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Improved diagnosis and prognostication of patients with pleural malignant mesothelioma using biomarkers in pleural effusions and peripheral blood samples – a short report

Purpose There is a lack of robust and clinically utilizable markers for the diagnosis and prognostication of malignant pleural mesothelioma (MPM). This research was aimed at optimizing and exploring novel approaches to improve the diagnosis and prognostication of MPM in pleural effusions and peripheral blood samples. Methods CellSearch-based and flow cytometry-based assays using ...

Relationship Between the Relative Age Effect and Lengths of Professional Careers in Male Japanese Baseball Players: a Retrospective Analysis

Background The mechanisms underlying the relative age effect in sport events have been investigated for more than two decades. The present study focused on the relationship between the relative age effect and lengths of professional careers among professional male Japanese baseball players. Methods The birth dates of players and lengths of professional careers were collected from ...

Bimetallic organic frameworks derived CuNi/carbon nanocomposites as efficient electrocatalysts for oxygen reduction reaction

Catalysts of oxygen reduction reaction (ORR) play key roles in renewable energy technologies such as metal-air batteries and fuel cells. Despite tremendous efforts, highly active catalysts with low cost remain elusive. This work used metal-organic frameworks to synthesize non-precious bimetallic carbon nanocomposites as efficient ORR catalysts. Although carbon-based Cu and Ni are ...

Buddhist-Catholic relations in Ho Chi Minh City

Relations between Buddhism and Catholicism began to take place in Vietnam in the sixteenth century and in Ho Chi Minh City in the seventeenth century. There have been conversions of Buddhists to Catholicism and a very few reconversions of Catholics to Buddhism. Dialogue and tension/conflict between Buddhists and Catholics have been also sometimes found. The article first examines ...

APIAN-INF: an aerodynamic and aeroacoustic investigation of pylon-interaction effects for pusher propellers

Advanced propellers promise significant fuel-burn savings compared to turbofans. When installed on the fuselage in a pusher configuration, the propeller interacts with the wake of the supporting pylon. This paper presents an experimental analysis of the aerodynamic and aeroacoustic characteristics of this pylon–propeller interaction. An isolated propeller was operated in ...

Insolvency administrator’s incentives and the tradeoff between creditor satisfaction and efficiency in bankruptcy procedures

An insolvency administrator replaces the manager of an insolvent firm to devise and organize a liquidation or reorganization plan in the creditors’ interest. In the course of the process, the insolvency administrator presents the most favourable option from his perspective, and the creditors choose to accept or reject this plan. Conflicts of interest arise because the insolvency ...

Progress in organic-inorganic hybrid halide perovskite single crystal: growth techniques and applications

As a new generation of solution-processable optoelectronic materials, organic-inorganic hybrid halide perovskites have attracted a great deal of interest due to their high and balanced carrier mobility, long carrier diffusion length and large light absorption coefficient. These materials have demonstrated wide applications in solar cell, light-emitting diode, laser, photodetector, ...

Hydrogel-based phototherapy for fighting cancer and bacterial infection

Hydrogels constitute a group of polymeric materials which can hold a large amount of water in their three-dimensional networks due to their hydrophilic structures. In the past few years, they have been researched for various biomedical applications, such as drug/cell carriers, tissue engineering, and biosensors. Particularly, the hydrogels used as drug delivery systems have shown ...

Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications

Biomedical applications of porous calcium carbonate (CaCO3) microspheres have been mainly restricted by their aqueous instability and low remineralization rate. To overcome these obstacles, a novel symmetry-breaking assembled porous calcite microsphere (PCMS) was constructed in an ethanol/water mixed system using a two-step vapor-diffusion/aging crystallization strategy. In ...

Comparative Effect of Calcium Channel Blockers on Glomerular Function in Hypertensive Patients with Diabetes Mellitus

Background We conducted a retrospective cohort study to evaluate and compare the longitudinal effect of monotherapy with L-, L/T-, L/N-, and L/N/T-type calcium channel blockers (CCBs) on estimated glomerular filtration rate (eGFR), and to investigate the association of treatment duration with eGFR in diabetic patients with hypertension. Methods Using a clinical database, we ...

Rice Bran Metabolome Contains Amino Acids, Vitamins & Cofactors, and Phytochemicals with Medicinal and Nutritional Properties

Background Rice bran is a functional food that has shown protection against major chronic diseases (e.g. obesity, diabetes, cardiovascular disease and cancer) in animals and humans, and these health effects have been associated with the presence of bioactive phytochemicals. Food metabolomics uses multiple chromatography and mass spectrometry platforms to detect and identify a ...

