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An antibody with Fab-constant domains exchanged for a pair of CH3 domains

We have designed a complete antibody-like construct where the CH1 and Cκ domains are exchanged for a pair of the CH3 domains and efficient pairing of the heavy and light variable domain is achieved using “Knobs-into-Holes” strategy. This construct, composed of only naturally occurring immunoglobulin sequences without artificial linkers, expressed at a high level in mammalian cells, ...

Implementation fidelity of a clinical medication review intervention: process evaluation

Background Implementation of clinical medication reviews in daily practice is scarcely evaluated. The Opti-Med intervention applied a structured approach with external expert teams (pharmacist and physician) to conduct medication reviews. The intervention was effective with respect to resolving drug related problems, but did not improve quality of life. Objective The objective of ...

Ethnicity and nationality among Ethiopians in Canada’s census data: a consideration of overlapping and divergent identities

This article addresses the intersection of ‘homeland’ politics and diaspora identities by assessing whether geopolitical changes in Ethiopia affect ethno-national identifications among Ethiopian-origin populations living abroad. Officials in Ethiopia’s largest ethnically-defined states recently began working to improve diaspora-homeland relations, historically characterised by ...

Characterization of carbon nanofiber (CNF)/polymer composite coated on cotton fabrics prepared with various circuit patterns

Fabric heating elements with carbon nanofiber (CNF)/Poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) composite coated cotton fabrics were prepared with various circuit patterns with the aim of providing more flexible and uniform heating performance compared to conventional fabric heating elements. To investigate the properties of the fabric heating element according to ...

Affectivity in Its Relation to Memory

It seems obvious that various feelings (various kinds of affectivity) are memorized, forgotten, and recollected to various degrees. Some of them are forgotten. Some of those forgotten can be recollected, while others are lost forever. For example, short and long-lasting feelings and shallow and deep feelings are memorized and remembered in different ways. In this paper I analyse ...

University Students’ Perceptions of Videotaping as a Teaching Tool in a Public Speaking Course

The purpose of this study was to investigate the effect of videotaping on college students’ public speaking skills development in English as a Foreign Language (EFL) from the learners’ perspective. Twenty Moroccan freshmen students majoring in Engineering, Business, and Humanities at Al Akhawayn University in Ifrane, Morocco, participated in the study. Using 60 videotaped ...

Dissecting cause and effect in host-microbiome interactions using the combined worm-bug model system

High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complexity and heterogeneity of the human microbiome we need robust ...

Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples

The liver plays a major role in whole-body energy homeostasis by releasing secretory factors, termed hepatokines. To identify novel target genes associated with insulin resistance, we performed a comprehensive analysis of gene expression profiles using a DNA chip method in liver biopsy samples from humans with varying degrees of insulin resistance. Inhibin βE (INHBE) was identified ...

Drivers of invasive tree and shrub natural regeneration in temperate forests

We assessed drivers of ecological success along resource availability gradients for three invasive woody species: Prunus serotina Ehrh., Quercus rubra L. and Robinia pseudoacacia L. We aimed to check how much of invasion success, measured by invader biomass, is explained by propagule pressure and plant community invasibility. Using 3 years of observations from 372 study plots (100 ...

Joint pricing, inventory, and preservation decisions for deteriorating items with stochastic demand and promotional efforts

This study models a joint pricing, inventory, and preservation decision-making problem for deteriorating items subject to stochastic demand and promotional effort. The generalized price-dependent stochastic demand, time proportional deterioration, and partial backlogging rates are used to model the inventory system. The objective is to find the optimal pricing, replenishment, and ...

JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma

Aims Jumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A ...

Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics

Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung cancer. Irinotecan therapy is characterized by several dose-limiting toxicities and large interindividual pharmacokinetic variability. Irinotecan has a highly complex metabolism, including hydrolyzation ...

Capacity solution to a coupled system of parabolic–elliptic equations in Orlicz–Sobolev spaces

The existence of a capacity solution to a coupled nonlinear parabolic–elliptic system is analyzed, the elliptic part in the parabolic equation being of the form \(-\,\mathrm{div}\, a(x,t,u,\nabla u)\). The growth and the coercivity conditions on the monotone vector field a are prescribed by an N-function, M, which does not have to satisfy a \(\Delta _2\) condition. Therefore we ...

Rating experiments in forestry: How much agreement is there in tree marking?

The process of selecting individual trees by humans for forest management purposes is the result of a plethora of factors and processes that are hard to disentangle. And yet in the past many textbooks and other publications have maintained that this selection leads to somewhat unanimous results. In this study, we analysed the data of 36 so-called marteloscope experiments from all ...

Nudge-Proof: Distributive Justice and the Ethics of Nudging

A review of Cass R. Sunstein, The Ethics of Influence: Government in the Age of Behavioral Science.

Estimating Water Retention in Post-mining Excavations Using LiDAR ALS Data for the Strzelin Quarry, in Lower Silesia

A digital terrain model of the Strzelin granite quarry was created from ISOK project data obtained from airborne laser scanning (ALS). Based on 2009, 2012, and 2014 data, the volume of water in the Strzelin quarry’s two excavations were determined. Additionally, the predicted volume of retained water after mining ceases was calculated, assuming a water level of 150.0 m a.s.l. In ...

Tailoring cross-sectional energy-efficiency measures to target groups in industry

The improvement of energy efficiency in industrial companies plays a crucial role for the energy transition. Although significant economic potentials have been identified, the concerned actors are still struggling to realize them fully. To support the implementation of energy efficiency measures by passing policies, a deeper understanding of the barriers affecting different kinds ...