobacterium tuberculosis infection. A non-caseating granuloma (Fig. 1) can occur with non-infectious causes such as sarcoidosis. Imaging findings can have a variable appearance and may mimic malignancy with irregular masses on mammography, ultrasound and magnetic resonance imaging (MRI), requiring biopsy. The diagnosis can be suggested if correlation is made with clinical history. This article reviews and illustrates the salient imaging features of granulomatous processes of the breast and axilla, including infectious, traumatic, autoimmune, as well as unknown causes (Fig. 2). Infectious causes Most breast infections are bacterial and are usually secondary to skin contamination, with most infections resolving without sequela. Specialised stains are occasionally necessary for specific diagnosis, including Gram, periodic acid-Schiff and Ziehl-Neelsen stains. Overall, chronic infections with granulomatous reactions are rare and a high index of clinical suspicion is necessary. Clinical Clinically patients present with a painful and/or palpable breast mass, often with axillary lymphadenopathy. A discharging sinus tract can be seen if treatment is delayed. The subareolar regions may be relatively spared. Reactive lymphadenopathy may be present in up to 15% of cases. Mammography Imaging features are variable depending on type of infection, but are unable to reliably separate based solely on imaging. Bacterial infections (Corynebacterium, etc.) often present as an erythematous, inflamed breast with skin thickening and complex cystic mass on ultrasound. An irregular hypoechoic mass or vague ill-defined hypoechoic mass with increased vascularity on Doppler evaluation can also be seen. Fungal infections (blastomycosis, cryptococcosis, histoplasmosis, actinomycosis) usually present as a lobulated, irregular or welldefined complex cystic mass sonographically. Less common parasitic infections (filarial, schistosomiasis, sparganosis, echinococcosis) can present with calcifications with or without a mass mammographically. Mycobacterium infections (tuberculous, atypical) present with axillary lymphadenopathy, skin thickening or ill-defined mass, often with sinus tracts and fistulae. Mammographically, tuberculosis can manifest as an ill-defined or irregular mass resembling cancer; however, skin bulging and sinus tracts can suggest tuberculous infection and large, dense, calcified axillary lymph nodes can also be a clue to tuberculous infection. Ultrasound MRI Ultrasonography is useful for evaluation of fistula or sinus tracts, and computed tomography (CT) or MRI is beneficial for assessing for chest wall involvement or invasion (Fig. 3). The coexistence of mammary tuberculosis and breast carcinoma has been reported [ 1, 2 ]. On MRI, the most frequent finding was focal or diffuse asymmetrical signal intensity changes without significant mass effect. Nodular lesions can also be seen with hypointense T1 regions and hyperintense T2 regions. Dynamic contrastenhanced MRI can show mass-like enhancement, ring-like enhancement and/or nodular enhancement, while timeintensity curves can vary. Histology The granulomas can show caseating Bcheesy^ necrosis, and occasionally acid-fast bacilli are found within the central portion of the granuloma [ 1, 2 ]. Caseous necrosis is often encountered in tuberculosis infections but can also be caused by syphilis and certain fungi. A similar appearance can be associated with histoplasmosis, cryptococcosis and coccidioidomycosis. Foreign bodies and traumatic causes Foreign body granuloma arises from reaction to any foreign materials that cannot be broken down, such as silicone, suture material, wood, gunpowder, plastic sewing needle and paraffin. Alternatively, traumatic granulomas originate from any (original magnification x20, hematoxylin-eosin) of a nonnecrotizing granuloma (left) composed of lymphocytes, macrophages, and giant cells and a necrotizing granuloma (right) with central necrosis procedure or injury resulting in fat necrosis. The granulomas that form around fat necrosis are the result of difficulty removing the necrotic fat because of its large size [ 3–6 ]. Silicone Silicone for breast augmentation was initially injected directly into the breast. This procedure was performed in the United States until it was prohibited in the 1970s because of reports of lymphadenopathy, infection, granulomatous masses and fibrosis. Silicone implants were introduced in the 1960s with the theory that the barrier shell would reduce the complications of direct silicone injection. Unfortunately, the shells