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Proline isomerization in the C-terminal region of HSP27

In mammals, small heat-shock proteins (sHSPs) typically assemble into interconverting, polydisperse oligomers. The dynamic exchange of sHSP oligomers is regulated, at least in part, by molecular interactions between the α-crystallin domain and the C-terminal region (CTR). Here we report solution-state nuclear magnetic resonance (NMR) spectroscopy investigations of the conformation ...

Imitating the brain with neurocomputer a “new” way towards artificial general intelligence

To achieve the artificial general intelligence (AGI), imitate the intelligence? or imitate the brain? This is the question! Most artificial intelligence (AI) approaches set the understanding of the intelligence principle as their premise. This may be correct to implement specific intelligence such as computing, symbolic logic, or what the AlphaGo could do. However, this is not ...

Fallow replacement and alternative nitrogen management for reducing nitrate leaching in a semiarid region

Nitrate (NO3 −) leaching into groundwater is a growing global concern for health, environmental, and economic reasons, yet little is known about the effects of agricultural management practices on the magnitude of leaching, especially in dryland semiarid regions. Groundwater nitrate–nitrogen (nitrate–N) concentrations above the drinking water standard of 10 mg L−1 are common in the ...

Effect of bone marrow-derived mesenchymal stem cells and stem cell supernatant on equine corneal wound healing in vitro

Background We aimed to determine and compare the in vitro effects of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) and mesenchymal stem cell supernatant (MSC-Sp) on the wound healing capacity of equine corneal fibroblasts using a scratch assay. Methods Bone marrow aspirates and eyes were collected from normal, euthanized horses with subsequent isolation and ...

Von der sozialen Neuzusammensetzung zur gewerkschaftlichen Erneuerung? MigrantInnen als Zielgruppe der österreichischen Gewerkschaftsbewegung

Der Beitrag fragt danach, wie sich österreichische Gewerkschaften und Arbeiterkammern beim Versuch, MigrantInnen als Zielgruppe zu erreichen, verändern. Diese Fragestellung wird ausgehend von konkreten Einrichtungen der solidarischen Beratungs- und Unterstützungsarbeit behandelt, wie sie von ArbeitnehmerInnenorganisationen mit Blick auf die besonderen Interessen und Bedürfnisse von ...

Multi-Layer SnSe Nanoflake Field-Effect Transistors with Low-Resistance Au Ohmic Contacts

We report p-type tin monoselenide (SnSe) single crystals, grown in double-sealed quartz ampoules using a modified Bridgman technique at 920 °C. X-ray powder diffraction (XRD) and energy dispersive X-ray spectroscopy (EDX) measurements clearly confirm that the grown SnSe consists of single-crystal SnSe. Electrical transport of multi-layer SnSe nanoflakes, which were prepared by ...

Magnetocaloric effect of LaFe11.35Co0.6Si1.05 alloy

The aim of the present paper was to study the large magnetocaloric effect observed in LaFe11.35Co0.6Si1.05 alloy. X-ray diffraction (XRD) result reveals a coexistence of two crystalline phases: a dominant La(Fe,Si)13-type and a minor α-Fe(Co,Si). It is confirmed by the Mössbauer spectroscopy and microstructural observations accompanied by an energy-dispersive spectroscopy (EDS) ...

Structural reforms in the euro area: a Greek view

Events in recent years have put the European economic integration project and the euro under pressure. The main cause of the euro crisis is loss of competitiveness, particularly on the periphery of the Economic and Monetary Union. To reverse this, Union members must promote structural reforms that increase long-term employment, productivity and external competitiveness. The ...

Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes

Background Skeletal muscle is one of the primary tissues involved in the development of type 2 diabetes (T2D). The close association between obesity and T2D makes it difficult to isolate specific effects attributed to the disease alone. Therefore, here we set out to identify and characterize intrinsic properties of myocytes, associated independently with T2D or obesity. Methods We ...

Systemic Therapy for Soft Tissue Sarcoma: Proposals for the Optimal Use of Pazopanib, Trabectedin, and Eribulin

Soft tissue sarcoma (STS) is a rare tumor with more than 50 histologic subtypes. Although treatment outcomes for patients with STS have improved greatly over the past few decades owing to the adoption of a multidisciplinary approach, patients with advanced disease have a poor prognosis. The development of anticancer drugs has been directed toward improving overall survival (OS). ...

