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Increased RHAMM expression relates to ovarian cancer progression

Elevated hyaluronan-mediated motility receptor (RHAMM) has been reported to contribute to disease progression, aggressive phenotype and poor prognosis in multiple cancer types, however, RHAMM’s role in ovarian cancer (OC) has not been elucidated. Therefore, we sought to evaluate the role for RHAMM in epithelial OC. Despite little to no expression in normal ovarian surface ...

Transient yellow discoloration of the nails for differential diagnosis with yellow nail syndrome

A differential diagnosis must be made between transient yellow discoloration of the nails and yellow nail syndrome. We highlight some practical aspects of yellow nail discoloration.

On Time

Contemporary philosophy discussions on the nature of time begin with McTaggart, who introduces two ways of describing temporal relation between events: the A-series, focusing on the past, present and future, is about positions of time; and the B-series, which an event’s position in the series is described only in relation to other events: “earlier than,” “later than,” or ...

Activity recognition with wearable sensors on loose clothing

Observing human motion in natural everyday environments (such as the home), has evoked a growing interest in the development of on-body wearable sensing technology. However, wearable sensors suffer from motion artefacts introduced by the non-rigid attachment of sensors to the body, and the prevailing view is that it is necessary to eliminate these artefacts. This paper presents ...

UWB pulse detection and TOA estimation using GLRT

In this paper, a novel statistical approach is presented for time-of-arrival (TOA) estimation based on first path (FP) pulse detection using a sub-Nyquist sampling ultra-wide band (UWB) receiver. The TOA measurement accuracy, which cannot be improved by averaging of the received signal, can be enhanced by the statistical processing of a number of TOA measurements. The TOA ...

Impact of Salmonid alphavirus infection in diploid and triploid Atlantic salmon (Salmo salar L.) fry

With increasing interest in the use of triploid salmon in commercial aquaculture, gaining an understanding of how economically important pathogens affect triploid stocks is important. To compare the susceptibility of diploid and triploid Atlantic salmon (Salmo salar L.) to viral pathogens, fry were experimentally infected with Salmonid alphavirus sub-type 1 (SAV1), the aetiological ...

Evolutionary thinking among biology students in a third world country

Background Evolutionary thinking is traditionally directly related to education and inversely to religiosity. Accordingly, biology students are naturally expected to be more prone to naturalist evolution due to their close contact with this theory and high scientific literacy. To test this, we performed a cross-national study surveying biology students’ evolutionary opinions in ...

Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus)

The development of novel therapeutics to prevent cognitive decline of Alzheimer's disease (AD) is facing paramount difficulties since the translational efficacy of rodent models did not resulted in better clinical results. Currently approved treatments, including the acetylcholinesterase inhibitor donepezil (DON) and the N-methyl-D-aspartate antagonist memantine (MEM) provide ...

Falling Short for Labor: Why the Trans-Pacific Partnership Does Not Do Enough for Workers

Using free trade agreements to increase labor standards in developing countries has not worked. Although most critics focus on lack of enforcement by the U.S., the real problem is the inherent tension between using free trade to make money, and spending money to improve labor standards. If the U.S. were to enforce labor standards, it would destroy the gains from free trade, which ...

Cost-Effectiveness of Golimumab in Ankylosing Spondylitis from the UK Payer Perspective

Introduction Golimumab is a tumor necrosis factor-α (TNF-α) inhibitor for treatment of patients with severe, active ankylosing spondylitis. This study evaluated the cost-effectiveness of golimumab compared with conventional care and other TNF-α inhibitors in treatment of AS from the UK National Health Service perspective. Methods A long-term Markov model (with initial decision ...

Phenolic compounds, flavonoids, lipids and antioxidant potential of apricot (Prunus armeniaca L.) pomace fermented by two filamentous fungal strains in solid state system

Background The use of agricultural and food by-products is an economical solution to industrial biotechnology. The apricot press residues are abounding by-products from juice industry which can be used as substrates in solid state fermentation process (SSF), thus allowing a liberation and increase of content from various biomolecules with high added value. Methods The evolutions of ...

Whole body magnetic resonance in indolent lymphomas under watchful waiting: The time is now

ᅟ The indolent non-Hodgkin lymphomas (i-NHLs) are characterised by ‘indolent’ clinical behaviour with slow growth and prolonged natural history. The watchful waiting (WW) strategy is a frequently employed treatment option in these patients. This implies a strict monitoring by imaging examinations, including 18F-fluorodeoxyglucose-positron emission tomography/computed tomography ...

Nasal and pharyngeal carriage of methicillin-resistant Staphylococcus sciuri among hospitalised patients and healthcare workers in a Serbian university hospital

There has been a paucity of data on methicillin-resistant Staphylococcus sciuri (MRSS) epidemiology in European healthcare settings. The aim of the study was to determine the prevalence of nasal and pharyngeal carriage and diversity of MRSS among inpatients and healthcare workers (HCWs) in the largest healthcare centre in Serbia, and to assess performance of different methods for ...

On the existence of solutions for some infinite coefficient-symmetric Caputo-Fabrizio fractional integro-differential equations

By mixing the idea of 2-arrays, continued fractions, and Caputo-Fabrizio fractional derivative, we introduce a new operator entitled the infinite coefficient-symmetric Caputo-Fabrizio fractional derivative. We investigate the approximate solutions for two infinite coefficient-symmetric Caputo-Fabrizio fractional integro-differential problems. Finally, we analyze two examples to ...

A new method to evaluate temperature vs. pH activity profiles for biotechnological relevant enzymes

Glycoside hydrolases are important for various industrial and scientific applications. Determination of their temperature as well as pH optima and range is crucial to evaluate whether an enzyme is suitable for application in a biotechnological process. These basic characteristics of enzymes are generally determined by two separate measurements. However, these lead to a ...

The effect of electronic monitoring feedback on medication adherence and clinical outcomes: A systematic review

Objective This study aims to assess the efficacy of Electronic Monitoring Feedback (EMF) as an intervention to improve medication adherence (i.e. dose- or full adherence) and clinical outcomes in adult patients. Methods A systematic search was performed in Medline, EMBASE, PsycINFO and Web of Science and reported according to the PRISMA guidelines. Randomised controlled trials ...

Roflumilast reverses CFTR-mediated ion transport dysfunction in cigarette smoke-exposed mice

Dysfunction in cystic fibrosis transmembrane conductance regulator (CFTR) can be elicited by cigarette smoke and is observed in patients with chronic bronchitis. We have previously demonstrated in human airway epithelial cell monolayers that roflumilast, a clinically approved phosphodiesterase 4 inhibitor that reduces the risk of exacerbations in chronic obstructive pulmonary ...

A multicenter, randomized study of decitabine as epigenetic priming with induction chemotherapy in children with AML

Background Decitabine is a deoxycytidine nucleoside derivative inhibitor of DNA-methyltransferases, which has been studied extensively and is approved for myelodysplastic syndrome in adults but with less focus in children. Accordingly, we conducted a phase 1 multicenter, randomized, open-label study to evaluate decitabine pre-treatment before standard induction therapy in children ...