Recently added

Amitriptyline-induced ventricular tachycardia: a case report

Background In Bangladesh, each emergency physician faces amitriptyline overdose nearly a day. An acute cardiovascular complication, one of the worst complications is mainly responsible for the mortality in tricyclic overdose. Recently, we managed ventricular tachycardia in a young female presented with an impaired consciousness 10 h after intentionally ingesting 2500 mg ...

Aldosterone antagonist therapy and its relationship with inflammation, fibrosis, thrombosis, mineral-bone disorder and cardiovascular complications in peritoneal dialysis (PD) patients

Background High aldosterone level may contribute to pathogenesis of hypertension, vessels damage and cardiovascular system deterioration in chronic kidney disease patients. Besides its classical action via mineralocorticoid receptor, aldosterone is also involved in cell growth, inflammation, oxidative stress, endothelial dysfunction and exerts fibroproliferative effects. The aim of ...

Time to immunologic recovery and determinant factors among adults who initiated ART in Felege Hiwot Referral Hospital, northwest Ethiopia

Background CD4 cells are the major targets for human immunodeficiency virus (HIV) and treatment with Antiretroviral Therapy (ART) influences the CD4 cell count of HIV patients. In addition to ART, the time required to reach normal range of CD4 counts (500 cells/mm3) can be affected by clinical, socio-demographic, and behavioral factors. This retrospective cohort study was conducted ...

Reconstructing El Niño Southern Oscillation using data from ships’ logbooks, 1815–1854. Part II: Comparisons with existing ENSO reconstructions and implications for reconstructing ENSO diversity

A systematic comparison of El Niño Southern Oscillation reconstructions during the early to mid-nineteenth century is presented using a range of proxy and documentary sources. Reconstructions of the boreal winter Southern Oscillation Index (SOI) using data from ships’ logbooks presented in a companion paper are evaluated and compared to previous ENSO reconstructions. Comparisons ...

Development of a Novel Tool to Assess the Impact of Itching in Pediatric Cholestasis

Objectives The aim was to develop a clinical outcome assessment (COA) for itching in children with cholestatic pruritus. Methods This prospective study aimed to enroll patients aged 4–30 years with Alagille syndrome (ALGS) or progressive familial intrahepatic cholestasis type 1 and caregivers of patients aged 5 months to 14 years. Eligible patients experienced itching during ≥3 of ...

Conserved sequences of BART and BHRF regions encoding viral microRNAs in Epstein-Barr virus-associated lymphoma

Objective Epstein-Barr virus (EBV) encodes at least 25 pri-microRNAs (miRNAs) in two regions of its DNA genome, BART and BHRF. B95-8, an EBV reference strain, has a deletion in the BART region. However, no information is available on the deletions or mutations in the BART and BHRF regions in clinical samples of EBV-associated lymphoma. Results Nine DNA fragments encoding miR-BARTs ...

Substitutional Doping for Aluminosilicate Mineral and Superior Water Splitting Performance

Substitutional doping is a strategy in which atomic impurities are optionally added to a host material to promote its properties, while the geometric and electronic structure evolution of natural nanoclay mineral upon substitutional metal doping is still ambiguous. This paper first designed an efficient lanthanum (La) doping strategy for nanotubular clay (halloysite nanotube, HNT) ...

Current insights into the aetiology of adolescent idiopathic scoliosis

Scoliosis occurs in about 0.2–0.6% of the general population. In the majority of cases the cause of this entity remains mostly unidentified. The search for the causes covers almost all aspects of its possible origin. We collected and systematised the contemporary theories and concepts concerning the aetiology of adolescent idiopathic scoliosis. Genetic and hereditary factors are ...

Burden and associated factors of anemia among pregnant women attending antenatal care in southern Ethiopia: cross sectional study

Background Anemia is a condition in which the number of red blood cells or their oxygen-carrying capacity is insufficient to meet physiologic needs, which varies by age, sex, altitude, smoking, and pregnancy status. The study aim is to determine the prevalence and factors associated with anemia among pregnant women attending a hospital in southern Ethiopia using a structured ...

A novel Alzheimer’s disease drug candidate targeting inflammation and fatty acid metabolism

Background CAD-31 is an Alzheimer’s disease (AD) drug candidate that was selected on the basis of its ability to stimulate the replication of human embryonic stem cell-derived neural precursor cells as well as in APPswe/PS1ΔE9 AD mice. To move CAD-31 toward the clinic, experiments were undertaken to determine its neuroprotective and pharmacological properties, as well as to assay ...