Improving care for people with heart failure in Uganda: serial in-depth interviews with patients’ and their health care professionals

Background The short prognosis of patients with advanced heart failure (HF) and the associated multidimensional distress as illustrated in literature from high income countries necessitates the integration of palliative care into the care of advanced HF patients to address these needs and improve their quality of life. These needs, which are subjective, have not been described from ...

Direct reprogramming of fibroblasts into cardiomyocytes

Cardiovascular diseases are the leading causes of death in the world. The limited regenerative capacity of adult cardiomyocytes is the major barrier for heart regeneration. After myocardial infarction, myofibroblasts are the dominant cell type in the infarct zone. Therefore, it is a good idea to reprogram terminally differentiated myofibroblasts into cardiomyocyte-like cells ...

Biocompatibility of Liposome Nanocarriers in the Rat Inner Ear After Intratympanic Administration

Liposome nanocarriers (LPNs) are potentially the future of inner ear therapy due to their high drug loading capacity and efficient uptake in the inner ear after a minimally invasive intratympanic administration. However, information on the biocompatibility of LPNs in the inner ear is lacking. The aim of the present study is to document the biocompatibility of LPNs in the inner ear ...

Proteomic analysis of the phycobiliprotein antenna of the cryptophyte alga Guillardia theta cultured under different light intensities

Plants and algae have developed various light-harvesting mechanisms for optimal delivery of excitation energy to the photosystems. Cryptophyte algae have evolved a novel soluble light-harvesting antenna utilizing phycobilin pigments to complement the membrane-intrinsic Chl a/c-binding LHC antenna. This new antenna consists of the plastid-encoded β-subunit, a relic of the ancestral ...

‘Sending them beyond the Sea’: Andrew Marvell, the Earl of Clare, and Tutoring in the Restoration

Going ‘beyond the sea’ was an important part of education in the seventeenth century. We know that Marvell traveled extensively in Europe as a tutor in the 1640s, and with William Dutton in the 1650s. Marvell’s career as a tutor has received a good deal of attention from modern scholars. Thanks to Nigel Smith’s recent biography and Nicholas von Maltzahn’s chronology of Marvell’s ...

Dissecting microsatellite instability in colorectal cancer: one size does not fit all

Microsatellite instability (MSI) marks distinct subsets of tumors in many cancer types and is caused by mutations in genes required for mismatch repair. A recent report analyses the molecular foundations of MSI-positive colorectal cancers and reveals substantial molecular heterogeneity, which might have consequences for the potential use of immunotherapy in MSI-positive cancers. ...

Lipid levels and risk of venous thrombosis: results from the MEGA-study

The relationship between lipid levels and risk of venous thrombosis is not well established. We aimed to assess the association between several lipids and risk of venous thrombosis using data from a population-based case–control study, and to evaluate the underlying mechanism, considering confounding by common risk factors and mediation via hemostatic factors and C-reactive ...

IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes

Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immune-system to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent T-cell lineage from common T cell precursors in the thymus. In this organ, their ...

Synthesis of Pyridinic-Rich N, S Co-doped Carbon Quantum Dots as Effective Enzyme Mimics

N and S co-doped carbon quantum dots (N, S-CQDs) with high N- and S-doping level were synthesized by microwave solid-phase pyrolysis within 50 s. Owing to the dominant pyridinic N injection into the conjugated framework, both high enzyme mimics catalytic activity and photoluminescence quantum yield are achieved simultaneously.

The impact of human adipose tissue-derived stem cells on breast cancer cells: implications for cell-assisted lipotransfers in breast reconstruction

Background In this study we evaluated the interactions of human adipose tissue-derived stem cells (ADSCs) and different human breast cancer cell lines (BRCAs) with regard to the safety of cell-assisted lipotransfers for breast reconstruction and a thereby unintended co-localization of ADSCs and BRCAs. Methods ADSCs were co-cultured with five different human BRCAs (MCF-7, ...