used in these early implants were semi-porous and allowed small amounts of silicone gel to Bbleed^ without implant rupture. These early implants were also prone to rupture with increasing age, and when they rupture result in large amounts of extracapsular silicone [ 7 ]. The complications of this free silicone were indistinguishable from those of direct silicone injection [ 8 ]. Clinical Patients may present with pain, soreness or swelling in the affected breast, change in breast size or shape, lumps in the affected breast or softening or hardening of the affected breast. Silicone granulomas may present distant from the implant site; primarily, the ipsilateral chest wall and axillary lymph nodes are involved. Ductal extension, with silicone being discharged from the nipple, and pectoralis muscle extension have also been reported [ 9, 10 ]. Mammography On mammography, high-density masses are seen outside the implant margins (Fig. 4) and dense lymph nodes may be seen. Implant asymmetry or irregular contour are less specific signs, but can also be visualized. Ultrasound Ultrasonography shows a Bsnowstorm^ appearance with welldefined echogenicity anteriorly and dirty posterior acoustic shadowing. The lymph nodes may also be echogenic with dirty shadowing. CT MRI Fat necrosis Clinical Dual-energy CT can perform material decomposition, identif y i n g i n t r a c a p s u l a r a n d e xt r a c a p s u l a r r u p t u r e a n d extracapsular silicone [ 11 ]. MRI shows low T1-signal and high T2-signal foci separate from the implant and high-signal foci on silicone-sensitive sequences. Enhancement may be noted if active inflammation or granulomas are present. Most cases of fat necrosis occur postoperatively or after radiation therapy. The condition is typically asymptomatic; however, when it is symptomatic, 97% of patients present with a palpable abnormality. This is usually within a periareolar or superficial location. In a few cases, bruising and tenderness (26%), skin tethering or dimpling (14%) or nipple retraction (9%) occur. Palpable breast abnormalities that are associated with fat necrosis may enlarge, remain unchanged, regress or resolve [ 12, 13 ]. The increasing use of breast-conserving surgery and mammoplasty has given rise to a greater number of cases of fat necrosis. Middle-aged women with pendulous breasts are at the most risk [ 12, 13 ]. Mammography On mammography, the most common findings of fat necrosis are oil cysts, coarse calcifications, focal asymmetries or spiculated masses, but there is a wide spectrum of mammographic imaging findings, ranging from benign to indeterminate to malignant appearing masses and calcifications. Visualised masses may be radiolucent with a thin, well-defined capsule, both radiolucent and dense with encapsulation, dense and sequence demonstrates the same findings of extracapsular free silicone (red arrow) and intact right implant. e Axial post-gadolinium breast MRI showed non-enhancing extracapsular silicone with enhancement surrounding the silicone deposits, consistent with granulomatous inflammation (red arrow). f Histological photomicrograph (magnification ×20, haematoxylin-eosin) showed Bsiliconomas^ with granulomas containing silicone particles (blue star), foreign body–type giant cells (yellow arrow), foamy macrophages and lymphocytes (red arrow) circumscribed, or may have indistinct or spiculated margins. Lipid cysts are pathognomonic of benign fat necrosis, although the fibrous rim of the cyst may collapse and produce an appearance that is mammographically suspicious (Fig. 5). Ultrasound On sonography, the appearance of fat necrosis ranges from a solid hypoechoic mass with posterior acoustic shadowing to complex intracystic masses that evolve over time (Fig. 5). The other common sonographic finding is an area of increased MRI echogenicity in the subcutaneous tissue with or without small cysts and architectural distortion. MRI shows a wide spectrum of appearances depending on the amount of inflammatory reaction, liquefied fat and the degree of fibrosis. The necrotic central fat is isointense or slightly lower signal on saturated T1-weighted images than the remaining fat in the breast. The BBlack hole^ sign of fat necrosis had been described with marked hypointensity on STIR images when compared with surrounding fat. The surrounding fibrosis shows enhancement on post-gadolinium images; the enhancement being most marked in the early stages of fat necrosis and decreasing with time. The enhancement may be thin, thick, irregular or spiculated and may mimic malignancy. Kinetic