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Size-conditional smolting and the response of Carmel River steelhead to two decades of conservation efforts

Threshold effects are common in ecosystems and can generate counterintuitive outcomes in management interventions. A threshold effect proposed for steelhead trout (Oncorhynchus mykiss) is size-conditional smolting and marine survival. Steelhead are anadromous, maturing in the ocean but migrating to freshwater to spawn, where their offspring reside for one or more years before ...

HMGA1 is a novel transcriptional regulator of the FoxO1 gene

Purpose The forkhead transcription factor (FoxO1) is a master transcriptional regulator of fundamental cellular processes ranging from cell proliferation and differentiation to inflammation and metabolism. However, despite its relevance, the mechanism(s) underlying FoxO1 gene regulation are largely unknown. We have previously shown that the chromatin factor high-mobility group A1 ...

Split-brain syndrome and extended perceptual consciousness

In this paper I argue that split-brain syndrome is best understood within an extended mind framework and, therefore, that its very existence provides support for an externalist account of conscious perception. I begin by outlining the experimental aberration model of split-brain syndrome and explain both: why this model provides the best account of split-brain syndrome; and, why it ...

Tocilizumab potentially prevents bone loss in patients with anticitrullinated protein antibody-positive rheumatoid arthritis

Rheumatoid arthritis (RA) is associated with a high risk of osteoporosis and fracture. Interleukin (IL)-6 inhibitors may suppress osteoclast activation. Anticitrullinated protein antibody (ACPA) titers are inversely associated with bone mineral density (BMD). However, the differential effect of ACPA on bone turnover marker (BTM) and BMD changes after IL-6 inhibition remains ...

Kinderboeken

Omdat vijfentwintig jaar geleden het eerste deel verscheen van De mooiste vis van de zee, nu aandacht voor dit achtste deel. Net als in de andere delen vallen de mooie illustraties op. De vissen zijn voornamelijk blauw, paars en groen.

The nutraceutical benefits of subfractions of Abelmoschus esculentus in treating type 2 diabetes mellitus

Abelmoschus esculentus (AE), a commonly consumed vegetable, is well-known for its anti-hyperglycemic effects. However, few scientific reports have identified its targets because mucilage increases the difficulty of manipulation. We recently reported extraction steps to obtain subfractions of AE, which were found to attenuate the adverse effects of high glucose and fatty acid in ...

Evaluation of the Potential HMGA1-EF24 Nexus in Human Colon Cancer

The architectural chromatin binding proteins High Mobility Group A1 (HMGA1) are proteins expressed at high levels in malignant cancers and induce neoplastic transformation. The protein is increased as the last step of the Wnt/B-catenin/TCF-4 pathway and mediates drug resistance, therefore correlating with a poor patient prognosis. HMGA1-mediated chemoresistance results from a ...

Modulation of thalamocortical oscillations by TRIP8b, an auxiliary subunit for HCN channels

Hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels have important functions in controlling neuronal excitability and generating rhythmic oscillatory activity. The role of tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) in regulation of hyperpolarization-activated inward current, I h, in the thalamocortical system and its functional ...

Analyzing the Effects of Growing Season Length on the Net Ecosystem Production of an Alpine Grassland Using Model–Data Fusion

Alpine ecosystems are, similar to arctic ecosystems, characterized by a very long snow season. Previous studies investigating arctic or alpine ecosystems have shown that winter CO2 effluxes can dominate the annual balance and that the timing and duration of the snow cover plays a crucial role for plant growth and phenology and might also influence the growing season ecosystem CO2 ...

Janowski type close-to-convex functions associated with conic regions

The analytic functions, mapping the open unit disk onto petal and oval type regions, introduced by Noor and Malik (Comput. Math. Appl. 62:2209-2217, 2011), are considered to define and study their associated close-to-convex functions. This work includes certain geometric properties like sufficiency criteria, coefficient estimates, arc length, the growth rate of coefficients of ...

Addressing the cost of infractions in the online literature and databases

Myocardial infarction sometimes appears misspelt as myocardial infraction in the cardiovascular research literature. With accurate citation of literature contributions important to advancing the field and its contributors, in this study we aimed to document the frequency and explore the causes and impact of this error specific to the cardiology literature. Literature databases ...

Assessing olfactory functions in patients with Barth syndrome

Barth syndrome is a rare X-linked disease affecting less than 200 individuals worldwide. Several comorbidities have been associated with the pathology and, among those, cardiac myopathy and neutropenia are the most life threatening. The appropriate nutritive support is important to sustain the everyday life of Barth syndrome patients given the chronic fatigue they experience. Since ...