Riparian Meadow Response to Modern Conservation Grazing Management

Riparian meadows occupy a small proportion of the public lands in the western United States but they provide numerous ecosystem services, including the production of high-quality forage for livestock grazing. Modern conservation management strategies (e.g., reductions in livestock stocking rates and adoption of new riparian grazing standards) have been implemented to better balance ...

A Dipeptidyl Peptidase-4 Inhibitor, Teneligliptin, Decreases Plasma Triglyceride-Rich Lipoprotein Remnants in Diabetic Patients with Chronic Kidney Disease Undergoing Hemodialysis

Objective A high plasma level of remnant-like particle cholesterol (RLP-C), which is equivalent to triglyceride-rich lipoprotein remnant, is an important coronary risk marker. RLP-C level is high, independent of other plasma lipids, in patients with chronic kidney disease (CKD) undergoing hemodialysis. The effect of teneligliptin, a dipeptidyl peptidase (DPP)-4 inhibitor, on plasma ...

Comparison of Generic Drug Reviews for Marketing Authorization between Japan and Canada

Purpose Generic drugs are assuming an increasingly important role in sustaining modern healthcare systems, as the cost of healthcare, including drug usage, is gradually expanding around the world. To date, published articles comparing generic drug reviews between different countries are scarce. Objective The objective of this study was to examine generic drug reviews in Japan and ...

Endovascular treatment in patients with carotid artery dissection and intracranial occlusion: a systematic review

Purpose Recently, multiple randomised controlled trials showed efficacy of endovascular treatment over traditional care in patients with acute ischemic stroke due to an intracranial anterior circulation occlusion. Internal carotid artery (ICA) dissection with a concomitant intracranial occlusion is a rare but important cause of severe acute ischemic stroke. Although this subtype of ...

Overexpression of Rice Auxilin-Like Protein, XB21, Induces Necrotic Lesions, up-Regulates Endocytosis-Related Genes, and Confers Enhanced Resistance to Xanthomonas oryzae pv. oryzae

Background The rice immune receptor XA21 confers resistance to the bacterial pathogen, Xanthomonas oryzae pv. oryzae (Xoo). To elucidate the mechanism of XA21-mediated immunity, we previously performed a yeast two-hybrid screening for XA21 interactors and identified XA21 binding protein 21 (XB21). Results Here, we report that XB21 is an auxilin-like protein predicted to function in ...

Pharmacokinetics of Bevacizumab in Three Patients Under the Age of 3 Years with CNS Malignancies

Background Bevacizumab is a recombinant antibody that is increasingly used in pediatric malignancies. The pharmacokinetics of bevacizumab in pediatric patients have been shown to be influenced by tumor localization and body weight. In this report, we present data on the pharmacokinetics and safety of bevacizumab in children under the age of 3 years with central nervous system (CNS) ...

The Coulomb Branch of 3d \({\mathcal{N}= 4}\) Theories

We propose a construction for the quantum-corrected Coulomb branch of a general 3d gauge theory with \({\mathcal{N}=4}\) supersymmetry, in terms of local coordinates associated with an abelianized theory. In a fixed complex structure, the holomorphic functions on the Coulomb branch are given by expectation values of chiral monopole operators. We construct the chiral ring of such ...

Total Mercury, Methylmercury, Inorganic Arsenic and Other Elements in Meat from Minke Whale (Balaenoptera acutorostrata) from the North East Atlantic Ocean

Meat samples of 84 minke whales (Balaenoptera acutorostrata) mainly from the Barents Sea, collected between 1 May and 16 August 2011, were analyzed for total mercury, methylmercury, cadmium, lead, total arsenic, inorganic arsenic and selenium. The average total mercury concentration found was 0.15 ± 0.09 mg/kg, with a range from 0.05 to 0.49 mg/kg. The molar ratio of selenium to ...

Influence of particle size distribution on the blast pressure profile from explosives buried in saturated soils

The spatial and temporal distribution of pressure and impulse from explosives buried in saturated cohesive and cohesionless soils has been measured experimentally for the first time. Ten experiments have been conducted at quarter-scale, where localised pressure loading was measured using an array of 17 Hopkinson pressure bars. The blast pressure measurements are used in conjunction ...

Anthropometric and Physical Qualities of Elite Male Youth Rugby League Players

Rugby league is a collision team sport played at junior and senior levels worldwide, whereby players require highly developed anthropometric and physical qualities (i.e. speed, change-of-direction speed, aerobic capacity, muscular strength and power). Within junior levels, professional clubs and national governing bodies implement talent identification and development programmes to ...

Path Integrals on Manifolds with Boundary

We give time-slicing path integral formulas for solutions to the heat equation corresponding to a self-adjoint Laplace type operator acting on sections of a vector bundle over a compact Riemannian manifold with boundary. More specifically, we show that such a solution can be approximated by integrals over finite-dimensional path spaces of piecewise geodesics subordinated to ...