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Structure and function of the Nppa–Nppb cluster locus during heart development and disease

Atrial natriuretic factor and brain natriuretic peptide are two important biomarkers in clinical cardiology. These two natriuretic peptide hormones are encoded by the paralogous genes Nppa and Nppb, which are evolutionary conserved. Both genes are predominantly expressed by the heart muscle during the embryonic and fetal stages, and in particular Nppa expression is strongly reduced ...

Mapping the evolution of entrepreneurship as a field of research (1990–2013): A scientometric analysis

This article applies scientometric techniques to study the evolution of the field of entrepreneurship between 1990 and 2013. Using a combination of topic mapping, author and journal co-citation analyses, and overlay visualization of new and hot topics in the field, this article makes important contribution to the entrepreneurship research by identifying 46 topics in the 24-year ...

Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation

Aims Medical treatment of arterial thrombosis is mainly directed against platelets and coagulation factors, and can lead to bleeding complications. Novel antithrombotic therapies targeting immune cells and neutrophil extracellular traps (NETs) are currently being investigated in animals. We addressed whether immune cell composition of arterial thrombi induced in mouse models of ...

Retraction Note to: Adsorptive removal of cadmium from aqueous media using Posidonia oceanica biomass: equilibrium, dynamic and thermodynamic studies

The authors are retracting this article (Krika et al., 2015) because Figure 2C and the text describing it are duplicated from a previously published article by Allouche et al. (2011). All authors agree to this retraction.

Germ-line and somatic EPHA2 coding variants in lens aging and cataract

Rare germ-line mutations in the coding regions of the human EPHA2 gene (EPHA2) have been associated with inherited forms of pediatric cataract, whereas, frequent, non-coding, single nucleotide variants (SNVs) have been associated with age-related cataract. Here we sought to determine if germ-line EPHA2 coding SNVs were associated with age-related cataract in a case-control DNA ...

Genetik der kortikalen Fehlbildungen

Kortikale Malformationen sind vielfältig und stellen eine wichtige Ursache der geistigen Entwicklungsstörung und der Epilepsie dar. Die Ätiologie der kortikalen Fehlbildungen ist sehr heterogen und beinhaltet sowohl rein exogene Ursachen als auch chromosomale und monogene Erkrankungen. Eine effiziente genetische Diagnostik bedarf der akkuraten Interpretation des ...

Sex-specific reference intervals of hematologic and biochemical analytes in Sprague-Dawley rats using the nonparametric rank percentile method

Background Hematologic and biochemical analytes of Sprague-Dawley rats are commonly used to determine effects that were induced by treatment and to evaluate organ dysfunction in toxicological safety assessments, but reference intervals have not been well established for these analytes. Reference intervals as presently defined for these analytes in Sprague-Dawley rats have not used ...

Web of Science use in published research and review papers 1997–2017: a selective, dynamic, cross-domain, content-based analysis

Clarivate Analytics’s Web of Science (WoS) is the world’s leading scientific citation search and analytical information platform. It is used as both a research tool supporting a broad array of scientific tasks across diverse knowledge domains as well as a dataset for large-scale data-intensive studies. WoS has been used in thousands of published academic studies over the past 20 ...

The Occasion-Sensitivity of Thought

On the most common interpretation of occasion-sensitivity what varies cross-contextually is the truth-conditional content of representations. Jerry Fodor argues that when extended to mental representation this view has some problematic consequences. In this paper I outline an approach to occasion-sensitivity which circumvents Fodor’s objections but still maintains that the aspect ...

Autoimmune rheumatic diseases increase dementia risk in middle-aged patients: A nationwide cohort study

Objective Dementia is a common neurological disease that substantially affects public health. A previous study revealed that dementia occurs when the body’s immune system attacks the cells of the brain, indicating that dementia may be similar to autoimmune rheumatic diseases (ARDs). In the current retrospective cohort study, we focused on middle-aged ARD patients (45 years or ...

Preoperative Prognostic Nutritional Index Predicts Long-Term Surgical Outcomes in Patients with Esophageal Squamous Cell Carcinoma

Background The purpose of the present study is to investigate the utility of prognostic nutritional index (PNI) as a simple and readily available marker in esophageal squamous cell carcinoma (ESCC). Methods We retrospectively analyzed 169 patients who underwent potentially curative esophagectomy, for histologically verified ESCC. We decided to set the optimal cutoff value for ...

Serum adiponectin levels are associated with worse cognitive function in postmenopausal women

Introduction Adiponectin may be a biomarker of cognitive impairment stage, and its clinical progression. In this study we aimed to evaluate the relationship between serum adiponectin levels and cognitive performances in menopausal women, and whether serum adiponectin levels may be differently associated with cognitive performances as compared to overweight/obese subjects. Methods ...

