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In vivo visualization of the locus coeruleus in humans: quantifying the test–retest reliability

The locus coeruleus (LC) is a brainstem nucleus involved in important cognitive functions. Recent developments in neuroimaging methods and scanning protocols have made it possible to visualize the human LC in vivo by utilizing a T1-weighted turbo spin echo (TSE) scan. Despite its frequent use and its application as a biomarker for tracking the progress of monoaminergic-related ...

Analysis of Newly Identified and Rare Synonymous Genetic Variants in the RET Gene in Patients with Medullary Thyroid Carcinoma in Polish Population

Gain-of-function germline mutations of the RET proto-oncogene are responsible for initiation of carcinogenesis within the thyroid gland and development of hereditary form of medullary thyroid carcinoma and MEN2 syndrome. Genotype-phenotype correlations are established for most RET mutations, but the importance of the synonymous changes in this gene remains debatable. We aimed to ...

Preoperative Education for Hip and Knee Replacement: Never Stop Learning

Purpose of review Participation in alternative payment models has focused efforts to improve outcomes and patient satisfaction while also lowering cost for elective hip and knee replacement. The purpose of this review is to determine if preoperative education classes for elective hip and knee replacement achieve these goals. Recent findings Recent literature demonstrates that ...

Automatic identification of coronary tree anatomy in coronary computed tomography angiography

An automatic coronary artery tree labeling algorithm is described to identify the anatomical segments of the extracted centerlines from coronary computed tomography angiography (CCTA) images. This method will facilitate the automatic lesion reporting and risk stratification of cardiovascular disease. Three-dimensional (3D) models for both right dominant (RD) and left dominant (LD) ...

On the 1-nucleolus

This paper analyzes the 1-nucleolus and, in particular, its relation to the nucleolus. It is seen that, contrary to the nucleolus, the 1-nucleolus can be computed in polynomial time due to a characterization using a combination of standard bankruptcy rules for associated bankruptcy problems. Sufficient conditions on a compromise stable game are derived such that the 1-nucleolus and ...

Predation Cues in Solitary bee Nests

Predation at the nesting site can significantly affect solitary bees’ reproductive success. We tested female red mason bees’ (Osmia bicornis L.) acceptance of potential nesting sites, some of which were marked with cues coming from predated conspecifics (crushed bees) or from a predator itself (rodent excreta). In our experiment, females did not avoid nests marked with either of ...

Genetically engineered orange petunias on the market

Main conclusion Unauthorized genetically engineered orange petunias were found on the market. Genetic engineering of petunia was shown to lead to novel flower color some 20 years ago. Here we show that petunia lines with orange flowers, generated for scientific purposes, apparently found their way to petunia breeding programmes, intentionally or unintentionally. Today they are ...

Edge minimality of EDF resource sharing networks

We consider a general real-time network with soft customer deadlines, in which users require service from several shared resources simultaneously. We call the service protocol for such a network edge minimal (locally edge minimal) if it minimizes globally (resp., locally) in time, in a suitable sense, the system resource idleness with respect to customers with lead times not ...

Characterization of Adipose-Derived Stem Cells Following Burn Injury

Severe burns induce a prolonged inflammatory response in subcutaneous adipose tissue that modulates signaling in adipose-derived stem cells (ASCs), which hold potential for healing burn wounds or generating skin substitutes. Using a 60% rat scald burn model, we conducted a series of experiments to determine which cells isolated from the adipose tissue produced inflammatory ...

Application of photochemical parameters and several indices based on phenotypical traits to assess intraspecific variation of oat (Avena sativa L.) tolerance to drought

Functionality of the photosynthetic system under water stress is of major importance in drought tolerance. Oat (Avena sativa L.) doubled haploid (DH) lines obtained by pollination of F 1 oat crosses with maize were used to assess the differences in plant genotypic response to soil drought. The investigations were based on the measurements of gas exchange and chlorophyll a ...

Cone-beam computed tomography for assessment of dens invaginatus in the Polish population

Objectives There are many developmental variations in the permanent dentition. Dens invaginatus can be recognized on many dental X-rays of affected patients, but not every image allows for assessment of the type of malformation. The aim of the present study was to assess the presence of dens invaginatus with radiological features using cone-beam computed tomography (CBCT). Methods ...

Multivariate peaks over thresholds models

Multivariate peaks over thresholds modelling based on generalized Pareto distributions has up to now only been used in few and mostly two-dimensional situations. This paper contributes theoretical understanding, models which can respect physical constraints, inference tools, and simulation methods to support routine use, with an aim at higher dimensions. We derive a general point ...

Chronic Childhood Stress: Psychometric Properties of the Chronic Stress Questionnaire for Children and Adolescents (CSQ-CA) in Three Independent Samples

Stress in children and adolescents is common and related to many developmental problems. However, most studies have made no distinction between temporary or chronic stress due to the lack of a suitable questionnaire. This study tested the factor structure, reliability and validity of the 17-item self-report Chronic Stress Questionnaire for Children and Adolescents (CSQ-CA) in three ...

The influence of head-of-bed elevation in patients with obstructive sleep apnea

Purpose The purpose of this study is to test the effects of a mild degree of head-of-bed elevation (HOBE) (7.5°) on obstructive sleep apnea (OSA) severity and sleep quality. Methods OSA patients were recruited from a single sleep clinic (Criciúma, Santa Catarina, Brazil). Following a baseline polysomnography (PSG), all patients underwent a PSG with HOBE (within 2 weeks). In ...

Age and intraspecific diversity of resilient Acropora communities in Belize

The corals Acropora palmata and A. cervicornis are important Caribbean reef-builders that have faced significant mortality in recent decades. While many studies have focused on the recent demise of these species, data from areas where Acropora spp. have continued to thrive are limited. Understanding the genetic diversity, recruitment, and temporal continuity of healthy populations ...

Marine long-term biodiversity assessment suggests loss of rare species in the Skagerrak and Kattegat region

Studies of cumulative and long-term effects of human activities in the ocean are essential for developing realistic conservation targets. Here, we report the results of a recent national marine biodiversity inventory along the Swedish West coast between 2004 and 2009. The expedition revisited many historical localities that have been sampled with the same methods in the early ...

Spin and Wind Directions II: A Bell State Quantum Model

In the first half of this two-part article (Aerts et al. in Found Sci. doi:10.​1007/​s10699-017-9528-9, 2017b), we analyzed a cognitive psychology experiment where participants were asked to select pairs of directions that they considered to be the best example of Two Different Wind Directions, and showed that the data violate the CHSH version of Bell’s inequality, with same ...

Isolation, speciation and antifungal susceptibility testing of Candida isolates from various clinical specimens at a tertiary care hospital, Nepal

Background Candida species are responsible for various clinical infections ranging from mucocutaneous infection to life threatening invasive diseases along with increased resistance to antifungal drugs has made a serious concern. Resistance to antifungal agents has increased during the last decade. Thus, identification of Candida up to species level and its antifungal ...

Polycaprolactone nanofiber scaffold enhances the osteogenic differentiation potency of various human tissue-derived mesenchymal stem cells

Background Polycaprolactone (PCL) has been regarded as a promising synthetic material for bone tissue engineering application. Owing to its unique biochemical properties and great compatibility, PCL fibers have come to be explored as a potential delivering scaffold for stem cells to support bone regeneration during clinical application. Methods The human derived mesenchymal stem ...