analysis is of little help in granulomatous fat necrosis as the full spectrum of enhancement patterns can be seen (Fig. 5). CT findings of fat necrosis are not well described but tend to correspond with MRI findings with central fat and peripheral Fig. 5 Fat necrosis. A 48-yearold woman with prior bilateral prophylactic mastectomies and implant reconstruction presented with a palpable abnormality on the inner aspect of the right breast. a Mammography showed new grouping of pleomorphicappearing calcifications with associated irregular mass in the upper outer quadrant of the left breast (red arrow). b Ultrasound showed a heterogeneous, complex, cystic and solid oval mass with no vascularity. c Postcontrast axial MRI showed mild peripheral enhancement with central, non-enhancing fat consistent with benign fat necrosis (red arrow). d Histological photomicrograph (original magnification ×10, haematoxylin-eosin) showed calcification (blue star), vacuolisation and saponification of the remnants of the necrotic fat (red arrow), epithelioid macrophages and lymphocytes (yellow arrow). Normal fat is also visualised (green arrow) enhancement if contrast is given. The fibrosis has attenuation values similar to fibroglandular tissue or linear densities resembling fibrous bands. Calcifications occasionally are seen on CT [ 14 ]. Histology Histologically, fat necrosis within the breast occurs when there is vacuolisation and saponification of the remnants of the necrotic fat, which become surrounded by lipid-laden macrophages, multinucleated giant cells and acute inflammatory cells. Fibrosis develops, enclosing the area of necrotic fat and cellular debris [ 12, 13, 15 ] (Fig. 5). Autoimmune causes Although rare, granulomatous reactions to autoimmune disease have been reported in the breast including Rheumatoid disease [ 16 ], Granulomatosis with polyangiitis [ 17 ] and Sjögren’s syndrome [ 18 ]. Sjögren’s syndrome Clinical Sjögren’s syndrome is an autoimmune disease typically affecting the salivary glands and often presents with dry eyes and mouth. Non-glandular manifestations are reported and are likely related to lymphocytic infiltration vasculitis. There is a female preponderance for Sjögren’s syndrome, and the incidence in the general population is 0.1–0.6%. There is a bimodal age distribution; peaks occur between 20 and 30 years and between 50 and 55 years. Those affected by Sjögren’s syndrome have a 5% increased risk for development of lymphoma, 18.9 times higher than that in the general population [ 19 ]. Mammography/US To our knowledge, the mammographic and ultrasound findings of Sjögren’s syndrome of the breast have not been described. Our case shows a mass with ill-defined margins on mammography and an oval, hyperechoic mass with illdefined margins, posterior shadowing, and absent vascularity on ultrasound (Fig. 6). Histology Histologically, Sjögren’s syndrome shows a chronic lymphocytic infiltration and is occasionally associated with granulomatous mastitis [ 18, 20 ]. Granulomas of unknown cause Idiopathic granulomatous mastitis As the name suggests, the cause of idiopathic granulomatous mastitis is unknown. This condition is more common in pregn a n t a n d l a c t a t i n g w o m e n a n d i n p a t i e n t s w i t h hyperprolactinaemia and may be related to increased ductal secretions. These increased ductal secretions may lead to damaged ductal epithelium with glandular secretions leaking into the connective tissue of the breast stroma. This process results in a chemical mastitis [ 21 ]. Clinical Interestingly, the majority of patients are from developing countries, and further investigation into the geographic disparity may be helpful towards elucidation of a cause [ 22 ]. Idiopathic granulomatous mastitis may present in any part of the breast but tends to spare the subareolar regions. It Fig. 6 Autoimmune cause: Sjögren’s syndrome. A 61-year-old woman with Sjögren’s syndrome was positive for anti-Ro/Sjögren’s syndrome antigen A antibody. a Mammographic right craniocaudal with craniocaudal spot compression views showed a mass with ill-defined margins at the 2 o’clock position of the right breast (red arrow). b Ultrasound of the right breast showed an oval, hyperechoic mass with ill-defined margins, posterior shadowing and absent vascularity. Ultrasound-guided biopsy showed non-necrotising granulomatous inflammation (not shown). Fungal and acid-fast bacilli stains were negative, and angiotensin-converting enzyme and immunoglobulin G4 levels were normal. The patient received treatment for Sjögren’s