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MSC stimulate ovarian tumor growth during intercellular communication but reduce tumorigenicity after fusion with ovarian cancer cells

The tumor microenvironment enables important cellular interactions between cancer cells and recruited adjacent populations including mesenchymal stroma/stem cells (MSC). In vivo cellular interactions of primary human MSC in co-culture with human SK-OV-3 ovarian cancer cells revealed an increased tumor growth as compared to mono-cultures of the ovarian cancer cells. Moreover, the...

Conceptual model for the health technology assessment of current and novel interventions in rheumatoid arthritis

The objective of this study was to evaluate current approaches to economic modeling in rheumatoid arthritis (RA) and propose a new conceptual model for evaluation of the cost-effectiveness of RA interventions. We followed recommendations from the International Society of Pharmacoeconomics and Outcomes Research-Society of Medical Decision Making (ISPOR-SMDM) Modeling Good Research...

The Canadian Association of Gastroenterology Education Committee Report

I am pleased to provide an update regarding the activities and future directions of the Canadian Association of Gastroenterology (CAG) Education Committee. The mandate of the CAG Education Committee is to facilitate, develop and promote excellence as it pertains to educational initiatives for the Canadian gastroenterology community. Professional education has long remained a...

A review of the spider genus Sinanapis, with the description of a new species from Tibet (Araneae, Anapidae)

The genus Sinanapis Wunderlich & Song, 1995 is reviewed in this paper. The material of all three known species was reexamined and photographed resulting in a new species, Sinanapis medogense sp. n. (♂, ♀) being described from Tibet, China. A key is provided for the genus, as well as species diagnoses, illustrations, and distribution maps for all four species of Sinanapis.

Early P2X7R-dependent activation of microglia during the asymptomatic phase of autoimmune encephalomyelitis

Microglia-mediated neuroinflammation accompanies many central nervous system (CNS) diseases, including multiple sclerosis (MS), and is strongly dependent on the purinergic P2X7 receptor. The nature of the inflammatory response in MS is studied for decades indicating, that proinflammatory microgliosis is involved in advanced stages of MS and is associated with active tissue damage...

Transcriptomic analysis of left-right differences in human embryonic forebrain and midbrain

Left-right asymmetry is subtle but pervasive in the human central nervous system. This asymmetry is initiated early during development, but its mechanisms are poorly known. Forebrains and midbrains were dissected from six human embryos at Carnegie stages 15 or 16, one of which was female. The structures were divided into left and right sides, and RNA was isolated. RNA was...

Initiale Diagnostik und Indikationsstellung zur Anti-Vascular-Endothelial Growth-Factor-Therapie bei Netzhauterkrankungen

BackgroundThe ORCA module of the non-interventional OCEAN study investigated the use of retinal imaging diagnostics in the clinical treatment of patients undergoing vascular endothelial growth factor (VEGF) inhibitor treatment as part of routine clinical care. This article analyzes the agreement between the diagnosis documented by the treating ophthalmologist and the evaluation...

Verteilungswirkungen von Staatsschulden

I propose a method by which one can derive unambiguous distribution effects of public debt policies. The benchmark is a generalized “Golden Rule of Accumulation” path. Certain deviations from that path by changes in public debt policies have unambiguous distributional effects. I provide examples for this method for the income distribution between generations as well as for the...

Cerebellar Structures and the Programming of Movement Sequences

Two patients with unilateral damage to the medial and lateral cerebellum were examined to determine whether local structures in the cerebellum are used to execute programmed movement sequences. Both patients performed a sequential tapping task which required the execution of either a single keystroke or of a sequence of three keystrokes. Movements executed with the contralateral...

Reduced Introgression of Sex Chromosome Markers in the Mexican Howler Monkey (Alouatta palliata × A. pigra) Hybrid Zone

Interspecific hybridization allows the introgression or movement of alleles from one genome to another. While some genomic regions freely exchange alleles during hybridization, loci associated with reproductive isolation do not intermix. In many model organisms, the X chromosome displays limited introgression compared to autosomes owing to the presence of multiple loci associated...

