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Competitive strategies among Ontario farms marketing direct to consumers

This paper examines the importance of two resources, namely a market orientation and an entrepreneurial orientation, in new product development and satisfaction with firm performance among direct and alternative marketers. Using a partial least squares structural equation model and data from a 2013 survey, this paper models the effect of a market orientation and entrepreneurial ...

Autoantibodies to Osteoprotegerin are Associated with Low Hip Bone Mineral Density and History of Fractures in Axial Spondyloarthritis: A Cross-Sectional Observational Study

Osteoporosis is a recognised complication of axial spondyloarthritis (axSpA) and is thought to be due to functional impairment and the osteoclast-activating effects of proinflammatory cytokines. The development of autoantibodies to OPG (OPG-Ab) has been associated with severe osteoporosis and increased bone resorption in rheumatoid arthritis. In this study, we screened for the ...

Efficient importance sampling in low dimensions using affine arithmetic

Despite the development of sophisticated techniques such as sequential Monte Carlo (Del Moral et al. in J R Stat Soc Ser B 68(3):411–436, 2006), importance sampling (IS) remains an important Monte Carlo method for low dimensional target distributions (Chopin and Ridgway in Leave Pima Indians alone: binary regression as a benchmark for Bayesian computation, 32:64–87, 2017). This ...

An evolutionary approach to a combined mixed integer programming model of seaside operations as arise in container ports

This paper puts forward an integrated optimisation model that combines three distinct problems, namely berth allocation, quay crane assignment, and quay crane scheduling that arise in container ports. Each one of these problems is difficult to solve in its own right. However, solving them individually leads almost surely to sub-optimal solutions. Hence, it is desirable to solve ...

Solidification Reaction Sequence of Co-Rich Nb-Al-Co Alloys

The freezing reaction sequence of Co-rich Nb-Al-Co ternary alloys with emphasis on the formation of Laves and Heusler phases has been examined. For Co-rich alloys, the solidification reaction sequence is observed as primary freezing of α-Co and CoAl phases, subsequent [Co + C36] and [CoAl + C36] eutectics, and the final ternary eutectic reaction [L → α-Co + C36 + CoAl]. The ...

Measuring outcomes in adult spinal deformity surgery: a systematic review to identify current strengths, weaknesses and gaps in patient-reported outcome measures

Purpose Adult spinal deformity (ASD) causes severe disability, reduces overall quality of life, and results in a substantial societal burden of disease. As healthcare is becoming more value based, and to facilitate global benchmarking, it is critical to identify and standardize patient-reported outcome measures (PROMs). This study aims to identify the current strengths, weaknesses, ...

Insights into the prevalence and underlying causes of clonal variation through transcriptomic analysis in Pichia pastoris

Clonal variation, wherein a range of specific productivities of secreted proteins are observed from supposedly identical transformants, is an accepted aspect of working with Pichia pastoris. It means that a significant number of transformants need to be tested to obtain a representative sample, and in commercial protein production, companies regularly screen thousands of ...

Prospects for rare and forbidden hyperon decays at BESIII

The study of hyperon decays at the Beijing Electron Spectrometer III (BESIII) is proposed to investigate the events of J/ψ decay into hyperon pairs, which provide a pristine experimental environment at the Beijing Electron–Positron Collider II. About 106–108 hyperons, i.e., Λ, Σ, Ξ, and Ω, will be produced in the J/ψ and ψ(2S) decays with the proposed data samples at BESIII. Based ...

Biomarker monitoring of controlled dietary acrylamide exposure indicates consistent human endogenous background

The aim of the present study was to explore the relation of controlled dietary acrylamide (AA) intake with the excretion of AA-related urinary mercapturic acids (MA), N-acetyl-S-(carbamoylethyl)-l-cysteine (AAMA) and N-acetyl-S-(1-carbamoyl-2-hydroxyethyl)-l-cysteine (GAMA). Excretion kinetics of these short-term exposure biomarkers were monitored under strictly controlled ...