syndrome, and the mass was no longer present at 6-month follow-up examination generally manifests as a distinct, firm mass (Fig. 7). Reactive lymphadenopathy may occur in up to 15% of patients [ 22 ]. Idiopathic granulomatous mastitis is frequently aggressive and demonstrates features of infectious mastitis or inflammatory carcinoma. The diagnosis is often delayed and treatment is often difficult and prolonged. The prognosis of idiopathic granulomatous mastitis is variable, and local recurrence has been reported. If the disease is localised, corticosteroid therapy has been proved effective. If it is diffuse and unresponsive to medical treatment, mastectomy may be required [ 22–25 ] (Fig. 7). Some species of Corynebacterium have been implicated as a cause for idiopathic granulomatous mastitis, although, strictly speaking, idiopathic granulomatous mastitis should contain no bacteria on microbiology or histology specimens [22] (Fig. 8). MRI Mammography Mammography shows variable features, ranging from normal-appearing in patients with dense breast tissue to discrete masses. There is often focal or regional asymmetry, solitary mass or masses, skin thickening, skin or nipple retraction and axillary lymphadenopathy. The affected breast is larger than the contralateral breast and calcifications are exceedingly rare. The mammographic appearance can be indistinguishable from invasive or inflammatory breast cancer. Ultrasound On ultrasonography, multiple contiguous hypoechoic masses have been considered suggestive of the disease with skin fistulae common in advanced cases. Posterior acoustic enhancement and shadowing have both been described. Doppler imaging demonstrates increased vascularity and in advanced cases fluid collections and cavities can be seen. Ultrasound is useful in documenting sinus tracts and in the evaluation of any enlarged axillary reactive lymph nodes. MRI is indicated to assess the extent of disease and in assessment of the contralateral breast. It is best reserved for advanced, aggressive or refractory disease and can be used to assess disease progression or regression over time. The MRI findings are variable depending on the severity of the inflammation, with both heterogeneous ill-defined masses and non-mass enhancement being described [ 22 ]. Idiopathic granulomatous mastitis demonstrates marked parenchymal enhancement most often with progressive or plateau kinetics. There are often areas of increase T2 signal representing fluid collections. The involved parenchyma demonstrates restricted diffusion with ADC valves consistently lower than seen in normal breast parenchyma [ 22 ]. Histology On histopathologic examination, non-caseating granulomatous inflammation is centred on lobules. Common end-stage features of idiopathic granulomatous mastitis a r e f a t n e c r o s i s , a bs c e s s f o r m a t i o n a nd f i b r os i s [ 22, 26, 27 ]. Fig. 7 Idiopathic granulomatous mastitis. A 30-year-old woman in the second trimester of pregnancy had a tender lump in the right breast. She had first noticed a lump in the upper outer right breast approximately 2 months previously, and it had increased in size. On physical examination, there was a 10 × 10-cm firm mass in the upper outer quadrant. Biopsies showed acute and chronic granulomatous inflammation with micro-abscesses. All cultures were negative. a Photographs of open wounds that developed after biopsy (left) but healed with antibiotics but no steroids (right). b Ultrasound showed a large hypoechoic irregular mass with draining sinus tract (red arrow). c Axial post-contrast MRI showed diffuse parenchymal enhancement with micro-abscesses (red arrow) Sarcoidosis Clinical The aetiology of sarcoidosis is unknown, and usually the lungs, lymph nodes, skin, spleen, and liver are involved. Breast involvement is rare, occurring in less than 1% of patients with systemic sarcoidosis. Mammary lesions are usually detected after the diagnosis of sarcoidosis has already been well established, and only rarely does sarcoidosis present initially as a breast disease. Like sarcoidosis elsewhere, it usually affects women in their 20s and 30s and can manifest as a firm, hard mass mimicking breast cancer or lymphadenopathy. In 20% of reported cases of sarcoidosis of the breast, the initial presentation is a breast mass. The characteristic clinical finding is a non-tender, mobile breast mass with other organ involvement and an increased level of angiotensin-converting enzyme [ 3–5, 28 ]. Mammography On mammography, breast sarcoidosis can present as bilateral, irregular or