Recently added

Wie viel Technik gehört ins Pflegeheim?

Technische Innovationen halten nur zaghaft Einzug in Pflegeeinrichtungen, obwohl Umfragen zufolge, die Akzeptanz unter den älteren Menschen zugenommen habe. Eine aktuelle Studie hat sich nun mit den Gründen für die Zurückhaltung befasst und Leiter von Pflegeeinrichtungen befragt.

Reliable radiosynthesis of 4-[10B]borono-2-[18F]fluoro-l-phenylalanine with quality assurance for boron neutron capture therapy-oriented diagnosis

ObjectiveThe aim of this study was to establish a reliable and routine method for the preparation of 4-[10B]borono-2-[18F]fluoro-l-phenylalanine (l-[18F]FBPA) for boron neutron capture therapy-oriented diagnosis using positron emission tomography.MethodsTo produce l-[18F]FBPA by electrophilic fluorination of 4-[10B]borono-l-phenylalanine (l-BPA) with [18F]acetylhypofluorite ([18F...

Discounting in Economic Evaluations

Appropriate discounting rules in economic evaluations have received considerable attention in the literature and in national guidelines for economic evaluations. Rightfully so, as discounting can be quite influential on the outcomes of economic evaluations. The most prominent controversies regarding discounting involve the basis for and height of the discount rate, whether costs...

Association between urinary free light chains and progression to end stage renal disease in chronic kidney disease

Background Patients with chronic kidney disease (CKD) are at an increased risk of developing end-stage renal disease (ESRD). We assessed for the first time whether urinary free light chains (FLC) are independently associated with risk of ESRD in patients with CKD, and whether they offer incremental value in risk stratification. Materials and methods We measured urinary FLCs in...

Associations between Oxytocin Receptor (OXTR) Genotype and Elementary School Children’s Likability, Dis-likability and Friendship among Classroom Peers: A Longitudinal Study

The single nucleotide polymorphism rs53576 of the oxytocin receptor (OXTR) gene is involved in forming and maintaining relationships in various social contexts. However, this has not been studied in the childhood peer context. The present study followed 359 children (51.6% girls) from age 9 to 12 to explore associations between OXTR rs53576 genotype (i.e., AA, AG or GG genotype...

Sexual behavior and testis morphology in the BACHD rat model

Background Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene, which results in brain neurodegeneration and peripheral pathology affecting different organs including testis. Patients with HD suffer from motor and cognitive impairment, and multiple psychiatric symptoms. Among behavioral abnormalities in HD...

Heavy-lifting of gauge theories by cosmic inflation

Abstract Future measurements of primordial non-Gaussianity can reveal cosmologically produced particles with masses of order the inflationary Hubble scale and their interactions with the inflaton, giving us crucial insights into the structure of fundamental physics at extremely high energies. We study gauge-Higgs theories that may be accessible in this regime, carefully imposing...

Shell Thickness Dependence of Interparticle Energy Transfer in Core-Shell ZnSe/ZnSe Quantum Dots Doping with Europium

Low-toxic core-shell ZnSe:Eu/ZnS quantum dots (QDs) were prepared through two steps in water solution: nucleation doping and epitaxial shell grown. The structural and morphological characteristics of ZnSe/ZnS:Eu QDs with different shell thickness were explored by transmission electron microscopy (TEM) and X-ray diffraction (XRD) results. The characteristic photoluminescence (PL...

Hospitalization due to stroke and myocardial infarction in self-employed individuals and small business owners compared with paid employees in Sweden—a 5-year study

Analysing Swedish population register data, the aim of the present study is to investigate differences in acute cardiovascular disease (CVD) in terms of stroke and myocardial infarction incidence between self-employed individuals and paid employees and to study whether the associations vary by gender or across industrial sectors. A cohort of nearly 4.8 million employed...

Approaches to identify and characterize microProteins and their potential uses in biotechnology

MicroProteins are small proteins that contain a single protein domain and are related to larger, often multi-domain proteins. At the molecular level, microProteins act by interfering with the formation of higher order protein complexes. In the past years, several microProteins have been identified in plants and animals that strongly influence biological processes. Due to their...

Prognostic value of diffuse splenic FDG uptake on PET/CT in patients with gastric cancer

Background This study investigated the prognostic value of diffuse splenic uptake on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in gastric cancer (GC) patients. Methods A total of 134 pathology confirmed GC patients who underwent PET/CT for staging work-ups were enrolled. The maximal standardized uptake value (SUVmax) of primary...

Site-specific glycosaminoglycan content is better maintained in the pericellular matrix than the extracellular matrix in early post-traumatic osteoarthritis

Introduction One of the characteristics of early osteoarthritis (OA) is the loss of fixed charged density (FCD) of glycosaminoglycans in the superficial zone of articular cartilage. However, possible local changes in the FCD content of the pericellular matrix (PCM) are not fully understood. Hence, our aim was to investigate the effect of unilateral anterior cruciate ligament...

Student help-seeking attitudes and behaviors in a digital era

This study examines college students’ attitudes and habits for seeking academic help. Students preferences for seeking academic help via digital and non-digital technologies are identified (N = 438). Students’ attitudes about seeking help are also analyzed. Factor analysis results indicate six attitudinal factors motivated students to seek help from peers and instructors...

Cost–utility analysis of an intervention designed to reduce the critical handling error of insufficient inspiratory effort

ObjectivesUp to 70–80% of patients use inhalers incorrectly. Dry-powder inhalers (DPIs) require forceful inhalation for optimal delivery, and approximately 40% of Global Initiative for Asthma (GINA)-defined Step-3+ patients inhale corticosteroid and long-acting beta-agonist through DPIs. The CRITIKAL study (Price et al. in J Allergy Clin Immunol Pract 5:1071-e9–1081-e9, 2017...

Sit still and pay attention: Using the Wii Balance-Board to detect lapses in concentration in children during psychophysical testing

During psychophysical testing, a loss of concentration can cause observers to answer incorrectly, even when the stimulus is clearly perceptible. Such lapses limit the accuracy and speed of many psychophysical measurements. This study evaluates an automated technique for detecting lapses based on body movement (postural instability). Thirty-five children (8–11 years of age) and 34...

Modeling the effect of surgical sterilization on owned dog population size in Villa de Tezontepec, Hidalgo, Mexico, using an individual-based computer simulation model

Surgical sterilization programs for dogs have been proposed as interventions to control dog population size. Models can be used to help identify the long-term impact of reproduction control interventions for dogs. The objective of this study was to determine the projected impact of surgical sterilization interventions on the owned dog population size in Villa de Tezontepec...

Where’s the cookie? The ability of monkeys to track object transpositions

Object permanence is the ability to represent mentally an object and follow its position even when it has disappeared from view. According to Piaget’s 6-stage scale of the sensorimotor period of development, it seems that object permanence appears in Stage 4 and fully develops in Stage 6. In this study, we investigated the ability of some species of monkeys (i.e. pig-tailed...

An annotated checklist of macrozoobenthic species in German waters of the North and Baltic Seas

The present compilation is the first attempt to generate a comprehensive list of all macrozoobenthic species recorded at least once in the German regions of the North Sea and Baltic Sea including non-indigenous species and freshwater species which occurred in brackish waters (estuaries, bays, fjords etc.). Based on the data of several research institutes and consultancies, the...