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Predicting essential proteins by integrating orthology, gene expressions, and PPI networks

Identifying essential proteins is very important for understanding the minimal requirements of cellular life and finding human disease genes as well as potential drug targets. Experimental methods for identifying essential proteins are often costly, time-consuming, and laborious. Many computational methods for such task have been proposed based on the topological properties of ...

Comparative Study of Solvent Extraction of Uranium with Alamine 336 and Aliquat 336: Application to the Uranium-Bearing Solutions of Niger Republic

This study focuses on the liquid-liquid extraction of uranium by anionic extractants of Alamine 336 and Aliquat 336. The objective of this study is to determine the parameters allowing the optimization of the extraction percentage of uranium, and other metals such as molybdenum, zirconium and vanadium. The extraction kinetics of uranium is achieved in 2 minutes. Sulfuric acid ...

Can a single pulse transcranial magnetic stimulation targeted to the motor cortex interrupt pain processing?

The modulatory role of the primary motor cortex (M1), reflected by an inhibitory effect of M1-stimulation on clinical pain, motivated us to deepen our understanding of M1’s role in pain modulation. We used Transcranial Magnetic Stimulation (TMS)-induced virtual lesion (VL) to interrupt with M1 activity during noxious heat pain. We hypothesized that TMS-VL will effect experimental ...

The Mexican Spanish version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)

The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the Mexican Spanish language. The ...

The effects of a dopamine agonist (apomorphine) on experimental and spontaneous pain in patients with chronic radicular pain: A randomized, double-blind, placebo-controlled, cross-over study

Background Although evidence suggests that dopaminergic systems are involved in pain processing, the effects of dopaminergic interventions on pain remains questionable. This randomized, double blinded, placebo-controlled, cross-over study was aimed at exploring the effect of the dopamine agonist apomorphine on experimental pain evoked by cold stimulation and on spontaneous pain in ...

Impacts of human recreation on carnivores in protected areas

Mammalian carnivores can be particularly sensitive to human disturbance, even within protected areas (PAs). Our objective was to understand how human disturbance affects carnivore communities in southern Arizona, USA by studying habitat occupancy based on data collected using non-invasive methods in three PAs with different levels of human disturbance. Carnivore occupancy varied ...

Accuracy of rapid diagnosis of Talaromyces marneffei: A systematic review and meta-analysis

Background To examine the accuracy of Rapid Diagnosis of Talaromyces marneffei (RDTM) in order to improve diagnosis and treatment for clinical measures and reduce the mortality due to associated infections. Methods In this systematic review and meta-analysis, we screened PubMed, Ovid (Cochrane library) and Web of Science, Chinese database CNKI and Wanfang for articles published ...

Partitioning of Calcium Between Liquid Silver and Liquid Iron

The partitioning of calcium between liquid silver and liquid iron at 1823 K and 1873 K (1550 °C and 1600 °C) was studied experimentally using a closed molybdenum container. The calcium potential in the container was controlled by the composition of the alloys in equilibrium. The results agreed well with previous experimental measurements and indicated that the effect of temperature ...

Childhood behavioral inhibition is associated with impaired mentalizing in adolescence

Recent advances suggest that impairment in social cognition (SC) may play a role in the development of social anxiety (SA). However, very few studies have analyzed whether SA fosters poorer social-cognitive development as it leads to social avoidance. This study aimed to analyze whether retrospectively assessed behavioral inhibition (BI) (i.e., an early form of SA) in childhood is ...

Length of hospitalization and mortality for bleeding during treatment with warfarin, dabigatran, or rivaroxaban

Background Different outcomes among patients hospitalized for bleeding after starting anticoagulation could influence choice of anticoagulant. We compared length of hospitalization, proportion of Intensive Care Unit (ICU) admissions, ICU length of stay, and 30- and 90-day mortality for adults with atrial fibrillation hospitalized for bleeding after starting warfarin, dabigatran, or ...

Hypertrophic Cardiomyopathy and Sports

Hypertrophic cardiomyopathy (HCM) is one of the most common causes of sudden cardiac death (SCD) in athletes. Knowledge of the problem is essential for detection of the disease. According to the current recommendations of the European Society of Cardiology (ESC), in individuals with established HCM disease, including those without phenotypic expression, participation in competitive ...

Pathologizing “Radicalization” and the Erosion of Patient Privacy Rights

Countering Violent Extremism (“CVE”) is a counterterrorism strategy ostensibly aimed at preventing “radicalization” through risk assessment and intervention. CVE involves recruitment of helping professionals, including mental health care providers, to monitor their patients for signs of “vulnerability to radicalization,” make referrals to “de-radicalization” programs, and ...

Performance evaluation of Active Melioidosis Detect-Lateral Flow Assay (AMD-LFA) for diagnosis of melioidosis in endemic settings with limited resources

Melioidosis is a fatal infection caused by the soil saprophyte Burkholderia pseudomallei. Early diagnosis and befitting medical management can significantly influence the clinical outcomes among patients with melioidosis. Witnessing an annual increment in the number of melioidosis cases, over the past few years, mainly from the developing tropical nations, the present study was ...

The immunological effect of Galectin-9/TIM-3 pathway after low dose Mifepristone treatment in mice at 14.5 day of pregnancy

The abortifacient Mifepristone (RU486) has proven to be a safe, effective, acceptable option for millions of women seeking abortion during the first and second trimester of pregnancy although its precise mechanism of action is not well understood. The main objective of this study was to investigate the impact of low dose Mifepristone administration on placental Galectin-9 (Gal-9) ...

Higher-curvature corrections to holographic entanglement with momentum dissipation

We study the effects of Gauss–Bonnet corrections on some nonlocal probes (entanglement entropy, n-partite information and Wilson loop) in the holographic model with momentum relaxation. Higher-curvature terms as well as scalar fields make in fact nontrivial corrections to the coefficient of the universal term in entanglement entropy. We use holographic methods to study such ...