The relationship between internalized stigma and quality of life among people with mental illness: are self-esteem and sense of coherence sequential mediators?

Purpose To elucidate the mechanism through which internalized stigma reduces the quality of life (QoL) of people with mental illness by exploring the mediating roles of self-esteem and sense of coherence (SOC). Methods A cross-sectional analysis of 229 patients diagnosed with schizophrenia or affective disorders was undertaken to test a sequential mediation model assuming that more ...

Interspecies differences in PTH-mediated PKA phosphorylation of the epithelial calcium channel TRPV5

The epithelial calcium (Ca2+) channel TRPV5 (transient receptor potential vanilloid 5) is expressed in the distal convoluted tubule of the kidney and facilitates active Ca2+ reabsorption. This process is instrumental for the maintenance of Ca2+ homeostasis. Therefore, all aspects of TRPV5 function are tightly regulated by the calciotropic parathyroid hormone (PTH). Rabbit (rb)TRPV5 ...

A Phenomenological and Dynamic View of Homology: Homologs as Persistently Reproducible Modules

Homology is a fundamental concept in biology. However, the metaphysical status of homology, especially whether a homolog is a part of an individual or a member of a natural kind, is still a matter of intense debate. The proponents of the individuality view of homology criticize the natural kind view of homology by pointing out that homologs are subject to evolutionary ...

Evaluation of ALK gene rearrangement in central nervous system metastases of non-small-cell lung cancer using two-step RT-PCR technique

Purpose RT-PCR technique has showed a promising value as pre-screening method for detection of mRNA containing abnormal ALK sequences, but its sensitivity and specificity is still discussable. Previously, we determined the incidence of ALK rearrangement in CNS metastases of NSCLC using IHC and FISH methods. Materials We evaluated ALK gene rearrangement using two-step RT-PCR method ...

A spiking neural network model of the midbrain superior colliculus that generates saccadic motor commands

Single-unit recordings suggest that the midbrain superior colliculus (SC) acts as an optimal controller for saccadic gaze shifts. The SC is proposed to be the site within the visuomotor system where the nonlinear spatial-to-temporal transformation is carried out: the population encodes the intended saccade vector by its location in the motor map (spatial), and its trajectory and ...

Diversity of low-molecular weight organic acids synthesized by Salix growing in soils characterized by different Cu, Pb and Zn concentrations

The aim of the study was to evaluate the biosynthesis and exudation of 10 low-molecular weight organic acids (LMWOAs) into the rhizosphere with a simultaneous analysis of the acid contents in the roots and leaves of 9 Salix taxa growing on two experimental areas, differing in their concentrations of copper (Cu), lead (Pb) and zinc (Zn) in the soil (Area 1—low, Area 2—high ...

Trust in haptic assistance: weighting visual and haptic cues based on error history

To effectively interpret and interact with the world, humans weight redundant estimates from different sensory cues to form one coherent, integrated estimate. Recent advancements in physical assistance systems, where guiding forces are computed by an intelligent agent, enable the presentation of augmented cues. It is unknown, however, if cue weighting can be extended to augmented ...

Inquiry and flow in science education

Ellwood’s and Abrams’s paper, Students’s social interaction in inquiry-based science education: how experiences of flow can increase motivation and achievement, describes two groups of students and their experiences in an extended inquiry unit. For one of these, the Off-Campus group, several educational aspects were enhanced compared with the group that stayed on campus for their ...

MicroRNAs: New Therapeutic Targets for Familial Hypercholesterolemia?

Familial hypercholesterolemia (FH) is the most common inherited form of dyslipidemia and a major cause of premature cardiovascular disease. Management of FH mainly relies on the efficiency of treatments that reduce plasma low-density lipoprotein (LDL) cholesterol (LDL-C) concentrations. MicroRNAs (miRs) have been suggested as emerging regulators of plasma LDL-C concentrations. ...