Chia-Chen Tan and genetics in modern China

Protein & Cell, Apr 2018

Lei Fu

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Chia-Chen Tan and genetics in modern China

Chia-Chen Tan and genetics in modern China Lei Fu 0 1 0 Chia-Chen Tan (谈家桢, 1909-2008) was one of the most important founders of genetics in modern China and made great effort to the internationalization of Chinese genetics (Fig. 1). Chia-Chen Tan was born on 1 Zhejiang Normal University , Jinhua 321004 , China - during war times, he continued his researches on genetics of lady-bird and fruit flies. It was in this period that he made world-famous discovery about mosaic dominant inheritance of color patterns in the lady-bird beetles, which is still a classical example in modern genetics textbooks. In 1940s, he went to USA again to continue his research on mosaic dominance in the inheritance of color patterns in the ladybird beetles, which had a significant impact on international genetics (Tan, 1946) . He considered lady-bird beetles as good model of micro-evolution. Tan figured out the genetic maps of autosomes in Drosophila pseudoobscura when he was in Morgan’s lab. Then he proved how gene evolved through repetition and differentiation by investigating the nature of the race-differential chromosomes in Drosophila montium (Tan, 1942) . From 1960s he paid attention to radiation cytogenetics. His team chose Macaca mulatta as experimental material and tested the effect of X-ray and γray to Macaca mulatta. They expanded their research to environmental toxicology which was pioneering in China. Later in his life, Tan suggested the government supporting researches on human genome for the sake of protection of l l e C & n i e t o r P Chinese human gene resources. Thanks to his advice, China established two national genome research centers. In his 70 years of teaching and researching, Tan published more than 100 articles, which are valuable treasure for science. Tan served as president of the Genetics Society of China, Chinese Environmental Mutagen Society and Chinese Society of Biotechnology and made substantial contributions to the development of the related disciplines. Chia-Chen Tan participated actively in international cooperation. He was the first to introduce the term “gene” to China. As early as 1945–1946, he went to USA again as visiting professor. In 1948 he was elected member of council of the 8th International Congress of Genetics. After a few decades, he visited America in 1978 and introduced the progress of genetics in China. And then he invited several American professors to China to lecture on molecular genetics. From 1980s to 1990s more and more scientists from America and Europe came to China for academic communication at his invitation. He was the leading proponent and chairman of the 18th International Congress of Genetics held in Beijing in 1998. Besides, more and more Chinese scholars went abroad for further research under his aid. He was awarded outstanding alumni by California Institute of Technology, Honorary Doctoral Degree by York University, Canada and Honorary Fellow of Japanese Society of Genetics. He was member of National Academy of Sciences of USA, Lincean Academy of Italy and The Third World Academy of Sciences (Zhao,1998) . Under efforts of Chia-Chen Tan and other excellent scientists, Chinese genetics and other sciences became known to the world. Chia-Chen Tan devoted himself to science education and cultivated several distinguished graduate students including Shi Lvji (施履吉), Sheng Zujia (盛祖嘉), Liu Zudong (刘祖洞), Xu Daojue (徐道觉) and so on. He considered the basics of knowledge, theories and experimental skills important for students. He supported his students to go abroad for further studies. More than that, He invited most of them to come back to work in China. He was continuously keen on science popularization and wrote several books and articles for public, such as Secret of Life, Gene and Heredity, Mendel and His Science Career, A Biography for Biologists in Modern China and so on, in which he laid stress on history of science and technology. Chia-Chen Tan is a world-renowned scientist. In 1999 the No. 3542 asteroid discovered by Purple Mountain Observatory, Chinese Academy of Sciences in 1964 was named 3542 Tanjiazhen, which is in honor of Chia-Chen Tan’s contribution to science. OPEN ACCESS This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Tan CC ( 1946 ) Mosaic dominance in the inheritance of color patterns in the lady-bird beetles Harmonia axyridis . Genetics 31 : 195 - 210 Tan CC ( 1942 ) The nature of the race-differential chromosomes in Drosophila montium De Meijere . Sci Rec 1 : 178 - 187 Zhang H (2017) Professor Ju-Chi Li, one of the pioneers and founders of modern genetics in China. Protein Cell . https://doi. org/10.1007/s13238-017-0487-2 Zhao G ( 1998 ) Geneticist Chia-Chen Tan . J Dialect Nat 20 ( 6 ): 60 - 72 (赵功民.智者魅力 学界楷模──遗传学家谈家桢[J]. 自然辩证法通 讯 , 1998 (第6期): 60 - 72 )

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Lei Fu. Chia-Chen Tan and genetics in modern China, Protein & Cell, 2018, 1-2, DOI: 10.1007/s13238-018-0539-2