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Involvement of Cytokines in the Pathogenesis of Hypersensitivity Pneumonitis: Evaluation of Immunotherapeutic Measures in a Mouse Model

C57BL/6 inbred strain mice were instilled intranasally with 150 μg/day of the actinomycete Faeni rectivirgula three days a week as a model of farmer's lung disease. Instilled mice developed a strong alveolitis manifested by a large increase in the number of cells in the bronchoalveolar lavage (BAL) (4.1 x 104 cells in saline controls versus 5.28x 105 cells in F rectivirgula...

Comprehensive Assessment of Degradation Behavior of Simvastatin by UHPLC/MS Method, Employing Experimental Design Methodology

This manuscript describes comprehensive approach for assessment of degradation behavior of simvastatin employing experimental design methodology as scientific multifactorial strategy. Experimental design methodology was used for sample preparation and UHPLC method development and optimization. Simvastatin was subjected to stress conditions of oxidative, acid, base, hydrolytic...

Winnowing the Chaff of Charlatanism from the Wheat of Science

Experts and lay people alike can sometimes find it difficult to demarcate the absurd. Here I propose a set of criteria that may be helpful in achieving this in the realm of healthcare: falsifiability, plausibility and some hallmarks of pseudoscience. Applying this method is unlikely to be fool-proof but it might be a valuable aid in discriminating credible from incredible health...

Exploratory Investigation on Functional Significance of ETS2 and SIM2 Genes in Down Syndrome

Trisomy of the 21st chromosome leads to an over dosage of several regulatory genes in Down syndrome (DS). Though allelic and genotypic combinations formed between genes are interesting, till date, this particular area has never been explored in DS. In the present investigation four SNPs in two transcription factors, Single minded 2 (SIM2) and V-ets erythroblastosis virus E26...

Spatial Tumor-Immune Modeling

In this paper, we carry out an examination of four mechanisms that can potentially lead to changing morphologies in a growing tumor: variations in nutrient consumption rates, cellular adhesion, excessive consumption of nutrients by tumor cells and immune cell interactions with the tumor. We present numerical simulations using a hybrid PDE-cellular automata (CA) model...

Rapid Modulation of Distributed Brain Activity by Transcranial Magnetic Stimulation of Human Motor Cortex

This paper reviews the effects of single and repetitive transcranial magnetic stimuli (rTMS) delivered to one cortical area and measured across distributed brain regions using electrophysiological measures (e.g. motor thresholds, motor evoked potentials, paired-pulse stimulation), functional neuroimaging (including EEG, PET and fMRI) and behavioural measures. Discussion is...

Fifty Shades of Sarcoidosis: A Case Report of Löfgren Syndrome

INTRODUCTION Sarcoidosis is a multi-organ disorder that is characterized by the presence of noncaseating granulomas in involved organs. It commonly affects young and middle-aged individuals of all races, but is 3-4 times more common in African Americans and typically presents earlier with more severe symptoms.1 The lungs are affected in 90% of patients and pulmonary disease...

Evaluation of the SpO2/FiO2 ratio as a predictor of intensive care unit transfers in respiratory ward patients for whom the rapid response system has been activated

Efforts to detect patient deterioration early have led to the development of early warning score (EWS) models. However, these models are disease-nonspecific and have shown variable accuracy in predicting unexpected critical events. Here, we propose a simpler and more accurate method for predicting risk in respiratory ward patients. This retrospective study analyzed adult patients...

Surface integrals approach to solution of some free boundary problems - II

This paper is a continuation of the publication [1] where integral equation techniques were applied to the solution of a generalized Stefan problem. The regularization of the corresponding system of nonlinear integral Volterra equations offered here is quite different from that in [1], hence - several new algorithms and numerical experiments. For consistency and easy reference we...

A 2D finite element procedure for magnetic field analysis taking into account a vector Preisach model

The main purpose of this paper is to incorporate a refined hysteresis model, viz. a vector Preisach model, in 2D magnetic field computations. To this end the governing Maxwell equations are rewritten in a suitable way, which allows to take into account the proper magnetic material parameters and, moreover, to pass to a variational formulation. The variational problem is solved...

Inner functions in QK type spaces

Inner functions in QK(p,q) are studied, provided K satisfies certain regularity conditions. In particular, it is shown that the only inner functions in QK(p,  p-2),   p≥1, are precisely the Blaschke products whose zeros {zn} satisfy sup⁡a∈D∑K(1-|φa(zn)|2)<∞.

Tactile Sensory Dysfunction in Children with ADHD

Objectives: While a group of children with ADHD may have normal behavioral responses to sensory stimuli, another group may be hyperreactive. The aim of this survey was studying association of tactile sensory responsivity with co-morbidity of oppositional defiant disorder (ODD) symptoms, subtypes of ADHD, and gender in children with ADHD.

Animal-Assisted Activity at A. Meyer Children's Hospital: A Pilot Study

The authors systematically studied the introduction of animal-assisted activity into a children's hospital in Italy. This pilot study examined the reactions of children, their parents and the hospital staff and the hospital-wide infection rate before and after the introduction of animals. The SAM (self-assessment manikin), three behavioral scales, analysis of children's graphic...

Biliary Sphincter Balloon Dilation: Who, When and How?

Biliary sphincter balloon dilation for biliary stone removal was introduced in 1983. In the early 1990s, several groups studied this technique further. The success rate of stone removal is comparable with that of endoscopic sphincterotomy in patients with fewer than three stones that are less then 1 cm in diameter. Fewer complications after balloon dilation than after endoscopic...

Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies

The incidence and prevalence of diabetes mellitus is rapidly increasing worldwide at an alarming rate. Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes, accounting for approximately 90–95% of the total diabetes cases worldwide. Besides affecting the ability of body to use glucose, it is associated with micro-vascular and macro-vascular complications...

Impulsive nonlocal nonlinear parabolic differential problems

The aim of the paper is to prove a theorem about a weak impulsive nonlinear parabolic differential inequality together with weak impulsive nonlocal nonlinear inequalities. A weak maximum principle for an impulsive nonlinear parabolic differential inequality together with weak impulsive nonlocal nonlinear inequalities and an uniqueness criterion for the existence of the classical...