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Characteristics of percutaneous core biopsies adequate for next generation genomic sequencing

Purpose Determine the characteristics of percutaneous core biopsies that are adequate for a next generation sequencing (NGS) genomic panel. Materials and methods All patients undergoing percutaneous core biopsies in interventional radiology (IR) with samples evaluated for a 46-gene NGS panel during 1-year were included in this retrospective study. Patient and procedure variables ...

“It was pain. That’s it. It was pain.” Lack of oral health care among otherwise healthy young adults living with HIV in South Africa: A qualitative study

Introduction The purpose of this study is to understand engagement with and availability of dental services among people living with HIV in a low-income community of South Africa. Methods In depth qualitative interviewing was used to collect data, which was analyzed using an inductive content analytical approach. The study was conducted in Gugulethu, a township community located ...

Risk of cardiovascular mortality predicted by the serum calcium level and calcification score at the initiation of dialysis

Background The relationship between serum corrected calcium (CCa) level and vessel calcification at dialysis initiation and survival has seldom been evaluated. Therefore, we evaluated the efficacy of CCa levels and the calcification score at the initiation of dialysis for predicting all-cause and cardiovascular (CV) mortality in patients with end-stage renal disease (ESRD). Methods ...

High throughput SNP discovery and genotyping in hexaploid wheat

Because of their abundance and their amenability to high-throughput genotyping techniques, Single Nucleotide Polymorphisms (SNPs) are powerful tools for efficient genetics and genomics studies, including characterization of genetic resources, genome-wide association studies and genomic selection. In wheat, most of the previous SNP discovery initiatives targeted the coding fraction, ...

Signed reward prediction errors drive declarative learning

Reward prediction errors (RPEs) are thought to drive learning. This has been established in procedural learning (e.g., classical and operant conditioning). However, empirical evidence on whether RPEs drive declarative learning–a quintessentially human form of learning–remains surprisingly absent. We therefore coupled RPEs to the acquisition of Dutch-Swahili word pairs in a ...

Reduction Kinetics of the Nanocluster [HxPMo12O40⊂H4Mo72Fe30(O2CMe)15O254(H2O)98-y(EtOH)y]

The reduction of the molecular iron-molybdenum-nanocluster, [HxPMo12O40⊂H4Mo72Fe30(O2CMe)15O254(H2O)98-y(EtOH)y](FeMoC), was studied using model free isoconversional methods. The reduction kinetics were evaluated using the non-isothermal thermogravimetric measurements at four different heating rates from 5 to 20 °C/min in a 5% hydrogen atmosphere (argon balance). The apparent ...

Personal relative deprivation associated with functional disorders via stress: An examination of fibromyalgia and gastrointestinal symptoms

Background Personal relative deprivation is a negative social comparison process typified by self-comparison, negative appraisal, and resultant negative emotionality. Personal relative deprivation has been associated with poorer physical and mental health in several domains. It has been hypothesized that the deprivation-health link operates through a stress pathway. Stress has been ...

Fusarium ershadii sp. nov., a Pathogen on Asparagus officinalis and Musa acuminata

Two Fusarium strains, isolated from Asparagus in Italy and Musa in Vietnam respectively, proved to be members of an undescribed clade within the Fusarium solani species complex based on phylogenetic species recognition on ITS, partial RPB2 and EF-1α gene fragments. Macro- and micro-morphological investigations followed with physiological studies done on this new species: Fusarium ...

Genetic analysis of Japanese primary open-angle glaucoma patients and clinical characterization of risk alleles near CDKN2B-AS1, SIX6 and GAS7

Purpose To test the genetic association between Japanese patients with primary open-angle glaucoma (POAG) and the previously reported POAG susceptibility loci and to perform genotype–phenotype analysis. Methods Genetic associations for 27 SNPs from 16 loci previously linked to POAG were assessed using genome-wide SNP data of the primary cohort (565 Japanese POAG patients and 1,104 ...

Correction to: Determining soil quality in urban agricultural regions by soil enzyme-based index

Unfortunately, in the original publication of the article, Prof. Yang Sik Ok’s affiliation was incorrectly published. The author’s affiliation is as follows.

