Corrigendum: Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent

Carcinogenesis, Jan 2017

Chu, Po-Chen, Kulp, Samuel K, Chen, Ching-Shih

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Corrigendum: Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent

Carcinogenesis Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent Po-Chen Chu Samuel K.Kulp Ching-Shih Chen - The authors of the manuscript referenced above wish to inform readers of corrections to Figs. 2A, 2F, and 8A in response to issues recently brought to the attention of the authors. In the original Fig. 2, the image of the blot of Sp1 in Fig. 2A is the same as the Sp1 blot in the left panel of Fig. 2F, resulting from the unintentional incorporation of the same image in two different figure panels. In the western blot panel of the immunoprecipitation experiment shown in the origi nal Fig.  8A, an inconsistency between the background of the blot and the area surrounding the bands in lanes 4 and 5 was detected. Attempts to identify the correct Sp1 blot for each of the figure panels in Fig. 2 and to verify the data in Fig. 8 were unsuccessful as the original films of these blots could not be located. Consequently, the experiments were repeated by an individual in the corresponding author’s laboratory who was not involved in the conduct of the experiments reported in the original article. The new results are essentially identical to those acquired previously and lead to the same conclusions reported in the original article. The corrected figure panels containing this new data are shown below. The authors regret the error in Fig.  2A and the anomaly in Fig. 8A, which they cannot explain, and apologize for not ident-i fying these issues earlier in the publication process. The authors appreciate and acknowledge the contribution of Dr. Hsiao-Ching Chuang, who repeated the experiments. Corrected Fig. 8A:


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Chu, Po-Chen, Kulp, Samuel K, Chen, Ching-Shih. Corrigendum: Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent, Carcinogenesis, 2017, 105-106, DOI: 10.1093/carcin/bgw117