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The role of properdin in complement-mediated renal diseases: a new player in complement-inhibiting therapy?

Properdin is known as the only positive regulator of the complement system. Properdin promotes the activity of this defense system by stabilizing its key enzymatic complexes: the complement alternative pathway (AP) convertases. Besides, some studies have indicated a role for properdin as an initiator of complement activity. Though the AP is a powerful activation route of the...

Design and Implementation of a Low Power Ternary Full Adder

In this work, the design and implementation of a low power ternary full adder are presented in CMOS technology. In a ternary full adder design, the basic building blocks, the positive ternary inverter (PTI) and negative ternary inverter (NTI) are developed using a CMOS inverter and pass transistors. In designs of PTI and NTI, W/L ratios of transistors have been varied for their...

LASIE: Large Area Spectroscopic Imaging Ellipsometry for Characterizing Multi-Layered Film Structures

In this investigation, we describe a spectroscopic imaging ellipsometry for large area measurements, named as large area spectroscopic ellipsometry (LASIE). LASIE uses a broadband light source and an imaging spectrometer in order to obtain the spectral-spatial intensity images corresponding to a measurement line of a specimen and it can characterize the 3D multi-film structures...

Fixed point theory for Mönch-type maps defined on closed subsets of Fréchet spaces: the projective limit approach

New Leray-Schauder alternatives are presented for Mönch-type maps defined between Fréchet spaces. The proof relies on viewing a Fréchet space as the projective limit of a sequence of Banach spaces.

Variational and numerical analysis of the Signorini′s contact problem in viscoplasticity with damage

We consider the quasistatic Signorini′s contact problem with damage for elastic-viscoplastic bodies. The mechanical damage of the material, caused by excessive stress or strain, is described by a damage function whose evolution is modeled by an inclusion of parabolic type. We provide a variational formulation for the mechanical problem and sketch a proof of the existence of a...

Measuring static complexity

The concept of “pattern” is introduced, formally defined, and used to analyze various measures of the complexity of finite binary sequences and other objects. The standard Kolmogoroff-Chaitin-Solomonoff complexity measure is considered, along with Bennett's ‘logical depth’, Koppel's ‘sophistication'’, and Chaitin's analysis of the complexity of geometric objects. The pattern...

Painful Neuropathic Disorders: An Analysis of the RéGie De L’Assurance Maladie du QuéBec Database

BACKGROUND/OBJECTIVE: Painful neuropathic disorders (PNDs) refer to neurological disorders involving nerves in which pain is a predominant symptom. In most cases, PNDs involve the peripheral nerves. Treatment of PNDs is likely to use large health care resources. However, little is known about the economic burden of PNDs in Canada.

Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory

PurposePhysiologically-based pharmacokinetic (PBPK) models are essential in drug development, but require parameters that are not always obtainable. We developed a methodology to investigate the feasibility and requirements for precise and accurate estimation of PBPK parameters using population modelling of clinical data and illustrate this for two key PBPK parameters for hepatic...

Some remarks concerning finitely Subadditive outer measures with applications

The present paper is intended as a first step toward the establishment of a general theory of finitely subadditive outer measures. First, a general method for constructing a finitely subadditive outer measure and an associated finitely additive measure on any space is presented. This is followed by a discussion of the theory of inner measures, their construction, and the...

Rh System and Intrauterine Growth. Interaction with Season of Birth

Based on the hypothesis that maternal-fetal genetic differences in membrane transport and signal transduction may influence intrauterine development, the recent acquisition on transport function of Rh protein prompted us to study the relationship between joint maternal-fetal Rh phenotype and birth weight. Considering that metabolic effect of maternal-fetal competition could be...

No difference in effectiveness of treatment simplification to boosted or unboosted atazanavir plus lamivudine in virologically suppressed in HIV-1-infected patients

Background Simplification strategies of antiretroviral treatment represent effective tools for the reduction of drug-induced toxicity, resistance mutations in case of virological failure and costs. Objectives To assess the effectiveness of simplification to atazanavir/ritonavir (ATVrtv) or unboosted atazanavir (ATV400) plus lamivudine, and if low plasma or intracellular ATV...

Turán inequalities for symmetric orthogonal polynomials

A method is outlined to express a Turán determinant of solutions of a three term recurrence relation as a weighted sum of squares. This method is shown to imply the positivity of Turán determinants of symmetric Pollaczek polynomials, Lommel polynomials and q-Bessel functions.

A problem related to the hall effect in a semiconductor with an electrode of an arbitrary shape

A problem on electric current in a semiconductor film from an electrode of an arbitrary shape is studied in the presence of a magnetic field. This situation describes the Hall effect, which indicates the deflection of electric, current from electric field in a semiconductor. From mathematical standpoint we consider the skew derivative problem for harmonic functions in the...

Assessment of Ground Water Quality in and around Gobichettipalayam Town Erode District, Tamilnadu

Ground water samples collected from different localities in and around Gobichettipalayam town, Erode District, Tamil Nadu were analyzed for their physico- chemical characteristics. This analysis result was compared with the WHO & ICMR standards of drinking water quality parameters with the following water quality parameters namely pH, Electrical conductivity, CN-, Cl-, SO42-, Na

A class of inequalities relating degrees of adjacent nodes to the average degree in edge-weighted uniform hypergraphs

In 1986, Johnson and Perry proved a class of inequalities for uniform hypergraphs which included the following: for any such hypergraph, the geometric mean over the hyperedges of the geometric means of the degrees of the nodes on the hyperedge is no less than the average degree in the hypergraph, with equality only if the hypergraph is regular. Here, we prove a wider class of...

Proinflammatory Liver and Antiinflammatory Intestinal Mediators Involved in Portal Hypertensive Rats

Proinflammatory (TNF-α, IL-1β, and NO) and antiinflammatory (IL-10, CO) levels were assayed in serum, liver, and small bowel in order to verify a hypothetic inflammatory etiopathogeny of portal hypertension that could be the cause of its evolutive heterogeneity. Male Wistar rats were divided into one control group (n=11) and one group with a triple stenosing ligation of the...

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Helicobacter pylori Infection in Various ABO Blood Groups of Kashmiri Population

Aim: This study was carried out to assess the prevalence of Helicobacter pylori infection in various ABO blood groups of people of Kashmir.

Nonalcoholic Fatty Liver Disease in Patients Investigated for Elevated Liver Enzymes

Nonalcoholic fatty liver disease (NAFLD) is a common diagnosis among patients referred to gastroenterology and hepatology clinics for the evaluation of elevated liver enzymes. The diagnosis of NAFLD is supported by blood work to exclude other liver diseases, and by ultrasound evidence of fat in the liver in patients without a significant history of alcohol intake. The gold...

Effectiveness of educational outreach visits compared with usual guideline dissemination to improve family physician prescribing—an 18-month open cluster-randomized trial

Educational outreach visits are meant to improve the practice of health professionals by promoting face-to-face visits to deliver educational contents. They have been shown to change prescription behavior, but long-term effects are still uncertain. This trial aimed to determine if they improve family physician prescribing compared with passive guideline dissemination. Parallel...

Association between use of antidepressants or benzodiazepines and the risk of subsequent fracture among those aged 65+ in the Netherlands

SummaryThis is the first study to examine the association between antidepressant and benzodiazepine use following a MOF and risk of subsequent fracture in those 65+. Using national data, drug use following MOF showed that the 1-year fully adjusted risk of subsequent MOF in those on antidepressants was more than doubled.IntroductionWe evaluated the association between the use of...