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Chloride intracellular channel proteins respond to heat stress in Caenorhabditis elegans

Chloride intracellular channel proteins (CLICs) are multi-functional proteins that are expressed in various cell types and differ in their subcellular location. Two CLIC homologs, EXL-1 (excretory canal abnormal like-1) and EXC-4 (excretory canal abnormal– 4), are encoded in the Caenorhabditis elegans genome, providing an excellent model to study the functional diversification of ...

Total and heterotrophic soil respiration in a swamp forest and oil palm plantations on peat in Central Kalimantan, Indonesia

Heterotrophic respiration is a major component of the soil C balance however we critically lack understanding of its variation upon conversion of peat swamp forests in tropical areas. Our research focused on a primary peat swamp forest and two oil palm plantations aged 1 (OP2012) and 6 years (OP2007). Total and heterotrophic soil respiration were monitored over 13 months in paired ...

Use of alcohol and drugs with addiction potential among older women and men in a population-based study. The Nord-Trøndelag Health Study 2006-2008 (HUNT3)

Background Little is known about the consumption habits of older adults in Norway with respect to alcohol and the use of drugs with addiction potential, such as benzodiazepines, z-hypnotics and opioids, among regular drinkers. We studied the prevalence of self-reported consumption of alcohol on a regular basis in community-living older men and women (≥ 65 years). Furthermore, we ...

Sleep quality in subjects suffering from chronic pain

Background Sleeping problems are very common in patients with chronic pain. The aim of the study was to investigate the association between different dimensions of chronic pain and sleep quality in chronic pain patients. Methods In this cross-sectional interview-based questionnaire study, patients from 3 different pain treatment centers in Vienna aged 18–65 years, with pain lasting ...

In vivo lineage tracing reveals Axin2-expressing, long-lived cortical thymic epithelial progenitors in the postnatal thymus

In the thymus, cortical and medullary thymic epithelial cells (TECs) are instrumental for generating a repertoire of functional T cells. Hence, there has been much interest in the ontogeny of TECs. While medullary TEC (mTEC) and bipotent progenitors have been identified, the existence of a cortical TEC (cTEC) progenitor remains ambiguous. In this study, we used lineage tracing ...

Prevalence of antibodies to Brucella species in commercial raw bovine milk in Southwestern Uganda

Objectives The purpose and objective of this research was to explore the prevalence of antibodies against Brucella species in raw milk samples collected in Southwestern Uganda, one of the biggest milk producing regions in the Country. We hypothesized that there is a high level of antibodies in milk samples from this region. This builds more evidence to other studies in the region ...

Osmotic behaviour of human mesenchymal stem cells: Implications for cryopreservation

Aimed at providing a contribution to the optimization of cryopreservation processes, the present work focuses on the osmotic behavior of human mesenchymal stem cells (hMSCs). Once isolated from the umbilical cord blood (UCB) of three different donors, hMSCs were characterized in terms of size distribution and their osmotic properties suitably evaluated through the exposure to ...

Statistische Modelle in der Gefäßchirurgie

Hintergrund Die statistische Modellwahl mit dazugehörender Analysestrategie bestimmt in einem Forschungsprojekt dessen quantitatives Ergebnis. Es existiert in der Regel kein Goldstandard zur Wahl der relevanten Modellierungsstrategie. Der Statistiker kann in Abstimmung mit den weiteren Teammitgliedern im Projekt zwischen einer Vielzahl alternativer Modelle wählen. Folglich kämen ...

Unique transcriptomic response to sepsis is observed among patients of different age groups

Sepsis is a major cause of morbidity and mortality, especially at the extremes of age. To understand the human age-specific transcriptomic response to sepsis, a multi-cohort, pooled analysis was conducted on adults, children, infants, and neonates with and without sepsis. Nine public whole-blood gene expression datasets (636 patients) were employed. Age impacted the transcriptomic ...

Women’s transit safety: making connections and defining future directions in research and practice

Drawing from a diverse range of examples, the guest editor aims to summarise and reflect upon the key material presented in this special issue. This ‘afterword’ to the special issue also highlights the key messages that emerge from the diverse research techniques and methodologies employed in the varied range of case studies, most of them small-scale studies. This final article ...

A new approach to keratoconus detection based on corneal morphogeometric analysis

Purpose To characterize corneal structural changes in keratoconus using a new morphogeometric approach and to evaluate its potential diagnostic ability. Methods Comparative study including 464 eyes of 464 patients (age, 16 and 72 years) divided into two groups: control group (143 healthy eyes) and keratoconus group (321 keratoconus eyes). Topographic information (Sirius, CSO, ...

