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Nonpher: computational method for design of hard-to-synthesize structures

In cheminformatics, machine learning methods are typically used to classify chemical compounds into distinctive classes such as active/nonactive or toxic/nontoxic. To train a classifier, a training data set must consist of examples from both positive and negative classes. While a biological activity or toxicity can be experimentally measured, another important molecular property, a ...

Should We Genetically Select for the Beauty Norm of Fair Skin?

Fair skin is often regarded as a beauty ideal in many parts of the world. Genetic selection for non-disease traits may allow reproducers to select fair skin for the purposes of beauty, and may be justified under various procreative principles. In this paper I assess the ethics of genetic selection for fair skin as a beauty feature. In particular, I explore the discriminatory ...

MtDNA-maintenance defects: syndromes and genes

A large group of mitochondrial disorders, ranging from early-onset pediatric encephalopathic syndromes to late-onset myopathy with chronic progressive external ophthalmoplegia (CPEOs), are inherited as Mendelian disorders characterized by disturbed mitochondrial DNA (mtDNA) maintenance. These errors of nuclear-mitochondrial intergenomic signaling may lead to mtDNA depletion, ...

A time-based process model of international entrepreneurial opportunity evaluation

This article investigates two important research gaps in international business (IB): how entrepreneurs evaluate international entrepreneurial opportunities (IEOs) and the role of time in the evaluation process. Drawing on the literature on decision-making models and the philosophical foundation of opportunity, this study employs Gioia’s methodology and content analysis to examine ...

The costs of locomotor activity? Maximum body temperatures and the use of torpor during the active season in edible dormice

Measuring T b during the active season can provide information about the timing of reproduction and the use of short bouts of torpor and may be used as a proxy for the locomotor activity of animals (i.e., maximum T b). This kind of information is especially important to understand life-history strategies and energetic costs and demands in hibernating mammals. We investigated T b ...

Feasibility of in vivo 18F-florbetaben PET/MR imaging of human carotid amyloid-β

Purpose Amyloid-beta (Aβ) peptides are involved in the inflammatory pathology of atherosclerosis. 18F-Florbetaben is a PET tracer for clinical imaging of cerebral Aβ plaques in Alzheimer’s disease (AD). We sought to determine whether specific uptake of 18F-florbetaben in the carotid arteries can be identified using a fully integrated hybrid PET/MRI system and whether this uptake is ...

Primary pain generator identification by CT–SPECT in a patient with low back pain: a case report

Background Chronic low back pain is one of the most common conditions encountered in the middle-age population. Identifying the primary pain generator is notoriously difficult. The computed tomography–single-photon emission computed tomography (CT–SPECT) is emerging as a new diagnostic modality for this purpose. Case presentation This 68-year-old Caucasian male presented with ...

The Hypernetted Chain Equations for Periodic Systems

Starting from the general inhomogeneous Fermi hypernetted chain equations, the equations for periodic systems are derived by simple Fourier transform. It is shown how the symmetry reduces the size of the involved quantities. First results for a one-dimensional (1D) model system are presented. The results allow a reliable estimation of the numerical demand even for realistic 3D ...

Microwave Hydrothermal Synthesis of Terbium Ions Complexed with Porous Graphene for Effective Absorbent for Organic Dye

A luminescent terbium ions/reduced graphene oxide complex (Tb-RGO) was successfully and rapidly synthesized by the microwave hydrothermal reaction via the interactions between terbium ions and the active oxygen functional groups of graphene oxide. The as-prepared material was porous stacked by multilayer graphene in all directions. Thus, the resulting product owed the high specific ...

Arthrose multidimensional behandeln

Die letzten Jahre haben eine Vervielfachung unseres medizinischen Wissens gebracht. Die Zunahme der Evidenz bedeutet jedoch nicht, dass dieses Wissen auch fachgerecht an den Patienten herangebracht wird. Im Unterschied zu akuten Erkrankungen, bei denen Heilung mit exakten therapeutischen Schritten ermöglicht wird, stellen chronische Erkrankungen eine große Herausforderung in ...

Automated guided vehicle mission reliability modelling using a combined fault tree and Petri net approach

Automated guided vehicles (AGVs) are being extensively used for intelligent transportation and distribution of materials in warehouses and autoproduction lines due to their attributes of high efficiency and low costs. Such vehicles travel along a predefined route to deliver desired tasks without the supervision of an operator. Much effort in this area has focused primarily on route ...