spiculated masses (Fig. 9). Very small, welldefined round masses have also been described and may Fig. 9 Sarcoidosis. A 72-year-old woman had a prior skin biopsy showing sarcoidosis. a Bilateral mediolateral-oblique views and magnification view show multiple spiculated masses in both breasts. These had been unchanged for 5 years. b Positron emission tomography showed multiple areas of increased uptake in mediastinal and axillary lymph nodes. Histopathological examination of left breast ultrasound-guided biopsy specimens showed non-caseating granulomas consistent with sarcoidosis (not shown) MRI Ultrasound represent i ntramammary lymph node involvement. Calcifications are typically not seen. Histology Irregular, hypoechoic masses with indistinct margins are the most common finding on ultrasonography. Va r i o u s a p p e a r a n c e s h a v e a l s o b e e n o b s e r v e d . Inhomogeneous signal intensity masses with irregular contours, rapid enhancement and early Bwashout^ are most common [ 5, 6, 28 ]. PET/CT Increased uptake on positron emission tomography can cause sarcoidosis to be mistaken for metastatic breast carcinoma (Fig. 9). It is important for clinicians and radiologists to be aware that imaging findings and systemic manifestations of sarcoidosis can be confused with those of metastatic breast cancer [ 29, 30 ]. Fig. 10 Granulomatous lymphadenitis. A 44-year-old woman had a tender lump in the right axillary region with recurrent draining sinuses. a Mammography showed a predominantly calcified right axillary mass with irregular mass and associated skin thickening. b Ultrasound showed multiple hypoechoic round and irregular masses in right axilla, some with calcifications (yellow arrow). c CT showed the calcified right axillary lymph node (yellow arrow) and sinus tract (red arrow). d Gross pathological specimen showed organising abscess with acute inflammation and fat necrosis. Special stains for bacteria, fungi and mycobacteria were negative Gross pathological findings consist of firm to hard, tan tissue that may have well-defined or indistinct borders and can measure up to 5 cm in diameter. Microscopic examination shows epithelioid granulomas with multinucleated giant cells. The lesions classically do not have caseous necrosis or calcification, and fat necrosis is not found in the surrounding breast. Associated lymphocytes and fibrosis are often present. Not all non-necrotising granulomas are sarcoidosis; however, other causes of non-necrotising granulomas need to be excluded. The diagnosis requires exclusion of these other causes and often clinical evidence of sarcoidosis elsewhere. Stains and cultures for bacteria, mycobacteria and fungus should be negative. These studies are indicated even in patients with previously diagnosed sarcoidosis, because secondary infections can develop, especially in patients who have had corticosteroid treatment. Axillary lymph nodes Granulomatous lymphadenitis The causes of granulomas within axillary lymph nodes are similar to the causes of granulomas within the breast parenchyma. Lymph node granulomas are often classified into infectious or non-infectious causes. Non-infectious causes of granulomatous lymphadenitis include sarcoidosis, berylliosis and sarcoid-like reaction, and these are rarely associated with abscesses or necrosis [ 31 ]. Infectious granulomatous lymphadenitis can be further categorised as suppurative or non-suppurative. Suppurative infections are associated with central abscesses, necrosis and granulomas and include tularaemia, cat-scratch disease, yersiniosis and lymphogranuloma venereum. Patients present with tenderness, erythema, swelling and abscess formation. Alternatively, non-suppurative infectious granulomatous lymphadenitis shows no signs of inflammation and results in Bcold^ abscesses. Causes of non-suppurative infections include tuberculous, atypical mycobacterium, toxoplasmosis, syphilis, brucellosis or various fungal infections [ 31 ]. Mammography/ultrasound On imaging, the findings of granulomatous lymphadenitis are non-specific and can mimic those of metastatic adenopathy. Mammographically and sonographically, lymph nodes may appear enlarged, round and of high density, and are commonly thickened with loss of their fatty hilum [ 31 ]. Occasionally these lymph nodes calcify (Fig. 10). Cat-scratch disease Although granulomatous lymphadenitis of the axilla has multiple causes, only a few specifically have a preference for the axilla and typically spare the breast parenchyma. Cat-scratch disease, or cat-scratch fever, is one of those