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Hydrophobe-substituted bPEI derivatives: boosting transfection on primary vascular cells

Gene therapy targeted to vascular cells represents a promising approach for prevention and treatment of pathological conditions such as intimal hyperplasia, in-stent and post-angioplasty restenosis. In this context, polymeric non-viral gene delivery systems are a safe alternative to viral vectors but a further improvement in efficiency and cytocompatibility is needed to improve ...

The Boundary Effect on the Energy Gap of High T c Superconductors

Spatial dependence of the pairing potential across the thickness of the superconducting CuO2 planes in high T c superconductors (HTSC) copper oxides is found by using the Ginzburg-Landau-Gor’kov (GLG) theory. The potential turned out to be significantly suppressed due to an effect of non-superconducting layers, which separate the CuO2 planes. The effect leads also to the reduction ...

Macroeconomic fluctuations in a New Keynesian disequilibrium model

This study extends the current New Keynesian modeling framework by changing one crucial aspect: it replaces the general equilibrium assumption by the arguably more realistic assumption of macroeconomic disequilibrium. As a result, more complex and less smooth macroeconomic adjustment dynamics result, as it is not necessary to assume that goods and labor markets continuously clear. ...

Skills, earnings, and employment: exploring causality in the estimation of returns to skills

Ample evidence indicates that a person’s human capital is important for success on the labor market in terms of both wages and employment prospects. However, unlike the efforts to identify the impact of school attainment on labor-market outcomes, the literature on returns to cognitive skills has not yet provided convincing evidence that the estimated returns can be causally ...

Current progresses of 3D bioprinting based tissue engineering

Background The shortage of available organs for transplantation is the major obstacle hindering the application of regenerative medicine, and has also become the desperate problem faced by more and more patients nowadays. The recent development and application of 3D printing technique in biological research (bioprinting) has revolutionized the tissue engineering methods, and become ...

Defining the execution semantics of stream processing engines

The ability to process large volumes of data on the fly, as soon as they become available, is a fundamental requirement in today’s information systems. Modern distributed stream processing engines (SPEs) address this requirement and provide low-latency and high-throughput data stream processing in cluster platforms, offering high-level programming interfaces that abstract from ...

Comment on the New Indian Injection Technique Recommendations: Critical Appraisal of the Real-World Implementation of the Current Guidelines

With an eye on the sequence of two Indian papers concurrently published in Diabetes Therapy, this paper analyzes skin differences among races and points to a lack of organized structured education sessions as the main cause of the high prevalence of lipodystrophy (LD) and consequent poor metabolic control. Only half of all insulin-treated patients reach their therapeutic targets ...

Understanding Action and Adventure Sports Participation—An Ecological Dynamics Perspective

Previous research has considered action and adventure sports using a variety of associated terms and definitions which has led to confusing discourse and contradictory research findings. Traditional narratives have typically considered participation exclusively as the pastime of young people with abnormal characteristics or personalities having unhealthy and pathological tendencies ...

Outlier edge detection using random graph generation models and applications

Outliers are samples that are generated by different mechanisms from other normal data samples. Graphs, in particular social network graphs, may contain nodes and edges that are made by scammers, malicious programs or mistakenly by normal users. Detecting outlier nodes and edges is important for data mining and graph analytics. However, previous research in the field has merely ...

Polygenic study of endurance-associated genetic markers ACE I/D, ACTN3 Arg(R)577Ter(X), CKMM A/G NcoI and eNOS Glu(G)298Asp(T) in male Gorkha soldiers

Background Gorkhas, a sub-mountainous population of the Himalayan region, are known for strength and bravery. In the present study when “Gorkha” is used without brackets, we are mentioning Gorkhas of Tibeto-Burman origin. Physical capability, strength and endurance are important components of fitness associated with genetic traits. The aim of this study was to examine the endurance ...

Magnetocaloric-Transport Properties Correlation in La0.8 Ca0.2MnO3-Doped Manganites

This investigation is interested in studying the relation between magnetocaloric effect and transport properties i La0.8Ca0.2MnO3 manganite compound. The value of the magnetocaloric effect has been determined from the calculation of magnetization as a function of temperature under different external magnetic fields. This study also provides an alternative method to determine the ...

