#### Motives for change of first-line antiretroviral therapy regimens in an unselected cohort of HIV/AIDS patients at a major referral centre in South-west Cameroon

Objective The rapid scale-up of antiretroviral therapy (ART) coverage in sub-Saharan Africa has encountered the challenge of maintaining international clinical standards of ART utilization and change of ART regimens. In Cameroon, scarce reports have documented the motives for change of ART. This study had as objective to investigate the reasons for switch in ART through a secondary ...

#### The Multifeature Gait Score: An accurate way to assess gait quality

Purpose This study introduces a novel way to accurately assess gait quality. This new method called Multifeature Gait Score (MGS) is based on the computation of multiple parameters characterizing six aspects of gait (temporal, amplitude, variability, regularity, symmetry and complexity) quantified with one inertial sensor. According to the aspects described, parameters were ...

#### The Impact of Predictor Variable(s) with Skewed Cell Probabilities on Wald Tests in Binary Logistic Regression

A series of simulation studies are reported that investigated the impact of a skewed predictor(s) on the Type I error rate and power of the Wald test in a logistic regression model. Five simulations were conducted for three different regression models. A detailed description of the impact of skewed cell predictor probabilities and sample size provide guidelines for practitioners ...

#### The Artificial Moral Advisor. The “Ideal Observer” Meets Artificial Intelligence

We describe a form of moral artificial intelligence that could be used to improve human moral decision-making. We call it the “artificial moral advisor” (AMA). The AMA would implement a quasi-relativistic version of the “ideal observer” famously described by Roderick Firth. We describe similarities and differences between the AMA and Firth’s ideal observer. Like Firth’s ideal ...

#### “The Longest Way Round Is The Shortest Way Home”: An Overhaul of Surgical Ward Rounds

Background Ward rounds, a keystone of hospital surgical practice, have recently been under the spotlight. Poor-quality ward rounds can lead to a greater number of adverse events, thereby cascading to an increased financial strain on our already burdened healthcare systems. Faced with mounting pressures from both outside and inside health organizations, concerted efforts are ...

#### How should we give vitamin D supplementation? evaluation of the pediatricians’ knowledge in Turkey

We aimed to determine the knowledge and attitudes of Turkish pediatricians concerning vitamin D supplement. The study was planned cross-sectional to be carried out between April–May 2015 in Turkey. A questionnaire form that determined the participants’ opinions and practices concerning vitamin D supplement was completed via face-to-face interview. A total of 107 pediatricians ...

#### Correction to: Uniaxial experimental study of the acoustic emission and deformation behavior of composite rock based on 3D digital image correlation (DIC)

In the original publication of this article, Table 2 is incorrectly published due to the negligence of the author’s proofreading. The correct version of Table 2 is provided below.

#### Constitutive modeling of cyclic deformation of metals under strain controlled axial extension and cyclic torsion

The present work provides a formulation of a constitutive model for metals with the aim to simulate cyclic deformation under axial extension or compression assisted by cyclic torsional (or shearing) straining of specified amplitude and frequency. Such a mode of deformation was recently implemented in technological processes such as extrusion, forging and rolling, cf. Bochniak and ...

#### A systematic approach to evaluate the influence of environmental conditions on eDNA detection success in aquatic ecosystems

The use of environmental DNA (eDNA) to determine the presence and distribution of aquatic organisms has become an important tool to monitor and investigate freshwater communities. The successful application of this method in the field, however, is dependent on the effectiveness of positive DNA verification, which is influenced by site-specific environmental parameters. Factors ...

#### Bio- and chemocatalysis cascades as a bridge between biology and chemistry for green polymer synthesis

The development and integration of bio- and chemocatalytic processes to convert renewable or biomass feedstocks into polymers is a vibrant field of research with enormous potential for environmental protection and the mitigation of global warming. Here, we review the biotechnological and chemical synthetic strategies for producing platform monomers from bio-based sources and ...

#### Transcriptome analysis of mRNA and microRNAs in intramuscular fat tissues of castrated and intact male Chinese Qinchuan cattle

Intramuscular fat (IMF) is known to enhance beef palatability and can be markedly increased by castration. However, there is little understanding of the molecular mechanism underlying the IMF deposition after castration of beef cattle. We hypothesize that genetic regulators function differently in IMF from bulls and steers. Therefore, after detecting serum testosterone and lipid ...