processes. It is caused by a bacterial infection and most commonly occurs in children after a cat scratches or bites an arm [ 12 ]. It has worldwide distribution and has been described in all areas of North America. In northern temperate zones, it occurs more often from August through October, usually in humid, warm locales. There are an estimated 22,000 new cases of catscratch disease per year in the United States [ 32 ]. Clinical Cat-scratch disease is usually limited to one side of the body and commonly presents as tender, swollen lymph nodes near the site of the bite or scratch. Regional lymphadenopathy occurs 1–3 weeks after inoculation. A vesicle or an erythematous papule may form at the site of initial infection, and regional lymphadenopathy (85%), axillary lymphadenopathy (27%), and fever, headache and malaise (77%) often develop. It may take 7–14 days before symptoms appear, and most cases are self-limited, resolving within 1 month with or without treatment. The lymphadenopathy may, however, persist for several months after the other symptoms have disappeared [ 33 ]. Clinical and imaging findings of granulomatous processes of the breast and axilla Imaging Mammo: serpiginous calcifications seen with parasitic infection US/MRI: lymphadenopathy, skin thickening, ill-defined mass, often with sinus tracts and fistulae Mammo: lipid cysts or dystrophic calcifications US/MRI/CT: fat seen within the centre of mass Mammo: Suture knots seen on mammography Mammo: high-density silicone on mammography US: snow storm on US MRI: high-signal on silicone-sensitive sequences CT: dual-energy CT identifying silicone Mammo: bilateral ill-defined or irregular masses US: Bilateral irregular hypoechoic masses Mammo/US: bilateral masses, asymmetry or architectural distortion [18F]-FDG-PET: Increased uptake Mammo/US: solitary mass, skin thickening and nipple retraction MRI: marked parenchymal enhancement with sterile micro-abscesses Mammo/US: lymph nodes enlarged and round Fistula to skin Infectious ANA antinuclear antibody, ANCA antineutrophil cytoplasmic antibody, ACE angiotensin-converting enzyme, FDG-PET fluorodeoxyglucose positron emission tomography, GPA granulomatosis with polyangiitis, IGM idiopathic granulomatous mastitis, Mammo mammography, RF rheumatoid factor, US ultrasound Lymph nodes are enlarged on mammography. On ultrasound they are hypoechoic lobular or oval masses with central hyperaemia and occasional adjacent fluid. The presence of asymmetry and a hyperechoic hilum may differentiate catscratch disease from other aetiologies (Fig. 11). Cat-scratch disease is characterised by granulomatous inflammation on histological examination of the lymph nodes. Breast parenchymal involvement occurs less commonly; when it does, it presents as a palpable mass with enlarged lymph nodes within the axilla in 38% of patients [ 33 ]. Conclusions Granulomatous processes of the breast and axilla are rare with variable imaging findings that can mimic malignancy. The diagnosis can, however, be made if there is relevant history (prior trauma, silicone breast implants, lactation), laboratory (systemic or infectious processes) and imaging findings (fistula, nipple retraction) (Table 1). Granulomatous breast disease commonly presents with a unilateral breast mass, and axillary lymphadenopathy can be seen. Fistula formation can suggest a granulomatous cause—either infectious or idiopathic granulomatous mastitis. Mammographic findings include asymmetric density or an ill-defined mass. Sonographic findings commonly demonstrate an irregular hypoechoic mass or masses with s p e c i f i c f i n d i n g s f o r g r a n u l o m a s , i n c l u d i n g : t h e Bsnowstorm^ appearance seen with extracapsular silicone; ill-defined confluent hypoechoic areas with marked vascularity and sinus tracts to the skin, as well as adjacent fluid collections, seen with Mycobacterium infections and idiopathic granulomatous mastitis; circumscribed hypoechoic masses with or without surrounding hyperechogenicity, which can be found with fat necrosis. MRI is beneficial in evaluation of the extent of disease and may demonstrate peripheral enhancement and abscess formation as the granuloma tries to wall-off the inciting antigen. 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Jeffery E. Illman, Simone B. Terra, Allison J. Clapp, Katie N. Hunt, Robert T. Fazzio, Sejal S. Shah, Katrina N. Glazebrook. Granulomatous diseases of the breast and axilla: radiological findings with pathological correlation, Insights into Imaging, 2018, 59-71, DOI: 10.1007/s13244-017-0587-9