Genome-wide identification of grain filling genes regulated by the OsSMF1 transcription factor in rice

Background Spatial- and temporal-specific expression patterns are primarily regulated at the transcriptional level by gene promoters. Therefore, it is important to identify the binding motifs of transcription factors to better understand the networks associated with embryogenesis. Results Here, we used a protein-binding microarray (PBM) to identify the binding motifs of OsSMF1, ...

The comparative study of resonance disorders for Vietnamese and Korean cleft palate speakers using nasometer

Background Nasalance is used to evaluate the velopharyngeal incompetence in clinical diagnoses using a nasometer. The aim of this study is to find the nasalance differences between Vietnamese cleft palate children and Korean cleft palate children by measuring the nasalance of five oral vowels. Methods Ten Vietnamese cleft palate children after surgery, three Vietnamese children for ...

Depositional environment and reservoir quality assessment of the “Bruks Field,” Niger Delta

This study is a contribution to the understanding of the depositional environment and reservoir architecture of the “Bruks Field,” Niger Delta, Nigeria. The objective is to use sequence stratigraphy and petrophysical evaluation in characterizing the reservoirs encountered in the study area. Well logs from six wells (B001, B002, B003, B009, B010 and B012-ST); biofacies data from ...

Human virus and microbial indicator occurrence in public-supply groundwater systems: meta-analysis of 12 international studies

Groundwater quality is often evaluated using microbial indicators. This study examines data from 12 international groundwater studies (conducted 1992–2013) of 718 public drinking-water systems located in a range of hydrogeological settings. Focus was on testing the value of indicator organisms for identifying virus-contaminated wells. One or more indicators and viruses were present ...

A Survey of Some Methods for Real Quantifier Elimination, Decision, and Satisfiability and Their Applications

Effective quantifier elimination procedures for first-order theories provide a powerful tool for generically solving a wide range of problems based on logical specifications. In contrast to general first-order provers, quantifier elimination procedures are based on a fixed set of admissible logical symbols with an implicitly fixed semantics. This admits the use of sub-algorithms ...

Timing a week later: The role of long-term memory in temporal preparation

Temporal preparation has been investigated extensively by manipulating the foreperiod, the interval between a warning stimulus and target stimulus requiring a speeded response. Although such research has revealed many effects of both the duration and distribution of foreperiods on reaction times, the underlying cognitive mechanism is still largely unknown. Here, we test a recent ...

The social and scientific values that shape national climate scenarios: a comparison of the Netherlands, Switzerland and the UK

This paper seeks to understand why climate information is produced differently from country to country. To do this, we critically examined and compared the social and scientific values that shaped the production of three national climate scenarios in the Netherlands, Switzerland and the UK. A comparative analysis of documentary materials and expert interviews linked to the climate ...

Continuity vs. the Crowd—Tradeoffs Between Continuous and Intermittent Citizen Hydrology Streamflow Observations

Hydrologic data has traditionally been collected with permanent installations of sophisticated and accurate but expensive monitoring equipment at limited numbers of sites. Consequently, observation frequency and costs are high, but spatial coverage of the data is limited. Citizen Hydrology can possibly overcome these challenges by leveraging easily scaled mobile technology and ...

Exploring the relationship between perceived barriers to healthy eating and dietary behaviours in European adults

Purpose Dietary behaviours may be influenced by perceptions of barriers to healthy eating. Using data from a large cross-European study (N = 5900), we explored associations between various perceived barriers to healthy eating and dietary behaviours among adults from urban regions in five European countries and examined whether associations differed across regions and ...

What Does “Without Loss of Generality” Mean, and How Do We Detect It

When one goes from a geometrical statement to an algebraic statement, the immediate translation is to replace every point by a pair of coordinates, if in the plane (or more as required). A statement with N points is then a statement with 2N (or 3N or more) variables, and the complexity of tools like cylindrical algebraic decomposition is doubly exponential in the number of ...