#### Hypoxia Increases Thyroid Cancer Stem Cell-Enriched Side Population

Introduction Hypoxic stress is a feature of rapidly growing thyroid tumours. Cancer progression is thought to be driven by a small population of tumour cells possessing stem cell properties. Hypoxia-inducible factors (HIFs) are important mediators of hypoxia. Both HIF-1alpha and HIF-2alpha have been reported to be expressed in thyroid cancers. There is growing evidence that the HIF ...

#### Determination of μ-, δ- and κ-opioid receptors in forebrain cortex of rats exposed to morphine for 10 days: Comparison with animals after 20 days of morphine withdrawal

Background Chronic exposure of mammalian organism to morphine results in adaption to persistent high opioid tone through homeostatic adjustments. Our previous results indicated that in the frontal brain cortex (FBC) of rats exposed to morphine for 10 days, such a compensatory adjustment was detected as large up-regulation of adenylylcyclases I (8-fold) and II (2.5–fold). The other ...

#### Doxorubicin combined with low intensity ultrasound suppresses the growth of oral squamous cell carcinoma in culture and in xenografts

Oral squamous cell carcinoma (OSCC) invades surrounding tissues by upregulating matrix metalloproteinases (MMPs) -2 and −9, which causes over-expression of the Hedgehog signaling proteins Shh and Gli-1 and degradation of the extracellular matrix, thereby creating a “highway” for tumor invasion. We explored the potential of low intensity ultrasound (LIUS) and doxorubicin (DOX) to ...

#### Synergistic Effects of Ag Nanoparticles/BiV1-xMoxO4 with Enhanced Photocatalytic Activity

In recent years, BiVO4 has drawn much attention as a novel photocatalyst given its excellent ability to absorb visible light. This work reports the development of Ag-modified BiV1-xMoxO4 composites through a facile hydrothermal synthesis with the subsequent photoinduced reduction of Ag+ at almost neutral pH conditions. Metallic Ag nanoparticles were deposited on the (040) facet of ...

#### Piecewise-regular maps

Let V, W be real algebraic varieties (that is, up to isomorphism, real algebraic sets), and $X \subseteq V$ some subset. A map from X into W is said to be regular if it can be extended to a regular map defined on some Zariski locally closed subvariety of V that contains X. Furthermore, a continuous map $f :X \rightarrow W$ is said to be piecewise-regular if there exists a ...

#### Paper-based laminates produced with kraft lignin-rich phenol–formaldehyde resoles meet requirements for outdoor usage

Suitability of lignin–phenol–formaldehyde (LPF) resoles was investigated for manufacturing paper-based high-pressure laminates. As lignin source, pine kraft lignin and spruce sodium lignosulfonate were compared, substituting 40 wt% of phenol by lignin in each case. The synthesized resins were characterized for their viscosity development, solid content, pH, free formaldehyde as ...

#### Influence of the type of training task on intermanual transfer effects in upper-limb prosthesis training: A randomized pre-posttest study

Intermanual transfer, the transfer of motor skills from the trained hand to the untrained hand, can be used to train upper limb prosthesis skills. The aim of this study was to determine the relation between the magnitude of the intermanual transfer effect and the type of training task. The used tasks were based on different aspects of prosthetic handling: reaching, grasping, ...

#### Anticoagulant Activities of Olea Europaea Leaves and Fruit Extract

The objective of this study is the evaluation of the anticoagulant activity of polyphenols obtained from extracts of the leaves, and fruits of olive (Olea europaea L.) of four varieties cultivated in the station Maazouzi Lakhdar (Mila, Algeria). The anticoagulant activity of the polyphenolic extracts, of the leaves and fruits of olive have been evaluated in vitro, using the test of ...

#### MOSCAB: a geyser-concept bubble chamber to be used in a dark matter search

The MOSCAB experiment (Materia OSCura A Bolle) uses the “geyser technique”, a variant of the superheated liquid technique of extreme simplicity. Operating principles of the new dark matter detector and technical solutions of the device are reported in detail. First results obtained in a series of test runs taken in laboratory demonstrate that we have successfully built and tested a ...

#### Combined short- and long-axis ultrasound-guided central venous catheterization is superior to conventional techniques: A cross-over randomized controlled manikin trial

Objectives Visualizing the needle tip using the short-axis (SA) ultrasound-guided central venous catheterization approach can be challenging. It has been suggested to start the process with the SA approach and then switch to the long-axis (LA); however, to our knowledge, this combination has not been evaluated. We compared the combined short- and long-axis (SLA) approach with the ...

#### Book Review: Realizing the Distinctive University: Vision and Values, Strategy and Culture

Review of Realizing the Distinctive University: Vision and Values, Strategy and Culture by Mark William Roche.