Perceived Sodium Reduction Barriers Among Patients with Chronic Kidney Disease: Which Barriers Are Important and Which Patients Experience Barriers?

Purpose The purposes of this study were to assess the importance of perceived sodium reduction barriers among patients with chronic kidney disease (CKD) and identify associated sociodemographic, clinical, and psychosocial factors. Method A total of 156 patients with CKD completed a questionnaire assessing sodium reduction barriers (18 self-formulated items), depressive symptoms ...

Inflammatory and non-inflammatory monocytes as novel prognostic biomarkers of survival in SOD1G93A mouse model of Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) has lately become a suitable scenario to study the interplay between the hematopoietic system and disease progression. Recent studies in C9orf72 null mice have demonstrated that C9orf72 is necessary for the normal function of myeloid cells. In this study, we aimed to analyze in depth the connection between the hematopoietic system and secondary ...

Imaging cardiac innervation in amyloidosis

Cardiac amyloidosis is a form of restrictive cardiomyopathy resulting in heart failure and potential risk on arrhythmia, due to amyloid infiltration of the nerve conduction system and the myocardial tissue. The prognosis in this progressive disease is poor, probably due the development of cardiac arrhythmias. Early detection of cardiac sympathetic innervation disturbances has ...

Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms

Alkylating agents are ubiquitous in our internal and external environments, causing DNA damage that contributes to mutations and cell death that can result in aging, tissue degeneration and cancer. Repair of methylated DNA bases occurs primarily through the base excision repair (BER) pathway, a multi-enzyme pathway initiated by the alkyladenine DNA glycosylase (Aag, also known as ...

Association between health literacy and patient experience of primary care attributes: A cross-sectional study in Japan

Primary care is regarded as a setting that potentially mitigate patient health literacy (HL) related inequalities. However, there is a lack of evidence about influence of patient HL on the patients’ perception of quality of primary care. We aimed to examine the association between HL and patient experience of primary care attributes. We conducted a cross-sectional survey, and sent ...

Detection of Cryptosporidium parvum and Cyclospora cayetanensis infections among people living in a slum area in Kathmandu valley, Nepal

Objective The aim of this study is to determine the prevalence of Cyclospora cayetanensis and Cryptosporidium parvum infections among people living a slum in Kathmandu valley, Nepal. Results Ten different parasites were detected in the stool samples; the prevalence of any parasite was in 27.1% (71/262). The prevalence of C. cayetanensis and C. parvum were 14.1% (10/71) and 5.6% ...

Processing language in face-to-face conversation: Questions with gestures get faster responses

The home of human language use is face-to-face interaction, a context in which communicative exchanges are characterised not only by bodily signals accompanying what is being said but also by a pattern of alternating turns at talk. This transition between turns is astonishingly fast—typically a mere 200-ms elapse between a current and a next speaker’s contribution—meaning that ...

Quality improvement of surface triangular mesh using a modified Laplacian smoothing approach avoiding intersection

We present a systematic procedure to improve the qualities of triangular molecular surface meshes and at the same time preserve the manifoldness. The procedure utilizes an algorithm to remove redundant points having three or four valences and another algorithm to smooth the mesh using a modified version of Laplacian method without causing intersecting triangles. This approach can ...

Prevalence of and factors associated with renal dysfunction in rheumatoid arthritis patients: a cross-sectional study in community hospitals

This study was designed to determine the prevalence of renal dysfunction in rheumatoid arthritis (RA) patients and to identify factors associated with this complication. Between October 2014 and May 2015, we consecutively recruited RA patients at rheumatology sections of community hospitals in Japan. Each patient’s absolute and body surface area (BSA)-indexed estimated glomerular ...

Biomechanical evaluation of tibial bone adaptation after revision total knee arthroplasty: A comparison of different implant systems

The best methods to manage tibial bone defects following total knee arthroplasty remain under debate. Different fixation systems exist to help surgeons reconstruct knee osseous bone loss (such as tantalum cones, cement, modular metal augments, autografts, allografts and porous metaphyseal sleeves) However, the effects of the various solutions on the long-term outcome remain ...

The Influence of Aluminium–Silicon Alloy on ZDDP Tribofilm Formation on the Counter-Surface

In order to reduce vehicle weight and thus improve fuel economy, aluminium (Al) alloys have been increasingly adopted as contact surfaces such as piston skirts and cylinder liners in current engines. In general, hypereutectic Al–Si alloys are used, in which hard silicon grains are embedded in a softer Al–Si single phase matrix. It is reported that after rubbing, the matrix is ...