Modeling of Gas Migration Through Low-Permeability Clay Rock Using Information on Pressure and Deformation from Fast Air Injection Tests

The characterization of gas migration through low-permeability clay formations has been a focus of R&D programs for radioactive waste disposal, which is also of great importance for shale gas exploration, cap-rock behavior of hydrocarbon reservoirs, and \(\hbox {CO}_{2}\) sequestration. Laboratory tests have been performed on Opalinus Clay, a Mesozoic claystone that is being ...

Sudakov representation of the Cachazo-He-Yuan scattering equations formalism

We show that the use of Sudakov variables greatly simplifies the study of the solutions to the scattering equations in the Cachazo-He-Yuan formalism. We work in the center-of-mass frame for the two incoming particles, which partially fixes the SL(2, ℂ) redundancy in the integrand defining the scattering amplitudes, the remaining freedom translates into a global shift in the ...

Pik3ca is required for mouse uterine gland development and pregnancy

The PI3K/AKT signaling pathway plays a critical role in the maintenance of equilibrium between cell survival and apoptosis. The Pik3ca gene is mutated in a range of human cancers. It has been found to be oncogenic, and mutations lead to constitutive activation of the PI3K/AKT pathway. The expression patterns of PIK3CA proteins in the uterus of mice during early pregnancy indicate ...

Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model

Vaccination with DNA that encodes cancer antigens is a simple and convenient way to raise immunity against cancer and has already shown promise in the clinical setting. Conventional plasmid DNA is commonly used which together with the encoded antigen also includes bacterial immunostimulatory CpG motifs to target the DNA sensor Toll-like receptor 9. Recently DNA vaccines using ...

Specialized attachment structure of the fish pathogenic oomycete Saprolegnia parasitica

The secondary cysts of the fish pathogen oomycete Saprolegnia parasitica possess bundles of long hooked hairs that are characteristic to this economically important pathogenic species. Few studies have been carried out on elucidating their specific role in the S. parasitica life cycle and the role they may have in the infection process. We show here their function by employing ...

Liver transplantation for alcoholic hepatitis: A systematic review with meta-analysis

Background The rate of alcohol relapse among patients who underwent liver transplantation for alcoholic hepatitis (AH) is not precisely known. Aim Synthesize the available evidence on liver transplantation for AH to assess alcohol relapse and 6-month survival. Methods Meta-analysis of trials evaluating liver transplantation for AH, either clinically severe or diagnosed on the ...

Early vascular responses to everolimus-eluting cobalt–chromium stent in the culprit lesions of st-elevation myocardial infarction: results from a multicenter prospective optical coherence tomography study (MECHANISM-AMI 2-week follow-up study)

The use of cobalt–chromium everolimus-eluting stents (CoCr-EES) for ST-segment elevation myocardial infarction (STEMI) reduces the incidence of stent thrombosis compared with bare metal stents, and a substantial difference is apparent in the initial 2 weeks. However, vascular behavior during this early period remains unclear. This was a prospective study (MECHANISM-AMI-2W) to ...

Nonautonomous Young Differential Equations Revisited

In this paper we prove that under mild conditions a nonautonomous Young differential equation possesses a unique solution which depends continuously on initial conditions. The proofs use estimates in p-variation norms, the construction of greedy sequence of times, and Gronwall-type lemma with the help of Shauder theorem of fixed points.

Prevalence of anemia and associated factors among school children in Gondar town public primary schools, northwest Ethiopia: A school-based cross-sectional study

Background Anemia is a global public health problem affecting 305 million school children (SC) worldwide. It has deleterious effects in SC, including lower school achievement due to impaired cognitive development and physical growth, fatigue and poor attention span, and increased morbidity because of reduced resistance to infection. Hence, the aim of this study was to assess the ...

Psychometric properties of the Arabic version of the 12-item diabetes fatalism scale

Background There are widespread fatalistic beliefs in Arab countries, especially among individuals with diabetes. However, there is no tool to assess diabetes fatalism in this population. This study describes the processes used to create an Arabic version of the Diabetes Fatalism Scale (DFS) and examine its psychometric properties. Methods A descriptive correlational design was ...