A Review of Ethical Leadership and Other Ethics- Related Leadership Theories

The role of ethics in leadership studies is very important for organizations. Leadership without ethics and integrity can be harmful both for the organizational stakeholders and society. The high-profiled scandals and the leadership involvement in unethical activities caused increase attention of the scholars and mainstream media in the leadership ethics (Hartog, 2015). This ...

Brain gray matter structural network in myotonic dystrophy type 1

This study aimed to investigate abnormalities in structural covariance network constructed from gray matter volume in myotonic dystrophy type 1 (DM1) patients by using graph theoretical analysis for further clarification of the underlying mechanisms of central nervous system involvement. Twenty-eight DM1 patients (4 childhood onset, 10 juvenile onset, 14 adult onset), excluding ...

Comparison of CK-IHC assay on serial frozen sections, the OSNA assay, and in combination for intraoperative evaluation of SLN metastases in breast cancer

Background Intraoperative evaluations of sentinel lymph node (SLN) metastases are performed for providing appropriate and immediate axillary treatments in breast cancer patients who do not meet Z0011 criteria; however, standard intraoperative procedure has not yet been established. Methods We consecutively performed intraoperative evaluation for SLN metastases using both a ...

Characterization of the first knock-out aldh7a1 zebrafish model for pyridoxine-dependent epilepsy using CRISPR-Cas9 technology

Pyridoxine dependent epilepsy (PDE) is caused by likely pathogenic variants in ALDH7A1 (PDE-ALDH7A1) and inherited autosomal recessively. Neurotoxic alpha-amino adipic semialdehyde (alpha-AASA), piperideine 6-carboxylate and pipecolic acid accumulate in body fluids. Neonatal or infantile onset seizures refractory to anti-epileptic medications are clinical features. Treatment with ...

Angiogenesis and VEGF-expressing cells are identified predominantly in the fascia rather than in the muscle during the early phase of dermatomyositis

We previously demonstrated that fasciitis is a common lesion in dermatomyositis (DM) and that DM-associated fasciitis is detectable, as the result of the increased vascularity in the fascia, by power Doppler ultrasonography. We aimed to investigate whether angiogenesis and vascular endothelial growth factor (VEGF)-expressing cells in the fascia are histologically demonstrated ...

Epoetin β pegol (continuous erythropoietin receptor activator, CERA) is another choice for the treatment of anemia in myelodysplastic syndrome: a case report

In most patients, anemia is present when myelodysplastic syndrome is diagnosed. Although darbepoetin α is the first-choice supportive therapy for low-risk myelodysplastic syndrome, half of all patients develop a loss of response to darbepoetin α within 12 months. However, few reports have described supportive therapy after the loss of response to darbepoetin α. We herein present a ...

The association between serum 25-hydroxyvitamin D3 concentration and serum lipids in the rural population of China

Vitamin D deficiency is implicated in some diseases, including cardiovascular. Few studies have assessed the correlation between 25-hydroxyvitamin D3 [25(OH) D3] and serum lipids. In this study, we explored the correlation between serum 25(OH) D3 concentrations and serum lipids with a typical sample of the rural population in China. Face-to-face research was used to gather some ...

Concurrent and Construct Validity of Methods to Estimate Fat-Free Mass in Children, Adolescents, and Young Adults

INTRODUCTION: Indirect methodologies are available to estimate fat-free mass (FFM) as a skeletal muscle mass surrogate in field settings at low cost. However, there is a lack of knowledge related with the FMM estimations variability introduced by the available methods and its correlations with performance constructs. The association between repeated measures of FFM by different ...

Use of QuantiFERON®-TB Gold in-tube culture supernatants for measurement of antibody responses

QuantiFERON®-TB Gold in-tube (QFT-GIT) supernatants may be important samples for use in assessment of anti-tuberculosis (TB) antibodies when only limited volumes of blood can be collected and when a combination of antibody and cytokine measurements are required. These analytes, when used together, may also have the potential to differentiate active pulmonary TB (APTB) from latent ...

Komplexe Gelenkrekonstruktion und Gelenktransplantation mit dem FLOCSAT-Konzept – Planung und chirurgische Umsetzung

Beim Erwachsenen sind Knorpeldefekte bislang nicht heilbar. Im Rahmen der Transplantation von frischen osteochondralen Allografts (OCA) wird lebender, ausgereifter und mechanisch belastbarer hyaliner Knorpel in den Defektbereich eingebracht, welcher knöchern einwächst. Das intakte hyaline Knorpelgewebe des OCA ist immunpriviligiert und löst keine Immunreaktion im Empfänger aus. ...