#### Chance involvement in goal scoring in football – an empirical approach

This study examines the impact of chance in football using the case of goal scoring. For this purpose, chance in goal scoring is defined as goals involving uncontrollable or not planned aspects. “Chance variables” were defined according to the principle of downward estimation, i.e. when one of these variables is involved this is an uncontrollable or not planned aspect of scoring...

#### Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype

Cdc2-like kinases (CLKs) represent a family of serine-threonine kinases involved in the regulation of splicing by phosphorylation of SR-proteins and other splicing factors. Although compounds acting against CLKs have been described, only a few show selectivity against dual-specificity tyrosine phosphorylation regulated-kinases (DYRKs). We here report a novel CLK inhibitor family...

#### Replication and reinsertion of stalagmites sampled for paleoclimatic purposes

Sampling stalagmites for paleoclimatic study can enter into conflict with preserving the beauty and integrity of caves. To minimize this impact, a variety of sampling strategies have been used by researches aware of cave-conservation issues. Based on our experience in two caves (El Soplao and La Buenita, Cantabria, N Spain), we propose to apply molding and casting laboratory...

#### Efficient approaches for multi-agent planning

Multi-agent planning (MAP) deals with planning systems that reason on long-term goals by multiple collaborative agents which want to maintain privacy on their knowledge. Recently, new MAP techniques have been devised to provide efficient solutions. Most approaches expand distributed searches using modified planners, where agents exchange public information. They present two...

#### Mapping hotspots and emerging trends of business model innovation under networking in Internet of Things

Networking in Internet of Things (IoT) has had an immeasurable impact on the existing business models. In this context, exploring the hotspots and trends of business model innovation has become particularly necessary. For the topic literature over the past 20 years retrieved from Science Citation Index and Social Sciences Citation Index databases, scientometrics with information...

#### c-Src kinase is involved in the tyrosine phosphorylation and activity of SLC11A1 in differentiating macrophages

Studies have demonstrated that the solute carrier family 11 member 1 (SLC11A1) is heavily glycosylated and phosphorylated in macrophages. However, the mechanisms of SLC11A1 phosphorylation, and the effects of phosphorylation on SLC11A1 activity remain largely unknown. Here, the tyrosine phosphorylation of SLC11A1 is observed in SLC11A1-expressing U937 cells when differentiated...

#### Surrounded Vaidya black holes: apparent horizon properties

We study the thermodynamical features and dynamical evolutions of various apparent horizons associated with the Vaidya evaporating black hole surrounded by the cosmological fields of dust, radiation, quintessence, cosmological constant-like and phantom. In this regard, we address in detail how do these surrounding fields contribute to the characteristic features of a surrounded...

#### Fast and simple tool for the quantification of biofilm-embedded cells sub-populations from fluorescent microscopic images

Fluorescent staining is a common tool for both quantitative and qualitative assessment of pro- and eukaryotic cells sub-population fractions by using microscopy and flow cytometry. However, direct cell counting by flow cytometry is often limited, for example when working with cells rigidly adhered either to each other or to external surfaces like bacterial biofilms or adherent...

#### The Size of the Rental Market and Housing Market Fluctuations

The paper investigates whether the size of the rental market affects house prices fluctuations or the volatility of construction sector activity over the business cycle. For that purpose we construct a database of variables describing the housing sector in a group of twelve initial euro area members and ten other OECD countries over the years 1995–2014 and conduct a series of...

#### Physico-chemical characterisation of three-component co-amorphous systems generated by a melt-quench method

The purpose of this work was to evaluate the possibility of creating a ternary co-amorphous system and to determine how the properties of a co-amorphous material are altered by the addition of a selected third component. Piroxicam and indomethacin form a stable co-amorphous with the Tg above room temperature. The third component added was selected based on tendency to crystallise...

#### Echocardiographic measurements of epicardial adipose tissue and comparative ability to predict adverse cardiovascular outcomes in patients with coronary artery disease

The present study aimed to compare echocardiography measurements of epicardial adipose tissue (EAT) thickness and other risk factors regarding their ability to predict adverse cardiovascular outcomes in patients with coronary artery disease (CAD). Outcomes of 107 patients (86 males, 21 females, mean age 63.6 years old) submitted to diagnostic echocardiography and coronary...

#### Determining the minimum number of protein-protein interactions required to support known protein complexes

The prediction of protein complexes from protein-protein interactions (PPIs) is a well-studied problem in bioinformatics. However, the currently available PPI data is not enough to describe all known protein complexes. In this paper, we express the problem of determining the minimum number of (additional) required protein-protein interactions as a graph theoretic problem under...

#### Review on Catalytic Cleavage of C–C Inter-unit Linkages in Lignin Model Compounds: Towards Lignin Depolymerisation

Lignin depolymerisation has received considerable attention recently due to the pressing need to find sustainable alternatives to fossil fuel feedstock to produce chemicals and fuels. Two types of interunit linkages (C–C and C–O linkages) link several aromatic units in the structure of lignin. Between these two inter-unit linkages, the bond energies of C–C linkages are higher...

#### The benefit of quality control charts (QCC) for routine quantitative BCR-ABL1 monitoring in chronic myeloid leukemia

Quantitative real-time polymerase chain reaction (qRT-PCR) is state of the art in molecular monitoring of minimal residual disease in chronic myeloid leukemia (CML). In this context, maintenance of assay fidelity and detection of technical inaccuracy are crucial. Beside multiple common negative controls for the clinical sample preparations, quality control charts (QCC) are a...

#### Hormontherapie kann depressiven Verstimmungen vorbeugen

Das Risiko, in der Perimenopause Symptome einer Depression zu entwickeln, konnte in einer randomisierten Studie durch eine Hormontherapie reduziert werden.

#### Universal dual amplitudes and asymptotic expansions for $$gg\rightarrow H$$ and $$H\rightarrow \gamma \gamma$$H→γγ in four dimensions

Though the one-loop amplitudes of the Higgs boson to massless gauge bosons are finite because there is no direct interaction at tree level in the Standard Model, a well-defined regularization scheme is still required for their correct evaluation. We reanalyze these amplitudes in the framework of the four-dimensional unsubtraction and the loop-tree duality (FDU/LTD), and show how...

#### Computationally identified novel agonists for GPRC6A

New insights into G protein coupled receptor regulation of glucose metabolism by β-cells, skeletal muscle and liver hepatocytes identify GPRC6A as a potential therapeutic target for treating type 2 diabetes mellitus (T2D). Activating GPRC6A with a small molecule drug represents a potential paradigm-shifting opportunity to make significant strides in regulating glucose homeostasis...

#### From Theory to Doctrine: An Empirical Analysis of the Right to Keep and Bear Arms After Heller

As a matter of constitutional doctrine, the right to keep and bear arms is coming of age. But although the doctrine has begun to mature in the decade since District of Columbia v. Heller , scholars, advocates, and judges disagree about (and sometimes simply do not know) how to characterize it. This Article is the first comprehensive empirical analysis of post- Heller Second...