The strength of co-authorship ties through different topological properties

Social networks are complex structures that describe individuals (graph nodes) connected in any social context (graph edges). Different metrics can be applied to those networks and their properties in order to understand behavior and even predict the future. One of such properties is tie strength, which allows to identify prominent individuals, analyze how relationships play ...

Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome

Background Adipose-derived mesenchymal stem cells (ASCs) are a promising cell therapy to treat inflammatory and immune-mediated diseases. Development of appropriate pre-clinical animal models is critical to determine safety and attain early efficacy data for the most promising therapeutic candidates. Naturally occurring diseases in cats already serve as valuable models to inform ...

Emiraten

Is een verpleegkundige hoofdzakelijk bezig met haar eigen carrière? Of voelt zij zich vooral ten dienste staan van de samenleving? Zorgen vanuit een altruïstisch beginsel. Dit laatste komt dicht bij waar Florence Nightingale voor stond: zorgen uit naastenliefde.

The presence of human papillomavirus (HPV) in placenta and/or cord blood might result in Th2 polarization

The purpose of this study was to evaluate if an early exposure to human papillomavirus (HPV) during the prenatal period or infancy could result in HPV16-specific T helper (Th) responses resembling those of adults with HPV-induced lesions. We tested HPV16-specific cell-mediated immunity (CMI) in children born with HPV-positive umbilical cord blood and/or placenta or having ...

The Scientific Perspective on Moral Objectivity

The naturalistic approach to metaethics is sometimes identified with a supervenience theory relating moral properties to underlying descriptive properties, thereby securing the possibility of objective knowledge in morality as in chemistry. I reject this approach along with the purely anthropological approach which leads to an objectionable form of relativism. There is no single ...

Hybrid wireless networks with FIB-based Named Data Networking

In Named Data Networking (NDN) architecture, packets carry data names rather than source or destination addresses. To realize this paradigm, each NDN router maintains three data structures CS, PIT, FIB in the forwarding plane. Designing a quick enough forwarding plane with high capacity is a major challenge within the overall NDN research area. In this paper, we present a novel ...

Case report: fast reversal of severe osteoporosis after correction of excessive levothyroxine treatment and long-term follow-up

Summary This case report describes a 38-year-old woman, who presented with bilateral femoral stress fractures and osteoporosis after years of excessive levothyroxine treatment. Her bone health was restored rapidly and long-lasting with the reduction of levothyroxine dosage. No bone-active treatment was warranted. Introduction Hyperthyroidism is a known risk factor for osteoporosis ...

Processing and selection of surgically-retrieved sperm for ICSI: a review

Although the technique of intracytoplasmic sperm injection (ICSI) has been a revolution in the alleviation of male infertility, the use of testicular sperm for ICSI was a formerly unseen breakthrough in the treatment of the azoospermic man with primary testicular failure. At the clinical level, different procedures of testicular sperm retrieval (conventional TESE, micro-TESE, ...

The impact of cognitive training in substance use disorder: the effect of working memory training on impulse control in methamphetamine users

Objectives Impulsivity is a vulnerability trait for poor self-regulation in substance use disorder (SUD). Working memory (WM) training improves impulsivity and self-regulation in psychiatric disorders. Here we test WM training in methamphetamine use disorder (MUD). Methods There are 15 MUD patients receiving inpatient treatment as usual (TAU) and 20 who additionally completed WM ...

Benefit of Rare-Earth “Smart Doping” and Material Nanostructuring for the Next Generation of Er-Doped Fibers

Erbium-doped fiber amplifiers (EDFAs) for harsh environments require to develop specific fabrication methods of Er 3+-doped fibers (EDFs) so as to limit the impact of radiation-induced absorption. In this context, a compromise has to be found between the concentration of Erbium and the glass composition. On the one hand, high concentration of Er 3+ ions helps to reduce the length ...

Recurrent bowel-blood translocations of Escherichia coli with the unique virulence characteristics over three-year period in the patient with acute myeloid leukaemia – case report

In patients with haematological malignancies, the bowel remains the main source of Escherichia coli bloodstream infections. We present the clinical example of recurrent bowel-blood translocations of E. coli with the unique virulence characteristics in a 55-year-old male with the diagnosis of acute myeloid leukaemia. The virulent factors profile of examined strains confirmed that ...

The risk and clinical outcome of candidemia depending on underlying malignancy

Purpose To assess the risk factors and outcomes associated with fungemia caused by the six most commonly occurring Candida species in patients with and without malignancies. Methods Analysis of the episodes of fungemia due to common Candida species in adults, based on an active hospital-based surveillance program (Paris area, France, 2002 to 2014). Results Of the 3417 patients ...