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Dynamic analysis of a class of neutral delay model based on the Runge-Kutta algorithm

In this paper, we study the dynamics of a class of second-order neutral delay nonlinear models. This study is applicable to many fields, such as engineering, cybernetics, and physics. We use the Runge-Kutta algorithm and the Riccati transform method. First, we give a neutral delay nonlinear model based on the Runge-Kutta algorithm. Then, we study the dynamic characteristics of...

Phase-III-Langzeitdaten zu Cabozantinib beim medullären Schilddrüsenkrebs

Der Kinasehemmer XL184 (Cabozantinib) hat in der Phase-III-Studie EXAM im Vergleich zu Placebo beim fortgeschrittenen medullären Schilddrüsenkrebs (MTC) überzeugt — zumindest beim progressionsfreien Überleben. Jetzt liegen die Langzeitdaten zum Gesamtüberleben vor.

Rhodococcus strains as source for ene-reductase activity

Rhodococcus strains are ubiquitous in nature and known to metabolise a wide variety of compounds. At the same time, asymmetric reduction of C=C bonds is important in the production of high-valued chiral building blocks. In order to evaluate if Rhodococci can be used for this task, we have probed several Rhodococcus rhodochrous and R. erythropolis strains for ene-reductase...

Levels of selected analytes in the emissions of “heat not burn” tobacco products that are relevant to assess human health risks

Consumers of combustible cigarettes are exposed to many different toxicologically relevant substances associated with negative health effects. Newly developed “heat not burn” (HNB) devices are able to contain lower levels of Harmful and Potentially Harmful Constituents (HPHCs) in their emissions compared to tobacco cigarettes. However, to develop toxicological risk assessment...

Lawsuit lead time prediction: Comparison of data mining techniques based on categorical response variable

The quality of the judicial system of a country can be verified by the overall length time of lawsuits, or the lead time. When the lead time is excessive, a country’s economy can be affected, leading to the adoption of measures such as the creation of the Saturn Center in Europe. Although there are performance indicators to measure the lead time of lawsuits, the analysis and the...

Protection of minors: lessons about the FIFA RSTP from the recent Spanish cases at the Court of Arbitration for Sport

The publication of recent CAS awards concerning minors in Spanish football involving two football giants, Fútbol Club Barcelona and Real Madrid Club de Fútbol, and the national association, The Real Federació Española de Fútbol, offers a valuable opportunity to analyse the operation of the regulatory regime for the protection of minors under FIFA’s Regulations on the Status and...

Lexical representation explains cortical entrainment during speech comprehension

Results from a recent neuroimaging study on spoken sentence comprehension have been interpreted as evidence for cortical entrainment to hierarchical syntactic structure. We present a simple computational model that predicts the power spectra from this study, even though the model’s linguistic knowledge is restricted to the lexical level, and word-level representations are not...

Analysis of b quark pair production signal from neutral 2HDM Higgs bosons at future linear colliders

In this paper, the b quark pair production events are analyzed as a source of neutral Higgs bosons of the two Higgs doublet model type I at linear colliders. The production mechanism is \(e^{+}e^{-} \rightarrow Z^{(*)} \rightarrow HA \rightarrow b{\bar{b}}b{\bar{b}}\) assuming a fully hadronic final state. The analysis aim is to identify both CP-even and CP-odd Higgs bosons in...

Short-term microbial effects of a large-scale mine-tailing storage facility collapse on the local natural environment

We investigated the impacts of the Mount Polley tailings impoundment failure on chemical, physical, and microbial properties of substrates within the affected watershed, comprised of 70 hectares of riparian wetlands and 40 km of stream and lake shore. We established a biomonitoring network in October of 2014, two months following the disturbance, and evaluated riparian and...

Smoluchowski Equation for Networks: Merger Induced Intermittent Giant Node Formation and Degree Gap

The dynamical phase diagram of a network undergoing annihilation, creation, and coagulation of nodes is found to exhibit two regimes controlled by the combined effect of preferential attachment for initiator and target nodes during coagulation and for link assignment to new nodes. The first regime exhibits smooth dynamics and power law degree distributions. In the second regime...

Determination of an effective scoring function for RNA–RNA interactions with a physics-based double-iterative method

RNA–RNA interactions play fundamental roles in gene and cell regulation. Therefore, accurate prediction of RNA–RNA interactions is critical to determine their complex structures and understand the molecular mechanism of the interactions. Here, we have developed a physics-based double-iterative strategy to determine the effective potentials for RNA–RNA interactions based on a...

Zu lange Zehennägel — hier braucht jemand Hilfe

Kann jemand noch seinen Alltag bewältigen? Das lässt sich oft an den Zehennägeln ablesen. Werden diese nicht mehr geschnitten, läuft wohl auch einiges andere schief.

Transcutaneous oxygen pressure as a predictor for short-term survival in patients with type 2 diabetes and foot ulcers: a comparison with ankle–brachial index and toe blood pressure

AimsAnkle–brachial index (ABI) is the most commonly used test when diagnosing peripheral vascular disease and is considered a marker for cardiovascular risk. Transcutaneous oxygen pressure (TcPO2), a test associated with microvascular function, has in several studies shown better correlation with diabetic foot ulcer (DFU) healing. Whether a low TcPO2 could be a marker for...

Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer’s Disease

Sphingolipid signaling disturbances correlate with Alzheimer’s disease (AD) progression. We examined the influence of FTY720/fingolimod, a sphingosine analog and sphingosine-1-phosphate (S1P) receptor modulator, on the expression of sphingolipid metabolism and signaling genes in a mouse transgenic AD model. Our results demonstrated that AβPP (V717I) transgene led with age to...

Incorporation of the novel bacterial blight resistance gene Xa38 into the genetic background of elite rice variety Improved Samba Mahsuri

Bacterial blight (BB) in rice caused by Xanthomonas oryzae pv. oryzae (Xoo) is a major global production constraint, particularly in irrigated and rain-fed lowland areas. Improved Samba Mahsuri (ISM) is an elite, high-yielding, fine-grain type, BB-resistant rice variety possessing three BB-resistant genes (Xa21, xa13 and xa5) and is highly popular in the southern parts of India...

Taking Charge: Moving from Peer to Supervisor

Leadership transitions occur frequently, and these times can be challenging for the individual and those they lead. Leaders must develop new knowledge and skills required of the position. Leaders also assume a new formal leadership role over prior peers. This can be a difficult task for junior leaders. The following article illustrates an example case faced by a junior Navy...

Optimization Design and Performance Analysis of Vehicle Powertrain Mounting System

The design strategies for powertrain mounting systems play an important role in the reduction of vehicular vibration and noise. As stiffness and damping elements connecting the transmission system and vehicle body, the rubber mount exhibits better vibration isolation performance than the rigid connection. This paper presents a complete design process of the mounting system...

Classification proposal for fractures of the processus condylaris mandibulae

ObjectiveThe current classification of mandibular condyle fractures as basal, low neck, and high neck as reported by Loukota et al. (Br J Oral Maxillofac Surg 43:72–73, 2005) and Neff et al. (Craniomaxillofac Trauma Reconstr 7:S44–S58, 2014) has a weakness. Nearly no high-neck fractures are reported (they are typically classified as type C head fractures) contrary to basal...

High relative risk of all-cause mortality attributed to smoking in China: Guangzhou Biobank Cohort Study

Background Prediction of disease burden in China arising from smoking based on earlier cohorts in the West and China could not reflect the disease burden at the current stage accurately. No cohort studies in China focused specifically on people born since 1950. We examined the risk of all-cause mortality attributed to smoking in adults in Guangzhou, the city with the most rapidly...