The Search for Ixodes dammini and Borrelia burgdorferi in Nova Scotia

Twenty-four Ixodes dammini ticks (23 adults and one nymph) have been recovered in Nova Scotia since 1984. There has not been a systematic search for larvae and none has been identified. The recovery of the nymph from a road-killed yellow throat bird, Geothypis trichas, in late May 1990 supports the contention that migrating birds are bringing deer ticks into the province every...

Evaluation of compaction parameters of fine-grained soils using standard and modified efforts

Compaction characteristics of the soil have the great importance for practically achieving the desired strength, permeability and compressibility of soil during the construction. Standard compaction test (SCT) and modified compaction test (MCT) are two very famous laboratory test methods to determine the compaction characteristics of soils worldwide. Modest efforts have been made...

The 1831 eruption of Babuyan Claro that never happened: has the source of the one of the largest volcanic climate forcing events of the nineteenth century been misattributed?

The 1831 eruption of Babuyan Claro in the Philippines is regarded as one of the most significant volcanic climate forcing events of the nineteenth century. Modern databases have assigned the eruption a VEI of 4? and Magnitude of 4.7. Our analysis of historical sources, however, suggests that there was no such eruption in 1831 and that this date is the result of a...

Storage of Verbal Associations Is Sufficient to Activate the Left Medial Temporal Lobe

Neuroimaging studies have shown that memory encoding activates the medial temporal lobe (MTL). Many believe that these activations are related to novelty but it remains unproven which is critical - novelty detection or the rich associative encoding it triggers. We examined MTL activation during verbal associative encoding using functional magnetic resonance imaging. First...

E-Zigaretten sind längst nicht so harmlos wie gehofft

Auch wenn es noch keine Daten bezüglich der Langzeitwirkung gibt, so mehren sich doch die Hinweise darauf, dass auch E-Zigaretten toxische Wirkungen in der Lunge entfalten.

Children’s Perspectives on Their Learning in School Spaces: What Can We Learn from Children in Brazil and Finland?

In this study, we investigated children’s perceptions of their learning experiences in early childhood education and care using data from two different settings: Brazil and Finland. We adopted a qualitative and cross-national research design. Photographs were used to gather children’s representations of their learning places and spaces and also later to elicit reflections during...

Berufsbedingte Infektionskrankheiten bei Beschäftigten im Gesundheitsdienst 2017

IntroductionHealth service employees are exposed to an increased risk of infection in the care of infectious patients. The prevalence of occupational infections (BK No. 3101) can be estimated from the routine data of the statutory health insurance.MethodsData were taken from the routine data sets of the Occupational Accident Insurance Association for healthcare and welfare...

CRAUL: Compiler and Run-Time Integration for Adaptation under Load

Clusters of workstations provide a cost‐effective, high performance parallel computing environment. These environments, however, are often shared by multiple users, or may consist of heterogeneous machines. As a result, parallel applications executing in these environments must operate despite unequal computational resources. For maximum performance, applications should...

Initial observations of water quality indicators in the unconfined shallow aquifer in Dili City, Timor-Leste: suggestions for its management

The management of groundwater quality is a critical issue in developing nations where sanitation and drinking water targets are commonly addressed by facilitating access to groundwater, which is then managed as a common-pool resource. We investigate the quality of the shallow unconfined groundwater in Dili’s alluvial fan system, which 50% of Dili’s rapidly growing population use...

SOX2OT knockdown derived changes in mitotic regulatory gene network of cancer cells

SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism explaining its function in cell proliferation regulation. Here we investigated cancer cell response to SOX2OT knockdown by RNA sequencing. SOX2OT expression was inhibited by...

Rose-Colored Answers: Neuropsychological Deficits and Patient-Reported Outcomes after Stroke

Patient-reported, subjective outcomes are promoted as a standard for ethical, valid studies in many neurological disorders. Such outcomes are considered potentially more sensitive and specific to important therapeutic effects, and may be more linked to disability and disease-related life losses than conventional assessments of impairment (e.g. ability to walk, performance on...