Effects of additional team-based learning on students’ clinical reasoning skills: a pilot study

Background In the field of Neurology good clinical reasoning skills are essential for successful diagnosing and treatment. Team-based learning (TBL), an active learning and small group instructional strategy, is a promising method for fostering these skills. The aim of this pilot study was to examine the effects of a supplementary TBL-class on students’ clinical decision-making ...

A possible dual effect of cigarette smoking on the risk of postmenopausal breast cancer

Smoking seems modestly associated with breast cancer, but the potential dual effect of smoking (with opposing properties: carcinogenic vs anti-estrogenic) is understudied. The relationship between smoking before and after menopause and risk of postmenopausal breast cancer was investigated in the Netherlands Cohort Study (NLCS). In the NLCS, 62,573 women aged 55–69 years provided ...

NAP: The Network Analysis Profiler, a web tool for easier topological analysis and comparison of medium-scale biological networks

Objective Nowadays, due to the technological advances of high-throughput techniques, Systems Biology has seen a tremendous growth of data generation. With network analysis, looking at biological systems at a higher level in order to better understand a system, its topology and the relationships between its components is of a great importance. Gene expression, signal transduction, ...

The Enhanced Photo-Electrochemical Detection of Uric Acid on Au Nanoparticles Modified Glassy Carbon Electrode

In this work, a sensitive and novel method for determining uric acid (UA) has been developed, in which the glassy carbon electrode (GCE) was modified with electrodeposition Au nanoparticles and used to monitor the concentration of UA with the assistant of visible light illumination. The morphology of the Au nanoparticles deposited on GCE surface were characterized by scanning ...

Local buckling failure analysis of high-strength pipelines

Pipelines in geological disaster regions typically suffer the risk of local buckling failure because of slender structure and complex load. This paper is meant to reveal the local buckling behavior of buried pipelines with a large diameter and high strength, which are under different conditions, including pure bending and bending combined with internal pressure. Finite element ...

Identifying behavioural determinants for interventions to increase handwashing practices among primary school children in rural Burundi and urban Zimbabwe

Background This article presents the development of a school handwashing programme in two different sub-Saharan countries that applies the RANAS (risk, attitudes, norms, ability, and self-regulation) systematic approach to behaviour change. Methods Interviews were conducted with 669 children enrolled in 20 primary schools in Burundi and 524 children in 20 primary schools in ...

Interleukin-3 enhances the migration of human mesenchymal stem cells by regulating expression of CXCR4

Background Mesenchymal stem cells (MSCs) represent an important source for cell therapy in regenerative medicine. MSCs have shown promising results for repair of damaged tissues in various degenerative diseases in animal models and also in human clinical trials. However, little is known about the factors that could enhance the migration and tissue-specific engraftment of ...

A rule-based electronic phenotyping algorithm for detecting clinically relevant cardiovascular disease cases

Background The implementation of electronic medical records (EMR) is becoming increasingly common. Error and data loss reduction, patient-care efficiency increase, decision-making assistance and facilitation of event surveillance, are some of the many processes that EMRs help improve. In addition, they show a lot of promise in terms of data collection to facilitate observational ...

Single-molecule quantification of 5-hydroxymethylcytosine for diagnosis of blood and colon cancers

Background The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene regulation and expression. This epigenetic mark was recently reported as a potential biomarker for multiple types of cancer, but its application in the clinic is limited by the utility of recent 5hmC ...

Testing the effectiveness of two natural selection simulations in the context of a large-enrollment undergraduate laboratory class

Background Simulations can be an active and engaging way for students to learn about natural selection, and many have been developed, including both physical and virtual simulations. In this study we assessed the student experience of, and learning from, two natural selection simulations, one physical and one virtual, in a large enrollment introductory biology lab course. We ...

Association of lipocalin-2 level, glycemic status and obesity in type 2 diabetes mellitus

Background Management of type 2 diabetes mellitus aims to maintain a normal glycemic status, which if not, it may lead to acute and/or chronic diabetic complications. Earlier studies found Lipocalin-2 elevated in complications associated with type 2 diabetes mellitus such as ischemic heart disease. These lipocalin-2 changes had been linked to obesity and uncontrolled diabetes. So, ...

Exploration tree approach to estimate historical earthquakes Mw and depth, test cases from the French past seismicity

The estimation of the seismological parameters of historical earthquakes is a key step when performing seismic hazard assessment in moderate seismicity regions as France. We propose an original method to assess magnitude and depth of historical earthquakes using intensity data points. A flowchart based on an exploration tree (ET) approach allows to apply a consistent methodology to ...