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Tissue-engineered smooth muscle cell and endothelial progenitor cell bi-level cell sheets prevent progression of cardiac dysfunction, microvascular dysfunction, and interstitial fibrosis in a rodent model of type 1 diabetes-induced cardiomyopathy

Diabetes mellitus is a risk factor for coronary artery disease and diabetic cardiomyopathy, and adversely impacts outcomes following coronary artery bypass grafting. Current treatments focus on macro-revascularization and neglect the microvascular disease typical of diabetes mellitus-induced cardiomyopathy (DMCM). We hypothesized that engineered smooth muscle cell (SMC)-endothelial ...

A conceptual model of avalanche hazard

This conceptual model of avalanche hazard identifies the key components of avalanche hazard and structures them into a systematic, consistent workflow for hazard and risk assessments. The method is applicable to all types of avalanche forecasting operations, and the underlying principles can be applied at any scale in space or time. The concept of an avalanche problem is ...

National epidemiology of initial and recurrent Clostridium difficile infection in the Veterans Health Administration from 2003 to 2014

Introduction Prior studies demonstrated marked increases in Clostridium difficile infection (CDI) in the United States (U.S.) in recent years. The objective of this study was to describe the epidemiology of initial and recurrent CDI in a national Veterans Health Administration (VHA) cohort over a 12-year period. Methods This was a retrospective cohort study of all adult VHA ...

Meaningful learning in business through serious games

Purpose: The requirements of a business executive include the talent and creativity to solve problems and adapt to continuous changes presented by the economic and social environment. However, the university does not often prepare students in these skills. Businesses simulations are didactic tools in which participants assume a role and make decisions which affect the results of ...

Optimization of the prescription isodose line for Gamma Knife radiosurgery using the shot within shot technique

This work explores how the choice of prescription isodose line (IDL) affects the dose gradient, target coverage, and treatment time for Gamma Knife radiosurgery when a smaller shot is encompassed within a larger shot at the same stereotactic coordinates (shot within shot technique). Beam profiles for the 4, 8, and 16 mm collimator settings were extracted from the treatment planning ...

Circulating cell-free DNA and circulating tumor cells, the “liquid biopsies” in ovarian cancer

Limited understanding of ovarian cancer (OC) genome portrait has hindered the therapeutic advances. The serial monitoring of tumor genotypes is becoming increasingly attainable with circulating cell-free DNA (cf-DNA) and circulating tumor cells (CTCs) emerging as “liquid biopsies”. They represent non-invasive biomarkers and are viable, as they can be isolated from human plasma, ...

Disentangling the influence of living place and socioeconomic position on health services use among diabetes patients: A population-based study

This research investigates the influence of place of residence and diabetic patient’s socioeconomic position on their use of health services in a universal health care system. This retrospective cross-sectional population-based study is based on the joint use of the Health Insurance information systems, an ecological indicator of social deprivation and an indicator of potential ...

Height and body fatness and colorectal cancer risk: an update of the WCRF–AICR systematic review of published prospective studies

Purpose There is no published dose–response meta-analysis on the association between height and colorectal cancer risk (CRC) by sex and anatomical sub-site. We conducted a meta-analysis of prospective studies on the association between height and CRC risk with subgroup analysis and updated evidence on the association between body fatness and CRC risk. Methods PubMed and several ...

Biological substantiation of antipsychotic-associated pneumonia: Systematic literature review and computational analyses

Introduction Antipsychotic (AP) safety has been widely investigated. However, mechanisms underlying AP-associated pneumonia are not well-defined. Aim The aim of this study was to investigate the known mechanisms of AP-associated pneumonia through a systematic literature review, confirm these mechanisms using an independent data source on drug targets and attempt to identify novel ...

Additive Effects of 3,4-Methylenedioxymethamphetamine (MDMA) and Compassionate Imagery on Self-Compassion in Recreational Users of Ecstasy

3,4-Methylenedioxymethylamphetamine (MDMA;‘ecstasy’) produces prosocial subjective effects that may extend to affiliative feelings towards the self. Behavioural techniques can produce similar self-directed affiliation. For example, compassionate imagery (CI) and ecstasy reduce self-criticism and increase self-compassion to a similar extent, with the effects of CI enhanced in the ...

Reflections on the Strong Growth of Citizen Science: An Interview with Abe Miller-Rushing

Abe Miller-Rushing shares his thoughts on the growth of citizen science, which he thinks is driven by a happy set of coincidences—developments in technology, computing, communication, and data analysis; growing interest in STEM (science, technology, engineering, math) education; growing recognition that volunteers can contribute meaningfully to science (after more than 100 years of ...

Investigation of drying characteristics in superheated steam drying of UF-impregnated Chinese fir

Urea formaldehyde (UF) resin-impregnated Chinese fir (Cunninghamia lanceolata (Lamb.)Hook.) was dried at different temperatures in an atmospheric pressure superheated steam dryer. Drying characteristics, moisture content, drying rate, temperature profile, drying defects, and color change were investigated. The moisture content was reduced from 66.21 to 11.79% within 30 h without ...

Connexin 32 and connexin 43 are involved in lineage restriction of hepatic progenitor cells to hepatocytes

Background Bi-potential hepatic progenitor cells can give rise to both hepatocytes and cholangiocytes, which is the last phase and critical juncture in terms of sequentially hepatic lineage restriction from any kind of stem cells. If their differentiation can be controlled, it might access to functional hepatocytes to develop pharmaceutical and biotechnology industries as well as ...

SEOM clinical guidelines in gestational trophoblastic disease (2017)

Gestational trophoblastic disease (GTD) is a rare but curable disease. Recent improvements in diagnosis and molecular biology have resulted in changes in staging and treatment. These guidelines provide evidence-based recommendation on how to manage GTD.

Writing with the ‘Other’: Combining Poetry and Participation to Study Leaders with Disabilities

In this paper, we describe the process of transformative co-authorship between researchers and a participant with disabilities. The researchers were conducting a larger study that aimed to identify different factors that shaped individuals with disabilities to assume leadership roles. Drawing from interview data obtained from the participant, one researcher wrote a poem that ...

Comparison of laser and circumlimbal suture induced elevation of intraocular pressure in albino CD-1 mice

Animal models of ocular hypertension are important tools for glaucoma studies. Both acute transient models and chronic models of ocular hypertension may be useful to investigate specific aspects of neurodegeneration. In this study, we compare the intraocular pressure (IOP) and inner retinal changes induced by 1) laser photocoagulation of both episcleral veins and limbal vessels and ...

Doping für das Gehirn

Ebenso wie die Steigerung der körperlichen Leistungsfähigkeit stellt auch die mögliche Verbesserung neurokognitiver Fähigkeiten wie Konzentration, Aufmerksamkeit oder Gedächtnis eine interessante Option dar. Als pharmakologisches „neuroenhancement“ bezeichnet man den Ge- oder Missbrauch psychoaktiver, nicht verbotener oder verschreibungspflichtiger Substanzen durch Gesunde mit Ziel ...

Nonword repetition in adults who stutter: The effects of stimuli stress and auditory-orthographic cues

Purpose Adults who stutter (AWS) are less accurate in their immediate repetition of novel phonological sequences compared to adults who do not stutter (AWNS). The present study examined whether manipulation of the following two aspects of traditional nonword repetition tasks unmask distinct weaknesses in phonological working memory in AWS: (1) presentation of stimuli with ...