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Equilibrium in risk-sharing games

The large majority of risk-sharing transactions involve few agents, each of whom can heavily influence the structure and the prices of securities. In this paper, we propose a game where agents’ strategic sets consist of all possible sharing securities and pricing kernels that are consistent with Arrow–Debreu sharing rules. First, it is shown that agents’ best response problems have ...

Is the Public Willing to Help the Nigerian Police During the Boko Haram Crisis? A Look at Moderating Factors

This paper sought the opinion of 200 Nigerians on their willingness to cooperate with the police during the Boko Haram crisis. Public perceptions of police effectiveness during the crisis, residence location, gender and religious affiliation were used as moderators. Data was analysed using an explanatory factor analysis and structural equation modelling. Results indicated a strong ...

Participatory Planning, Monitoring and Evaluation of Multi-Stakeholder Platforms in Integrated Landscape Initiatives

Integrated landscape initiatives typically aim to strengthen landscape governance by developing and facilitating multi-stakeholder platforms. These are institutional coordination mechanisms that enable discussions, negotiations, and joint planning between stak4eholders from various sectors in a given landscape. Multi-stakeholder platforms tend to involve complex processes with ...

Tienerleed of tienerlol?

Moeders van tieners ervaren veel stress en voelen zich meer geïsoleerd en ontevreden in hun ouderrol, blijkt uit Amerikaans onderzoek. Dat lees ik op de website van Ouders J/M, waar ik wat zit te grasduinen in artikelen over pubers. Ook vind ik er veel tips over omgaan met lastige pubers, over hun irritante gewoonten en over hoe je overleeft met een puber in huis. Eerlijk gezegd ...

Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3

The purpose of this study was to describe the impact of sex and cytochrome P450 3A5 (CYP3A5) variant on the blood concentration of tacrolimus in patients with systemic lupus erythematosus or rheumatoid arthritis. The blood concentration of tacrolimus (ng/mL) divided by the daily dose of tacrolimus (mg/day) and the patient’s weight (kg) (C/D) was obtained from 55 patients. The C/D ...

Explaining Conflicting Results in Research on the Heterogeneous Effects of Parental Separation on Children’s Educational Attainment According to Social Background

In recent years, researchers have become increasingly interested in how the effects of parental separation on children’s educational attainment vary with social background. On the one hand, parents with more resources might be better able to prevent possible adverse events like separation to affect their children’s outcomes. On the other hand, children from higher social ...

A theoretical model of the relationship between the h-index and other simple citation indicators

Of the existing theoretical formulas for the h-index, those recently suggested by Burrell (J Informetr 7:774–783, 2013b) and by Bertoli-Barsotti and Lando (J Informetr 9(4):762–776, 2015) have proved very effective in estimating the actual value of the h-index Hirsch (Proc Natl Acad Sci USA 102:16569–16572, 2005), at least at the level of the individual scientist. These approaches ...

A Review of Ranibizumab for the Treatment of Diabetic Retinopathy

Introduction Laser photocoagulation has been the standard treatment for diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) for several decades. The discovery of vascular endothelial growth factor (VEGF) and the subsequent determination of its critical role in the development DME and PDR has led to the development of VEGF inhibitory drugs. Ranibizumab was the ...

Do general innovation policy tools fit all? Analysis of the regional impact of the Norwegian Skattefunn scheme

Background The paper examines the regional effects of a general innovation policy, i.e. a policy tool that does not target specific industries or subnational regions. General policy tools are an important part of the portfolio of innovation policy measures. However, there is a question over whether general tools are equally relevant for all types of firms, irrespective of their ...

Mesenchymal stem cells increase expression of heme oxygenase-1 leading to anti-inflammatory activity in treatment of acute liver failure

Background Mesenchymal stem cells (MSCs) have been studied for the treatment of acute liver failure (ALF) for several years. MSCs may exert their effect via complex paracrine mechanisms. Heme oxygenase (HO) 1, a rate-limiting enzyme in heme metabolism, exerts a wide range of anti-inflammatory, anti-apoptotic and immunoregulatory effects in a variety of diseases. However, the ...

Disrupted functional connectivity of periaqueductal gray subregions in episodic migraine

Background The periaqueductal gray (PAG) dysfunction was recognized in migraine, and the altered dysfunction of PAG subregions were not totally detected up to now. The aim of this study is to investigate the altered functional connectivity of PAG subregions in EM patients. Methods The brain structural images and resting state functional MR imaging (rs-fMRI) data were obtained from ...

Can red deer antlers be used as an indicator of environmental and edible tissues’ trace element contamination?

Venison is an attractive product for consumers concerned with healthy lifestyle; however, it can contain high levels of toxic elements, and therefore, it is a possible source of hazardous contaminants in human diet. Antlers are suitable bioindicators of environmental metal contamination, and herein, we assessed the ability of trace element levels in antlers to indicate levels in ...

Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept)

Purpose The present study evaluated the platelet distribution pattern and growth factor release (VEGF, TGF-β1 and EGF) within three PRF (platelet-rich-fibrin) matrices (PRF, A-PRF and A-PRF+) that were prepared using different relative centrifugation forces (RCF) and centrifugation times. Materials and methods immunohistochemistry was conducted to assess the platelet distribution ...

Study of Electron Ionization and Fragmentation of Non-hydrated and Hydrated Tetrahydrofuran Clusters

Mass spectroscopic investigations on tetrahydrofuran (THF, C4H8O), a common model molecule of the DNA-backbone, have been carried out. We irradiated isolated THF and (hydrated) THF clusters with low energy electrons (electron energy ~70 eV) in order to study electron ionization and ionic fragmentation. For elucidation of fragmentation pathways, deuterated TDF (C4D8O) was ...

Lessons learned from additional research analyses of unsolved clinical exome cases

Background Given the rarity of most single-gene Mendelian disorders, concerted efforts of data exchange between clinical and scientific communities are critical to optimize molecular diagnosis and novel disease gene discovery. Methods We designed and implemented protocols for the study of cases for which a plausible molecular diagnosis was not achieved in a clinical genomics ...

Lung adenocarcinoma with thyroid metastasis: a case report

Background The metastases of a primary lung cancer over the thyroid gland are extremely rare. We report on an unusual presentation of thyroid metastasis of lung cancer in order to improve the management of similar cases. Case presentation Three years ago, a Moroccan male 59-year-old was admitted for dyspnea, dry cough, and chest pain. He had smoked about 30 cigarette packs a year. ...

Sodium-Glucose Co-transporter 2 (SGLT2) Inhibitor: Comparing Trial Data and Real-World Use

Introduction The first cardiovascular safety trial in the sodium-glucose co-transporter-2 (SGLT2) inhibitor drug class, the Empagliflozin Cardiovascular Outcomes and Mortality in Type 2 Diabetes (EMPA-REG OUTCOME) trial, demonstrated significant cardiovascular risk reduction with empagliflozin. It is currently not clear what proportions of people with type 2 diabetes (T2DM) have ...

Sepsis risk factors in infants with congenital diaphragmatic hernia

Background Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly and remains among the most challenging ICU-managed disease. Beside severe pulmonary hypertension, lung hypoplasia and major abdominal surgery, infective complications remain major determinants of outcome. However, the specific incidence of sepsis as well as associated risk factors is unknown. Methods This ...