Developing evaluative judgement: enabling students to make decisions about the quality of work

Evaluative judgement is the capability to make decisions about the quality of work of oneself and others. In this paper, we propose that developing students’ evaluative judgement should be a goal of higher education, to enable students to improve their work and to meet their future learning needs: a necessary capability of graduates. We explore evaluative judgement within a ...

Association between serum aluminum levels and cardiothoracic ratio in patients on chronic hemodialysis

The cardiothoracic ratio (CTR) and serum aluminum levels are both associated with mortality in hemodialysis patients. However, limited data regarding the association between serum aluminum levels and the CTR have been published to date. Therefore, we aimed to elucidate this association in patients on chronic hemodialysis (CHD). We investigated the association between the serum ...

Formation of Pt Skin Layer on Ordered and Disordered Pt-Co Alloys and Corrosion Resistance in Sulfuric Acid

The formation of the Pt-enriched layer (Pt skin layer) formed at the surface of the ordered and disordered Pt-Co alloy specimens by a dealloying treatment and its corrosion resistance under potential cycling in sulfuric acid were examined to clarify the dissolution behavior of the Pt skin layer in polymer electrolyte fuel cell-operating conditions. The ordered and disordered Pt-Co ...

On the analysis of random replacement caches using static probabilistic timing methods for multi-path programs

Probabilistic hard real-time systems, based on hardware architectures that use a random replacement cache, provide a potential means of reducing the hardware over-provision required to accommodate pathological scenarios and the associated extremely rare, but excessively long, worst-case execution times that can occur in deterministic systems. Timing analysis for probabilistic hard ...

Role of N-glycosylation in activation of proMMP-9. A molecular dynamics simulations study

Human matrix metalloproteinase proMMP-9 is secreted as latent zymogen, which requires two-steps proteolytic activation. The secreted proMMP-9 is glycosylated at two positions: Asn38 and Asn120 located in the prodomain and catalytic domain, respectively. It has been demonstrated that glycosylation at Asn120 is required for secretion of the enzyme, while the role of Asn38 ...

Identification of chemosensory genes from the antennal transcriptome of Indian meal moth Plodia interpunctella

Olfaction plays an indispensable role in mediating insect behavior, such as locating host plants, mating partners, and avoidance of toxins and predators. Olfactory-related proteins are required for olfactory perception of insects. However, very few olfactory-related genes have been reported in Plodia interpunctella up to now. In the present study, we sequenced the antennae ...

Anterior cruciate ligament injury: Identifying information sources and risk factor awareness among the general population

Introduction Raising awareness on a disorder is important for its prevention and for promoting public health. However, for sports injuries like the anterior cruciate ligament (ACL) injury no studies have investigated the awareness on risk factors for injury and possible preventative measures in the general population. The sources of information among the population are also ...

Effects of dietary level of tannic acid and protein on internal organ weights and biochemical blood parameters of rats

Tannic acid (TA) is a polyphenolic compound with a health-promoting potential for humans. It is hypothesised that TA effects on the relative weight of internal organs and biochemical blood indices are modified by dietary protein level in rats. The study involved 72 rats divided into 12 groups fed diets with 10 or 18% of crude protein (CP) and supplemented with 0, 0.25, 0.5, 1, 1.5 ...

Substance P signalling in primary motor cortex facilitates motor learning in rats

Among the genes that are up-regulated in response to a reaching training in rats, Tachykinin 1 (Tac1)—a gene that encodes the neuropeptide Substance P (Sub P)—shows an especially strong expression. Using Real-Time RT-PCR, a detailed time-course of Tac1 expression could be defined: a significant peak occurs 7 hours after training ended at the first and second training session, ...

Annexin A5 reduces early plaque formation in ApoE -/- mice

Annexin A5 (AnxA5) exerts anti-inflammatory, anticoagulant and anti-apoptotic effects through its binding to cell surface expressed phosphatidylserine. We previously showed that AnxA5 can stabilize advanced atherosclerotic plaques by reducing macrophage infiltration. We now investigated the effects of AnxA5 administration on the onset of atherosclerosis development. Eight-week-old ...

Enterprise Social Media Use and Impact on Performance: The Role of Workplace Integration and Positive Emotions

Organizations struggle to find ways to improve employees’ performance. To date, little research has empirically examined the relationship between enterprise social media use and knowledge workers’ performance. Using social capital theory and the broaden-and-build theory of positive emotions as our theoretical framework, we investigate the relationship between enterprise social ...